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| 1 | Systematic review of noninvasive treatments to arrest dentin non-cavitated caries lesions显示文摘AIM: To systematically review the literature on the efficacy of noninvasive methods of arresting the progression of non-cavitated occlusal carious lesions in dentin.METHODS: The Medline/Pub Med,LILACS,Sci ELO and Scopus databases were searched to identify relevant publications through to November 2013.Only clinical trials evaluating the ability of noninvasive methods to arrest the progression of occlusal non-cavitated carious lesions in dentin were included.Screening,data extraction and quality assessment were conducted independently and in duplicate.RESULTS: Of 167 citations identified,nine full text articles were screened and five were included in the analysis.All papers reported on occlusal fissure sealing using a self-curing glass ionomer(n = 1) or resin-based(n = 4) sealant.Only the use of resin-based sealant to obliterate occlusal fissures arrested the progression of non-cavitated occlusal carious lesions in dentin.CONCLUSION: Occlusal fissure sealing with a resin-based sealant may arrest the progression of non-cavitated occlusal dentinal caries.Further clinical trials with longer follow-up times should be performed to increase scientific evidence. | Isauremi Vieira de Assun??o Giovanna de Fátima Alves da Costa Boniek Castillo Dutra Borges | 2014 | World Journal of Clinical Cases2014，2，5： | 3 |
| 2 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 3 | An Assessment of Ad- vanced Mobile Services Acceptance: Contributions from TAM and Diffusion Theory Models 显示文摘 | Nicolas C L Castillo F J M Bouwman H | 2008 | Information & Management2008，45，6： | 1 |
| 4 | Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 30562, endophytic on Kennedia nigriscans 显示文摘 | Castillo U F Strobel G A Ford E J | 2002 | Microbiology2002，148，9： | 1 |
| 5 | Munumbicins, wide spectrum antibiotics produced by Streptomyces endophytic on Kennedia nigriscans显示文摘 | CASTILLO U F STROBEL G A FORD E J | 2002 | Microbiology2002，148，： | 1 |
| 6 | Neonatal chylothorax: aetinlogy, clini-cal course and efficacy of treatment显示文摘 | Capons Fernandez C Benifez Segura I Castillo Salinas F Salcedo Ahizanda S | 2008 | An Pediatr (Barc)2008，68，3： | 1 |
| 7 | Interactive effects of ozone and drought stress on pigments and activities of antioxidantive enzymes in Pinus halepensis 显示文摘 | Alonso R Elvira S Castillo F J | 2001 | Plant Cell Environ2001，24，： | 1 |
| 8 | Impact of hypercalcemia and parathyroid hormone level on the sensitivity of preoperative sestamibi scanning for primary hyperparathyroidism显示文摘 | Parikshak M Castillo E D Conrad M F | 2003 | Am Surg2003，69，5： | 1 |
| 9 | Munumbicins,Wide-spectrum Antibiotics Produced by Streptomyces NRRL 30562,Endophyfic on Kennedia nigfiscans显示文摘 | CASTILLO U F STROBEL G A FORD EJ | 2002 | Microbiology2002，148，： | 1 |
| 10 | Generalized anxiety after stroke显示文摘 | Castillo C S Strarkstein S E Fedorof F | 1993 | J Nerv Ment Dis1993，181，2： | 1 |
| 11 | Film Formation by Col- loidal Overbased Detergents in Lubricated Contacts显示文摘 | F Chinas - Castillo H A Spikes | 2000 | Tribology Transactions2000，43，3： | 1 |
| 12 | Advances in the recovering of spent lithium battery compounds 显示文摘 | CASTILLO S ANSART F LABERTY-ROBERT C | 2002 | J Power Source2002，112，1： | 1 |
| 13 | Query reformulation mining: Models, patterns, and applications 显示文摘 | Boldi B Bonchi F Castillo C | 2011 | Information Retrieval2011，14，3： | 1 |
| 14 | Use and refuse of nasal CPAP in obstructive sleep apneas/hypopneas显示文摘 | Castillo JL Araya F Bustamante G | | 0，，12： | 1 |
| 15 | Geochemistry of late Paleo- zoic mafic igneous rocks from the kuerti area,Xinjiang,northwest China;Impplications for back arc mantle evolution显示文摘 | Xu J F Castillo P R Chen F R | 2002 | Chemical Ge- ology2002，193，12： | 1 |
| 16 | Cost- t of ventilator- associated pneumonia with linezolid or vancomycin in Spain显示文摘 | Grau S Alvarez-Lerma F del Castillo effectiveness analysis of the treatmen A | 2005 | J Chemother2005，17，2： | 1 |
| 17 | Efficacy of 1-MCP Treatment in Tomato Fruit显示文摘 | GUILLEN F CASTILLO S ZAPATA P J | 2007 | Postharvest Biology and Technology2007，43，： | 1 |
| 18 | Enantiomeric purity of ( +/- )-Methyl Jasmonate in fresh leaf samples and commercial fragrances 显示文摘 | Castillo M L R D Blanch F P | 2007 | Journal of Separation Sci- ence2007，30，13： | 1 |
| 19 | On the functional form of the speed-density relationship - I : general theory显示文摘 | DEL CASTILLO J M BENITEZ F G | 1995 | Transportation Research B1995，29，5： | 1 |
| 20 | Impact of hypercalcemia and parathyroid hormone level on the sensitivity of preoperative sestamibi scanning for primary hyperparathyroidism显示文摘 | Parikshak M Castillo E D Conrad M F | 2003 | Am Surg2003，69，5： | 1 |
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