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| 1 | No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk显示文摘AIM:To investigate the association of variations in the cyclooxygenase-2(COX2) and uridine diphosphate glucuronosyltransferase 1A6(UGT1A6) genes and non-steroidal anti-inflammatory drugs(NSAIDs) use with risk of colon cancer.METHODS:NSAIDs,which are known to reduce the risk of colon cancer,act directly on COX2 and reduce its activity.Epidemiological studies have associated variations in the COX2 gene with colon cancer risk,but others were unable to replicate this finding.Similarly,enzymes in the UGT1A6 gene have been demonstrated to modify the therapeutic effect of NSAIDs on colon adenomas.Polymorphisms in the UGT1A6 gene have been statistically shown to interact with NSAID intake to influence risk of developing colon adenomas,but not colon cancer.Here we examined the association of tagging single nucleotide polymorphisms(SNPs) in the COX2 and UGT1A6 genes,and their interaction with NSAID consumption,on risk of colon cancer in a population of 422 colon cancer cases and 481 population controls.RESULTS:No SNP in either gene was individually statistically significantly associated with colon cancer,nor did they statistically significantly change the protective effect of NSAID consumption in our sample.Like others,we were unable to replicate the association of variants in the COX2 gene with colon cancer risk(P > 0.05),and we did not observe that these variants modify the protective effect of NSAIDs(P > 0.05).We were able to confirm the lack of association of variants in UGT1A6 with colon cancer risk,although further studies will have to be conducted to confirm the association of these variants with colon adenomas.CONCLUSION:Our study does not support a role of COX2 and UGT1A6 genetic variations in the development of colon cancer. | Cheryl L Thompson Sarah J Plummer Alona Merkulova Iona Cheng Thomas C Tucker Graham Casey Li Li | 2009 | World Journal of Gastroenterology2009，15，18： | 11 |
| 2 | 2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines显示文摘 | Mariell Jessup William T. Abraham Donald E. Casey Arthur M. Feldman Gary S. Francis Theodore G. Ganiats Marvin A. Konstam Donna M. Mancini Peter S. Rahko Marc A. Silver Lynne Warner Stevenson Clyde W. Yancy Sharon Ann Hunt William T. Abraham Marshall H. C | 2009 | Circulation2009，，14： | 2 |
| 3 | Benign central neurocytoma显示文摘 | Ashkan K Casey AT D'Arrigo C | 2009 | Cancer2009，89，5： | 1 |
| 4 | Sediment and nutrient accumulation in floodplain and depressional freshwater wetlands of Georgia, USA显示文摘 | Craft C B and Casey W P | 2000 | Wetlands2000，20，2： | 1 |
| 5 | Gills:Cemented heminarthroplasties for elderypatients with intertrochanteric fractures显示文摘 | Casey K Gurden C | 2000 | Clin Orthop2000，317，2： | 1 |
| 6 | Inducible Nitric Oxide Synthase Gene Expression in Vascular Cells after Transient Focal Cerebral Ischemia 显示文摘 | Zhang F Casey R | 1996 | Stroke1996，27，3： | 1 |
| 7 | Endothelin-1 gene expression and biosynthesis in human endometrial HEC-IA cancer cells 显示文摘 | Economos K Macdonald P C Casey M L | 1992 | Caner Res1992，52，3： | 1 |
| 8 | Benign central neurocytoma显示文摘 | Ashkan K Casey AT D'Arrigo C | 2000 | Cancer2000，89，5： | 1 |
| 9 | Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene显示文摘 | IADECOLA C ZHANG F CASEY R | 1997 | Neuroscience1997，17，23： | 1 |
| 10 | High gravity brewing: nutrient enhanced production of high concentrations of ethanol by brewing yeast显示文摘 | CASEY G P MAGNUS C A INGLEDEW W M | 1983 | Biotechnol Lett1983，5，6： | 1 |
| 11 | Crack detection in a rotor dynamic system by vibration monitoring Part I :analysis显示文摘 | Green I Casey C | 2005 | Journal of Engineering for Gas Turbines and Power2005，127，2： | 1 |
| 12 | Symptom management in gynecologic malignancies显示文摘 | Casey C Chen L M Rabow M W | 2011 | Expert Rev Anticancer Ther2011，11，7： | 1 |
| 13 | A hypothesis for the causes and control of anoxic-aerobic (AA) filament hulking in nutrient removal activated sludge systems 显示文摘 | Casey T G Wentzel M C Ekama G A Loewenthal R E | 1994 | Water Science and Technology1994，29，7： | 1 |
| 14 | Clinical significance of betero- topic ossification in cervical disc replacement: a prospective mul- ticenter clinical trial显示文摘 | Leung C Casey AT Coffin J | 2005 | Neurosurgery2005，57，4： | 1 |
| 15 | Posterior reversible encephalopathy syndrome: utility of fluid-atten- uated inversion recovery MR imaging in the detection of cortical and subcortical lesions 显示文摘 | CASEY S O SAMPAIO R C MICHEL E | 2000 | Am J Neuroradiol2000，21，7： | 1 |
| 16 | Peroxisome proliferator-activated receptor-gamma induces regression of endometrial explants in a rat model of endometriosis 显示文摘 | Lebovic D Kir M Casey C | 2004 | Fertil Steril2004，82，3： | 1 |
| 17 | Five-strain probiotie combi- nation reduces pathogen shedding and alleviates disease signs in pigs ehallenged with salmonella enteriea serovar typhimurium显示文摘 | Casey P G Gardiner C E Casey C A | 2007 | Appl Environ Microhiol2007，73，6： | 1 |
| 18 | Familial vasopressin-sensitiveACTH-independent macronodular adrenal hyperplasia(VPs-AIMAH):clinical studies of three kindreds显示文摘 | Gagliardi L Hotu C Casey G | 2009 | Clin Endocrinol(Oxf)2009，70，6： | 1 |
| 19 | Tau protectsagainst PMN dysfunction and death in urine显示文摘 | Condron C M Toomey D M Casey R G | 2004 | Urol Res2004，32，5： | 1 |
| 20 | Inducible nitric oxidesynthase gene expression in vascular cells after transient focalcerebral ischemia显示文摘 | Iadecola C Zhang F Casey R | 1996 | Stroke1996，27，： | 1 |
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