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| 1 | Hypertension and renal disease显示文摘The relationship between chronic kidney disease(CKD)and hypertension remains enigmatic and a matter of considerable clinical and academic interest with evidence indicating that hypertension is both a cause and a consequence of kidney disease[1-2]. | Huang Chunfa Louis Stokes Cleveland Veteran Affairs Medical Center Division of Nephrology,Departments of Medicine,Case Western Reserve University and Rammelkamp Center for Research and Education,MetroHealth System Campus,Cleveland,Ohio 441061 | 2011 | 中华高血压杂志2011，19，12： | 23 |
| 2 | Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apc^(min) mice显示文摘AIM:To investigate whether Recql5,a DNA helicase that plays an important role in the maintenance of genome integrity,is a tumor suppressor in the gastrointestinal tract in mice.METHODS:We generated cohorts of both Recql5-proficient and Recql5-deficient Apcmin/+mice and compared the tumor susceptibility in their gastrointestinal tracts.RESULTS:Recql5 deficiency in Apcmin/+mice resulted in a significant increase in the tumor incidence in both the colon(P=0.0162)and the small intestine(P<0.01).These findings have provided the first genetic evidence for a tumor suppression role of Recql5 in the gastrointestinal tract of mice.Importantly,since mouse Recql5 and human RECQL5 are highly conserved,these findings also suggest that RECQL5 may be a tu-mor suppressor for human colon cancer.CONCLUSION:Recql5 has a tumor suppression role in the mouse gastrointestinal tract. | Yiduo Hu,Xincheng Lu,Guangbin Luo,Department of Genetics,Case Comprehensive Cancer Center and University Hospitals of Cleveland,Case Western Reserve University,Cleveland,OH 44106,United States Yiduo Hu,Department of Cancer Biology,Dana-Farber Cancer Institute,Boston,MA 02115,United States | 2010 | World Journal of Gastroenterology2010，16，12： | 6 |
| 3 | Conducting health policy analysis in primary care research: turning clinical ideas into action显示文摘Healthcare guidelines play a prominent role in the daytoday practice of primary care providers,and health policy research leads to the formation of these guidelines.Health policy research is the multidisciplinary approach to public policy explaining the interaction between health institutions,special interests and theoretical constructs.In this article,we demonstrate how primary care providers can conduct high-impact health policy research using Eugene Bardach’s eightfold policy analysis framework in a primary care context.In a medical case,a woman with a history of total hysterectomy had scheduled a visit for a Papanicolaou(Pap)smear screening test as part of a well-woman health check-up with a family medicine resident.Conflicting recommendations on Pap smear screening after total hysterectomy sparked an investigation using the US Preventive Services Task Force criteria for conducting a health policy analysis.We illustrate broadly how clinical care dilemmas can be examined by using Bardach’s broadly applicable health policy framework in order to inform meaningful policy change.Bardach’s framework includes(1)defining the problem,(2)assembling evidence,(3)constructing alternatives,(4)selecting criteria,(5)projecting outcomes,(6)confronting trade-offs,(7)decision-making and(8)sharing the results of the process.The policy analysis demonstrated insufficient evidence to recommend Pap test screening after hysterectomy and the findings contributed to national recommendations.By following Bardach’s steps,primary care researchers have a feasible and powerful tool for conducting meaningful health policy research and analysis that can influence clinical practice. | Alina Engelman Ben Case Lisa Meeks Michael D Fetters | 2019 | Family Medicine and Community Health2019，7，2： | 6 |
| 4 | Variation in the methods leads to variation in the interpretation of biodiversity-ecosystem multifunctionality relationships显示文摘生物多样性常常和生态系统多功能性(生态系统同时提供多个生态系统功能的能力)正相关。然而,生物多样性与生态系统多功能性的关系是否依赖于生态系统功能的数目有诸多争议。其中,生物多样性对生态系统多功能性的影响或许不随生态系统功能数目的变化而变化,或者随生态系统功能数目的增多而增强。我们期望通过研究不同生态系统多功能性指数的统计原理来解决这些争议。我们使用了模型模拟和一系列来自不同空间尺度(从局域到全球)和不同生物群系(温带和高寒草地、森林和干旱地)的经验数据。我们回顾了量化生态系统多功能性的三种方法,包括平均值法、加和法和阈值法。我们发现随着生态系统功能数目的增加,生物多样性与生态系统多功能性的关系要么不变,要么增强。这些结果可由平均和加和的多功能性指数的统计原理来解释。具体来讲,当利用生态系统功能的平均值计算多功能性指数时,由于多样性对多功能性的效应等于多样性对单个生态系统功能效应的平均值,所以不会随生态系统功能数目的变化而变化。同样的道理,当利用单个生态系统的加和值计算多功能性指数时,多样性的效应会随着生态系统功能数目的增加而增强。我们提出了一个改进的多功能性指数,将平均或加和多功能性指数转化为标准化的多功能性指数,以便于对不同研究的结果进行比较。此外,我们提出了基于变量数值范围的标准化方法来解决阈值法的数学假象问题(多样性效应随生态系统功能数目的增加而增强)。我们的研究结果表明,量化多功能性指数的方法不同,结果也不同。因此,有必要加深对不同方法数理基础的理解。而标准化的多功能性指数为比较不同研究中的生物多样性与生态系统多功能性的关系提供了有效的方法。 | Xin Jing Case M.Prager Aimée T.Classen Fernando T.Maestre Jin-Sheng He Nathan J.Sanders | 2020 | Journal of Plant Ecology2020，13，4： | 5 |
| 5 | “漂绿”环保六宗罪显示文摘有关公司环保报道造假被称作'漂绿'。面对越来越多的'漂绿'行为,北美一些国家的政府和标准制定组织,已经开始尝试对这一行为予以治理。 | Scot Case 张凌宁 | 2010 | WTO经济导刊2010，，2： | 3 |
| 6 | A study of loculated tuberculous pleural effusions treated with intrapleural urokinase显示文摘 | Enrique Cases Viedma María José Lorenzo Dus Andrés González-Molina José Luis Sanchis Aldás | 2006 | Respiratory Medicine2006，，11： | 2 |
| 7 | No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer显示文摘AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based casecontrol study of incident colon cancer individuals (n= 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene. | Lynette S Phillips Cheryl L Thompson Alona Merkulova Sarah J Plummer Thomas C Tucker Graham Case Li Li | 2009 | World Journal of Gastroenterology2009，15，30： | 2 |
| 8 | SAMMIE:A Computer-aided Ergonomics Design System显示文摘 | Case K Porter J M | 1980 | Engineering1980，220，： | 2 |
| 9 | An infertile male with dilated seminal vesicles due to functional obstruction显示文摘 | Michael D Font Alexander W Pastuszak John R Case Larry I Lipshult | 2017 | Asian Journal of Andrology2017，19，2： | 2 |
| 10 | 对于荡秋千的动力学分析显示文摘 | Case,WB 武菁 | 1991 | 数理译丛1991，，1： | 2 |
| 11 | Pragmatic and grammatical competence, length of residence, and overall L2 proficiency显示文摘 | Wei Xu Rod E. Case Yu Wang | 2009 | System2009，，2： | 2 |
| 12 | Defining the nature of human pluripotent stem cell progeny显示文摘当人的 pluripotent 干细胞(hPSCs ) 能区分产生各种各样的房间类型的一件礼服,是清楚的时,在 vitro,开发怎么仔细反射那,是未知的哪个发生在 vivo。决定人的胚胎的干细胞(hESCs ) 和导致人的 pluripotent 干细胞(hiPSCs ) 是否做相等的子孙,并且是否也使房间成为那类似于导出织物的房间,我们执行了净化的 PSC 衍生物和他们的导出织物的对应物介绍的全面 transcriptome。表示介绍证明 hESCs 和 hiPSCs 在 hiPSC 子孙用外长的 reprogramming 因素为重新表示的神经、肝、间充质的系,和缺席做将近相同的子孙。不管多么与一个导出织物的对应物相比, hESCs 和 hiPSCs 的子孙维持了通常与早哺乳动物的开发联系的基因的一个子集的表示,不管产生的房间的类型。当 pluripotent 基因(OCT4, SOX2, REX1,和 NANOG ) 看起来在从 hPSCs 的区别之上立即是 silenced 时,对早胚胎(LIN28A, LIN28B, DPPA4,和其它) 通常独特的基因不是充分在 hPSC 衍生物的 silenced。从在早人的胎儿的织物(开发的 3-16 星期) 的表达式模式的这些数据和证据建议 hPSCs 的区分的子孙很早人的开发是反射的(< 6 个星期) 。这些调查结果为 hPSCs 能在早人的开发的 vitro 模型作为有用服务的想法提供支持,而且为疾病建模和 hPSC 衍生物的临床的申请提出重要问题。 | Michaela Patterson David N Chan IrisHa Dana Case Yongyan Cui Ben Van Hande Hanna KA Mikkola William E Lowry | 2012 | Cell Research2012，22，1： | 2 |
| 13 | A framework to integrate design knowledge reuse and requirements management in engineering design显示文摘 | BAXTER D GAO J CASE K | 2008 | Robotics and Computer-lntegrated Manufacturing2008，24，4： | 1 |
| 14 | Histories of polymer drag reduction in crude oil line显示文摘 | Prilutski F Case D J | 1998 | Pipe Line Industry1998，，6： | 1 |
| 15 | The patient with rhabdomyolysis: Have you considered quail poisoning? 显示文摘 | Teaching case report | 2004 | JAMC2004，171，4： | 1 |
| 16 | Hypertension and Risk of Brain Metastasis from Small Cell Lung Cancer: A Retrospective Follow-up Study 显示文摘 | Sahmoun AE Case LD Chavour S | 2004 | Anticancer Res2004，24，5： | 1 |
| 17 | The International Registry of Lung Metastases显示文摘 | Long-term results of lung metastasectomy : prognostic analyses based on 5206 cases | 1997 | J Thorac Cardiovasc Surg1997，113，1： | 1 |
| 18 | Cemented hemiarthroplasties for elderly patients with intertroehanteric fractures显示文摘 | Cases CK Gill GS | 2000 | Clin Orthop2000，2，： | 1 |
| 19 | Biochemical characterization of the mammalian Cux2 protein显示文摘 | Gingras H Cases O Krasilnikova M | 2005 | Gene2005，344，1： | 1 |
| 20 | Density functional calculations of proton chemical shifts in model peptides 显示文摘 | Sitkoff D Case D A | 1997 | J Am Chem Soc1997，119，12： | 1 |
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