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| 1 | Metabolite profile comparisons between ascending and descending colon tissue in healthy adults显示文摘BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese adults.AIM To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk.METHODS Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite profiles.The colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal cancer.RESULTS Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass index.Amino acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite profiles.Normal weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending colon.Primary and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese adults.CONCLUSION There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy adults.Colon lipids and other metabolites in obese and overweight adults were distinguished from normal weight participants and associated with gut inflammation,nutrient absorption,and products of microbiota metabolism. | Bridget A Baxter Kristopher D Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan | 2020 | World Journal of Gastroenterology2020，26，3： | 2 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | A framework to integrate design knowledge reuse and requirements management in engineering design显示文摘 | BAXTER D GAO J CASE K | 2008 | Robotics and Computer-lntegrated Manufacturing2008，24，4： | 1 |
| 4 | Production of IGF-I and its bindingprotein by breeding cow hepatocytes in primary culture显示文摘 | STICK C D MARTIN J L BAXTER R C | 1998 | Endocrinology1998，163，： | 1 |
| 5 | Wettability of porous surfaces 显示文摘 | Cassie A B D Baxter S | 1944 | Transactions of the Faraday Society1944，40，： | 1 |
| 6 | Wettability of porous surface 显示文摘 | CASSIE A B D BAXTER S | 1944 | Transactions of the Faraday Society1944，40，： | 1 |
| 7 | Frequency selectivity, multistability, and oscillations emerge from models ofgenetic regulatory systems显示文摘 | SMOLEN P BAXTER D A BYRNE J H | 1998 | Amer J Phys1998，274，： | 1 |
| 8 | Wettability of porous surfaces显示文摘 | CASSIE A B D BAXTER S | 1944 | Transactions of the Faraday Society1944，40，： | 1 |
| 9 | Comparison of Field Performance of a High Efficiency Heat Pump with and without a Desuperheater Water Heater显示文摘 | V D Baxter E E | 1984 | ASHRAE Trans1984，，2： | 1 |
| 10 | Abdominal aortic aneurysms are associated with altered matrix proteins of the nonaneurysmal aortic segments显示文摘 | BAXTER B T DAVIS V A Minion D J | 1994 | J Vasc Surg1994，19，： | 1 |
| 11 | Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury-evidence for a role of KATP channels显示文摘 | Johansen D Ytrehus K Baxter G F | 2006 | Basic Res Cardiol2006，101，1： | 1 |
| 12 | Laser spark emission spectroscopy for in-situ,realtime monitoring of pulverized coal particle composition显示文摘 | Ottesen D K Baxter L L Radziemski L J | | 0，，02： | 1 |
| 13 | Wettability of porous surfaces显示文摘 | Cassie A B D Baxter S | | 0，，05： | 1 |
| 14 | Wettability of porous surfaces显示文摘 | Cassie A B D Baxter S | | 0，，： | 1 |
| 15 | Exogenous hydrogen sulfide (H2S) protects against regional myocardial ischemia-reperfusion injury--Evidence for a role of K ATP channels显示文摘 | Johansen D Ytrehus K Baxter GF | 2006 | Basic Res Cardiol2006，101，1： | 1 |
| 16 | Mathematical modeling of gene networks review显示文摘 | Smolen P Baxter D A Byme J H | 2000 | Neuron2000，26，： | 1 |
| 17 | Phytase, high - available - phosphorus corn, and storage effects on phosphorus levels in pig excreta显示文摘 | Baxter C A Joern B C Ragland D | 2003 | J Environ Qual2003，32，： | 1 |
| 18 | Impaired acquisition of spatial memory 2 weeks after isoflurane and isoflurane-nitrous oxide anesthesia in aged rats 显示文摘 | Culley D J Baxter M G Croshy C A | 2004 | Anesth Analg2004，99，5： | 1 |
| 19 | Performance of a groundcoupled heat pump with multiple dissimilar U-tube colls in series显示文摘 | MEI V C BAXTER V D | 1986 | ASHRAE Transactions1986，92，2： | 1 |
| 20 | Stratification in poured granular heaps显示文摘 | Baxter J Tuzun U Heyes D | 1998 | Nature1998，391，8： | 1 |
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