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| 1 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 2 | Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings显示文摘 | Adler D D Carson P L Rubin J M | 1990 | Ultrasound MedBiol1990，16，6： | 1 |
| 3 | Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinasdmTOR inhibitor显示文摘 | Van Aller G S Carson J D Tang W | 2011 | Biochem Biophys Res Cornmun2011，406，2： | 1 |
| 4 | Heparan sulfate pro- teoglyeans and their binding proteins in embryo implantation and plaeentation显示文摘 | Kirn-Safran CB D'souza SS Carson DD | 2008 | Semin Cell Dev Biol2008，19，2： | 1 |
| 5 | Control-pollinated seed orchards of best general combiners - a new strategy for radiata pine improvement显示文摘 | Carson S D | 1986 | Agronomy Society of New Zealand1986，5，： | 1 |
| 6 | Drought stress and tropical for-est woody seedlings:Effect on community structure and composi-tion显示文摘 | BUNKER D E CARSON W P | 2005 | Journal of Ecology2005，93，4： | 1 |
| 7 | Doppler ultrasound flow imaging in the study of breast cancer:Preliminary findings显示文摘 | Alder D D Carson P L Rubin J M | 1990 | UItrasound Med Biol1990，16，6： | 1 |
| 8 | Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings显示文摘 | Alder D D Carson P L Rubin J M | 1990 | Ultrasound Med boi11990，16，4： | 1 |
| 9 | Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings 显示文摘 | ADLER D D CARSON P L RUBIN J M | 1990 | Utrasound Med Biol1990，16，： | 1 |
| 10 | Genetic variation in the alpha 7 nicotinic acetylcholine receptor is associated with delusional symptoms in Alzheimer's disease显示文摘 | Carson R Craig D Hart D | 2008 | Neuromolecular Med2008，10，4： | 1 |
| 11 | Doppler ultrasound flowimaging in the study of breast cancer:preliminary findings显示文摘 | Adler D D Carson P L Rubin J M | | 0，，06： | 1 |
| 12 | An industry performance analyzer for tourism (IPA): The internet and re- search collaboration in a diverse industry in Australia's capital territory显示文摘 | Carson D Richards F | 2007 | The Journal of Cas- es on Information Technology2007，9，1： | 1 |
| 13 | The glycobiology of implantation显示文摘 | Carson D D | 2002 | Front Biosci2002，7，： | 1 |
| 14 | Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter显示文摘 | Guzman LM Belin D Carson M J | 1995 | Journal of Bacteriology1995，177，14： | 1 |
| 15 | An analysis of the influenee of material structure on the effeetive thermal eonduetivity of porous materials using finite element simulations 显示文摘 | Carson J K Lovatt S J Tanner D J | 2003 | Int J Refrigeration2003，26，： | 1 |
| 16 | Sustaining four wheel drive tourism in desert Australia: Exploring the evi- deuce from a demand perspective显示文摘 | Carson D Taylor A | 2008 | Tbe Rangeland Journal2008，30，1： | 1 |
| 17 | Apoptosis and disease显示文摘 | Carson D J M Ribeiro | 1993 | Lancet1993，341，： | 1 |
| 18 | Electrolyte concentration differences between left and right vitreous humor samples显示文摘 | Pounder D J Carson D O Johnston K | 1998 | J Forensic Sci1998，43，3： | 1 |
| 19 | Inhibition of HER-kinase activation prevents ERK-mediated degradation of PPARgamma 显示文摘 | Hedvat M Jain A Carson D A st al | 2004 | Cancer Cell2004，5，6： | 1 |
| 20 | Intravenoustherapy: Are - view of complications and economic considerations of peripheral access显示文摘 | Dyehter SS Gold DA Carson D | 2012 | J Infus Nurs2012，35，2： | 1 |
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