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| 1 | Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate显示文摘Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive cell lineage specification and differentiation steps. Here we show that Isl1 acts as a pioneer factor driving cardiomyocyte lineage commitment by shaping the chromatin landscape of cardiac progenitor cells. Using an Isl1 hypomorphic mouse line which shows congenital heart defects, genome-wide profiling of Isl1 binding together with RNA- and ATAC-sequencing of cardiac progenitor cells and their derivatives, we uncover a regulatory network downstream of Isl1 that orchestrates cardiogenesis. Mechanistically, we show that Isl1 binds to compacted chromatin and works in concert with the Brg1-Baf60c-based SWI/SNF complex to promote permissive cardiac lineage-specific alterations in the chromatin landscape not only of genes with critical functions in cardiac progenitor cells, but also of cardiomyocyte structural genes that are highly expressed when Isl1 itself is no longer present. Thus, the Isl1/Brg1-Baf60c complex plays a crucial role in orchestrating proper cardiogenesis and in establishing epigenetic memory of cardiomyocyte fate commitment. | Rui Gao Xingqun Liang Sirisha Cheedipudi Julio Cordero Xue Jiang Qingquan Zhang Luca Caputo Stefan Günther Carsten Kuenne Yonggang Ren Shoumo Bhattacharya Xuejun Yuan Guillermo Barreto Yihan Chen Thomas Braun Sylvia M. Evans Yunfu Sun Gergana Dobreva | 2019 | Cell Research2019，29，6： | 5 |
| 2 | Efficacy and tolerability of vinorelbine in the cancer therapy 显示文摘 | Galano G Caputo M Tecce M F | 2011 | Curr Drug Sq[2011，6，3： | 1 |
| 3 | Recent technical advances in polypropylene显示文摘 | MEI G BECCARINI E CAPUTO T | 2009 | Journal of Plastic Film and Sheeting2009，25，2： | 1 |
| 4 | Pilot scale micronization of amoxicillin by supercritical antisolvent precipitation 显示文摘 | REVERCHON E DE MARCO I CAPUTO G | 2003 | J Supercrit Fluids2003，26，1： | 1 |
| 5 | Safety and feasibility of robotic percutaneous coronary intervention PRECISE(Percutaneous Robotically-Enhanced Coronary Intervention) study显示文摘 | Weisz G Metzger D Caputo R | | 0，，15： | 1 |
| 6 | Loss of efficacy during long-term irffliximab therapy for sight-threatening childhood uveitis 显示文摘 | Simonini G Zannin ME Caputo R Falcini F de Martino M Zu- lian F | 2008 | Rheumatology ( Ox- ford)2008，47，10： | 1 |
| 7 | Combined targeted inhibition of bcl-2,bcl-xl,epidermal growth factor receptor and protein kinase a type Ⅰ cause potent antitumor,apoptotic and antiangiogenci activity显示文摘 | Caputo R Damiano V | 2003 | Clin Cancer Res2003，9，2： | 1 |
| 8 | Tissue plasminogen acti- vator, tissue plasminogen activator inhibitor and lipoprotein(a) in patients with coronary,epinortic and peripheral occlusive artery disease显示文摘 | Caputo M Mantini G Floriani I | 1996 | Eur Heart J1996，17，9： | 1 |
| 9 | Analysis of Heat Recovery in Gas-Solid Moving Beds Using a Simulation Ap- proach显示文摘 | Caputo A C Cardarelli G Pelagagge P M | 1996 | Applied Thermal Engineering1996，16，1： | 1 |
| 10 | Doxombicin with cyclophosphamide followed by docetaxel every 21 days compared with doxombicin and docetaxel every 14 days as preoperative treatment in operable breast cancer: the GEPARDUO study of the German Breast Group显示文摘 | von Minckwitz G Raab G Caputo A | 2005 | J Clin Oncol2005，23，12： | 1 |
| 11 | Optimization Cri- teria of Heat Recovery From Solid Beds显示文摘 | Pelagagge P M Caputo A C Cardarelli G | 1997 | Applied Thermal Engineering1997，17，1： | 1 |
| 12 | Resistance to taxanes is induced by c-erbB-2 overexpression in human MCF-10A mammary epithelial cells and is blocked by combined treatment with an antisense oligonueleotide targeting type I protein kinase A 显示文摘 | Ciardiello F Caputo R Pomatico G | 2000 | Int J Cancer2000，85，5： | 1 |
| 13 | Comparing Heat Recovery Schemes in Solid Beds Cooling显示文摘 | Pelagagge P M Caputo A C Cardarelli G | 1997 | Applied Ther- mal Engineering1997，17，11： | 1 |
| 14 | Prevention of flare recurrences in childhood-refrac- tory chronic uveit is:an open-label comparative study of adali- mumab versus infliximab 显示文摘 | Simonini G Taddio A Cattalini M Caputo R De Libero C Nav- iglio S | 2011 | Arthritis CareRes ( Hoboken )2011，63，4： | 1 |
| 15 | Screening, evaluation and man-agement of depression in people with diabetes in primary care显示文摘 | Hermanns N Caputo S Dzida G | 2013 | Prim Care Diabetes2013，7，1： | 1 |
| 16 | Tissue plasminogen activator,tissue plasminogen activator inhibitor and lipoprotein(a) in patients with coronary,epiaortic and peripheral occlusive artery disease显示文摘 | Caputo M Mantini G Floriani I | 1996 | Eur Heart J1996，17，9： | 1 |
| 17 | Experimental study of two phase separation in the Bunsen section of the sulfur-iodine thermochemical cycle 显示文摘 | Giaconia A Caputo G Ceroli A | 2007 | International Journal of Hydrogen Energy2007，32，5： | 1 |
| 18 | Recent technical advances in polypropylene显示文摘 | Mei G Beccarini E Caputo T | 2009 | Journal of Plastic Film and Sheeting2009，25，2： | 1 |
| 19 | Surgical strategy in primary restropenitoneal tumors显示文摘 | Scrio G Savarino V Caputo E | 1989 | Br J Surg1989，76，： | 1 |
| 20 | Antimicrobial and healing activity of kefir and kefiran extract显示文摘 | RODRIGUES K L CAPUTO L R G CARVALHO J C T | 2005 | International Journal of Antimicrobial Agents2005，25，5： | 1 |
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