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| 1 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 2 | Percutaneous fixation of displaced proximal humeral fractures: Indications based on the correlation between clinical and radiographic results显示文摘 | Emilio Calvo Ignacio de Miguel Juan J. de la Cruz Néstor López-Martín | 2007 | Journal of Shoulder and Elbow Surgery2007，，6： | 2 |
| 3 | Pharmacological properties of Anagallis arvensis L. (“scarlet pimpernel”) and Anagallis foemina Mill. (“blue pimpernel”) traditionally used as wound healing remedies in Navarra (Spain)显示文摘 | Víctor López Anna K. J?ger Silvia Akerreta Rita Yolanda Cavero Maria Isabel Calvo | 2011 | Journal of Ethnopharmacology2011，，3： | 2 |
| 4 | 在经历 transcatheter 的病人的 atrial 纤维性颤动的临床、预示的含意大动脉的阀门培植显示文摘 AIM: To study a cohort of consecutive patients under-going transcatheter aortic valve implantation (TAVI) and compare the outcomes of atrial fibrillation (AF) patients vs patients in sinus rhythm (SR). METHODS: All consecutive patients undergoing TAVI in our hospital were included. The AF group comprised patients in AF at the time of TAVI or with history of AF, and were compared with the SR group. Procedural, echocardiographic and follow-up variables were compared. Likewise, the CHA 2 DS 2-VASC stroke risk score and HAS-BLED bleeding risk score and antithrombotic treatment at discharge in AF patients were compared with that in SR patients. RESULTS: From a total of 34 patients undergoing TAVI, 17 (50%) were allocated to the AF group, of whom 15 (88%) were under chronic oral anticoagulation. Patients in the AF group were similar to those in the SR group except for a trend (P = 0.07) for a higher logistic EuroSCORE (28% vs 19%), and a higher prevalence of hypertension (82% vs 53%) and chronic renal failure (17% vs 0%). Risk of both stroke and bleeding was high in the AF group (mean CHA 2 DS 2-VASC 4.3, mean HAS-BLED 2.9). In the AF group, treatment at discharge included chronic oral anticoagulation in all except one case, and in association with an antiplatelet drug in 57% of patients. During a mean follow-up of 11 mo (maximum 32), there were only two strokes, none of them during the peri-procedural period: one in the AF group at 30 mo and one in the SR group at 3 mo. There were no statistical differences in procedural success, and clinical outcome (survival at 1 year 81% vs 74% in AF and SR groups, respectively, P = NS). CONCLUSION: Patients in AF undergoing TAVI show a trend to a higher surgical risk. However, in our cohort, patients in AF did not have a higher stroke rate compared to the SR group, and the prognosis was similar in both groups. | Pablo Salinas Raúl Moreno Luis Calvo Santiago Jiménez-Valero Guillermo Galeote Angel Sánchez-Recalde Teresa López-Fernández Sergio Garcia-Blas Diego Iglesias Luis Riera Isidro Moreno-Gómez Jose María Mesa Ignacio Plaza Rocio Ayala Rosa Gonzalez José-Luis López-Sendón | 2012 | World Journal of Cardiology2012，4，1： | 2 |
| 5 | Elimination of organic water pollutants using adsorbents obtained from sewage sludge 显示文摘 | Otero M Rozada F Calvo L F | 2003 | Dyes and Pigments2003，57，： | 1 |
| 6 | Influence of formula- tion on propofol pharmacokineties and pharmacodynam ics in anesthetized patients显示文摘 | Calvo R Telletxea S Leal N et a l | 2004 | Acta Anaesthesiol Scand2004，48，8： | 1 |
| 7 | Experimental implementation of the gyrator transform 显示文摘 | RODRIGO J A AIAEVA T CALVO M L | 2007 | Journal of Optics Society of America A2007，24，10： | 1 |
| 8 | Detection of new respiratory viruses in hospitalized infants with bronchiolitis: a three-year r prospective study显示文摘 | Calvo C Pozo F Garcia-Garcia M L | 2010 | Acta Paediatrica2010，99，6： | 1 |
| 9 | Biosimilars approval process显示文摘 | Zuniga L Calvo B | 2010 | Regulatory Toxicology and Pharmacology2010，56，3： | 1 |
| 10 | Exploring new routes in the synthesis of carbon xerogels for their application in electric double-layer capacitors显示文摘 | Calvo E G Ania C O Zubizarreta L | 2010 | Energy Fuels2010，24，6： | 1 |
| 11 | Role of magnetic resonance cholangiopancreatography in patients with suspected choledocholithiasis显示文摘 | Calvo MM Bujanda L Calderon A | 2002 | Mayo Clin Proc2002，77，5： | 1 |
| 12 | Follicular fluid-induced acrosome reaction distinguishes a subgroup of men with unexplained infertility not identified by semen analysis显示文摘 | Calvo L Vantman D Banks SM | 1989 | Fertil Steril1989，52，6： | 1 |
| 13 | Layer-by-layer self-assembly of glucose oxidase and Os(Bpy)2ClPyCH2NHpoly(allylamine) bioelectrode显示文摘 | CALVO E J ETCHNIQUE R PIETRASANTA L | | 0，，06： | 1 |
| 14 | A Comparative Study of Trochanteric Fractures Treated with the Gamma Nail or the Proximal Femoral Nail 显示文摘 | Herrera A Domingo L J Calvo A | 2002 | Int Orthop2002，26，6： | 1 |
| 15 | 1,4-Benzodiazepine-2,5-dionesas small molecule antagonists of the HDM2-p53 interaction : discovery and SAR 显示文摘 | PARKS D J LAFRANCE L V CALVO R R | 2005 | Bioorg Med Chem Lett2005，15，： | 1 |
| 16 | Analysis of the cocombustion of sewage sludge and coal by TG-MS显示文摘 | Orero M Diez C Calvo L F | 2002 | Biomass&Bioenergy2002，22，4： | 1 |
| 17 | Biosimilars: pharmacovigilance and risk management显示文摘 | Zuniga L Calvo B | 2010 | Pharmacoepidemiology and Drug Safety2010，19，7： | 1 |
| 18 | Adenovirus-mediated endostatin delivery results in inhibition of mammary gland tumor growth in C3 (1)/SV40 T-antigen transgene mice显示文摘 | Calvo A Feldman A L Libutti S K | 2002 | Cancer Res2002，62，14： | 1 |
| 19 | Short-term effects of experimental burning on soil nutrients in the Cantabrian heathlands 显示文摘 | Marcos E Villalón C Calvo L Luis-Calabuig E | 2009 | Ecol Eng2009，35，5： | 1 |
| 20 | Infrared spectroscopy studies on stability of dimethyl sulfoxide for application in Li-air battery显示文摘 | Mozhzhukhina N Mrndez De Leo L P Calvo E J | 2013 | The Journal of Physical Chemistry C2013，117，18： | 1 |
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