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| 1 | Brucellosis in China:history,progress and challenge显示文摘Brucellosis is a neglected zoonosis.It causes acute febrile illness and a potentially debilitating chronic infection in humans,and livestock infection has substantial socioeconomic impact.Over the past two decades,improvements have been made to better understand the various aspects of human and animal brucellosis.Meanwhile,especially in the developing world,immense challenges that remain in controlling and eradicating brucellosis are novel diagnostics tools and efficacious vaccines.Here,we will focus on the remarkable issues on epidemiological survey,as well as the priority and challenge of brucellosis in China.Brucellosis will be controlled with meaningful collaboration between local and public partnerships effectively applying a One Health framework. | Hai Jiang David O’Callaghan Jia-Bo Ding | 2020 | Infectious Diseases of Poverty2020，9，3： | 25 |
| 2 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 3 | 儿童原发性纤毛运动障碍的相关问题显示文摘申昆玲教授非常高兴受《中国循证儿科杂志》编辑部的邀请,与英国Leicester大学感染和免疫系国家原发性纤毛运动障碍(primary ciliary dyskinesia,PCD)诊断服务中心(简称诊断中心)Christopher Liam O'Callaghan教授和首都医科大学附属北京儿童医院徐保平主任医师及郎志奇副主任医师共同就“儿童PCD的相关问题”进行探讨。 | Christopher Liam O'Callaghan 申昆玲 徐保平 郎志奇 | 2012 | 中国循证儿科杂志2012，7，2： | 5 |
| 4 | BRAF inhibitor treatment of melanoma causing colonic polyps:An alternative hypothesis显示文摘Colonic polyps may arise from BRAF inhibitor treatment of melanoma, possibly due paradoxical activation of the mitogen-activated protein(MAP)-kinase pathway. In an alternative evidence based scenario, tubular colonic adenomas with APC gene mutations have also been identified in the context of BRAF inhibitor treatment, in the absence of mutations of MAPK genes. A minority of colorectal cancers develop by an alternative 'serrated polyp pathway'. This article postulates a novel hypothesis, that the established phenotypic and molecular characteristics of serrated colonic polyps/CRC offer an intriguing insight into the pathobiology of BRAF inhibitor induced colonic polyps. Serrated polyps are characterized by a Cp G island methylation phenotype, MLH1 silencing and cellular senescence. They also have BRAF mutations. The contention is that BRAF inhibitor induced polyps mimic the afore-described histology and molecular features of serrated polyps with the exception that instead of the presence of BRAF mutations they induce C-RAF homodimers and B-RAF: C-RAF heterodimers. | Fergal C Kelleher Grainne Callaghan Catriona Gallagher Hazel O'Sullivan | 2017 | World Journal of Gastroenterology2017，23，17： | 2 |
| 5 | Small-scale spatial variability of selected soil biological properties显示文摘 | C.H.E. Stark L.M. Condron A. Stewart H.J. Di M. O’Callaghan | 2004 | Soil Biology and Biochemistry2004，，4： | 2 |
| 6 | The Extraction of Drainage networks from digital elevation data 显示文摘 | O 'CALLAGHAN J F MARK D M | 1984 | Computer Vision Graphics and Image Processing1984，28，： | 1 |
| 7 | Application of fragment screening by X-ray crystallography to β-secretase 显示文摘 | MURRAY C W CALLAGHAN O CHESSARI G | 2007 | J Med Chem2007，50，6： | 1 |
| 8 | Combined morphological-spectral unsupervised image segmentation显示文摘 | O'Callaghan R J Bull D R | 2005 | IEEE Transactions on Image Processing2005，14，1： | 1 |
| 9 | Mechanical strain-induced extracellular matrix production by human vascular smooth muscle cells: role of TGF-beta (1) 显示文摘 | Williams B | 2000 | Hypertension2000，36，3： | 1 |
| 10 | Effects of plant genetically modified for insect resistance on nontarget organism显示文摘 | O'Callaghan M Glare T R Burgess E P J | 2005 | Annual Review of Entomology2005，50，： | 1 |
| 11 | Acute arsenic poisoning: absence of polyneu- ropathy after treatment with 2, 3 - dimercapto- propanesulphonate ( DMPS ) 显示文摘 | Moore DF O'Callaghan CA Berlyne G | 1994 | J Neurol Neumsurg Psychiatry1994，57，9： | 1 |
| 12 | Comparison of Digital Subtraction Angiography with Gadolinium-Enhanced Magnetic Resonance Angiography in the Diagnosis of Renal Artery Stenosis显示文摘 | Thornton J O'Callaghan J Walshe J | 1999 | Eur Radiol1999，9，5： | 1 |
| 13 | Combined Morphological-Spectral Unsupervised Image Segmentation显示文摘 | O'CALLAGHAN R J BULL DR | 2005 | IEEE Transactions on Image Process2005，4，1： | 1 |
| 14 | Double blind, placebo controlled trial of two probiotic strains in interleukin 10 knockout mice and mechanistic link with cytokine balance 显示文摘 | Mccarthy J Mahony L O Callaghan L O | 2003 | Gut2003，52，： | 1 |
| 15 | Thermodynamic and thermophysical properties of organic working fluids for Rankine cycle engines显示文摘 | Badr O O'Callaghan | 1985 | Applied Energy1985，19，1： | 1 |
| 16 | Assessing the prospects and commercial viabilities of small scale CHP schemes 显示文摘 | Babus' HaqRF ProbertSD O' Callaghan | 1988 | Applied Energy1988，31，1： | 1 |
| 17 | Surgical correction of tracheo-oesophageal fistula and oesophageal atresia in infants with VACTERL association: a retrospective ease-control study显示文摘 | Morgan RD O'Callaghan JM Wagener S | 2012 | Pediatr Surg Int2012，28，10： | 1 |
| 18 | Preva- lence of tuberous sclerosis estimated by capturerecapture analysis 显示文摘 | O'Callaghan FJ Shiell AW Osborne JP | 1998 | Lancet1998，351，9114： | 1 |
| 19 | Targeting CXCR4 with cell-penetrating pepducins in lymphoma and lymphocytic leukemia显示文摘 | O' Callaghan K Lee L Nguyen N | 2012 | Blood2012，119，7： | 1 |
| 20 | Learning disability and epilepsy in an epidemiological sample of individuals with tuberous sclerosis显示文摘 | Joinson C O'Callaghan FJ Osborne JP | 2003 | Psychol Med2003，32，2： | 1 |
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