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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Hepatic lipid metabolism changes in short-and long-term prehepatic portal hypertensive rats显示文摘AIM: To verify the impairment of the hepatic lipid metabolism in prehepatic portal hypertension. METHODS: The concentrations of free fatty acids, diacylglycerol, triglycerides, and phospholipids were assayed by using D-[U-14C] glucose incorporation in the different lipid fractions and thin-layer chromatography and cholesterol was measured by spectrophotometry, in liver samples of Wistar rats with partial portal vein ligation at short- (1 mo) and long-term (1 year) (i.e. portal hypertensive rats) and the control rats. RESULTS: In the portal hypertensive rats, liver phospholipid synthesis significantly decreased (7.42 ± 0.50 vs 4.70 ± 0.44 nCi/g protein; P < 0.01) and was associated with an increased synthesis of free fatty acids (2.08 ± 0.14 vs 3.36 ± 0.33 nCi/g protein; P < 0.05), diacylglycerol (1.93 ± 0.2 vs 2.26 ± 0.28 nCi/g protein), triglycerides (2.40 ± 0.30 vs 4.49 ± 0.15 nCi/g protein) and cholesterol (24.28 ± 2.12 vs 57.66 ± 3.26 mg/g protein; P < 0.01). CONCLUSION: Prehepatic portal hypertension in rats impairs the liver lipid metabolism. This impairment consists in an increase in lipid deposits (triglycerides,diacylglycerol and cholesterol) in the liver, accompanied by a decrease in phospholipid synthesis. | Maria-Angeles Aller Elena Vara Cruz García Maria-Paz Nava Alejandra Angulo Fernando Sánchez-Patán Ana Calderón Patri Vergara Jaime Arias | 2006 | World Journal of Gastroenterology2006，12，42： | 2 |
| 3 | A novel methodology for the monitoring of the agricultural production process based on wireless sensor networks显示文摘 | Soledad Escolar Díaz Jesús Carretero Pérez Alejandro Calderón Mateos Maria-Cristina Marinescu Borja Bergua Guerra | 2011 | Computers and Electronics in Agriculture2011，，2： | 2 |
| 4 | Development and evaluation of sediment quality guidelines for Florida coastal waters显示文摘 | MACDONALD D D CARR R S CALDER F D | 1996 | Ecotoxicology1996，5，： | 1 |
| 5 | Entropia: Ar-chitecture and Performance of An Enterprise DesktopGrid System 显示文摘 | CHIEN A CALDER B ELBERT S et ol | 2003 | Journal of Parallel and Distributed Com-puting2003，63，5： | 1 |
| 6 | Multifactorial index of cardiac risk in non-cardiac surgical procedures显示文摘 | Goldman L Calder D L Nussbaum S R | 1977 | N Eng J Med1977，297，16： | 1 |
| 7 | Development and evaluation of sediment quality guidelines for Florida coastal waters显示文摘 | MacDonald D D Carr R S Calder F D | 1996 | Ecotoxicology1996，5，： | 1 |
| 8 | Development and evaluation of sediment quality guidelines for Florida coastal waters显示文摘 | MacDonald D D Carr R S Calder F D | 1996 | Ecotoxicology1996，5，4： | 1 |
| 9 | Early nutrition and immunity-progress and perspectives 显示文摘 | CALDER P C KRAUSS-ETSCHMANN S DE JONG E C et al | 2006 | Br J Nutr2006，96，4： | 1 |
| 10 | The fate of absorbed and exogenous ammonia as influenced by forage or forage- concentrate diets in growing sheep显示文摘 | Lobley G E Weijs P J M Connell A Calder A G Brown D S Milne E | 1996 | British Journal of Nutrition1996，76，： | 1 |
| 11 | Microstructure evolution in magnetorheological suspensions governed by Mason number显示文摘 | Melle S Calderón O G Rubio M A | 2003 | Phys Rev2003，68，04： | 1 |
| 12 | In situ identification of the silicide phase in super-oL titanium alloys 显示文摘 | KOTVAL P S CALDER R W | 1972 | Metallurgical and Materials Transaction (B)1972，3，5： | 1 |
| 13 | Devel- opment and evaluation of sediment quality guidelines for Florida coastal waters 显示文摘 | MacDonald D D Carr R S Calder F D | 1996 | Ecotoxicology1996，5，4： | 1 |
| 14 | Development and evaluation of sediment quality guidelines for Florida coastal waters显示文摘 | Macdonald D D Carr R S Calder F D | 1996 | Ecotoxicology1996，5，4： | 1 |
| 15 | Inductive shielding of NMR phase noise显示文摘 | Sigmund E E Mitrovic V F Calder E S | 2002 | J Magn Reson2002，159，2： | 1 |
| 16 | Microbiotas of the Late Precambrian Ryss6 Formation, Nordaustlandet, Svalbard显示文摘 | Knoll A H Calder S | 1983 | Palaeontology1983，26，3： | 1 |
| 17 | The immune system:a target for functional foods显示文摘 | CALDER P C KEW S | 2002 | British Journal of Nutrition2002，88，2： | 1 |
| 18 | Development and evaluation of sediment quality guidelines for Florida coastal waters 显示文摘 | MacDonald D D Cart R S Calder F D | 1996 | Ecotoxicology1996，5，： | 1 |
| 19 | Analysis of high frequency micro seismicity recorded at an underground hard rock mine显示文摘 | BUTT S D APEL D B CALDER P N | 1997 | Pure and Applied Geophysics1997，150，34： | 1 |
| 20 | Development and evaluation of sediment quality guidelines for Florida coastal waters显示文摘 | MACDONALD D D Carr R S Calder F D acdonald | 1996 | Ecotoxicology1996，5，： | 1 |
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