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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Development and evaluation of sediment quality guidelines for Florida coastal waters显示文摘 | MACDONALD D D CARR R S CALDER F D | 1996 | Ecotoxicology1996，5，： | 1 |
| 3 | Machine Reasoning about Anomalous Sensor Data显示文摘 | Calder M Morris R A Peri F | 2010 | Ecological In- formatics2010，5，1： | 1 |
| 4 | Efficient Procedure Mapping Using Cache Line Coloring显示文摘 | Hashemi A H Kaeli D R Calder B | 1997 | ACM SIGPLAN Notices1997，32，5： | 1 |
| 5 | Multifactorial index of cardiac risk in non-cardiac surgical procedures显示文摘 | Goldman L Calder D L Nussbaum S R | 1977 | N Eng J Med1977，297，16： | 1 |
| 6 | DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children 显示文摘 | Pérez-Maldonado IN D??az-Barriga F de la Fuente H González-Amaro R Calderón J Yá?ez L | 2004 | Environ Res2004，94，1： | 1 |
| 7 | Development and evaluation of sediment quality guidelines for Florida coastal waters显示文摘 | MacDonald D D Carr R S Calder F D | 1996 | Ecotoxicology1996，5，： | 1 |
| 8 | Development and evaluation of sediment quality guidelines for Florida coastal waters显示文摘 | MacDonald D D Carr R S Calder F D | 1996 | Ecotoxicology1996，5，4： | 1 |
| 9 | The operative management of displaced intraarticular fractures of the calcaneum : a two- centre study using a defined pmtoeol 显示文摘 | TENNENT T CALDER P SALISBURY R | 2010 | Injury2010，32，6： | 1 |
| 10 | The operative management of displaced intra-articular fractures of the calcaneum : a two-centre study using a defined protocol 显示文摘 | Tennent T D Calder P R Salisbury R D | 2001 | Injury2001，32，6： | 1 |
| 11 | The operative management of disp laced inraarticular fractures of the calcaneum:a two center study using a defined protocol显示文摘 | Tennen T D Calder P R Salisbury R D | 2005 | Injury2005，36，10： | 1 |
| 12 | Water use by forests, limits and controls显示文摘 | Calder I R | 1998 | Tree Physiology1998，18，： | 1 |
| 13 | Chemical and biological weathering of oil from the Amoco Cadiz spillage,within the littoral zone显示文摘 | BOEHM P D CALDER J A | 1981 | Estuar Coast Shelf Sci1981，12，： | 1 |
| 14 | Inflammatory disease processes and interactions with nutrition 显示文摘 | Calder PC Albers R Antoine JM | 2009 | Br J Nutr2009，101，1： | 1 |
| 15 | In vitro transdermal delivery of the major catechins and caffeine from extract of Camellia sinensis显示文摘 | Batchelder R J Calder R J Thomas C P | 2004 | International Journal of Pharmaceutics2004，4551，： | 1 |
| 16 | In situ identification of the silicide phase in super-oL titanium alloys 显示文摘 | KOTVAL P S CALDER R W | 1972 | Metallurgical and Materials Transaction (B)1972，3，5： | 1 |
| 17 | Devel- opment and evaluation of sediment quality guidelines for Florida coastal waters 显示文摘 | MacDonald D D Carr R S Calder F D | 1996 | Ecotoxicology1996，5，4： | 1 |
| 18 | Development and evaluation of sediment quality guidelines for Florida coastal waters显示文摘 | Macdonald D D Carr R S Calder F D | 1996 | Ecotoxicology1996，5，4： | 1 |
| 19 | Rainfall interception and drop size-development and calibration of the two-layer stochastic interception model显示文摘 | Calder I R | | 0，，8： | 1 |
| 20 | Oxidation of natural hydroxybenzoic acids by grapevine peroxidases:kinetic characteristics and substrate specificity显示文摘 | Zapata J M Calderón A A Mu-oz R | 1992 | Am J Enol Vitic1992，43，1： | 1 |
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