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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | Leuprolide acetate induces structural and functional recovery of injured spinal cord in rats显示文摘Gonadotropin-releasing hormone(Gn RH) and its synthetic analog leuprolide acetate, a Gn RH agonist, have neurotrophic properties. This study was designed to determine whether administration of leuprolide acetate can improve locomotor behavior, gait, micturition reflex, spinal cord morphology and the amount of microglia in the lesion epicenter after spinal cord injury in rats. Rats with spinal cord compression injury were administered leuprolide acetate or saline solution for 5 weeks. At the 5th week, leuprolide acetate-treated rats showed locomotor activity recovery by 38%, had improvement in kinematic gait and exhibited voiding reflex recovery by 60%, as compared with the 1st week. By contrast, saline solution-treated rats showed locomotor activity recovery only by 7%, but voiding reflex did not recover. More importantly, leuprolide acetate treatment reduced microglial immunological reaction and induced a trend towards greater area of white and gray matter in the spinal cord. Therefore, leuprolide acetate has great potential to repair spinal cord injury. | Carmen Díaz Galindo Beatriz Gómez-González Eva Salinas Denisse Calderón-Vallejo Irma Hernández-Jasso Eduardo Bautista J Luis Quintanar | 2015 | Neural Regeneration Research2015，10，11： | 2 |
| 3 | A novel methodology for the monitoring of the agricultural production process based on wireless sensor networks显示文摘 | Soledad Escolar Díaz Jesús Carretero Pérez Alejandro Calderón Mateos Maria-Cristina Marinescu Borja Bergua Guerra | 2011 | Computers and Electronics in Agriculture2011，，2： | 2 |
| 4 | Development and evaluation of sediment quality guidelines for Florida coastal waters显示文摘 | MACDONALD D D CARR R S CALDER F D | 1996 | Ecotoxicology1996，5，： | 1 |
| 5 | Computer simulation of point defect properties in dilute Fe-Cu alloy using a many-body interatomic potential显示文摘 | ACKLAND G BACON D CALDER A | 1997 | Philosophical Magazine A1997，75，3： | 1 |
| 6 | Efficient Procedure Mapping Using Cache Line Coloring显示文摘 | Hashemi A H Kaeli D R Calder B | 1997 | ACM SIGPLAN Notices1997，32，5： | 1 |
| 7 | Multifactorial index of cardiac risk in non-cardiac surgical procedures显示文摘 | Goldman L Calder D L Nussbaum S R | 1977 | N Eng J Med1977，297，16： | 1 |
| 8 | DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children 显示文摘 | Pérez-Maldonado IN D??az-Barriga F de la Fuente H González-Amaro R Calderón J Yá?ez L | 2004 | Environ Res2004，94，1： | 1 |
| 9 | Amino acid exchange by the mammary gland of lactating goats when histidine limits milk production 显示文摘 | BEQUETI'E B J HANIGAN M D CALDER A G | 2000 | J Dairy Sci2000，83，4： | 1 |
| 10 | Development and evaluation of sediment quality guidelines for Florida coastal waters显示文摘 | MacDonald D D Carr R S Calder F D | 1996 | Ecotoxicology1996，5，： | 1 |
| 11 | Development and evaluation of sediment quality guidelines for Florida coastal waters显示文摘 | MacDonald D D Carr R S Calder F D | 1996 | Ecotoxicology1996，5，4： | 1 |
| 12 | The operative management of displaced intra-articular fractures of the calcaneum : a two-centre study using a defined protocol 显示文摘 | Tennent T D Calder P R Salisbury R D | 2001 | Injury2001，32，6： | 1 |
| 13 | Apoptosis-a significant cause of bone cell death in osteonecrosis of the femoral head显示文摘 | CALDER J D BUTTERY L REVELL P A | 2004 | J Bone Joint Surg Br2004，86，8： | 1 |
| 14 | The operative management of disp laced inraarticular fractures of the calcaneum:a two center study using a defined protocol显示文摘 | Tennen T D Calder P R Salisbury R D | 2005 | Injury2005，36，10： | 1 |
| 15 | Chemical and biological weathering of oil from the Amoco Cadiz spillage,within the littoral zone显示文摘 | BOEHM P D CALDER J A | 1981 | Estuar Coast Shelf Sci1981，12，： | 1 |
| 16 | The role of the striatum in the mouse in behavioral sensitization to amphetamine 显示文摘 | Bedingfield JB Calder LD Thai D K | 1997 | Pharmacol Biochem Behav1997，56，： | 1 |
| 17 | The fate of absorbed and exogenous ammonia as influenced by forage or forage- concentrate diets in growing sheep显示文摘 | Lobley G E Weijs P J M Connell A Calder A G Brown D S Milne E | 1996 | British Journal of Nutrition1996，76，： | 1 |
| 18 | Incorporation of fatty acids by concavalin A- stimulated lymphocytes and the effect of fatty acid composition and membrane fluidity 显示文摘 | CALDER P C YAQOOB P HARVEY D J | 1994 | Biochemical Journal1994，300，： | 1 |
| 19 | Devel- opment and evaluation of sediment quality guidelines for Florida coastal waters 显示文摘 | MacDonald D D Carr R S Calder F D | 1996 | Ecotoxicology1996，5，4： | 1 |
| 20 | Development and evaluation of sediment quality guidelines for Florida coastal waters显示文摘 | Macdonald D D Carr R S Calder F D | 1996 | Ecotoxicology1996，5，4： | 1 |
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