7篇
您的检索式：作者名="Cai Dingfang"
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| 1 | Echinacoside Protects Against MPP+-Induced Neuronal Apoptosis via ROS/ATF3/CHOP Pathway Regulation显示文摘Echinacoside(ECH) is protective in a mouse model of Parkinson's disease(PD) induced by 1-methyl-4-phenylpyridinium ion(MPP^+). To investigate the mechanisms involved, SH-SY5Y neuroblastoma cells were treated with MPP^+or a combination of MPP^+and ECH,and the expression of ATF3(activating transcription factor3), CHOP(C/EBP-homologous protein), SCNA(synuclein alpha), and GDNF(glial cell line-derived neurotrophic factor) was assessed. The results showed that ECH significantly improved cell survival by inhibiting the generation of MPP^+-induced reactive oxygen species(ROS). In addition, ECH suppressed the ROS and MPP^+-induced expression of apoptotic genes(ATF3, CHOP, and SCNA). ECH markedly decreased the MPP^+-induced caspase-3 activity in a dose-dependent manner. ATF3-knockdown also decreased the CHOP and cleaved caspase-3 levels and inhibited the apoptosis induced by MPP^+.Interestingly, ECH partially restored the GDNF expression that was down-regulated by MPP^+. ECH also improved dopaminergic neuron survival during MPP^+treatment and protected these neurons against the apoptosis induced by MPTP. Taken together, these data suggest that the ROS/ATF3/CHOP pathway plays a critical role in mechanisms by which ECH protects against MPP^+-induced apoptosis in PD. | Qing Zhao Xiaoyan Yang Dingfang Cai Ling Ye Yuqing Hou Lijun Zhang Jiwei Cheng Yuan Shen Kaizhe Wang Yu Bai | 2016 | Neuroscience Bulletin2016，32，4： | 14 |
| 2 | Quantitative assessment of the influence of prostate stem cell antigen polymorphisms on gastric cancer risk显示文摘 | Xixi Gu Wen Zhang Lili Xu Dingfang Cai | 2014 | Tumor Biology2014，，3： | 2 |
| 3 | Study of the Effect of Bu Yi Drugs显示文摘 | Cai dingfang Cojima satoru Shen ziyin | 1996 | Japanese Journal of Basic and Clinical1996，，30： | 1 |
| 4 | Thinking of study on neuroendocrino-immunological network of integrated traditional and western medicine显示文摘 | CAI Dingfang SHEN Ziyin | 1997 | Chinese Journal of Integrated Traditional and Western Medicine1997，17，7： | 1 |
| 5 | Open Randomized Clinical Trial on JWSJZ Decoction for the Treatment of ALS Patients显示文摘 | Weidong Pan Xiaojing Su Jie Bao Jun Wang Jin Zhu Dingfang Cai Li Yu Hua Zhou Paul Siu-Po Ip | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 1 |
| 6 | The effect of Xingnaojing on hippocampal N-methy1-D-aspartic acid receptor of focal cerebral ischemia in rats显示文摘 | Shen Siyu Cai Dingfang Chen Weihua | 2003 | SJIM2003，9，1： | 1 |
| 7 | Thrombin inhibits aquaporin 4 expression through protein kinase C-dependent pathway in cultured astrocytes显示文摘 | Yuping Tang Dingfang Cai Yiping Chen | 2007 | Journal of Molecular Neuroscience2007，，1： | 1 |
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