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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | The dependences of osteocyte network on bone compartment, age, and disease显示文摘Osteocytes, the most abundant bone cells, form an interconnected network in the lacunar-canalicular pore system(LCS) buried within the mineralized matrix, which allows osteocytes to obtain nutrients from the blood supply, sense external mechanical signals, and communicate among themselves and with other cells on bone surfaces. In this study, we examined key features of the LCS network including the topological parameter and the detailed structure of individual connections and their variations in cortical and cancellous compartments, at different ages, and in two disease conditions with altered mechanosensing(perlecan deficiency and diabetes).LCS network showed both topological stability, in terms of conservation of connectivity among osteocyte lacunae(similar to the ‘‘nodes' ' in a computer network), and considerable variability the pericellular annular fluid gap surrounding lacunae and canaliculi(similar to the ‘‘bandwidth'' of individual links in a computer network). Age, in the range of our study(15–32 weeks), affected only the pericellular fluid annulus in cortical bone but not in cancellous bone. Diabetes impacted the spacing of the lacunae, while the perlecan deficiency had a profound influence on the pericellular fluid annulus. The LCS network features play important roles in osteocyte signaling and regulation of bone growth and adaptation. | Xiaohan Lai Christopher Price Shannon Modla William R Thompson Jeffrey Caplan Catherine B Kirn-Safran Liyun Wang | 2015 | Bone Research2015，3，2： | 6 |
| 3 | Intracranial atherosclerosis显示文摘 | Adnan I Qureshi Louis R Caplan | 2014 | The Lancet . 2014 (9921)2014，，9921： | 2 |
| 4 | Thoughts evoked by MATCH and other trials显示文摘 | Caplan L R | 2004 | Stroke2004，35，： | 1 |
| 5 | Adrenal Insufficiency after Operative Removal of Apparently Nonfuntioning Adrenal Adenomas显示文摘 | Harias C M Pehling G g Caplan R H | 1989 | JAMA1989，216，： | 1 |
| 6 | Race,sex and occlusive cerebrovascular disease:a review显示文摘 | Caplan L R Gorelick P B Hier D B | | 0，，4： | 1 |
| 7 | Stress,anxiety, and depression in hospital consultancies, general practitioners, and senior health service managers显示文摘 | Caplan R P | 1994 | Br Med J1994，309，6964： | 1 |
| 8 | New England Medical Center Posterior Circulation registry显示文摘 | Caplan LR Wityk R J Glass TA | 2004 | Ann Neurol2004，56，3： | 1 |
| 9 | Tolyporphin, a novel multidrug resistance reversing agent from the blue-green alga Tolypothrix nodosa显示文摘 | Prinsep M R Caplan F R Moore R E | 1992 | J Am Chem Soc1992，114，： | 1 |
| 10 | Hypertensive intracerabral hemorrhage,epidemiology and clinical pathology 显示文摘 | Wityk R J caplan LR | 1992 | Neurosurgery Clin N Am1992，3，3： | 1 |
| 11 | Vertebrobasilar disease 显示文摘 | Savitz S I Caplan L R | 2005 | N Engl J Med2005，352，25： | 1 |
| 12 | Vertebral artery compression of the medulla显示文摘 | Savitz SI Michael R Caplan LR | 2006 | Arch Neurol2006，63，： | 1 |
| 13 | Transient ischemic attack-proposal for a new definition显示文摘 | Albers G W Caplan L R Easton J D | 2002 | N Engl J Med2002，347，21： | 1 |
| 14 | New England Medical Center Posterior Circulation Regislry显示文摘 | Caplan LtL Wityk R J Glass TA | 2004 | ArchNeurol2004，56，： | 1 |
| 15 | Medical complications after stroke 显示文摘 | Sandeep Kumar Magdy H Selim Louis R Caplan | 2010 | The Lancet Neurology2010，9，1： | 1 |
| 16 | Practice guidelines for preoperative fasting and the use of phar- macologic agents to reduce the risk of pulmonary aspira- Lion: application to healthy patients undergoing elective 显示文摘 | Warner M A Caplan R A Epstein B S | 1999 | Anesthesiology1999，90，3： | 1 |
| 17 | Transdermal Fentanyl for Postoperative Pain Management 显示文摘 | CAPLAN R A READY L B ODEN R V | 1989 | JAMA1989，261，7： | 1 |
| 18 | New England Medical Center Posterior Circulation Registry 显示文摘 | Caplan L R Wityk R J Glass T A | 2004 | Ann Neurol2004，56，3： | 1 |
| 19 | Short-term memory,working memory,and syntactic comprehension in aphasia显示文摘 | Caplan D Michaud J Hufford R | 2013 | Cogn Neuropsychol2013，30，2： | 1 |
| 20 | Applying the Toyota Production System: using a patient safety alert system to reduce error显示文摘 | Furman C Caplan R | 2007 | Jt Comm J Qual Patient Saf2007，33，7： | 1 |
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