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| 1 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 2 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 3 | L-forms of H. pylori显示文摘AIM: To study the occurrence of L-forms of H. pyloriinfection in patients with peptic ulcers and its association with possible changes of cellular immune function in the patients.METHODS: Endoscopic biopsy specimens of gastric antrum and gastric corpus were taken from 228 patients with peptic ulcers and inoculated into Skirrow selective medium for H.pylorivegetative forms and special medium for H. pylori Lforms, followed by bacterial isolation and identification. And peripheral venous blood of the patients was taken to detect the percentage of CD3+, CD4+ and CD8+ with biotin-streptavidin (BSA) and the level of IL-2, IL-6 and IL-8 with ElISA.RESULTS: (1) The detection rates of H. pyloriL-forms and vegetative forms in the patients were 50.88 % (116/228)and 64.91 % (148/228) respectively, and the co-infection rate of H. pyloriL-forms and vegetative forms was 78.38 % (116/148). To be more exact, the detection rates of H. pylori L-forms in male and female patients were 57.04 % (77/135) and 41.94 % (39/93) respectively, and statistics found significant difference between them (P<0.05). Furthermore, the detection rates of H. pyloriL-forms in patients aged 14 years-, 30 years-, 40 years- and 50 years- were 31.91%(15/47), 42.86 % (24/56), 56.94 % (41/72) and 67.92 %(36/53) respectively, and there was significant difference between them (P<0.011). (2) The percentages of CD3+, CD4+,CD8+, the ratio of CD4+/CD8+, and the level of IL-2, IL-6,IL-8 in H. pylori-positive patients were (52.59±5.44) %,(35.51±5.74) %, (27.77±8.64) %, (1.56±0.51), (2.66±0.47)mg/L, (108.62±5.85) ng/L and (115.79±7.18) ng/Lrespectively, compared with those in H. pylori-negative patients, the percentages of CD3+, CD4+ and the ratio of CD4+/CD8+ decreased, but the level of IL-2, IL-6 increased, and the difference was significant (P<0.001-P<0.011).Moreover, the percentages of CD3+, CD4+, CD8+, the ratio of CD4+/CD8+, and the level of IL-2, IL-6, IL-8 in the patients with mixed infection of bothH. pyloriL-forms and vegetative forms were (51.69±5.28) %, (34.75±5.89) %, (27.15±7.45) %, (1.48±0.47), (2.16±0.38) mg/L, (119.45±5.44) ng/L and (123.64±6.24) ng/L respectively, compared with those in patients with simple infection of H. pylorivegetative forms,the percentage of CD4+, the ratio of CD4+/CD8+ and the level of IL-2 increased, but the level of IL-6 and IL-8decreased, statistical difference was found between them (P<0.001-P<0.05).CONCLUSION: L-forms variation often occurs in patients with peptic ulcers who are infected byH. pylori, which is commonly found in male patients and related to ages. The L-forms variation of H. pylori can be an important factor causing disorder of cellular immune function in the patients with peptic ulcers who are infected by H. pylori. | Ke-Xia Wang Chao-Pin Li Yu-Bao Cui Ye Tian Qing-Gui Yang School of Medicine, Anhui University of Science & Technology Huainan 232001, Anhui Province, China | 2003 | World Journal of Gastroenterology2003，9，3： | 47 |
| 4 | Acaroid mite,intestinal and urinary acariasis显示文摘AIM: To investigate epidemiology and pathogenic mite species of intestinal and urinary acariasis in individuals with different occupations.METHODS: A total of 1994 individuals were tested in this study. History collection, skin prick test and pathogen identification were conducted. The mites were isolated from stool and urine samples by saturated saline flotation methods and sieving following centrifugation, respectively.RESULTS: Among the 1994 individuals examined, responses to the skin prick test of '+++', '++', '+','±' and '-' were observed at frequencies of 3.96 % (79), 3.21% (64), 2.31%(46), 1.25 % (25) and 89.27 % (1780), respectively. A total number of 161 (8.07 %) individuals were shown to carry mites, with 92 (4.61%) positive only for stool samples, 37(1.86 %) positive only for urine samples and 32 (1.60 %)for both. The positive rate of mites in stool samples was 6.22 % (124/1994), being 6.84 % (78/1140) for males and 5.39 % (46/854) for females. No gender difference was observed in this study (χ2=1.77, P>0.05). The mites from stool samples included Acarus siro, TynoPhagus putrescentiae,Dermatophagoides farinae, D. pteronyssinus, Glycyphagus domesticus, G.ornatus, Carpoglyphus lactis and Tarsonemus granaries. The positive rate of mites in urine samples was 3.46 % (69/1994). The positive rates for male and female subjects were found to be 3.95 % (45/1140) and 2.81%(24/854) respectively, with no gender difference observed (χ2=1.89, P>0.05). Mites species in urine samples included Acar us siro, Tynophagus putrescentiae, T. longior, Aleunocglyphus ovatus, Caloglyphus berlesei, C mycophagus, Suidasia nesbitti, Lardoglyphus konoi, Glycyphagus domesticus,Carpoglyphus lactis, Lepidoglyphus destructor,Dermatophagoides farinae, D. pteronyssinus, Euroglyphus magnei, Caloglyphus hughesi, Tarsonemus granarus and T.hominis. The species of mites in stool and urine samples were consistent with those separated from working environment. A significant difference was found among the frequencies of mite infection in individuals with different occupations (χ2=82.55, P<0.001), with its frequencies in those working in medicinal herb storehouses, those in rice storehouse or mills, miners, railway workers, pupils and teachers being 15.89 % (68/428), 12.96 % (53/409), 3.28 %(18/549), 2.54 % (6/236), 5.10 % (13/255) and 2.56 % (3/117), respectively.CONCLUSION: The prevalence of human intestinal and urinary acariasis was not associated with gender, and these diseases are more frequently found in individuals working in medicinal herb, rice storehouses or mills and other sites with high density of mites. More attention should be paid to the mite prevention and labor protection for these highrisk groups. | Chao-Pin Li Yu-Bao Cui Jian Wang Qing-Gui Yang Ye Tian Department of Etiology and Immunology,School of Medicine,Anhui University of Science & Technology,Huainan 232001,Anhui Province,China | 2003 | World Journal of Gastroenterology2003，9，4： | 30 |
| 5 | Sleep and Cognitive Abnormalities in Acute Minor Thalamic Infarction显示文摘In order to characterize sleep and the cognitive patterns in patients with acute minor thalamic infarction(AMTI), we enrolled 27 patients with AMTI and 12 matched healthy individuals. Questionnaires about sleep and cognition as well as polysomnography(PSG) were performed on days 14 and 90 post-stroke. Compared to healthy controls, in patients with AMTI, hyposomnia was more prevalent; sleep architecture was disrupted as indicated by decreased sleep efficiency, increased sleep latency, and decreased non-rapid eye movement sleep stages 2 and 3;more sleep-related breathing disorders occurred; and cognitive functions were worse, especially memory. While sleep apnea and long-delay memory recovered to a large extent in the patients, other sleep and cognitive function deficit often persisted. Patients with AMTI are at an increased risk for hyposomnia, sleep structure disturbance,sleep apnea, and memory deficits. Although these abnormalities improved over time, the slow and incomplete improvement suggest that early management should be considered in these patients. | Wei Wu Linyang Cui Ying Fu Qianqian Tian Lei Liu Xuan Zhang Ning Du Ying Chen Zhijun Qiu Yijun Song Fu-Dong Shi Rong Xue | 2016 | Neuroscience Bulletin2016，32，4： | 28 |
| 6 | Coseismic vertical deformation of the M_S8.0 Wenchuan earthquake from repeated levelings and its constraint on listric fault geometry显示文摘The devastating MS8.0 Wenchuan earthquake ruptured two large parallel thrust faults along the middle segment of the Longmenshan thrust belt.Preseismic and postseismic leveling data indicated the hanging wall of the YingxiuBeichuan-Nanba thrust fault mainly presented coseismic uplift with respect to the reference point at Pingwu county town, and the observed maximum uplift of 4.7 m is located at Beichuan county(Qushan town)which is about 100 m west of the fault scarp.The foot wall of the Yingxiu-Beichuan-Nanba thrust fault mainly showed subsidence with maximum subsidence of 0.6 m near the rupture.By employing a listric dislocation model,we found that the fault geometry model of exponential dip angleδ=88°×[1-exp(-9/h)]with depth of 18 km and uniform thrust-slip of 5.6 m could fit the observed coseismic vertical deformation very well,which verifies the listric thrust model of the Longmenshan orogenic zone. | Qingliang Wang Duxin Cui Xi Zhang Wenping Wang Jinwen Liu Kang Tian Zhaoshan Song | 2009 | Earthquake Science2009，22，6： | 25 |
| 7 | Comparison of modified percutaneous transhepatic variceal embolization and endoscopic cyanoacrylate injection for gastric variceal rebleeding显示文摘AIM:To compare the efficacy of modified percutaneous transhepatic variceal embolization(PTVE)with 2-octyl-cyanoacrylate(2-OCA)and endoscopic variceal obturation(EVO)with an injection of 2-OCA for prophylaxis of gastric variceal rebleeding. METHODS:In this retrospective study,the medical records of liver cirrhosis patients with gastric variceal bleeding who underwent either endoscopic 2-OCA(EVO) or modified PTVE using 2-OCA at Shandong Provincial Hospital from January 2006 to December 2008 were reviewed.Patient demographics,rebleeding rate,survival rate,and complications were compared between the two groups(PTVE and EVO).All results were expressed as mean±SD,or as a percentage.Quantitative variables were compared by two sample Student t tests, and qualitative variables were compared by the Fisher exact test or theχ 2 test(with Yates correction)where appropriate.A P value less than 0.05 was considered significant.Statistical computation was performed using SPSS 13.0 software. RESULTS:A total of 77 patients were included;45 patients who underwent EVO and 32 patients who received PTVE.During the follow-up(19.78±7.70 mo in the EVO group,vs 21.53±8.56 mo in the PTVE group) rebleeding occurred in 17 patients in the EVO group and in 4 patients in the PTVE group(37.78%vs 12.5%, P=0.028).The cumulative rebleeding-free rate was 75%,59%,and 49%in 1,2,and 3 years respectively for EVO,and 93%,84%,and 84%for PTVE(P=0.011). Cox analysis was used to identify independent factors that predicted rebleeding after treatment.Variables including age,gender,cause,Child-Pugh classification, size of gastric varices(GV),location of GV,and treatment methods were analyzed.It was revealed that Child-Pugh classification[risk ratio(RR)2.10,95%CI:1.03-4.28,P=0.040],choice of treatment(RR 0.25, 95%CI:0.08-0.80,P=0.019),and size of GV(RR 2.14, 95%CI:1.07-4.28,P=0.032)were the independent factors for predicting rebleeding.Follow-up computed tomography revealed that cyanoacrylate was retained in the varices and in the feeding veins of PTVE patients. During the follow-up,eight patients in the EVO group and four patients in the PTVE group died.The cumulative survival rates at 1,2,and 3 years were 93%,84%, and 67%respectively in the EVO group,and 97%, 88%,and 74%respectively in the PTVE group.The survival rates were not significantly different between the two groups(P=0.432).Cox analysis showed that the Child-Pugh classification was the most significant prognostic factor of survival(RR 2.77,95%CI:1.12-6.80,P=0.027).The incidence of complications was similar in both groups. CONCLUSION:With extensive and permanent obliteration of gastric varices and its feeding veins,PTVE with 2-OCA is superior to endoscopic 2-OCA injection for preventing gastric variceal rebleeding. | Jing Wang Xiang-Guo Tian Yan Li Chun-Qing Zhang Fu-Li Liu Yi Cui Ji-Yong Liu | 2013 | World Journal of Gastroenterology2013，19，5： | 21 |
| 8 | High-speed maneuvering target detection approach based on joint RFT and keystone transform显示文摘Increasing the integration time is an effective method to improve small maneuvering target detection performance in radar applications.However,range migration and Doppler spread caused by maneuvering target motion during the integration time make it difficult to improve the coherent accumulation of target's energy and detection performance.In this study,a new method based on Radon Fourier transform(RFT) and keystone transform(KT) for high-speed maneuvering target detection is proposed.The proposed algorithm utilizes second-order KT to correct the range curvature,and the improved dechirping method to compensate for the Doppler spread.RFT is then used to correct the range walk for target coherent detection.The method is capable of correcting the range migration and the time-varied Doppler frequency of the target without knowing its velocity and acceleration.The advantage of the proposed method is that it can increase the coherent integration time and improve detection performance under the condition of Doppler frequency ambiguity.Compared with the second-order RFT algorithm,the computational burden of the proposed method is greatly reduced under the premise that the two methods have similar estimation accuracy of range,velocity and acceleration.Numerical experiments demonstrate the validity of the proposed algorithm. | TIAN Jing CUI Wei SHEN Qing WEI ZiXiang WU SiLiang | 2013 | Science China(Information Sciences)2013，56，6： | 19 |
| 9 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 10 | Effects of rare earths on the microarc oxidation of a magnesium alloy显示文摘The effects of rare earths on the properties of the microarc oxidation(MAO) coating on a magnesium alloy were investigated by means of scanning electron microscopy(SEM),energy dispersive X-ray spectroscopy(EDS),and electrochemistry methods.The results show that a nice and compact MAO coating was successfully obtained when the magnesium alloy was treated in nitrate solutions as the pre-treatment of MAO.However,the MAO was not successfully completed for the silicate electrolytes with the addition of rare earths.After the magnesium alloy being treated by rare earth nitrate,the obtained MAO coating has advantages such as uniform distribution of thickness,improved corrosion resistance,and nice-uniform surface,as compared with the untreated magnesium alloy.In addition,the time of non-ESP,the voltage and current density of the MAO process obviously decrease.Cerium oxide doped on the surface of the magnesium alloy can significantly improve the corrosion resistance of the MAO coating and decrease the current density of the MAO process,as compared with lanthanum oxide,whereas the doped rare earths have no significant effect on the components of the MAO coating. | LI Jianzhong TIAN Yanwen CUI Zuoxing HUANG Zhenqi | 2008 | Rare Metals2008，27，1： | 14 |
| 11 | Exploration of the mechanisms of Ge Gen Decoction against influenza A virus infection显示文摘Ge Gen Decoction(GGD),a Traditional Chinese Medicine prescription,is mainly used to treat infectious respiratory diseases and can relieve the symptoms of influenza A virus(IAV)infection.However,the underlying mechanism of GGD against IAV infection remains unclear.In this study,we found that GGD had moderate anti-IAV activity in vitro.GGD was more effective when given before the viral infection and targeted the viral attachment and replication stages rather than the internalization sta ge.In vivo,GGD treatment reduced the virus titers of lung tissue significantly and improved the survival rate,lung index,and pulmonary hist opathological changes in H1N1-infected mice.We observed the changes in several key immuno-related indexes in GGD administrated H1N1-infected mice with anti-IAV drug oseltamivir phosphate as the control.GGD treatment decreased the expression of TNF-αand improved Th1/Th2 immune balance to reduce the excessive immune response in H1N1-infected mice.Besides,the expression of the toll-like receptor 7 signaling pathway in H1N1-infected mice decreased after GGD treatment.Our results showed that GGD has anti-IAV activity and can modulate the immune system to relieve lung inflammation. | GENG Zi-Kai LI Ya-Qun CUI Qing-Hua DU Rui-Kun TIAN Jing-Zhen | 2019 | Chinese Journal of Natural Medicines2019，17，9： | 14 |
| 12 | Propofol Attenuates a-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke显示文摘a-Synuclein is a soluble monomer abundant in the central nervous system. Aggregates of a-synuclein,consisting of higher-level oligomers and insoluble fibrils,have been observed in many chronic neurological diseases and are implicated in neurotoxicity and neurodegeneration.a-Synuclein has recently been shown to aggregate following acute ischemic stroke, exacerbating neuronal damage.Propofol is an intravenous anesthetic that is commonly used during intravascular embolectomy following acute ischemic stroke. While propofol has demonstrated neuroprotective properties following brain injury, the mechanism of protection in the setting of ischemic stroke is unclear. In this study, propofol administration significantly reduced the neurotoxic aggregation of a-synuclein, decreased the infarct area, and attenuated the neurological deficits after ischemic stroke in a mouse model. We then demonstrated that the propofol-induced reduction of a-synuclein aggregation was associated with increased mammalian target of rapamycin/ribosomal protein S6 kinase beta-1 signaling pathway activity and reduction of the excessive autophagy occurring after acute ischemic stroke. | Yuzhu Wang Dan Tian Changwei Wei Victoria Cui Huan Wang Yanbing Zhu Anshi Wu Yun Yue | 2020 | Neuroscience Bulletin2020，36，3： | 14 |
| 13 | Spatial distribution and focal mechanism solutions of the Wenchuan earthquake series:Results and implications显示文摘We relocate the spatial distribution of the devastating 12 May 2008 Wenchuan earthquake and its aftershocks.The relocation database is obtained from 89 stations deployed by the China Earthquake Administration,including 54 525 seismograms from 1 376 local earthquakes over MS3.5 between 12 May 2008 and 3 August 2008.The cross-correlation technique used in this paper has greatly improved the relocation precision by giving much more accurate P-wave differential travel-time measurements than those obtained from routinely picked phase onsets.At the same time,we pick P-wave polarity observations of the Wenchuan earthquake series (hereafter referred to as WES) from 1 023 stations in China and 59 IRIS (Incorporated Research Institutions of Seismology) stations.Then,employing a newly developed program CHNYTX,we obtain 83 well-determined focal mechanism solutions (hereafter referred to as FMSs).Based on spatial distribution and FMSs of the WES,we draw following conclusions:(1) The region near the main shock exhibits a buried low-angle northwest-dipping seismic zone with the main shock at its upper end and two conjugated seismic zones dipping southeast with roughly equal dip-angle;(2) The compressional directions of all kinds of FMSs of the WES are subhorizontal,which reflects the dominant stress in this area is compressional;(3) The principal compressional direction of the regional stress around Wenchuan is roughly perpendicular to the strike of Beichuan-Yingxiu fault,while around Qingchuan it is roughly parallel to the strike of Qingchuan fault.In intermediate part of the Longmenshan area,the principal compressional direction of the stress should be in-between;(4) The possibly existed molten materials in the lower crust of Songpan-Garze terrain have small contribution to the local stress state in Longmenshan area.The listric geometries of the Longmenshan faults most probably resulted from subhorizontal compression along NW-SE direction in history. | Chen Cai Chunquan Yu Kai Tao Xingping Hu Yuan Tian Hao Zhang Xiaofeng Cui Jieyuan Ning | 2011 | Earthquake Science2011，24，1： | 13 |
| 14 | Molecular Typing of Brucella Suis Collected from 1960s to 2010s in China by MLVA and PFGE显示文摘Brucellosis is a bacterial anthropozoonosis usually caused by Brucella abortus, Brucella melitensis, Brucella suis and Brucella canis. Brucella suis, the causative agent of swine brucellosis, is classified into five biovars and preferentially infects different animal hosts [1] . | LI Zhen Jun CUI Bu Yun CHEN Hai CHEN Jing Diao ZHAO Hong Yan PIAO Dong Ri JIANG Hai ZHANG Li TANG Xu KE Chang Wen YAO zhen TIAN Guo Zhong | 2013 | Biomedical and Environmental Sciences2013，26，6： | 13 |
| 15 | Molecular Typing of Leptospira interrogans Strains Isolated from Rattus tanezumi in Guizhou Province,Southwest of China显示文摘Objective To identify and type three leptospires isolated from Rattus tanezumi in Guizhou Province by using three molecular techniques (PFGE, MLVA, and MLST), reveal the molecular characteristic of causative agents of local leptospirosis and evaluate these three molecular methods based on their detection resolution and efficiency. Methods Three Leptospira strains were isolated from the kidney of Rattus tanezumi and cultured with EMJH medium. PFGE, MLVA, and MLST assays were applied to type the three strains isolated from Rattus tanezumi in Guizhou Province. Results PFGE, MLVA, and MLST typing showed that the three leptospiral isolates matched with leptospiral serogroup Icterohaemorrhagiae serovar Lai. The findings of the genotyping methods were consistent. MLVA and MLST defined genotypes, whereas PFGE allowed the recognition of additional subgroups within the genotypes, and the findings of molecular typing were also consistent with those of traditional techniques. Conclusion Three leptospiral isolates from Guizhou Province matched with leptospiral serogroup Icterohaemorrhagiae serovar Lai, and PFGE, MLVA, and MLST, as reliable molecular techniques for identifying and typing of Leptospira interrogans, would contribute to the active surveillance, outbreak investigation and source tracking for leptospirosis in Guizhou Province. | LI Shi Jun ZHANG Cui Cai LI Xiu Wen TIAN Ke Cheng TANG Guang Peng WANG Ding Ming LIU Ying NIE Yi Xin JIANG Xiu Gao | 2012 | Biomedical and Environmental Sciences2012，25，5： | 12 |
| 16 | Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China显示文摘The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Genetic analysis indicated that the 36 viruses formed two different genotypes: one genotype viruses were widely detected from different wild birds and domestic waterfowls;the other genotype was isolated from a whopper swan. We further revealed the origin and spatiotemporal spread of these two distinct H5N8 virus genotypes in 2020 and 2021. Animal studies indicated that the H5N8 isolates are highly pathogenic to chickens, mildly pathogenic in ducks, but have distinct pathotypes in mice. Moreover, we found that vaccinated poultry in China could be completely protected against H5N8 virus challenge. Given that the H5N8 viruses are likely to continue to spread in wild birds, vaccination of poultry is highly recommended in high-risk countries to prevent H5N8 avian influenza. | Pengfei Cui Xianying Zeng Xuyong Li Yanbing Li Jianzhong Shi Conghui Zhao Zhiyuan Qu Yanwen Wang Jing Guo Wenli Gu Qi Ma Yuancheng Zhang Weipeng Lin Minghui Li Jingman Tian Dongxue Wang Xin Xing Yanjing Liu Shuxin Pan Yaping Zhang Hongmei Bao Liling Liu Guobin Tian Chengjun Li Guohua Deng Hualan Chen | 2022 | Science China(Life Sciences)2022，65，4： | 12 |
| 17 | Livelihood changes and evolution of upland ethnic communities driven by tourism:a case study in Guizhou Province,southwest China显示文摘As an effective livelihood approach to alleviate poverty without rural population migration, ethnic tourism has become the primary choice of economic development in ethnic areas worldwide in addition to traditional livelihood approaches. This article applies the theories of livelihood to study the community evolution driven by tourism livelihood and examine three mountainous tourism communities in different stages of tourist area life cycle. Drawing on the methods of GIS spatial analysis, semi-structured interviews and questionnaires, this article proposes a sustainable livelihood framework for ethnic tourism to explore the evolution of ethnic tourism communities by identifying changes in livelihood assets(natural, financial, social, cultural and human capitals) in the process of tourism development. The results show that the development of ethnic tourism has led to changes in the increase of building land, and the diversification of land use functions with a trend of shifting from meeting local villagers' living needs to satisfying tourists, income composition and uneven distribution of tourism income spatially. Ethnic tourism also led to the deterioration of traditional social management structure, collapse of neighboring relationship, the over- commercialization and staged authenticity of ethnic culture, as well as the gradual vanish of agricultural knowledge with a trend of increasing modern business knowledge and higher education. In addition, these changes, involving livelihood assets from natural, economic, human, social and cultural aspects are interrelated and interactive, which form new evolution characters of ethnic community. This study reveals the conflicts over livelihood approaches which have formed new vulnerabilities to impact on sustainable evolution of ethnic communities. This research provides implications for achieving the sustainable development of ethnic communities with the driving force of tourism livelihood. | LI Ya-juan VV Hu CHEN Tian HU Jing CUI Hai-yang | 2016 | Journal of Mountain Science2016，13，7： | 11 |
| 18 | Effect of High Suspension and Low Incision Surgery Based on Traditional Ligation of Chinese Medicine in Treatment of Mixed Haemorrhoids:A Multi-centre,Randomized,Single-Blind,Non-inferiority Clinical Trial显示文摘Objective:To observe the clinical effect of high suspension and low incision(HSLI)surgery on mixed haemorrhoids,compared with Milligan-Morgan haemorrhoidectomy.Methods:A multi-centre,randomized,singleblind,non-inferiority clinical trial was performed.Participants with mixed haemorrhoids from Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing Rectum Hospital,Air Force Medical Center of People's Liberation Army of China,and Puyang Hospital of Traditional Chinese Medicine were enrolled from September 2016 to March 2018.By using a blocked randomization scheme,participants were assigned to two groups.The experimental group was treated with HSLI,while the control group was treated with Milligan-Morgan haemorrhoidectomy.The primary outcome was the clinical effect evaluated at 12 weeks after operation.The secondary outcomes included the number of haemorrhoids treated during the operation,pain scores,use of analgesics,postoperative oedema,wound healing,incidence of anal stenosis,anorectal manometry after operation,as well as surgical duration,length of stay and total hospitalization expenses.A safety evaluation was also conducted.Results:In total,246 eligible participants were enrolled,with 123 cases in each group.There was no significant difference in the clinical effect between the two groups(100.00% vs.99.19%,P>0.05).Compared with the control group,the number of external haemorrhoids treated during the operation and the pain scores after operation were significantly reduced in the experimental group(P<0.05 or P<0.01);the patient number with wound healing at 2 weeks after operation and the functional length of anal canal at 12 weeks after operation were significantly increased in the experimental group(P<0.05).There was no significant difference in the incidence of anal stenosis,the numbers of patients using analgesics and patients with postoperative oedema between the two groups after operation(P>0.05).The surgical duration and length of stay in the experimental group were significantly longer than those in the control group,and the total hospitalization expense was significantly higher than that in the control group(all P<0.05).No adverse events were reported in either group during the whole trial or follow-up period.Conclusion:HSLI had the advantages of preserving the skin of anal canal completely,alleviating postsurgical pain and promoting rapid recovery after operation.(Registration No.Chi CTR1900022883). | JIA Xiao-qiang CAO Wei-wei QUAN Long-fang ZHAO Wei-bing CHENG Fang JIA Shan FENG Liu-quan WEI Xu-feng XIE Zhen-nian WANG Dong XU Chun-yan CUI Chun-hui CAI Xing-juan HE Lan-ye WANG Zhan-jun TIAN Ying SHI Shu-min SUN Si-miao SU Liang ZHAI Meng-fan | 2021 | Chinese Journal of Integrative Medicine2021，27，9： | 11 |
| 19 | Apatite Fission Track Evidence of Uplift Cooling in the Qiangtang Basin and Constraints on the Tibetan Plateau Uplift显示文摘The Qiangtang basin is located in the central Tibetan Plateau. This basin has an important structural position,and further study of its tectonic and thermal histories has great significance for understanding the evolution of the Tibetan Plateau and the hydrocarbon potential of marine carbonates in the basin. This study focuses on low temperature thermochronology and in particular conducted apatite fission track analysis. Under constraints provided by the geological background,the thermal history in different tectonic units is characterized by the degree of annealing of samples,and the timing of major(uplift-erosion related) cooling episodes is inferred. The cooling history in the Qiangtang basin can be divided into two distinct episodes. The first stage is mainly from the late Early Cretaceous to the Late Cretaceous(69.8 Ma to 108.7 Ma),while the second is mainly from the MiddleLate Eocene to the late Miocene(10.3 Ma to 44.4 Ma). The first cooling episode records the uplift of strata in the central Qiangtang basin caused by continued convergent extrusion after the BangongNujiang ocean closed. The second episode can be further divided into three periods,which are respectively 10.3 Ma,22.6–26.1 Ma and 30.8–44.4 Ma. The late Oligocene-early Miocene(22.6–26.1 Ma) is the main cooling period. The distribution and times of the earlier uplift-related cooling show that the effect of extrusion after the collision between Eurasian plate and India plate obviously influenced the Qiangtang basin at 44.4 Ma. The Qiangtang basin underwent compression and started to be uplifted from the middle-late Eocene to the early Oligocene(45.0–30.8 Ma). Subsequently,a large-scale and intensive uplift process occurred during the late Oligocene to early Miocene(26.1–22.6 Ma) and the basin continued to undergo compression and uplift up to the late Miocene(10.3 Ma). Thus,uplift-erosion in the Qiangtang basin was intensive from 44.5 Ma to about 10 Ma. The timing of cooling in the second episode shows that the uplift of the Qiangtang basin was caused by the strong compression after the collision of the Indian plate and Eurasian plate. On the whole,the new apatite fission-track data from the Qiangtang basin show that the Tibetan Plateau started to extrude and uplift during 45–30.8 Ma. The main period of uplift and formation of the Tibetan Plateau took place about 22.6–26.1 Ma,and uplift and extrusion continued until the late Miocene(10.3 Ma). | REN Zhanli CUI Junping LIU Chiyang LI Tiejun CHEN Gang DOU Shuang TIAN Tao LUO Yating | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 11 |
| 20 | Ice radar investigation at Dome A, East Antarctica:Ice thickness and subglacial topography显示文摘Dome A, located in the central East Antarctic ice sheet (EAIS), is the highest summit of the Antarctic ice sheet. From ice-sheet evolution modeling results, Dome A is likely to preserve over one million years of the Earth's paleo-climatic and -environmental records, and considered an ideal deep ice core drilling site. Ice thickness and subglacial topography are critical factors for ice-sheet models to determine the timescale and location of a deep ice core. During the 21st and 24th Chinese National Antarctic Research Expedition (CHINARE 21, 2004/05; CHINARE 24, 2007/08), ground-based ice radar systems were used to a three-dimensional investigation in the central 30 km×30 km region at Dome A. The successfully obtained high resolution and accuracy data of ice thickness and subglacial topography were then interpolated into the ice thickness distribution and subglacial topography digital elevation model (DEM) with a regular grid resolution of 140.5 m×140.5 m. The results of the ice radar investigation indicate that the average ice thickness in the Dome A central 30 km×30 km region is 2233 m, with a minimal ice thickness of 1618 m and a maximal ice thickness of 3139 m at Kunlun Station. The subglacial topography is relatively sharp, with an elevation range of 949-2445 m. The typical, clear mountain glaciation morphology is likely to reflect the early evolution of the Antarctic ice sheet. Based on the ice thickness distribution and subglacial topography characteristics, the location of Kunlun Station was suggested to carry out the first high-resolution, long time-scale deep ice core drilling. However, the internal structure and basal environments at Kunlun Station still need further research to determine. | CUI XiangBin SUN Bo TIAN Gang TANG XueYuan ZHANG XiangPei JIANG YunYun GUO JingXue LI Xin | 2010 | Chinese Science Bulletin2010，55，4： | 11 |
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