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| 1 | DEC1 nuclear expression:A marker of differentiation grade in hepatocellular carcinoma显示文摘AIM: To investigate the expression patterns of human differentiated embryo chondrocyte 1 (DEC1) in hepatocellular carcinoma (HCC) and corresponding adjacent non-tumor and the normal liver tissues, the association between DEC1 expression and histopathological variables and the role of DEC1 in hepatocarcinogenesis. METHODS: The expression of DEC1 was detected immunohistochemically in 176 paraffin-embedded sections from 63 patients with HCC and 50 subjects with normal liver tissues. RESULTS: DEC1 protein was persistently expressed in the cytoplasm of hepatocytes in normal liver and HCC tissues. Compared with adjacent non-tumor liver tissues, HCC tissues showed high nuclear expression of DEC1 protein. However, high DEC1 nuclear expression was more frequently detected in well-differentiated (83.3%) than in moderately (27.3%) and poorly differentiated HCC (16.7%). Low DEC1 expression was associated with poor histological differentiation and malignancy progression. A correlation was found between the nuclear expression of DEC1 protein and histological differentiation (r = 0.376, P = 0.024). CONCLUSION: DEC1 is expressed in the cytoplasm of hepatocytes and because nuclear DEC1 expression is decreased with decreasing differentiation status of HCC, nuclear DEC1 might be a marker of HCC differentiation. | Xiao-Hong Shi Yan Zheng Qing Sun Jing Cui Qing-Hua Liu Fei Qü Yun-Shan Wang | 2011 | World Journal of Gastroenterology2011，17，15： | 15 |
| 2 | Bone morphogenetic protein-2 gene controls tooth root development in coordination with formation of the periodontium显示文摘Formation of the periodontium begins following onset of tooth-root formation in a coordinated manner after birth. Dental follicle progenitor cells are thought to form the cementum, alveolar bone and Sharpey's fibers of the periodontal ligament (PDL). However, little is known about the regulatory morphogens that control differentiation and function of these progenitor cells, as well as the progenitor cells involved in crown and root formation. We investigated the role of bone morphogenetic protein-2 (Bmp2) in these processes by the conditional removal of the Bmp2 gene using the Sp7-Cre-EGFP mouse model. Sp7-Cre-EGFP first becomes active at E18 in the first molar, with robust Cre activity at postnatal day 0 (P0), followed by Cre activity in the second molar, which occurs after P0. There is robust Cre activity in the periodontium and third molars by 2 weeks of age. When the Bmp2 gene is removed from Sp7+ (Osterix+) cells, major defects are noted in root, cellular cementum and periodontium formation. First, there are major cell autonomous defects in root-odontoblast terminal differentiation. Second, there are major alterations in formation of the PDLs and cellular cementum, correlated with decreased nuclear factor IC (Nfic), periostin and α-SMA+ cells. Third, there is a failure to produce vascular endothelial growth factor A (VEGF-A) in the periodontium and the pulp leading to decreased formation of the microvascular and associated candidate stem cells in the Bmp2-cKOSp7-Cre-EGFP . Fourth, ameloblast function and enamel formation are indirectly altered in the Bmp2-cKOSp7-Cre-EGFP . These data demonstrate that the Bmp2 gene has complex roles in postnatal tooth development and periodontium formation. | Audrey Rakian Wu-Chen Yang Jelica Gluhak-Heinrich Yong Cui Marie A Harris Demitri Villarreal Jerry Q Feng Mary MacDougall Stephen E Harris | 2013 | International Journal of Oral Science2013，5，2： | 14 |
| 3 | 半髋表面置换治疗股骨头缺血性坏死的近、中期疗效分析显示文摘目的探讨半髋表面置换术治疗股骨头缺血性坏死的近、中期疗效与股骨假体的柄干角和下沉的关系。方法41例(48髋)金属半髋表面置换患者手术时的平均年龄为36.7岁,随访至少3年。均诊为股骨头缺血性坏死,FicatⅢ期35髋、Ⅳ期13髋;其髋臼相对正常。在术后骨盆X线片上测量股骨假体的柄干角,观察其下沉情况。结果全部病例均获随访,平均5.2年(3~8年)。平均的UCLA髋关节功能评分明显改善(P=0.001),5年生存率为83%。按UCLA评分标准,FicatⅢ期35髋术后的满意率为88.6%;Ⅳ期13髋术后的满意率为69.2%(P<0.05)。8髋(FicatⅢ期、Ⅳ期各4髋)疗效差,归为失败组。计算机辅助的X线片分析显示6髋的股骨假体有明显下沉(其柄干角小于130°),2髋的髋臼有破坏(1髋柄干角为128°,1髋为136°)。疗效好的40髋(成功组)的平均柄干角为139°,而失败组的平均柄干角为127°(P<0.05)。失败组中,6髋假体头中心和假体柄尖的下沉分别为5.02mm和4.85mm,其柄干角均小于130°;而成功组假体头中心和假体柄尖的下沉仅为1.48mm和1.04mm(P<0.05)。柄干角小于130°者其发生不良后果的机会增加7.1倍。计算机辅助的X线片分析显示股骨假体超过2mm下沉的时间为19.5个月,临床出现症状的时间为35.6个月(P<0.01)。结论金属半髋表面置换术的近、中期疗效满意。较大的股骨假体的柄干角可以减少股骨头颈区域的压力,从而可以减少下沉,提高存活率。运用计算机辅助的X线片分析可以预测假体的失败。 | 肖增明 詹新立 李世德 Cui Q Wang GJ | 2005 | 中华骨科杂志2005，25，12： | 10 |
| 4 | Isolation and Structure Elucidation of Autolytimycin, A New Compound Produced by Streptomyces Autolyticus JX-47显示文摘Autolytimycin 1 was isolated from the culture filtrate of Streptomyces autolyticus JX-47, together with two known compounds, lebstatin 2 and 17-O-demethyl-geldanamycin 3. These compounds showed the activities of anti-HSV-I. The structure of 1 was determined by spectral analysis. | Li, MG Wu, SH Zhao, LX Zhang, Q Li, WJ Cui, XL Xu, LH Wu, DG Jiang, CL | 2001 | Chinese Chemical Letters2001，12，10： | 10 |
| 5 | Potent antitumor efficacy of an E1B 55kDa-deficient adenovirus carrying murine endostatin in hepatocellular carcinoma显示文摘 | Li G Sham J Yang J Su C Xue H Chua D Sun L Zhang Q Cui Z Wu M Qian Q | 2005 | 第二军医大学学报2005，26，11： | 9 |
| 6 | FAILURE ANALYSIS OF PEELING PROCESS FOR TITANIUM ANODES COATINGS显示文摘FAILUREANALYSISOFPEELINGPROCESSFORTITANIUMANODESCOATINGSTangDian;ChenShiren(InstituteforMaterialsResearch,FuzhouUniversity,Fu... | Tang, DA Chen, SR Lin, XA Cui, X Yan, Q | 1995 | 中国有色金属学会会刊:英文版1995，5，4： | 3 |
| 7 | Alloy development and shell mould casting of gamma TiAl显示文摘 | R Yang Y.Y Cui L.M Dong Q Jia | 2002 | Journal of Materials Processing Tech2002，，2： | 2 |
| 8 | 高血压患者血清磷酸盐与新发高尿酸血症风险的关系显示文摘血清磷酸盐与新发高尿酸血症的关系仍不确定。该研究对中国脑卒中一级预防试验(China stroke primary prevention trial,CSPPT)的尿酸亚组研究进行事后分析,旨在评估血清磷酸盐与新发高血尿酸症的风险之间的关系。研究包括基线尿酸水平正常(<357μmol/L)的参与者共10612人。主要观察指标是新发高血尿酸症,其定义为男性血尿酸浓度≥417或女性≥357μmol/L。在中位数为4.4年的随访期间,1663名(15.7%)参与者发生了新发高尿酸血症。 | 刘莉(译) 叶鹏(摘、审校) Cao J Zhang J Li Q Jiang C Song Y Liu C Liu L Wang B Li J Zhang Y Cui Y Huo Y Wang X Tang G Xu X Qin X | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 9 | The ASIC Design for Synthesizing Dual Channel Gauss White Noise显示文摘 | Cui W Han Y Q Long T | 2002 | Chinese Journal of Electronics2002，11，3： | 2 |
| 10 | 髋关节表面置换术治疗Ficat Ⅲ期股骨头坏死的疗效分析显示文摘目的探讨半髋关节表面置换术和全髋关节表面置换术治疗股骨头缺血性坏死的疗效。方法从1997年6月至2006年7月广西医科大学第一附属医院脊柱骨病科收治的FicatⅢ期股骨头缺血性坏死的患者38例(42髋),患者手术时的年龄29~51岁,平均(37.5±9.2)岁,其中男31例,女7例。其中31例(35髋)行了半髋关节表面置换术,7例(7髋)行了全髋关节表面置换术,所有患者病变部位的术后病理检查均为股骨头缺血性坏死。于术前和随访时采用UCLA髋关节功能评分标准对患者手术前后疼痛、步行、功能、活动进行评分。采用复诊的方式进行随访,于术后2个月开始第1次随访,每年随访1次,共随访1~13年。两组样本间均数比较采用独立样本t检验(并做方差齐性检验)。结果全部患者均获随访,平均8.4年。主要观察指标为:纳入患者髋关节表面置换手术前后UCLA评分的比较;患者半髋和全髋关节表面置换术后疗效的比较。UCLA髋关节功能评分:疼痛、步行、功能、活动的评分由术前的(3.4±1.3)分、(4.8±1.9)分、(5.9±2.8)分、(5.8±2.7)分分别提高到术后的(8.7±2.4)分、(9.0±2.8)分、(8.4±3.3)分、(7.6±3.0)分,两者之间的差异有统计学意义(t值分别为11.48、7.34、3.42、2.64,P<0.01)。其中半髋关节表面置换术35髋术后的满意率为89%,与全髋关节表面置换术7髋术后的满意率相近(100%,2=0.05,P>0.05)。结论半髋关节表面置换术和全髋关节表面置换术是一种可供选择的向全髋关节置换术过渡的较好的治疗方法,可以恢复中FicatⅢ期股骨头缺血性坏死患者的髋关节功能;半髋关节表面置换术和全髋关节表面置换术的中远期疗效是否有差异尚有待进一步观察。 | 肖增明 詹新立 CUI Q WANG GJ | 2008 | 中华关节外科杂志(电子版)2008，2，1： | 2 |
| 11 | Grain Refinement of High Purity Aluminium byAsymmetric Rolling 显示文摘 | Cui Q Ohori | 2000 | Materials Science and Technology2000，16，： | 2 |
| 12 | Effect of ultrasonic vibration on unmixed zone formation 显示文摘 | Cui Y Xu C L Han Q | 2006 | Scripta Materialia2006，55，11： | 1 |
| 13 | Investigation of flow in a steam turbine exhaust hood with/without turbine exit conditions simulated显示文摘 | LIU J J CUI Y Q JIANG H D | 2003 | Journal of Engineering for Gas Turbines and Power2003，125，1： | 1 |
| 14 | Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid 显示文摘 | Cui X Zuo P Zhang Q | 2006 | J Neurosci Res2006，83，8： | 1 |
| 15 | Effect of a feeding stimulant on feeding adaptation of gibel carp Carassius auratus gibelio (Bloch),fed diets with replacement of fish meal by meat and bone meal显示文摘 | Xue M Xie S Q Cui Y B | 2004 | Aquaculture Research2004，35，： | 1 |
| 16 | Studies on the phase separation of a polyetherlmide- modified epoxy Resin, 4: Kinetic effect on the phase separation mechanism of a blend at different cure rates 显示文摘 | Peng L Q Cui J Li S J | 2000 | Macromolecular Chemistry and Physics2000，201，6： | 1 |
| 17 | Responses of saltcedar (Tamarix chinensis) to water table depth and soil salinity in the Yellow River Delta, China显示文摘 | CUI B S YANG Q C ZHANG K J | 2010 | Plant Ecology2010，209，2： | 1 |
| 18 | AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinalganglion cells显示文摘 | Leaver SG Cui Q Plant GW | 2006 | Gene Ther2006，13，18： | 1 |
| 19 | Transgenic rice plants with a synthetic cry1Ab gene from Bacillus thuringiensis were highly resistant to eight lepidopteran rice pest species显示文摘 | Sbu Q Ye G Cui H | 2000 | Molecular Breeding2000，6，： | 1 |
| 20 | A new approach to CNS repair using chimeric peripheral nerve grafts显示文摘 | Cui Q Pollett MA Symons NA | 2003 | J Neurotrauma2003，20，1： | 1 |
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