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| 1 | Immobilization of functional nano-objects in living engineered bacterial biofilms for catalytic applications显示文摘Nanoscale objects feature very large surface-area-to-volume ratios and are now understood as powerful tools for catalysis,but their nature as nanomaterials brings challenges including toxicity and nanomaterial pollution.Immobilization is considered a feasible strategy for addressing these limitations.Here,as a proof-of-concept for the immobilization of nanoscale catalysts in the extracellular matrix of bacterial biofilms,we genetically engineered amyloid monomers of the Escherichia coli curli nanofiber system that are secreted and can self-assemble and anchor nano-objects in a spatially precise manner.We demonstrated three scalable,tunable and reusable catalysis systems:biofilm-anchored gold nanoparticles to reduce nitro aromatic compounds such as the pollutant p-nitrophenol,biofilm-anchored hybrid Cd0.9Zn0.1S quantum dots and gold nanoparticles to degrade organic dyes and biofilm-anchored CdSeS@ZnS quantum dots in a semi-artificial photosynthesis system for hydrogen production.Our work demonstrates how the ability of biofilms to grow in scalable and complex spatial arrangements can be exploited for catalytic applications and clearly illustrates the design utility of segregating high-energy nano-objects from injury-prone cellular components by engineering anchoring points in an extracellular matrix. | Xinyu Wang Jiahua Pu Yi Liu Fang Ba Mengkui Cui Ke Li Yu Xie Yan Nie Qixi Mi Tao Li Lingli Liu Manzhou Zhu Chao Zhong | 2019 | National Science Review2019，6，5： | 9 |
| 2 | 基于小波分析的大型齿轮箱低速轴故障诊断显示文摘针对大型齿轮箱低速轴故障信息难以提取的问题,采用小波分析方法对故障数据进行处理以实现信号在时/频域的局域性分析,将其无冗余、无泄漏地分解到一组具有紧支撑性的小波基上.文中采用小波分层突变系数作为判别故障隐患的特征值,并对该特征值进行趋势分析.结果表明:小波变换能有效捕捉冲击信号的时域特征和故障发生的时间历程,用小波分层突变系数所做的趋势图能有效地预测故障发展趋势,避免突发故障. | 高立新 韩金顺 张建宇 丁庆新 崔玲丽 CUI Lingli | 2005 | 北京科技大学学报2005，27，3： | 8 |
| 3 | Quantitative Diagnosis of Fault Severity Trend of Rolling Element Bearings显示文摘The condition monitoring and fault diagnosis of rolling element bearings are particularly crucial in rotating mechanical applications in industry. A bearing fault signal contains information not only about fault condition and fault type but also the severity of the fault. This means fault severity quantitative analysis is one of most active and valid ways to realize proper maintenance decision. Aiming at the deficiency of the research in bearing single point pitting fault quantitative diagnosis, a new back-propagation neural network method based on wavelet packet decomposition coefficient entropy is proposed. The three levels of wavelet packet coefficient entropy(WPCE) is introduced as a characteristic input vector to the BPNN. Compared with the wavelet packet decomposition energy ratio input vector, WPCE shows more sensitive in distinguishing from the different fault severity degree of the measured signal. The engineering application results show that the quantitative trend fault diagnosis is realized in the different fault degree of the single point bearing pitting fault. The breakthrough attempt from quantitative to qualitative on the pattern recognition of rolling element bearings fault diagnosis is realized. | CUI Lingli MA Chunqing ZHANG Feibin WANG Huaqing | 2015 | Chinese Journal of Mechanical Engineering2015，28，6： | 6 |
| 4 | Functional identification of the terpene synthase family involved in diterpenoid alkaloids biosynthesis in Aconitum carmichaelii显示文摘Aconitum carmichaelii is a high-value medicinal herb widely used across China,Japan,and other Asian countries.Aconitine-type diterpene alkaloids(DAs)are the characteristic compounds in Aconitum.Although six transcriptomes,based on short-read next generation sequencing technology,have been reported from the Aconitum species,the terpene synthase(TPS)corresponding to DAs biosynthesis remains unidentified.We apply a combination of Pacbio isoform sequencing and RNA sequencing to provide a comprehensive view of the A.carmichaelii transcriptome.Nineteen TPSs and five alternative splicing isoforms belonging to TPS-b,TPS-c,and TPS-e/f subfamilies were identified.In vitro enzyme reaction analysis functional identified two sesqui-TPSs and twelve di TPSs.Seven of the TPS-c subfamily genes reacted with GGPP to produce the intermediate ent-copalyl diphosphate.Five Ac KSLs separately reacted with ent-CPP to produce ent-kaurene,ent-atiserene,and ent-13-epi-sandaracopimaradie:a new diterpene found in Aconitum.Ac TPSs gene expression in conjunction DAs content analysis in different tissues validated that ent-CPP is the sole precursor to all DAs biosynthesis,with Ac KSL1,Ac KSL2 s and Ac KSL3-1 responsible for C20 atisine and napelline type DAs biosynthesis,respectively.These data clarified the molecular basis for the C20-DAs biosynthetic pathway in A.carmichaelii and pave the way for further exploration of C19-DAs biosynthesis in the Aconitum species. | Liuying Mao Baolong Jin Lingli Chen Mei Tian Rui Ma Biwei Yin Haiyan Zhang Juan Guo Jinfu Tang Tong Chen Changjiangsheng Lai Guanghong Cui Luqi Huang | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 6 |
| 5 | Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling显示文摘Dear Editor,At present,the world is suffering from an ongoing pandemic of 2019 novel coronavirus(COVID-19)which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2/2019-nCoV).To date,>20 million cases were confirmed with a death toll at>700,000.Although there are no clinically specific and effective antiviral treatments toward SARS-CoV-2 infection so far,the pathological study of SARS-CoV-2 infection and the development of SARS-CoV-2-specific vaccines are progressing rapidly within these several months.1 However,few reports mentioned the mechanism employed by SARS-CoV-2 for evading from surveillance of immune system. | Yaoxing Wu Ling Ma Zhen Zhuang Sihui Cai Zhiyao Zhao Lingli Zhou Jing Zhang Pei-Hui Wang Jincun Zhao Jun Cui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 6 | Hot deformation behavior of a spray-deposited AZ31 magnesium alloy显示文摘The flow stress behavior of an as-spray-deposited AZ31 magnesium alloy with fine grains was investigated by means of compression tests with a Gleeble 1500 thermal mechanical simulator at isothermal constant strain rates of 0.01, 0.1, 1.0, and 10 s-1; the testing temperatures ranged from 623 to 723 K. It is demonstrated that a linear equation can be fitted between the Zemer-Hollomon parameter Z and stress in a double-log scale. The effect of deformation parameters on the behavior of recrystallization was analyzed. Dynamic recrystallization (DRX) generally occurs at a higher temperature and at a lower strain rate. The constitutive equation of the spray-deposited AZ31 magnesium alloy is presented by calculating the deformation activation energy (199.8 kJ·mol-1). The as-spray-formed AZ31 alloy is easier for DRX nucleation at elevated temperatures due to the fine grain, which provides a large amount of nucleation sites and a high-diffusivity path for the atom. | LI Yongbing CHEN Yunbo CUI Hua DING Jie ZUO Lingli ZHANG Jishan | 2009 | Rare Metals2009，28，1： | 2 |
| 7 | Clarification of the Field Concept for a New General System Theory显示文摘Field is an essential concept for us to understand the physical phenomena in the universe.Since the field concept was proposed in electromagnetism during nineteenth century,the understanding of the field concept has experienced great changes.This paper re-examines the concept of field from its origin and evolution history,with the purpose of a better understanding of the concept in order to be used in our new general system theory to unify different theories.Our main conclusion is that the concept of field should not be regarded as an independent physical existence but a property of matter of both living and nonliving.Through a discussion on an isolated two-body system from the perspective of gravitational field,a psychic field is introduced to address the active force produced by living creatures with minds. | PAN Lingli CUI Weicheng | 2021 | Journal of Philosophy Study2021，11，10： | 2 |
| 8 | Sensitivity of supplementation of thyroid hormone on treatmentof idiopathic short-stature children during therapy withrecombinant human growth hormone显示文摘This study aimed to evaluate the effects of thyroid hormone supplementation on growth rate of childrenwith idiopathic short stature (ISS) and low-normal serum free thyroxine FT4 who were receiving growth hormonetherapy. We selected 64 prepubertal children with FT4 levels in the lowest third of the normal range as the lowerFT4 group, and these children were divided randomly into two subgroups: L-thyroxine (L-T4)-treated subgroupwas treated with L-T4 (0.5-3.0 g/(kg, d)) from the beginning of the study, and the non-L-T4-treated subgroupreceived placebo. We also selected 39 ISS children with FT4 in the upper two-thirds of the normal range as thehigher FT4 group. During the first year, the lower FT4 group featured lower FT3, FT4, thyroid stimulatinghormone (TSH), and insulin-like growth factor-I standard deviation score (IGF-I SDS) and significantly lowerheight velocity (HV) compared with the higher FT4 group. However, in the lower FT4 group, the L-T4-treatedsubgroup presented higher FT4, FT3, TSH, and IGF-I SDS concentrations and significantly higher HV comparedwith children in the non-L-T4-treated subgroup. In children with ISS, the negative effect of thyroid hormonedeficiency on growth rate should be considered when FT4 level lies in the low-normal range prior to recombinant human growth hormone treatment. | Wei Wang Shuqin Jiang Zhirui Cui Xiangyang Luo Lingli Shi Heli Zheng | 2018 | Frontiers of Medicine2018，12，5： | 2 |
| 9 | RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-kB hyper-activation and inflammation显示文摘The ongoing 2019 novel coronavirus disease(COVID-19)caused by SARS-CoV-2 has posed a worldwide pandemic and a major global public health threat.The severity and mortality of COVID-19 are associated with virus-induced dysfunctional inflammatory responses and cytokine storms.However,the interplay between host inflammatory responses and SARS-CoV-2 infection remains largely unknown.Here,we demonstrate that SARS-CoV-2 nucleocapsid(N)protein,the major structural protein of the virion,promotes the virus-triggered activation of NF-kB signaling.After binding to viral RNA,N protein robustly undergoes liquid-liquid phase separation(LLPS),which recruits TAK1 and IKK complex,the key kinases of NF-kB signaling,to enhance NF-kB activation.Moreover,1,6-hexanediol,the inhibitor of LLPS,can attenuate the phase separation of N protein and restrict its regulatory functions in NF-kB activation.These results suggest that LLPS of N protein provides a platform to Induce NF-kB hyper-activation,which could be a potential therapeutic target against COVID-19 severe pneumonia. | Yaoxing Wu Ling Ma Sihui Cai Zhen Zhuang Zhiyao Zhaou Shouheng Jin Weihong Xie Lingli Zhou Lei Zhang Jincun Zhao Jun Cui | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 2 |
| 10 | Re-examination of the Two-Body Problem Using Our New General System Theory显示文摘It is well-known that philosophical conflicts exist among classical mechanics,quantum mechanics and relativistic mechanics.In order to use the framework of general system theory to unify these three mechanics subjects,a new general system theory is developed based on a new ontology of ether and minds as the fundamental existences in the world.The two-body problem is the simplest model in mechanics and in this paper,it is re-examined by using our new general system theory.It is found that the current description of the classical full two-body problem is inappropriate since the observer and the measurement apparatus have not been explicitly considered.After considering these,it is actually a three-body problem while only the special case of the Kepler problem is the two-body problem.By introducing the concepts of psychic force and psychic field,all the possible movement states in the two-body problem can be explained within the framework of classical mechanics.There is no need to change the meanings of many fundamental concepts,such as time,space,matter,mass,and energy as done in quantum mechanics and relativity theory.This points out a new direction for the unification of different theories. | PAN Lingli CUI Weicheng | 2021 | Journal of Philosophy Study2021，11，12： | 2 |
| 11 | Targeting lactate dehydrogenase A (LDHA) exerts antileukemic effects on T-cell acute lymphoblastic leukemia显示文摘Background:T-cell acute lymphoblastic leukemia(T-ALL)is an uncommon and aggressive subtype of acute lymphoblastic leukemia(ALL).In the serum of T-ALL patients,the activity of lactate dehydrogenase A(LDHA)is increased.We proposed that targeting LDHA may be a potential strategy to improve T-ALL outcomes.The current study was conducted to investigate the antileukemic effect of LDHA gene-targeting treatment on T-ALL and the underlying molecular mechanism.Methods:Primary T-ALL cell lines Jurkat and DU528 were treated with the LDH inhibitor oxamate.MTT,colony formation,apoptosis,and cell cycle assays were performed to investigate the effects of oxamate on T-ALL cells.Quantitative real-time PCR(qPCR)and Western blotting analyses were applied to determine the related signaling pathways.A mitochondrial reactive oxygen species(ROS)assay was performed to evaluate ROS production after T-ALL cells were treated with oxamate.A T-ALL transgenic zebrafish model with LDHA gene knockdown was established using CRISPR/Cas9 gene-editing technology,and then TUNEL,Western blotting,and T-ALL tumor progression analyses were conducted to investigate the effects of LDHA gene knockdown on T-ALL transgenic zebrafish.Results:Oxamate significantly inhibited proliferation and induced apoptosis of Jurkat and DU528 cells.It also arrested Jurkat and DU528 cells in G0/G1 phase and stimulated ROS production(all P<0.001).Blocking LDHA significantly decreased the gene and protein expression of c-Myc,as well as the levels of phosphorylated serine/threonine kinase(AKT)and glycogen synthase kinase 3 beta(GSK-3β)in the phosphatidylinositol 3′-kinase(PI3K)signaling pathway.LDHA gene knockdown delayed disease progression and down-regulated c-Myc mRNA and protein expression in T-ALL transgenic zebrafish.Conclusion:Targeting LDHA exerted an antileukemic effect on T-ALL,representing a potential strategy for T-ALL treatment. | Haizhi Yu Yafei Yin Yifang Yi Zhao Cheng Wenyong Kuang Ruijuan Li Haiying Zhong Yajuan Cui Lingli Yuan Fanjie Gong Zhihua Wang Heng Li Hongling Peng Guangsen Zhang | 2020 | Cancer Communications2020，40，10： | 2 |
| 12 | Research on Remote Monitoring and Fault Diagnosis Technology of Numerical Control Machine显示文摘Based on the internet technology,it has become possible to complete remote monitoring and fault diagnosis for the numerical control machine.In order to capture the micro-shock signal induced by the incipient fault on the rotating parts,the reso- nance demodulation technology is utilized in the system.As a subsystem of the remote monitoring system,the embedded data acquisi- tion instrument not only integrates the demodulation board but also complete the collection and preprocess of monitoring data from different machines.Furthermore,through connecting to the internet,the data can be transferred to the remote diagnosis center and data reading and writing function can be finished in the database.At the same time,the problem of the IP address floating in the dial-up of web server is solved by the dynamic DNS technology.Finally,the remote diagnosis software developed on the Lab VIEW platform can analyze the monitoring data from manufacturing field.The research results have indicated that the equipment status can be monitored by the system effectively. | ZHANG Jianyu~1 GAO Lixin~1 CUI Lingli~1 LI Xianghui~2 WANG Yingwang~2 1.Key Laboratory.of Advanced Manufacturing Technology,Beijing University of Technology,Beijing 100022,China 2.Tangshan Iron and Steel Corp.LTD,Tangshan 063000,China | 2006 | 武汉理工大学学报2006，28，S2： | 1 |
| 13 | Re-examination of Fundamental Concepts of Heat, Work, Energy, Entropy, and Information Based on NGST显示文摘In order to use the framework of general system theory(GST)to unify the three mechanics subjects of classical mechanics,quantum mechanics,and relativistic mechanics,a new general system theory(NGST)is developed based on a new ontology of ether and minds as the fundamental existences in the world.Based on this new ontology,many fundamental concepts have been detected to be ambiguously defined nowadays and particularly lack of ontological support.In our previous work,some of the fundamental concepts such as universe,world,time,space,matter,ether,mind,life,field,force have been redefined.The purpose of this paper is to clarify the concepts of energy,heat,work,entropy,and information in our NGST.This is an important and necessary step in the development of the NGST. | PAN Lingli CUI Weicheng | 2022 | Journal of Philosophy Study2022，12，1： | 1 |
| 14 | A Comparison of New General System Theory Philosophy With Einstein and Bohr显示文摘The New General System theory was developed to be a theory of everything for complex systems within the world we can observe.This theory was constructed by supplementing a new mind-ether ontology into Bertalanffy’s general system theory framework.This theory is basically a generalization of classical mechanics rather than a revolution to it taken both by Einstein and Bohr in developing their relativity theory and quantum mechanics.The purpose of this paper is to reveal the reasons why Einstein and many others fail to unify relativity theory with quantum mechanics through comparing the main differences in philosophical opinions among NGST,Einstein,and Bohr.It is the hope of the authors that this clarification could speed up the unification process. | CUI Weicheng LI Rong PAN Lingli | 2023 | Journal of Philosophy Study2023，13，1： | 0 |
| 15 | Research on the Comprehensive Demodulation of Gear Tooth Crack Early Fault显示文摘The component of gear vibration signal is very complex,when a localized tooth defect such as a tooth crack is pre- sent,the engagement of the cracked tooth will induce an impulsive change with comparatively low energy to the gear mesh signal and the background noise.This paper presents a new comprehensive demodulation method which combined with amplitude envelop demodulation and phase demodulation to extract gear crack early fault.A mathematical model of gear vibration signal contain crack fault is put forward.Simulation results based on this model show that the new comprehensive demodulation method is more effective in finding fault and judging fault level then conventional single amplitude demodulation at present. | CUI Lingli DING Fang GAO Lixin ZHANG Jianyu (College of Mechanical Engineering and Applied Electronics Technology,Beijing University of Technology,Advanced Manufacturing Technology,The Key Laboratory of Beijing Municipality,Beijing 100022,China | 2006 | 武汉理工大学学报2006，28，S2： | 0 |
| 16 | Remote Monitoring and Diagnosis System for High-speed Wire Rolling Mills显示文摘Traditional fault diagnosis systems of rolling mills mostly use single machine monitoring net,which leads the re- al-time data running only in the enterprise locally and can not monitor and manage the high-speed wire rolling mills between units, workshops and factories concentratedly.A new-type structure of remote diagnosis system for high-speed wire rolling mills is pre- sented in this paper.The signal processing,computer network and remote diagnosis etc techniques are used to predictive maintenance manage the rolling mills units in this system.The new structure reinforced the remote feedback function,made up the existing fault diagnosis systems’ insufficiency in the extension and the function,promoted resource sharing and avoided the repeat develop- ment.The remote diagnosis example shows that the system can monitor and diagnose the fault information of remote machine timely and effectively. | CUI Lingli ZHANG Jianyu DING Fang GAO Lixin WANG Dapeng (College of Mechanical Engineering and Applied Electronics Technology,Beijing University of Technology,Advanced Manufacturing Technology,The Key Laboratory of Beijing Municipality,Beijing 100022,China | 2006 | 武汉理工大学学报2006，28，S2： | 0 |
| 17 | Research on HCI Prototype Design of Ink Automatic Control System for Offset Printer显示文摘In order to solve the low efficiency and poor precision problems of traditional ink control methods on domestic offset printers,developing modern ink automatic control system has become more and more urgent.As an important subsystem,the hu- man computer interface (HCI) is a key function for the wholly automatic control.Once this goal is obtained,all the printing pro- cedures especially the automatic control of ink volume should be finished with human computer interface in different areas.consid- ering the HCI design theory and structure characteristics of domestic printers comprehensively,the HCI prototype for automatic ink control system has been developed based on Visual Basic platform.As the individual ink key is instead of the integrated key,the di- vision result of ink fountain can be displayed on the interface.Through the interface,the dynamic adjusting functions such as mod- ifying ink volume,locking or unlocking each ink key and real-time displaying the adjusting results etc.can be completed.The sim- ulation test has shown that the opening and practical feature of the prototype is satisfactory. | ZHANG Jianyu~1 GAO Lixin~1 CUI Lingli~1 WANG Yingwang~2 LI Xianghui~2 1.Key Laboratory of Advanced Manufacturing Technology,Beijing University of Technology,Beijing 100022,China, 2.Tangshan Iron and Steel Corp.LTD,Tangshan 063000,China | 2006 | 武汉理工大学学报2006，28，S2： | 0 |
| 18 | CVRgram for Demodulation Band Determination in Bearing Fault Diagnosis under Strong Gear Interference显示文摘Fault-related resonance frequency band extraction-based demodulation methods are widely used for bearing diagnostics.However,due to the high peaks of strong gear meshing interference,the classical band selection methods have poor performance and cannot work well for bearing fault type detection.As such,the CVRgram-based bearing fault diagnosis method is proposed in this paper.In the proposed method,inspired by the conditional variance(CV)index and root mean square(RMS),a novel index,named the CV/root mean square(CVR),is first proposed.The CVR index has high robustness for the interference of non-Gaussian or Gaussian noise and has the ability to determine the center frequency of the weak bearing fault-related resonance frequency band under strong interference.Secondly,motived by the Kurtogram,the CVRgram algorithm is developed for adaptively determining the optimal filtering parameters.Finally,the CVRgram-based bearing fault diagnosis method under strong gear meshing interference is proposed.The performance of the CVRgram-based method is verified by both the simulation signal and the experiment signal.The comparison analysis with the Kurtogram,Protrugram,and CVgram-based method shows that the proposed technique has a much better ability for bearing fault detection under strong noise interference. | Pengda Wang Dezun Zhao Dongdong Liu Lingli Cui | 2022 | Journal of Dynamics, Monitoring and Diagnostics2022，1，4： | 0 |
| 19 | Reciprocal costimulatory molecules control the activation of mucosal type 3 innate lymphoid cells during engagement with B cells显示文摘Innate lymphoid cells(ILCs)are the counterpart of T helper cells in the innate immune system and share multiple phenotypes with T helper cells.Inducible T-cell costimulator(ICOS)is recognized on T cells and participates in T-cell activation and T and B-cell engagement in lymphoid tissues.However,the role of ICOS in ILC3s and ILC3-involved interactions with the immune microenvironment remains unclear.Here,we found that ICOS expression on human ILC3s was correlated with the activated state of ILC3s.ICOS costimulation enhanced the survival,proliferation,and capacity of ILC3s to produce cytokines(IL-22,IL-17A,IFN-γ,TNF,and GM-CSF).Via synergistic effects of ICOS and CD40 signaling,B cells promoted ILC3 functions,and ILC3-induced T-cellindependent B-cell IgA and IgM secretion primarily required CD40 signaling.Hence,ICOS is essential for the nonredundant role of ILC3s and their interaction with adjacent B cells. | Xinping Lv Shan Zhu Jing Wu Jinfeng Shi Qiuyu Wei Tete Li Ning Yang Chunyan Liu Lingli Qi Guoxia Zang Hang Cheng Zhiguang Yang Chengyan Jin Yusheng Wang Jiuwei Cui Hideki Ueno Yong-Jun Liu Jingtao Chen | 2023 | Cellular & Molecular Immunology2023，20，7： | 0 |
| 20 | Diagnosis of Gearbox Typical Fault in Rolling Mills Based on the Wavelet Packets Technology显示文摘The early impulse fault diagnosis of the gearbox in rolling mills is often difficult and labour intensive because the gearbox of that high speed machine is multi-shafting transmission system,in which many gearsets and rolling bears work together at the same time and there are much complex frequency structure and various disturb.A new time-frequency method based on the wavelet packets technique was developed and used to extract the impact feature from signals collected from faulty data of one rolling mills gearbox.The method improves the signal to noise ration so that results obtained using this method represents features with fine resolution in both low-frequency and the high frequency bands.The results of analysis indicate the validity and the practicability of the method proposed here. | CUI Lingli GAO Lixin ZHANG Jianyu DING Fang College of Mechanical Engineering and Applied Electronics Technology,Beijing University of Technology,Advanced Manufacturing Technology,The Key Laboratory of Beijing Municipality,Beijing 100022,China, | 2006 | 武汉理工大学学报2006，28，S3： | 0 |
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