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| 1 | 中国定量CT(QCT)骨质疏松症诊断指南(2018)显示文摘骨密度测量在骨质疏松症防治中具有重要作用,定量CT(quantitative computed tomography,QCT)因其成像技术优势,近年来在骨质疏松症的临床和科研以及健康管理中的应用越来越广。为了更好地规范QCT在骨质疏松症诊疗和健康管理中的应用,中国老年学和老年医学学会、中华医学会健康管理学分会联合11个学术团体,组织全国著名的专家对近年来国内外QCT的研究进展和临床文献进行认真复习,并重点结合中国国内研究的最新数据和研究成果,参考国际临床骨密度学会、美国放射学院和中国老年学和老年医学学会骨质疏松分会已经发布的相关指南,制定了本QCT诊断指南。为临床医务工作者在QCT临床应用方面提供科学、具体的指导,促进骨质疏松症的规范诊疗。 | 程晓光 王亮 曾强 吴静 《中国定量CT(QCT)骨质疏松症诊断指南》工作组 | 2019 | 中国骨质疏松杂志2019，0，6： | 169 |
| 2 | The ReaxFF reactive force-field: development, applications and future directions显示文摘The reactive force-field(ReaxFF)interatomic potential is a powerful computational tool for exploring,developing and optimizing material properties.Methods based on the principles of quantum mechanics(QM),while offering valuable theoretical guidance at the electronic level,are often too computationally intense for simulations that consider the full dynamic evolution of a system.Alternatively,empirical interatomic potentials that are based on classical principles require significantly fewer computational resources,which enables simulations to better describe dynamic processes over longer timeframes and on larger scales.Such methods,however,typically require a predefined connectivity between atoms,precluding simulations that involve reactive events.The ReaxFF method was developed to help bridge this gap.Approaching the gap from the classical side,ReaxFF casts the empirical interatomic potential within a bond-order formalism,thus implicitly describing chemical bonding without expensive QM calculations.This article provides an overview of the development,application,and future directions of the ReaxFF method. | Thomas P Senftle Sungwook Hong Md Mahbubul Islam Sudhir B Kylasa Yuanxia Zheng Yun Kyung Shin Chad Junkermeier Roman Engel-Herbert Michael J Janik Hasan Metin Aktulga Toon Verstraelen Ananth Grama Adri CT van Duin | 2016 | npj Computational Materials2016，，1： | 22 |
| 3 | 中国定量CT骨质疏松症诊断指南(2018)显示文摘骨密度测量在骨质疏松症防治中具有重要作用,定量CT( quantitative computedtomography, QCT)因其成像技术优势,近年来在骨质疏松症的临床和科研,以及健康管理的应用越来越广泛。为了更好地规范QCT在骨质疏松症诊疗和健康管理中的应用,中国老年学和老年医学学会骨质疏松分会、中华医学会健康管理学分会联合11个学术团体.组织全国影像、健康管理、骨质疏松等专业专家对近年来国内外QCT的研究进展和临床文献进行认真复习,重点结合中国的最新研究成果和数据,参考国际临床骨密度学会、美国放射学院和中国老年学和老年医学学会骨质疏松分会已经发布的诊断标准,制定本指南。为临床医务工作者在QCT临床应用方面提供科学、具体的指导,促进骨质疏松症的规范诊疗。 | 《中国定量CT骨质疏松症诊断指南(2018)》工作组 程晓光 王亮 曾强 吴静 | 2019 | 中华健康管理学杂志2019，13，3： | 21 |
| 4 | 孤立性肺结节CT动态增强研究显示文摘目的 评价CT动态增强特性对孤立性肺结节 (SPNs)性质的鉴别诊断价值。方法 49例SPNs分为 3组 ,恶性组2 9例 ,炎性组 12例及其它良性结节组 8例 ,均做了CT动态增强扫描。分析动态增强时间 -密度曲线走势 ,评价强化峰值 (PH)和强化方式在 3组间有无差异。采用免疫组织化学染色抗CD3 4抗体标记血管内皮 ,计数微血管密度 (MVD) ,分析PH与MVD有无相关性。结果 3组SPNs时间 -密度曲线走势不同 ;恶性组和炎性组PH均高于其它良性组 [PH分别为 ( 4 5 .4± 19.0 6)HU、( 5 3 .7± 10 .98)HU、( 9.0± 4.77)HU ,P <0 .0 1] ,恶性组与炎性组PH无统计学差异 (P >0 .0 5 ) ;PH与MVD呈正相关 (rs=0 .62 3 3 ,P <0 .0 1) ;3组SPNs的强化方式有极显著差异 (Ρ <0 .0 0 1)。结论 SPNsCT动态增强扫描可反映结节的血管化程度、血流动态变化过程及强化特征 。 | 丁庆国 曹文洪 季珊维 马明华江苏省常熟市第一人民医院CT室 赵芳 唐利吉 王晓燕 夏逸星 | 2004 | 实用放射学杂志2004，20，11： | 18 |
| 5 | Inflammatory pseudotumor of the liver: 13 cases of MRI findings显示文摘INTRODUCTIONInflammatory pseudotumor of the liver ,a rare benign lesion ,is often confused with the malignant tumors .Until 1998,less than 80 cases had been reported in the world [1,2].The accuracy of the pre-surgical diagnosis was low p[3,4] ,and very few materials on the diagnosis using dynamic MRI were reported [5-7] .We collected thirteen cases of inflammatory pseudotumor of the liver were collected and roved by pathology with MRI studies .Our purpose is to describe and analyze the MRI findings of this lesion and find out the valuable signs suggesting the diagnosis so as to avoid unnecessary operations. | Fu Hua Yan Kang Rong Zhou Ya Ping Jiang Wei Bin Shi Department of Radiology,Zhongshan Hospital,Medical Center of Fudan University (Former Shanghai Medical University),180 Fenglin Road,Shanghai 200032,ChinaDr.Fu Hua Yan graduated from Shanghai Medical University as a postgraduate in 1996,now an associated professor,a radiologist in chief specialized in the diagnosis of CT and MRI in hepatic diseases,having 22 papers published.She is the associated editor of the books Spiral CT and Body MRI. | 2001 | World Journal of Gastroenterology2001，7，3： | 8 |
| 6 | Enhancement of glioblastoma radioresponse by a selective COX-2 inhibitor celecoxib: inhibition of tumor angiogenesis with extensive tumor necrosis显示文摘 | Kang KB Wang TT Woon CT Cheah ES Moore XL Zhu C Wong MC | 2007 | 中国神经肿瘤杂志2007，5，2： | 8 |
| 7 | 血管内皮生长因子受体3通过β抑制蛋白1调节内皮功能显示文摘受体信号转导对于维持血管内皮功能至关重要,其在动脉粥样硬化和肺动脉高压(pulmonary arterial hypertension,PAH)等血管疾病中出现失调。内皮功能相关受体信号包括血管内皮生长因子(vascular endothelial growth factor,VEGF)受体(VEGFR)和G蛋白耦联受体(G protein-coupled receptor,GPCR),激活特异的细胞内信号通路和反应。 | 刘青 叶鹏 Ma Z Yu YR Badea CT Kovacs JJ Xiong X Comhair S Piantadosi CA Rajagopal S | 2019 | 中华高血压杂志2019，27，1： | 5 |
| 8 | Effect of Biophytum sensitivum on streptozotocin and nicotinamideinduced diabetic rats显示文摘Objective:To investigate the effect of aqueous solution of Biophytum sensUiuum leaf extract(BSEt)on normal and strcptozotocin(STZ)-nicotinamide-induced diabetic rats.Methods:Diabetes was induced in adult male Wislar rata by the administration of STZ-nicotinamide(40,110 mg/kg b.w.,respectively)intraperitoneally.BSEt(200 mg/kg)was administered to diabetic rats for 28 days.The effect of extract on blood glucose,plasma insulin,total haemoglobin,glycosylated haemoglobin,liver glycogen and carbohydrate melatxilism regulating enzymes of liver was studied in diabetic rats.Results:BSEt significantly reduced the blood glucose and glycosylated haemoglobin levels and significantly increased the total haemoglobin,plasma insulin and liver glycogen levels in diabetic rats.It also increased the hexokinase activity and decreased glucose-6-phosphatase,fructose-1,6-bisphosphatase activities in diabetic rats.Conclusions:The results of our study suggest that BSEt possesses a promising effecl on STZ-nicotinamide-induced diabetes. | Ananda Prabu K Kumarappan CT Sunil Christudas Kalaichelvan VK | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，1： | 5 |
| 9 | Recurrent ectopic pancreatitis of the jejunum and mesentery over a 30-year period显示文摘BACKGROUND:Ectopic pancreas is defined as pancreatic tissue found outside its usual anatomical position,with no ductal or vascular communication with the native pancreas. We describe a case of ectopic pancreas of the small bowel and mesentery causing recurrent episodes of pancreatitis, initially suspected on computed tomography(CT)and magnetic resonance cholangiopancreatography(MRCP),and confirmed on histological review of the resection. METHODS:A 67-year-old woman presented with clinical symptoms and biochemical evidence of pancreatitis.She had similar episodes over the past 30 years with unrevealing investigations,and was concluded to have idiopathic pancreatitis. She underwent CT and MRCP,with findings suggestive of ectopic pancreas,a diagnosis confirmed on histology of the resection. RESULTS:MRCP identified a mass in the proximal small bowel mesentery isointense to the native pancreas,with a small duct draining into a proximal jejunal loop.The resected specimen consisted of normal parenchyma with lobulated acinar tissue with scattered islets of Langerhans,an occasional ductular structure,and admixed areas of adipose tissue.The patient remained asymptomatic with normal biochemistry six months post-operatively. CONCLUSION:In an individual with abdominal pain,elevated serum amylase/lipase,but imaging findings of a normal native pancreas,ectopic pancreatitis should be considered,and can be evaluated by CT and MRCP. | John CT Wong Charlotte Robinson Edward C Jones Alison Harris Charles Zwirewich Robert Wakefield Richard K Simons Eric M Yoshida | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，2： | 4 |
| 10 | X射线正电子发射断层扫描仪(PET/CT)图像融合软件临床应用质量检测技术专家共识显示文摘PET/CT通过获取疾病的功能代谢信息与解剖结构信息提高诊断的准确性,对其图像融合软件的临床应用质量控制至关重要。国内外学者在利用模拟呼吸运动的动态体模对PET与CT图像融合软件进行质量评价过程中,在检测条件、检测项目、检测方法及评价标准等方面存在一定差异,检测结果难以互认。因此,有必要对基于模拟呼吸运动动态体模的PET/CT图像融合软件临床应用质量检测形成专家共识。在2019年3月召开的专家共识会上经充分征求核医学、放射学和临床工程专家意见,结合PET/CT图像融合软件符合性评价研究结果,专家共识组发布《X射线正电子发射断层扫描仪(PET/CT)图像融合软件临床应用质量检测技术专家共识》。该共识结合了理论与实践,讨论了一种模拟呼吸运动的动态体模,详细阐述其对PET/CT图像融合软件质量控制中的检测条件、检测项目、检测方法及评价标准,以期更好地规范利用动态体模对PET/CT图像融合软件临床应用质量进行评价。 | PET/CT图像融合软件临床应用质量检测技术专家共识协作组(2019) 种银保 孙钢 陈自谦 | 2019 | 中国医学装备2019，16，6： | 4 |
| 11 | Therapeutic effect of transcatheter arterial chemoembolization and percutaneous injection of acetic acids on primary liver cancer显示文摘BACKGROUND: The resection rate of primary liver tumor in China is only about 20%. A lot of patients with moderate and advanced liver tumor may lose the chance of opera- tion. The objective of present research was to study the ef- ficacy of transcatheter arterial chemoembolization (TACE) combined with percutaneous injection of chemical agents and acetic acids in the treatment of patients with primary liver cancer (PLC). METHODS: Thirty-three patients with middle and ad- vanced stage of PLC were divided into two groups: percu- taneous injection of chemical agents and acetic acids (15 patients, group A) and TACE (18 patients, group B). RESULTS: Tumor diameter and serum AFP level reduced to 86.6% and 83.3% in group A, and 55.5% and 40% in group B, respectively. There was significant difference be- tween the two groups ( P < 0 . 0 1 ) . The 1-, 2-, 3-, 4-year survival rates of group A were 96.7%, 86.6%, 51.3%, 33.3%, respectively and in group B were 66.7%, 44.4%, 16.7%, 0%, respectively (P<0.01). CONCLUSION: TACE combined with percutaneous injec- tion of chemical agents and acetic acids is efficacious to in- crease the survival rate of patients with PLC. | Hong-Bin Chen, Yue Huang, Dong-Ling Dai, Xia Zhang, Zhong-Wen Huang, Qi-Kai Zhang, Hui-Hua Wang, Jun-Su Zhang and Ge Pan Sanming, China Departments of Gastroenterology , Interventional Therapy , Ultrasonography and CT , Sanming Municipal First Hospital, Sanming 365000, China Department of Gastroenterology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400000, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，1： | 4 |
| 12 | The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein.显示文摘 | Chen TY Liu PH Ruan CT Chiu L Kung FL | 2006 | 中国生物学文摘2006，20，9： | 4 |
| 13 | Gastric cancer显示文摘 | Henk H Hartgrink Edwin PM Jansen Nicole CT van Grieken Cornelis JH van de Velde | 2009 | The Lancet . 2009 (9688)2009，，9688： | 4 |
| 14 | 可卡因暴露通过miR-30C-5P/苹果酸酶1/活性氧通路升高血压和加强主动脉僵硬度显示文摘滥用可卡因可增加心血管病死亡和发病风险,然而,其中潜在的分子机制仍然未知。通过可卡因滥用小鼠模型,Zhu等发现重复注射可卡因可导致小鼠血压升高和主动脉僵硬度增加(主动脉中活性氧水平同时升高),这种现象类似于人类高血压中观察到的现象。 | 刘莉 叶鹏 Zhu W Wang H Wei J Sartor GC Bao MM Pierce CT Wahlestedt CR Dykxhoorn DM Dong C | 2018 | 中华高血压杂志2018，26，4： | 4 |
| 15 | The discovery of eclogite dikes in low-greenschist facies volcaniclastic rocks of the Dabie Mountains显示文摘ECLOGITE occurs in different metamorphic rocks in the Dabie Mountains. Some dike-likeeclogite and garnet amphibolite were discovered when we investigated the newly founded low-greenschist facies volcaniclastic rocks in Changpu, Yuexi County and Siqian, Taihu County(fig.1). Coesite and quartz pseudomorphs exist in garnet and omphacite. By studying the oc-currence and petrography-mineralogy characteristic, we believe that the eclogite is of | Gao, TS Tang, JF Zhou, CT Hou, MJ Qian, CC | 1997 | Chinese Science Bulletin1997，42，20： | 3 |
| 16 | 64排CT辅助眶上锁孔入路治疗前交通动脉瘤(附17例分析)显示文摘目的探讨利用64排CT辅助眶上锁孔入路治疗前交通动脉瘤的可行性。方法回顾性分析17例前交通动脉瘤病人的病例资料。术前行64排CT扫描模拟手术。均行经额下锁孔入路动脉瘤夹闭术。结果本组动脉瘤均成功夹闭。病人生活自理15例,双颞侧偏盲1例,术后长期植物生存1例。结论对拟行眶上锁孔入路手术治疗的前交通动脉瘤病人,术前64排CT扫描有助于设计个体化的手术方案。 | 赵江 大庆油田总医院神经外科 付振宇 王玉春 王晶 刘影 大庆油田总医院CT室 肖玉强 | 2008 | 中国微侵袭神经外科杂志2008，13，9： | 3 |
| 17 | Murine fertilized ovum, blastomere and morula cells lacking SP phenotype显示文摘In the field of stem cell research, SP (side population) phenotype is used to define the property that cells maintain a high efflux capability for some fluorescent dye, such as Hoechst 33342. Recently, many researches proposed that SP phenotype is a phenotype shared by some stem cells and some pro- genitor cells, and that SP phenotype is regarded as a candidate purification marker for stem cells. In this research, murine fertilized ova (including conjugate and single nucleus fertilized ova), 2-cell stage and 8-cell stage blastomeres, morulas and blastocysts were isolated and directly stained by Hoechst 33342 dye. The results show that fertilized ovum, blastomere and morula cells do not demonstrate any ability to efflux the dye. However, the inner cell mass (ICM) cells of blastocyst exhibit SP phenotype, which is consistent with the result of embryonic stem cells (ESCs) in vitro. These results indicate that the SP phenotype of ICM-derived ESCs is an intrinsic property and independent of the culture condition in vitro, and that SP phenotype is one of the characteristics of at least some pluripotent stem cells, but is not shared by totipotent stem cells. In addition, the result that the SP phenotype of ICM cells disap- peared when the inhibitor verapamil was added into medium implies that the SP phenotype is directly associated with ABCG2. These results suggest that not all the stem cells demonstrate SP phenotype, and that SP phenotype might act as a purification marker for partial stem cells such as some pluripo- tent embryonic stem cells and multipotent adult stem cells, but not for all stem cells exampled by the totipotent stem cells in the very early stage of mouse embryos. | XU YiXin1, HE ZhiYing2, ZHU HaiYing2, CHEN XueSong2, LI JianXiu2, ZHANG HongXia2, PAN XingHua3 & HU YiPing2 1 ChangZheng Hospital, affiliated to Second Military Medical University, Shanghai 200003, China 2 Department of Cell Biology, Second Military Medical University, Shanghai 200433, China 3 Department of Genetics, Yale University School of Medicine, New Haven, CT 06519, USA | 2007 | Science China(Life Sciences)2007，50，6： | 2 |
| 18 | 急性脑缺血的弥散和灌注磁共振成像显示文摘最近 ,磁共振成像 (MRI) ,特别是弥散加权成像 (DWI)和灌注加权成像 (PWI)的进展 ,已使临床医生具备了区分不可逆性脑梗死和潜在的可逆性缺血半暗带的能力。本文探讨了DWI和PWI的工作原理和应用。随着急性脑缺血溶栓和其他治疗的不断进展 ,在急性卒中的决策方面 ,神经影像学会随时起到越来越重要的作用。 | Lim TCC Tan CT 陈兴洲 李宏建 | 2001 | 国外医学(脑血管疾病分册)2001，9，2： | 2 |
| 19 | Atrophy of the left dorsolateral prefrontal cortex is associated with poor performance in verbal fluency in elderly poststroke women显示文摘This study aimed to investigate the association between atrophy in the prefrontal cortex with executive function and verbal fluency in elderly male and female patients poststroke.Thirty elderly female patients with non-aphasic ischemic stroke aged ≥ 60 years and 30 age-matched non-aphasic male patients with ischemic stroke were recruited.Automatic magnetic resonance imaging segmentation was used to assess the volume of the whole prefrontal cortex,along with its subdivisions:anterior cingulate cortex,orbitofrontal cortex and dorsolateral prefrontal cortex.The Semantic Verbal Fluency Test was administered at 3 and 15 months poststroke.At 3 months poststroke,left dorsolateral prefrontal cortex volume was significantly correlated with Verbal Fluency Test score in female patients only(partial coefficient = 0.453,P = 0.045),after controlling for age,education,diabetes,neurological deficit,white matter lesions volume,as well as the location and volume of infarcts.At 15 months poststroke,there remained a significant association between the left dorsolateral prefrontal cortex volume and Verbal Fluency Test(partial coefficient = 0.661,P = 0.001) and between the left prefrontal cortex volume and Verbal Fluency Test(partial coefficient = 0.573,P = 0.004) in female patients after the same adjustments.These findings indicate that atrophy of the left dorsolateral prefrontal cortex contributes to the impairment of verbal fluency in elderly female patients with stroke.Sex differences may be present in the neuropsychological mechanisms of verbal fluency impairment in patients with stroke. | Yang-Kun Chen Wei-Min Xiao Defeng Wang Lin Shi Winnie CW Chu Vincent CT Mok Ka Sing Wong Gabor S Ungvari Wai Kwong Tang | 2013 | Neural Regeneration Research2013，8，4： | 2 |
| 20 | Gastric cancer显示文摘 | Henk H Hartgrink Edwin PM Jansen Nicole CT van Grieken Cornelis JH van de Velde | 2009 | The Lancet2009，，9688： | 2 |
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