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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | 新型除草剂快杀稗在水田环境中归宿的研究显示文摘快杀稗为新型选择性水田除草剂,正在世界各地实验推广.快杀稗在太阳光下,纯水中稳定,田水中光解较快.在模拟太阳光的紫外光下(即光解反应器内),在灭菌的田水中光解较慢,H_2O_2可大大加快光解速率,主要光解产物为3,7-二氯喹啉.在pH8的水中稳定,不易为微生物降解,几乎不与水田底泥结合,且不易挥发.在田间,快杀稗在30天内消解93—99%,其中第一天消解约50%.稻田底泥中快杀稗含量很低.可以推测,快杀稗污染环境的潜在危险性较小. | 王一茹 Crosby D G | 1992 | 环境科学学报1992，12，3： | 17 |
| 3 | 用键合硅柱和色谱技术分析水中快杀稗残留显示文摘本文提供了两种简便、快速、灵敏、经济的快杀稗残留分析方法。用C_8键合硅柱萃取、富集水中的快杀稗,与MTBSTFA衍生,用GC-FID测定。添加回收率为90—108%,检测极限为1ppb。HPLC法,水样不必净化可直接测定,检测极限为20ppb。水样浓度过低时,需用C_8键合硅柱萃取,富集后用HPLC测定,20ppb的添加回收率为101.3%,可检测到2ppb。 | 王一茹 Crosby D G | 1992 | 环境化学1992，11，1： | 12 |
| 4 | Relationship Quality in Services Selling:An Interpersonal Influence Perspective显示文摘 | CROSBY L A EVANS K R COWLES D | 1990 | Journal of Marketing1990，54，3： | 1 |
| 5 | Vibration Control Using Semi-Active Force Generators显示文摘 | Karnopp D Crosby M Harwood R A | 1974 | ASME Journal of Engineering for Industry1974，96，2： | 1 |
| 6 | Personality subtyping and bulimia nervosa psychopathological and genetic correlates 显示文摘 | Wonderlich S A Crosby R D Joiner T | 2005 | Psychol Med2005，35，5： | 1 |
| 7 | Relationship Quality in Service Selling : An Interpersonal Influence Perspective 显示文摘 | Crosby L A K Evans D Cowles | 1990 | Journal of Marketing1990，54，： | 1 |
| 8 | Relationshipquality in services selling : An interpersonal influenceperspective显示文摘 | Crosby L A Evans K R Cowles D | 1990 | Journal of Marketing1990，54，3： | 1 |
| 9 | Vibration control using semi--active fore generations 显示文摘 | Karnopp D C Crosby M J Harwood R A | 1974 | Transactions of the ASME jour- nal of Engineering for industry series B1974，96，2： | 1 |
| 10 | 'Relationship quality in services selling: An interpersonal influence perspective' 显示文摘 | CROSBY L A EVANS K R COWLES S D | 1990 | Journal of Mar- keting1990，54，3： | 1 |
| 11 | Vibration control using semi-active force generators显示文摘 | Karnopp D Crosby M J Harwood R A | 1974 | ASME Journal of Engi-neering for Industry1974，96，2： | 1 |
| 12 | Spatial memory performance 2 weeks after general anesthesia in adult rats 显示文摘 | Crosby C Culley D J Baxter MG | 2005 | Anesth Analg2005，101，5： | 1 |
| 13 | Biochemical and geneticcharacterization of Arabidopsis flavanone 3-hydroxylase 显示文摘 | OWENS D K CROSBY K C RUNAC J | 2008 | Plant Physiol- ogy and Biochemistry2008，46，： | 1 |
| 14 | Photodecomposition of chlorinated dibenzo-p-dioxins 显示文摘 | CROSBY D G WONG A S PLIMMER J R | 1979 | Ssicence1979，173，： | 1 |
| 15 | Practice guideline development task force of the College of American Pathologists : hereditary hemochromatosis 显示文摘 | WITTE D L CROSBY W H EDWARDS C Q | 1996 | Clin Chim Acta1996，245，2： | 1 |
| 16 | Pentachlorophenol and 3, 4-dichloroaniline as models for photochemical reaction in seawater 显示文摘 | Mille M J Crosby D G | 1983 | MarChern1983，14，： | 1 |
| 17 | Measurements of the elastic thickness under ancient lunar terrain显示文摘 | Crosby A McKenzie D | 2005 | Icarus2005，173，1： | 1 |
| 18 | A three-dimentional model of human immunodeficiency virus type 1 integrase complex 显示文摘 | Wielens J Crosby I T Chalmers D K | 2005 | J Comput Aided Mol Des2005，19，5： | 1 |
| 19 | Environmental fate of rice pesticides in California显示文摘 | Mabury S A Cox J S Crosby D G | 1996 | Reviews of Environmental Contamination and Toxicology1996，147，： | 1 |
| 20 | No evidence for decreased incidence of aspiration after rapid sequence induction显示文摘 | NEILIPOVITZ D T CROSBY E T | 2007 | Can J Anaesth2007，54，9： | 1 |
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