|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Personalized medicine in gastric cancer:Where are we andwhere are we going?显示文摘Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis. The major improvement in the treatment of recurrent or metastatic gastric cancer in recent years has been the incorporation of trastuzumab, a monoclonal antibody that inhibits human epidermal growth factor receptor 2(HER2) heterodimerization, after the demonstrated predictive value of the overexpression and/or amplification of this receptor. Beyond HER2, other genetic abnormalities have been identified, and these mutations may be targetable by tyrosine kinase inhibitors or monoclonal antibodies. The demonstration of four distinct molecular subtypes of gastric cancer by the Cancer Genome Atlas study highlight the enormous heterogeneity of the disease and its complex interplay between genetic and epigenetic alterations and provide a roadmap to implement genome-guided personalized therapy in gastric cancer. In the present review, we aim to discuss, from a clinical point of view, the genomic landscape of gastric cancer described in recent studies, the therapeutic insights derived from these findings, and the clinical trials that have been conducted and those in progress that take into account tailored therapies for gastric cancer. | Alexandre A Jácome Anelisa K Coutinho Enaldo M Lima Aline C Andrade JoséSebastião dos Santos | 2016 | World Journal of Gastroenterology2016，22，3： | 2 |
| 2 | Performance of LCD iterative method in the finite element and finite difference solution of convection-diffusion equations显示文摘 | Catabriga L Vail A Melotti Z Pessoa M Coutinho A | | Communications in numerical methods in engineering0，22，6： | 1 |
| 3 | A Walk with Francisco Vavela From First- to Second- generation Networks:In Search of the Structure,Dynamics and Mctadynmnics of An Organismcentered Immune System显示文摘 | Coutinho A | | 0，，： | 1 |
| 4 | Dynamic rheological analysisof the gelation behaviour of waxy crude oils显示文摘 | Lopes da Silva J A Coutinho JAP | 2004 | Rheologica Ac-ta2004，43，5： | 1 |
| 5 | Comparison of purity and enrichment of CD34 + cell of bone marrow , umbilical cord and peripheral blood (primed of apheresis) using five separation systems显示文摘 | de Wynter E A Coutinho L H Pei X | 1995 | Stem cells1995，13，5： | 1 |
| 6 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 7 | Surface and subsurface characterization of epoxy - mesoporous silica composites to clarify tribological properties显示文摘 | M C Romanes N A DSouza D Coutinho | 2008 | Wear2008，265，12： | 1 |
| 8 | Characterization of Sphaeropsis sapinea isolates from South Africa, Mexico, and Indonesia 显示文摘 | De Wet J Wingfield M J Coutinho T A | 2000 | Plant Disease2000，84，2： | 1 |
| 9 | Do neuronal autoanti- bodies cause psychosis? A neuroimmunological perspective显示文摘 | Coutinho E Harrison P Vincent A | 2014 | Biol Psychiatry2014，75，4： | 1 |
| 10 | L2-Galn analysis and control of uncertain nonlinear systems with bounded disturbance inputs显示文摘 | Coutinho D F Fu M Trofino A | 2008 | Int J of Robust and Nonlinear Control2008，18，1： | 1 |
| 11 | Second generation immune networks显示文摘 | Varela F J Coutinho A | 1991 | Immunol Today1991，12，5： | 1 |
| 12 | Characterization of raindrop size distributions at the Vale Formoso Experimental Erosion Center显示文摘 | Coutinho M A Tomtis P P | 1995 | Catena1995，25，： | 1 |
| 13 | Analysis of the neuroligin 3and 4 genes in autism and other neuropsychiatric patients显示文摘 | Yan J Oliveira G Coutinho A | 2005 | MolPsychiatry2005，10，4： | 1 |
| 14 | Modal Solution of Transient Heat Conduction UtilizingLanczos Algorithm显示文摘 | COUTINHO A L G A LANDAU L WROBEL L C | 1989 | International Journal for NumericalMethods in Engineering1989，28，1： | 1 |
| 15 | PCR-based identification of MAT-1 and MAT-2 in the Gibberella fujikuroi species complex显示文摘 | Steenkamp E A Wingfield B D Coutinho T A | 2000 | Applied and Environmental Microbiology2000，66，10： | 1 |
| 16 | Trehalose as cryoprotectant for preservation of yeast strains显示文摘 | Coutinho C Bemardes E Panek A D | 1988 | Journal of biotechnology1988，7，1： | 1 |
| 17 | Ionic liquid solutions as extractive solvents for value-added compounds from biomass显示文摘 | Passos H Freire M G Coutinho J A | 2014 | Green Chem2014，16，12： | 1 |
| 18 | Synthesis, anti-tuberculosis activity, and 3D-QSAR study of ring-substituted-2/d-quinolinecarbaldehyde derivatives显示文摘 | NAYYAR A MALDE A COUTINHO E | 2006 | Bioorg Med Chem2006，14，21： | 1 |
| 19 | Morphological, cultural and pathogenic characteristics of Coniothyrium zu- luense isolates from different plantation regions in South Af- flea显示文摘 | Van Zyl L M Coutinho T A Wingfield M J | 2002 | Mycopathologia2002，155，3： | 1 |
| 20 | Maternal IgG stimulates B lineage cell development in the progeny显示文摘 | MALANCHERE E HUETZ F COUTINHO A | 1997 | EurJ Immunol1997，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员