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	题名	作者	年代	出处	被引量
1	Formation mechanisms of sub-micron pharmaceutical composite particles derived from far-and near-field Raman microscopy显示文摘Surface enhanced Raman spectroscopy(SERS) and confocal Raman microscopy are applied to investigate the structure and the molecular arrangement of sub-micron furosemide and polyvinylpyrrolidone(furosemide/PVP) particles produced by spray flash evaporation(SFE). Morphology, size and crystallinity of furosemide/PVP particles are analyzed by scanning electron microscopy(SEM) and X-ray powder diffraction(XRPD). Far-field Raman spectra and confocal far-field Raman maps of furosemide/PVP particles are interpreted based on the far-field Raman spectra of pure furosemide and PVP precursors.Confocal far-field Raman microscopy shows that furosemide/PVP particles feature an intermixture of furosemide and PVP molecules at the sub-micron scale. SERS and surface-enhanced confocal Raman microscopy(SECo RM) are performed on furosemide, PVP and furosemide/PVP composite particles sputtered with silver(40 nm). SERS and SECo RM maps reveal that furosemide/PVP particle surfaces mainly consist of PVP molecules. The combination of surface and bulk sensitive analyses reveal that furosemide/PVP sub-micron particles are formed by the agglomeration of primary furosemide nanocrystals embedded in a thin PVP matrix. Interestingly, both far-field Raman microscopy and SECo RM provide molecular information on a statistically-relevant amount of sub-micron particles in a single microscopic map;this combination is thus an effective and time-saving tool for investigating organic sub-micron composites.	Jakob Hübner Jean-Baptiste Coty Yan Busby Denis Spitzer	2021	Journal of Pharmaceutical Analysis2021，11，4：	2
2	Apopwsis fascinating death factor 显示文摘	Coty S	1994	Nature1994，367，6461：	1
3	Maehinability of Austeni- tic Stainless Steel SS303 显示文摘	OSULLIVAN D COTI'ERELL M	2002	Journal of Materials Process- ing Technology2002，124，3：	1
4	transmembrane topology of the sulfonylurea receptor SUR1 显示文摘	Coti LR Radeke CM Shyng SL	2001	Jbiol Chem2001，276，41：	1
5	ESPEN Guidelines on Enteral Nutrition: Geriatrics显示文摘	D. Volkert Y.N. Berner E. Berry T. Cederholm P. Coti Bertrand A. Milne J. Palmblad St. Schneider L. Sobotka Z. Stanga R. Lenzen-Grossimlinghaus U. Krys M. Pirlich B. Herbst T. Schütz W. Schr?er W. Weinrebe J. Ockenga H. Lochs	2006	Clinical Nutrition2006，，2：	1
6	Sul- foxides as ligands: II: The infrared spectra of some dimethyl sulfoxide complexes显示文摘	COTI'ON F A FRANCIS R HORROCKS J W D	1960	J Phys Chem1960，64，10：	1
7	Relaxation of crystals with the quasi-Newton method 显示文摘	PFROMMER B G COTI~ M LOUIE S G	1997	J Com- put Phys1997，131，：	1
8	Procaleitonin as a marker of micro-inflammation in hemodialysis显示文摘	Coti G Amore M Chiesa		0，，03：	1
9	Homoclinic orbits for second order Hamiltonian systems possessing superquadratic potentials显示文摘	Vittorio Coti Zelati Paul H. Rabinowitz	1991	Journal of the American Mathematical Society1991，，4：	1
10	Identification of differentially methylated sequences in colorectal cancer by methylated c pG island amplification1显示文摘	Minoru Toyota Coty Ho Nita Ahuja	1999	Cancer Research1999，59，：	1
11	Magnetic resonance angiography (MRA) of the circle of Willis: a prospective comparison with conventional angiography in 54 subjects显示文摘	B. Patrux J. P. Laissy S. Jouini W. Kawiecki P. Coty J. Thiébot	1994	Neuroradiology1994，，3：	1
12	A variational approach to homoclinic orbits in Hamiltonian systems 显示文摘	Coti Zelati Ekeland Sere	1990	Math Ann1990，288，：	1
13	Mechanised nanoparticles for drug delivery 显示文摘	Coti M E B Karla K Monty Long Ambrogio Michael W	2009	Nanoseale2009，1，：	1
14	Critical points with lack of compactness and singular dynamical system显示文摘	Ambrosetti A Coti Zelati V		0，，：	1
15	Closed orbits of fixed energy for singular Hamiltonian systems显示文摘	Ambrosetti A Coti Zelati V		0，，：	1
16	Closed orbits of fixed energy for a class of N-body problems显示文摘	Ambrosetti A Coti Zelati V		0，，：	1
17	Genetic and environmental contributions to alcohol abuse and dependence in apopu-lation-based sample of male twins 显示文摘	PRES COTI' CA KENDLER KS	1999	Am J Psychiatry1999，156，1：	1
18	Template-assisted fabrication of dense, aligned arrays of titania nanotubes with well-controlled dimensions on substrates 显示文摘	SANDER M S COTI M J GU W	2004	Advanced Materials2004，16，22：	1
19	Memes and copyright 显示文摘	THOMAS F COTI'ER	2005	Journal of Law and Technology2005，，80：	1
20	EMPATH: Face, emotion and gender recognition using holons 显示文摘	COTI'RELL G W METCALFE J	1991	Advances in Neu- ral Information Processing Systems1991，，2：	1

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