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| 1 | Esophageal tissue engineering:A new approach for esophageal replacement显示文摘A number of congenital and acquired disorders require esophageal tissue replacement.Various surgical techniques,such as gastric and colonic interposition,are standards of treatment,but frequently complicated by stenosis and other problems.Regenerative medicine approaches facilitate the use of biological constructs to replace or regenerate normal tissue function.We review the literature of esophageal tissue engineering,discuss its implications,compare the methodologies that have been employed and suggest possible directions for the future.Medline,Embase,the Cochrane Library,National Research Register and ClinicalTrials.gov databases were searched with the following search terms:stem cell and esophagus,esophageal replacement,esophageal tissue engineering,esophageal substitution.Reference lists of papers identified were also examined and experts in this field contacted for further information.All full-text articles in English of all potentially relevant abstracts were reviewed.Tissue engineering has involved acellular scaffolds that were either transplanted with the aim of being repopulated by host cells or seeded prior to transplantation.When acellular scaffolds were used to replace patch and short tubular defects they allowed epithelial and partial muscular migration whereas when employed for long tubular defects the results were poor leading to an increased rate of stenosis and mortality.Stenting has been shown as an effective means to reduce stenotic changes and promote cell migration,whilst omental wrapping to induce vascularization of the construct has an uncertain benefit.Decellularized matrices have been recently suggested as the optimal choice for scaffolds,but smart polymers that will incorporate signalling to promote cell-scaffold interaction may provide a more reproducible and available solution.Results in animal models that have used seeded scaffolds strongly suggest that seeding of both muscle and epithelial cells on scaffolds prior to implantation is a prerequisite for complete esophageal replacement.Novel approaches need to be designed to allow for peristalsis and vascularization in the engineered esophagus.Although esophageal tissue engineering potentially offers a real alternative to conventional treatments for severe esophageal disease,important barriers remain that need to be addressed. | Giorgia Totonelli Panagiotis Maghsoudlou Jonathan M Fishman Giuseppe Orlando Tahera Ansari Paul Sibbons Martin A Birchall Agostino Pierro Simon Eaton Paolo De Coppi | 2012 | World Journal of Gastroenterology2012，18，47： | 5 |
| 2 | Antimalarial activity of allicin,abiolo gically active compound from garlic cloves显示文摘 | Coppi A Abini A N M Mirelmand | 2006 | Antimicro Agents Chemoth2006，50，17： | 1 |
| 3 | Protective effects of pidotimod against experimental bacterial infections in mice显示文摘 | Coppi G Falcone A Manzardo S | 1994 | Arzneimittelforsch1994，44，： | 1 |
| 4 | Protective effects of pidotimod against experimental bacterial infections in mice显示文摘 | Coppi G Falcone A Manzardo S | 1994 | Arzneimittel- forsch1994，44，12： | 1 |
| 5 | Hepa?ran sulfate proteoglycans provide a signal to Plasmo?dium sporozoites to stop migrating and productively invade cells显示文摘 | COPPI A TEWARI R BISHOPJ R | 2007 | Cell Host Microbe2007，2，5： | 1 |
| 6 | Exercise Training Restores Hypertension-Induced Changes in the Elastic Tissue of the Thoracic Aorta显示文摘 | Jor(a)o MT Ladd FV Coppi AA | | 0，，06： | 1 |
| 7 | Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoite to stop migrating and productively invade host cells 显示文摘 | Coppi A Tewari R Bishop JR | 2007 | Cell Host Microbe2007，2，5： | 1 |
| 8 | Data Acquisition for a 16 CCD Drift-Scan Survey 显示文摘 | Sabbey C N Coppi P Oemler A | 1998 | The Astronomical Society of the Pacific(S0004-6280)1998，110，： | 1 |
| 9 | Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells 显示文摘 | Coppi A Tewari R Bishop J R | 2007 | Cell Host Microbe2007，2，5： | 1 |
| 10 | The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host显示文摘 | Coppi A Natarajan R Pradel G | 2011 | J Exp Med2011，208，2： | 1 |
| 11 | Increase in the prevalence of symptomatic upper urinary tract stones during the last ten years显示文摘 | TRINCHIERR A COPPI F MONTANARI E | 2000 | Eur Urol2000，14，1： | 1 |
| 12 | The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion显示文摘 | Coppi A Pinzon-Ortiz C Hutter C | | 0，，01： | 1 |
| 13 | Amniotic fluid and bone marrow derived mesenchymal stem cells can be converted to smooth muscle cells in the cryo-injured rat bladder and prevent compensatory hypertrophy of surviving smooth muscle cells 显示文摘 | De Coppi P Callegari A Chiavegato A | 2007 | Journal of Urology2007，177，1： | 1 |
| 14 | The malaria circumsporozoite protein has two functional domains,each with distinct roles as sporozoites journey from mosquito to mammalian host显示文摘 | Coppi A Natarajan R Pradel G | | 0，，02： | 1 |
| 15 | Characterization of metabolism in the Fe(IIl)-reducing organism Geobacter sulfurreducens by constraint-based modeling 显示文摘 | Mahadevan R Bond DR Butler JE Esteve-Nufiez A Coppi MV Palsson BO Schilling CH and Lovley DR | 2006 | Appl Environ Microbiol2006，72，2： | 1 |
| 16 | Least squaresestimation of a linear regression model with LR fuzzy response显示文摘 | Coppi C D'Urso P Giordani P Santoro A | 2006 | Computational Statistics and Data Analysis2006，51，： | 1 |
| 17 | The malaria circumsporo- zoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host显示文摘 | Coppi A Natarajan R Pradel G | 2011 | Exp Med2011，208，2： | 1 |
| 18 | Least squares estimation of a linear regression model with LR fuzzy response显示文摘 | Coppi R. D Urso P Giordani P Santoro A | | 0，，01： | 1 |
| 19 | Identification of an up- take hydrogenase required for hydrogen-dependent reduc- tion of Fe( Ⅲ ) and other electron acceptors by Geobacter sulfurreducens显示文摘 | Coppi M V O'Neil R A Lovley D R | 2004 | Journal of Bacteriology2004，186，10： | 1 |
| 20 | The Plasmodium cir- cumsporozoite protein is proteolytically processed during cell inva- sion显示文摘 | Coppi A Pinzon-Ortiz C Hutter C | 2005 | J Exp Med2005，201，1： | 1 |
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