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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Multiple organ dysfunction score:a reliable descriptor of a complex clinical outcome显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，： | 2 |
| 3 | Strain Induced Martensite Formation in StainlessSteel 显示文摘 | Cook D C | 1978 | Metall Trans A1978，18，2： | 2 |
| 4 | Multiple organ dysfunction score:a reliable description of a complex clinical outcome显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，10： | 1 |
| 5 | Systematic reviews: synthesis of best evidence for clinical decisions 显示文摘 | COOK D J MULROW C D HAYNES R B | 1997 | Aim Intern Med1997，126，5： | 1 |
| 6 | Probiotics in prevention of antibiotic-associated diarrhoea: meta-analysis显示文摘 | D'Souza AL Rajkumar C Cooke J | 2002 | BMJ2002，324，7350： | 1 |
| 7 | Biodiversity and the tourism value of Changbai Mountain Biosphere Reserve, China: A travel cost approach 显示文摘 | Xue D Cook A Tisdell C | 2000 | Tourism Economics2000，6，4： | 1 |
| 8 | A recombinant fowlpox virus that expresses the VP2 antigen of infectious bursal disease virus induces protection against mortality caused by the virus显示文摘 | BAYLISS C D PETERS R W COOK J K A | 1991 | Arch Virol1991，120，： | 1 |
| 9 | Atmospheric Corrosion of Different Steels in Marine, Rural and Industrial Environments 显示文摘 | Oh S J Cook D C Townsend H E | 1999 | Corrosion Science1999，41，3： | 1 |
| 10 | The deglacial history of surface and intermediate water of the Bering Sea显示文摘 | Cook M S Keigwin L D Sancetta C A | 2005 | Deep-Sea Research IT2005，52，： | 1 |
| 11 | Multiple organ dysfunction score:a reliable descriptor of a complex clinical outcome显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，10： | 1 |
| 12 | Vegetative pro- duction of kenaf and canola under irrigation in central Califor- nia显示文摘 | BANUELOS G S BRYLA D R COOK C G | 2002 | Industrial Crops and Products2002，15，3： | 1 |
| 13 | LX-17 comer turning显示文摘 | Souers P C Andreski H G Cook C FⅢ Garza R Pastrone R Phillips D Roeske F Vitello P Molitoris J D | 2004 | Propellants Explosives and Pyrotechnics2004，29，1： | 1 |
| 14 | Sequencing the genespaces of Medicago truncatula and Lotus japonicusl显示文摘 | Cannon S Sato S Kim D Cook D Town C Roe B Tabata S | 2005 | Plant Physiology2005，137，： | 1 |
| 15 | Analysis of the human type I insulin - like growth factor receptor promoter region 显示文摘 | Cooke D W Bankert L A Roberts C T Jr | 1991 | Biochemical and Biophysical Research Communications1991，177，3： | 1 |
| 16 | Theory of beam coupling in a hybrid photorefractive-liquid crystal cell显示文摘 | Jones D C Cook G | 2004 | Optics communications2004，232，1： | 1 |
| 17 | Electroencephalographic quantitation of opioid effect:Comparative pharmacodynamics of fentanyl and sufentanil显示文摘 | SCOTT J C COOKE J E STANSKI D R | 1991 | Anesthesiology1991，74，1： | 1 |
| 18 | Using and understanding sedation scoring systems:a systematic review显示文摘 | De Jonghe B Cook D Appere-De-Vecchi C | 2000 | Intensive Care Med2000，26，3： | 1 |
| 19 | Effects of synthetic and naturally occurring flavonoids on metabolic activation of benzopyrene in hamster embryo cell cultures显示文摘 | CHAE Y H HO D K CASSADY J M COOK V M MARCUS C B BAIRD W M | 1992 | Chemico-biological Interactions1992，82，2： | 1 |
| 20 | Probiotics in prevention of antibiotic-associated diarrhoea:meta-analysis显示文摘 | D'Souza AL Rajkumar C Cooke J | 2002 | BMJ2002，324，7350： | 1 |
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