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| 1 | Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration显示文摘Mitotic inheritance of the DNA methylome is a challenging task for the maintenance of cell identity.Whether DNA methylation pattern in different genomic contexts can all be faithfully maintained is an open question.A replication-coupled DNA methylation maintenance model was proposed decades ago,but some observations suggest that a replication-uncoupled maintenance mechanism exists.However,the capacity and the underlying molecular events of replication-uncoupled maintenance are unclear.By measuring maintenance kinetics at the single-molecule level and assessing mutant cells with perturbation of various mechanisms,we found that the kinetics of replication-coupled maintenance are governed by the UHRF1–Ligase 1 and PCNA–DNMT1 interactions,whereas nucleosome occupancy and the interaction between UHRF1 and methylated H3K9 specifically regulate replication-uncoupled maintenance.Surprisingly,replication-uncoupled maintenance is sufficiently robust to largely restore the methylome when replication-coupled maintenance is severely impaired.However,solo-WCGW sites and other CpG sites displaying aging-and cancer-associated hypomethylation exhibit low maintenance efficiency,suggesting that although quite robust,mitotic inheritance of methylation is imperfect and that this imperfection may contribute to selective hypomethylation during aging and tumorigenesis. | Xuan Ming Zhuqiang Zhang Zhuoning Zou Cong Lv Qiang Dong Qixiang He Yangyang Yi Yingfeng Li Hailin Wang Bing Zhu | 2020 | Cell Research2020，30，11： | 4 |
| 2 | Author Correction: Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration显示文摘We apologize for the mistake of the fund information in the acknowledgements.The correct information is as follows.This correction does not affect the conclusion of the work. | Xuan Ming Zhuqiang Zhang Zhuoning Zou Cong Lv Qiang Dong Qixiang He Yangyang Yi Yingfeng Li Hailin Wang Bing Zhu | 2021 | Cell Research2021，31，3： | 2 |
| 3 | CT radiomics can help screen the coronavirus disease2019(COVID-19): a preliminary study显示文摘The coronavirus disease 2019(COVID-19) is raging across the world.The radiomics,which explores huge amounts of features from medical image for disease diagnosis,may help the screen of the COVID-19.In this study,we aim to develop a radiomic signature to screen COVID-19 from CT images.We retrospectively collect 75 pneumonia patients from Beijing Youan Hospital,including 46 patients with COVID-19 and 29 other types of pneumonias.These patients are divided into training set(n = 50) and test set(n = 25) at random.We segment the lung lesions from the CT images,and extract 77 radiomic features from the lesions.Then unsupervised consensus clustering and multiple cross-validation are utilized to select the key features that are associated with the COVID-19.In the experiments,while twenty-three radiomic features are found to be highly associated with COVID-19,four key features are screened and used as the inputs of support vector machine to build the radiomic signature.We use area under the receiver operating characteristic curve(AUC) and calibration curve to assess the performance of our model.It yields AUCs of 0.862 and 0.826 in the training set and the test set respectively.We also perform the stratified analysis and find that its predictive ability is not affected by gender,age,chronic disease and degree of severity.In conclusion,we investigate the value of radiomics in screening COVID-19,and the experimental results suggest the radiomic signature could be a potential tool for diagnosis of COVID-19. | Mengjie FANG Bingxi HE Li LI Di DONG Xin YANG Cong LI Lingwei MENG Lianzhen ZHONG Hailin LI Hongjun LI Jie TIAN | 2020 | Science China(Information Sciences)2020，63，7： | 2 |
| 4 | The Impacts on Spinach Growth and Yield by Biological Organic Fertilizer显示文摘To decrease fertilization amount of chemical fertilizer and improve the quality of vegetable crops,spinach was taken as the test material,and the impact of different fertilizer on spinach growth and yield was studied via the manners of biological organic fertilizer and organic fertilizer + chemical fertilizer. Experimental results showed that in the formula of organic fertilizer + chemical fertilizer,chlorophyll and nitrogen contents in spinach leaves obviously increased; in the formula of only adding organic fertilizer,spinach leaf temperature,leaf width,root length,plant height and fresh weight were all better than those in the formula of organic fertilizer + chemical fertilizer,and better formulas were A_5,E_5,F_3 and I_5,in which spinach plant height in E_5 was 5. 63 times higher than G_5,root length in E_5 was 2. 67 times higher than G_5,and fresh weight in G_5 was 32. 6 times higher than G_5. By comprehensive analysis,the most suitable formula for spinach production was E_5,and the research could provide theoretic basis for fertilization amount of organic fertilizer required by spinach growth and development. | Hongdou LIU Hailin JIN Nan LI Xinhe LIU Xue LI Fanteng CONG Renzhe PIAO Hongyan ZHAO | 2018 | Asian Agricultural Research2018，10，3： | 2 |
| 5 | Thin film nanofibrous com- posite ultrafiltration membrane for oil removal from oilfield wastewater显示文摘 | Cong Hailin Yu Bing Lu Xing | 2013 | Adv Mater Res2013，669，： | 1 |
| 6 | Recent progress in preparation and application of microfluidic chip electrophoresis显示文摘 | CONG Hailin XU Xiaodan YU Bing | 2015 | Journal of Micromechanics & Microengineering2015，25，05： | 1 |
| 7 | Polymer-inorganic nanoeomposite membranes for gas separation 显示文摘 | Hailin Cong Maciej Radosz Brian Francis Towler | 2007 | Separation and Purification Technology2007，55，3： | 1 |
| 8 | Polymer–inorganic nanocomposite membranes for gas separation显示文摘 | Hailin Cong Maciej Radosz Brian Francis Towler Youqing Shen | 2007 | Separation and Purification Technology2007，，3： | 1 |
| 9 | Carbon nanotube composite membranes of brominated poly( 2, 6-di- pbenyl-1,4 phenylene oxide) for gas separation显示文摘 | CONG Hailin ZHANG Jianmin RADOSZ M | 2007 | Journal of Membrane Science2007，294，12： | 1 |
| 10 | Fabri- cation of monodisperse anisotropic silica hollow mi- crospheres using polymeric cave particles as templates 显示文摘 | CONG Hailin WANG Jilei YU Bing | 2013 | Journal of Colloid and Interface Science2013，411，1： | 1 |
| 11 | Ionic liquid modified poly(2,6-dimethyl-1,4-phenylene oxide) for CO2 separation显示文摘 | Hailin Cong Bing Yu Jianguo Tang Xiu Song Zhao | 2012 | Journal of Polymer Research2012，，2： | 1 |
| 12 | Carbon nanotube composite membranes of brominated poly(2,6-diphenyl-1,4-phenylene oxide) for gas separation显示文摘 | Hailin Cong Jianmin Zhang Maciej Radosz Youqing Shen | 2007 | Journal of Membrane Science2007，，1： | 1 |
| 13 | Carbon nanotube composite membranes of brominated poly(2,6-diphenyl 1,4-phenylene oxide) for gas separation显示文摘 | Cong Hailin Zhang Jianmin Radosz M | 2007 | Journal of Membrane Science2007，294，12： | 1 |
| 14 | Hybrid brominated sulfonated poly(2,6-diphenyl-1,4-phenylene oxide) and SiO_2 nanocomposite membranes for CO_2/N_2 separation | Bing Yu Hailin Cong Xiusong Zhao | 2012 | Progress in Natural Science:Materials International2012，22，6： | 0 |
| 15 | Preparation and anti-tumor application of hyaluronic acid-based material for disulfide and copper ions co-delivery显示文摘Disulfide(DSF) has been proved good anti-tumor effect and even better with coadministration of Cu^(2+). In this work, we report the use of hyaluronic acid(HA) based materials to construct vectors for the delivery of both DSF and Cu^(2+). HA was firstly modified with polyethylene glycol monomethyl ether(mPEG) and polycaprolactone(PCL) to synthesize an amphiphilic polymer(HA-PEG-PCL). DSF could be loaded in the hydrophobic core and Cu^(2+) could be cooperated to the negative hydrophilic segment. The Cu^(2+) also played a role as crosslinking agent, which prevented DSF leakage prematurely, avoiding the bad side effects to normal tissues. The interaction between HA and CD44 improved the distribution of nanodrugs in tumor cells. When the nanodrugs were delivered to the cancer cell, the acidic micro-environment would separate the Cu^(2+) from the surface, leading to the disintegration of the micelles, promoting the release of DSF from the micelle core. The results of in vitro and in vivo experiments showed that the DSF and Cu^(2+) co-delivery vector constructed in this work could enhance the antitumor effect and have low biological toxicity. | PANG Long ZHONG Wei WANG QiuBo FENG HaoHui DONG HaoNan WANG Song CONG HaiLin SHEN YouQing YU Bing | 2021 | Science China(Technological Sciences)2021，64，9： | 0 |
| 16 | N^(6)-methyladenine is incorporated into mammalian genome by DNA polymerase显示文摘Dear Editor,DNA N^(6)-methylade nine(6mA),one of the most prevale nt epigenetic base modifications in prokaryotes,1 is recently found in multicellular eukaryotes.2-8 This nucleobase may have epigenetic roles in regulation of retrotransposons,chromatin organization,and so on.2-8 However,both our group9 and Greeks group10 noticed that eukaryotic DNA is easily contaminated with a minute of bacterial DNA,which carries overwhelmingly abundant 6mA(〜2%6mA/dA). | Xiaoling Liu Weiyi Lai Yao Li Shaokun Chen Baodong Liu Ning Zhang Jiezhen Mo Cong Lyu Jing ZhengL Ya-Rui Du Guibin Jiang Guo-Liang Xu Hailin Wang | 2021 | Cell Research2021，31，1： | 0 |
| 17 | Seed Propagation Technology and Quality Standards of Zhuoyou 1032显示文摘The breeder’s seeds of 56 A are produced through individual selection,sib mating in pairs and selection in isolation zone(net) plant line nursery.The foundation seeds are produced by isolated propagation of the breeder’s seeds,and the sterile line seeds for field production are produced by isolated propagation of the foundation seeds.The breeder’s seeds of restorer line 8020 R are produced by bagging and selfing and selection in isolation zone(net) plant line nursery,and the foundation seeds are produced by re-propagation.The hybrid seed production requires better isolation conditions,which can be realized using natural forests,mountains,rivers,roads(railways,highways),houses,etc.,and the isolation distance in open areas is equal to or larger than 800 m.It also requires early sowing of the male parent,so that the male parent can make full use of the light and temperature resources before winter to grow vegetatively,forming strong male parent plants that can provide more pollen.The seeds of the male parent are sown on September 8-10,and those of the female seeds are sown on September 12-16.Quality test is conducted during breeding and seed production in accordance with relevant national standards.The purity standards of the parent seeds are as follows: purity≥99%,neatness≥98%,germination rate≥80%,moisture≤9%,glucosinolate content≤20 μmol/g,and erucic acid content≤0.5%;the quality standards for parental field production seeds are as follows: purity≥98%,neatness≥98%,germination rate≥80% and moisture≤9%;and quality standards for hybrid seeds: purity≥85%,neatness≥98%,germination rate≥80% and moisture≤9%. | Hua WANG Hailin WANG Yao ZHAO Cong LU Fuwen KE | 2020 | Agricultural Biotechnology2020，9，2： | 0 |
| 18 | Author Correction:N^(6)-methyladenine is incorporated into mammalian genome by DNA polymerase显示文摘We apologize for the mistake of the fund information in the acknowledgements.The correct information is as follows.This correction does not affect the description of the results or the conclusion of this work. | Xialing Liu Weiyi Lai Yao Li Shaokun Chen Baodong Liu Ning Zhang Jiezhen Mo Cong Lyu Jing Zheng Ya-Rui Du Guibin Jiang Guo-Liang Xu Hailin Wang | 2021 | Cell Research2021，31，2： | 0 |
| 19 | Research on GGT-responsive drug carrier with active transport effect显示文摘Although a great quantity research has been done on cancer nano-drug carriers,how to deliver more cancer nano-drugs to tumor sites accurately and then endocytosis by cells is still a key problem in the process of cancer treatment.Since the concentration ofγ-glutamyl transpeptidase(GGT)in the microenvironment will be greatly increased when the liver,kidney,other organs become cancerous,we have designed a polymer nanomicelle as drug carrier that can respond to the GGT in the tumor microenvironment.When the drug delivery system participates in blood circulation through the vascular wall cells to the tumor tissue,the overexpressed GGT on the surface of the cancer cells will recognize and cut theγ-glutamyl group on the carrier,the primary amines will be released to make the system with weak positive charge,which not only improves the carrier’s active transport ability for nanodrugs,but also improves the cell’s endocytosis ability for nano-drugs,so as to realize the release of nano-drugs in cancer cells.What’s more,the positive charge on the surface of the carrier also improves the permeability of the carrier in the tumor tissue,so that the cancer cells in the hypoxic area can also endocytosis drugs. | Han Yan He Ma Bin He Bing Yu Youqing Shen Hailin Cong | 2023 | Nano Research2023，16，5： | 0 |
| 20 | Bimetallic selenide heterostructure with directional built-in electricfield confined in N-doped carbon nanofibers for superior sodium storage with ultralong lifespan显示文摘Constructing heterostructure is considered as an effective strategy to address the sluggish electronic and ionic kinetics of anode materials for sodium ion batteries(SIBs).However,realizing the orientated growth and uniform distribution of the heterostructure is still a great challenge.Herein,the regulated novel CoSe_(2)/NiSe_(2)heterostructure confined in N-doped carbon nanofibers(CoSe_(2)/NiSe_(2)@N-C)are prepared by using Co/Ni-ZIF template,in which,the CoSe_(2)/NiSe_(2)heterostructures realize uniform distribution on a micro level.Benefiting from the unique heterostructure and N-doped carbon nanofibers,the CoSe_(2)/NiSe_(2)@N-C deliveries superior rate capability and durable cycle lifespan with a reversible capacity of 400.5 mA h g^(-1)after 5000 cycles at 2 A g^(-1).The Na-ion full battery with CoSe_(2)/NiSe_(2)@N-C anode and layered oxide cathode displays a remarkable energy density of 563 W h kg^(-1)with 241.1 W kg^(-1)at 0.1 A g^(-1).The theoretical calculations disclose that the periodic and directional built-in electric-field along with the heterointerfaces of CoSe_(2)/NiSe_(2)@N-C can accelerate electrochemical reaction kinetics.The in(ex)situ experimental measurements reveal the reversible conversion reaction and stable structure of CoSe_(2)/NiSe_(2)@N-C during Na+insertion/extraction.The study highlights the potential ability of precisely controlled heterostructure to stimulate the electrochemical performances of advanced anode for SIBs. | Junying Weng Degui Zou Wenyong Yuan Pengfei Zhou Minghui Ding Jin Zhou Hailin Cong Fangyi Cheng | 2024 | Journal of Energy Chemistry2024，91，4： | 0 |
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