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| 1 | UGT1A1 gene polymorphism: Impact on toxicity and efficacy of irinotecan-based regimens in metastatic colorectal cancer显示文摘AIM: To investigate the correlation between uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) gene polymorphisms and irinotecan-associated side effects and parameters of drug efficacy in patients with metastatic colorectal cancer (mCRC) receiving a low-dose weekly irinotecan chemotherapeutic regimen. METHODS: Genotypes were retrospectively evaluated by gene scan analysis on the ABI 310 sequencer of the TATAA box in the promoter region of the UGT1A1 gene in blood samples from 105 patients who had received 1st line irinotecan-based chemotherapy for mCRC. RESULTS: The distribution of the genotypes was as follows: wild type genotype (WT) (6/6 ) 39.0%, heterozygous genotype (6/7) 49.5%, and homozygous genotype (7/7) 9.5%. The overall response rate (OR) was similar between patients carrying the (6/7, 7/7) or the WT genotype (6/6) (44.3% vs 43.2%, P = 0.75). Neither time to progression [(TTP) 8.1 vs 8.2 mo, P = 0.97] nor overall survival [(OS) 21.2 vs 18.9 mo, P = 0.73] differed significantly in patients who carried the(6/6) when compared to the (6/7, 7/7) genotype. No significant differences in toxicity were observed: Grade 3 and 4 delayed diarrhoea [(6/7, 7/7) vs (6/6); 13.0% vs 6.2%, P =0.08], treatment delays [(6/7, 7/7) vs (6/6); 25.1% vs 19.3%, P = 0.24] or dose reductions [(6/7, 7/7) vs (6/6); 21.5% vs 27.2%, P = 0.07].CONCLUSION: This analysis demonstrates the non-significant influence of the UGT1A1 gene polymorphism on efficacy and rate of irinotecan-associated toxicity in mCRC patients receiving low-dose irinotecan based chemotherapy. | Christoph Schulz Volker Heinemann Andreas Schalhorn Nikolas Moosmann Thomas Zwingers Stefan Boeck Clemens Giessen Hans-Joachim Stemmler | 2009 | World Journal of Gastroenterology2009，15，40： | 31 |
| 2 | 温度与有机负荷对猪粪厌氧发酵过程的影响显示文摘为提高畜禽养殖场沼气工程能源利用效率,降低工程运行成本。该文通过全混式半连续试验,以猪粪为发酵原料,研究不同温度(20、28、38℃)和有机负荷(0.3、1.3、2.3、3.3、4.3kg/(m3·d))条件下,甲烷产率、挥发性脂肪酸(volatile fattyacid,VFA)及总无机碳(total inorganic carbon,TIC)的变化特征。结果表明:20℃条件下,反应器启动缓慢,甲烷产率低。当有机负荷增加至1.3kg/(m3·d)以上时,反应器运行不稳定,需外加NaHCO3调节pH值;在28℃与38℃条件下,各有机负荷甲烷产率无明显差异,但是在较高有机负荷3.3和4.3kg/(m3·d)下运行时,28℃条件下产生挥发性脂肪酸积累的现象,系统缓冲能力缺乏,VFA/TIC值分别达到0.4和0.6。当实际沼气工程低负荷率运行时,可选择28℃作为发酵温度,以达到节省能源、提高沼气工程经济效益的目的。该研究可为实际沼气工程运行管理提供数据参考。 | 郭建斌 董仁杰 程辉彩 Joachim Clemens 庞昌乐 | 2011 | 农业工程学报2011，27，12： | 29 |
| 3 | 纳秒脉冲在普通单模光纤中产生超连续谱的实验研究显示文摘利用中心波长1064 nm的纳秒激光脉冲入射到普通单模光纤中,获得了从700 nm到超过1750 nm的超连续谱输出。在正常色散区抽运下,光谱首先出现多级拉曼斯托克斯线,随着抽运功率或光纤长度的增加,斯托克斯能量将进入光纤反常色散区,形成光孤子,随后与孤子相关的非线性效应将使光谱进一步展宽。实验结果表明,当单模光纤长度为28 m时,产生的光谱在1260~1750 nm范围内,有较好的光谱平坦度(小于3.8 dB)、较强的光谱光功率密度(平均约为0.4 mW/nm)并且单模输出。 | 刘楚 Eric Rees Toni Laurila 简水生 Clemens Kaminski | 2011 | 中国激光2011，38，7： | 10 |
| 4 | From Wisdom of the Crowd to Crowdfunding显示文摘 | Clemens Bechter Stefan Jentzsch Michael Frey | 2011 | 通讯和计算机(中英文版)2011，8，11： | 10 |
| 5 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 6 | In vivo radiometric analysis of glucose uptake and distribution in mouse bone显示文摘Bone formation and remodeling occurs throughout life and requires the sustained activity of osteoblasts and osteoclasts,particularly during periods of rapid bone growth.Despite increasing evidence linking bone cell activity to global energy homeostasis,little is known about the relative energy requirements or substrate utilization of bone cells.In these studies,we measured the uptake and distribution of glucose in the skeleton in vivo using positron-emitting^(18)F-fluorodeoxyglucose([^(18)F]-FDG) and non-invasive,high-resolution positron emission tomography/computed tomography(PET/CT) imaging and ex vivo autoradiography.Assessment of [^(18)F]-FDG uptake demonstrated that relative to other tissues bone accumulated a significant fraction of the total dose of the glucose analog.Skeletal accumulation was greatest in young mice undergoing the rapid bone formation that characterizes early development.PET/CT imaging revealed that [^(18)F]-FDG uptake was greatest in the epiphyseal and metaphyseal regions of long bones,which accords with the increased osteoblast numbers and activity at this skeletal site.Insulin administration significantly increased skeletal accumulation of [^(18)F]-FDG,while uptake was reduced in mice lacking the insulin receptor specifically in osteoblasts or fed a high-fat diet.Our results indicated that the skeleton is a site of significant glucose uptake and that its consumption by bone cells is subject to regulation by insulin and disturbances in whole-body metabolism. | Meredith L Zoch Diane S Abou Thomas L Clemens Daniel LJ Thorek Ryan C Riddle | 2016 | Bone Research2016，4，1： | 9 |
| 7 | 地理信息系统技术在伤寒发热监测中应用显示文摘目的运用地理信息系统(GIS)技术,了解各居民点发热流行率和评价以医疗机构为哨点的伤寒发热监测系统的敏感性。方法收集医学人口普查数据、疾病监测系统信息数据、现场采集居民居住点全球卫星定位数据等资料,建立GIS系统和以人口为基数的发热监测系统;对所有发热就诊病人进行身份和居住地址确认,并制作各居民点年发热就诊率GIS分布图。结果共采集3776个居民居住的全球定位系统(GPS)定位点,人群发热就诊率为1.11‰,发热就诊人次占总门诊人次的16.3%,监测区内的发热就诊病人占所有发热就诊病人的83.5%。在3种类型的医疗机构中,门诊量以个体门诊类最多,但其发热就诊人次占总门诊人次的比率最低(12.6%)。监测区内发热1d或以上的病人地址和身份(ADDRESS-ID)确认率达到95%。根据居民点年发热就诊率GIS分布图,发热就诊率最高的居民点达到17.81‰,最低为0;发热就诊率高的居民点多集中在城市。结论利用GIS技术可直观准确的了解疾病流行率的分布,可迅速直观的寻找出监测系统中的薄弱环节和推断出可能存在的问题。 | 杨进 董柏青 张杰 廖和壮 梁大斌 吴兴华 司国爱 杨宏徽 Jin Kyung Park R Leon Ochiai Camilo J Acosta Moharmmad Ali John D Clemens | 2007 | 中国公共卫生2007，23，9： | 8 |
| 8 | 低氧诱导因子-1α在绝经后骨质疏松中调控作用的实验研究显示文摘目的探讨在绝经后骨质疏松的发生、发展过程中,低氧诱导因子-lα(HIF-1α)对于成骨细胞功能的调控作用。方法 2004年10月至2006年5月,应用 Cre-Loxp 重组酶技术,建立成骨细胞条件性敲除 HIF-1α小鼠,取3个月龄雌性野生型和敲除型小鼠各24只行卵巢切除术,术后0、4、8周取材行 HE 染色、四环素荧光双标记、Micro-CT、RT-PCR、Western-blotting 检测。结果与野生型小鼠相比,敲除型小鼠骨小梁的数目、体积、厚度,骨密度,骨矿沉积速度,血管内皮生长因子(VEGF)、RunX2、ALP、OC 基因在 mRNA 水平的表达,VEGF、RunX2在蛋白水平的表达均明显降低,尤其以术后8周最为明显。结论在绝经后骨质疏松的发生、发展过程中,成骨细胞条件性敲除 HIF-1α后成骨功能降低,HIF-1α能够调控成骨细胞的成骨功能。 | 刘晓东 邓廉夫 王君 齐进 周琦 王晋申 魏立 朱雅萍 Clemens TL | 2007 | 中华外科杂志2007，45，18： | 8 |
| 9 | A+C群脑膜炎球菌多糖疫苗安全性评估显示文摘目的 评估A+C群脑膜炎球菌多糖疫苗的安全性。方法 以A+C群脑膜炎球菌多糖疫苗为观察组,伤寒Vi多糖疫苗为对照组,按整群随机分层配对的原则,将研究现场分为108个组群,观察组和对照组各分配54个组。对两组同时建立接种反应监测系统,按统一表格和方法对两组的接种反应进行监测、记录,并进行流行病学调查。结果 两组共接种34543人,其中A+C群脑膜炎球菌多糖疫苗接种18167人,伤寒Vi疫苗接种16376人。A+C群脑膜炎球菌多糖疫苗速发接种反应率为0.44‰,一般接种反应率为0.38%o;伤寒Vi疫苗速发接种反应率为0.79%,一般接种反应率为0.73%o;跟踪随访接种反应对象共1239人,其中接种A+C群脑膜炎球菌多糖疫苗的771人,接种伤寒Vi疫苗的468人。接种后第1天,A+C群脑膜炎球菌多糖疫苗组的局部反应发生率要明显高于伤寒Vi疫苗(X^2。=13.98,P=0.0002);接种后第2—3天局部反应和全身反应的发生率,两组差异无统计学意义;两组各自接种人群和未接种人群发热发生率的差异无统计学意义,两组已接种人群的发热发生率差异也无统计学意义;两组均未发现严重反应。结论 A+C群脑膜炎球菌多糖疫苗与伤寒Vi疫苗均可在不同年龄组人群开展大规模接种,局部及全身接种反应轻微,接种反应率低,有良好的安全性。 | 董柏青 叶强 崔萱林 杨进 龚健 杨明 廖和壮 韦士良 张杰 吴兴华 司国爱 杨宏徽 Ataru Tsuzuki JinKyung Park Mohammad Ali R. Leon Ochiai John D. Clemens | 2007 | 中华流行病学杂志2007，28，5： | 8 |
| 10 | The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients. | Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens | 2016 | Bone Research2016，4，2： | 6 |
| 11 | 言语噪声下汉语普通话声调测试系统的编制显示文摘目的 基于汉语普通话的语音学特点,编写叠加有言语背景噪声并符合成人心理物理学特征的声调识别测试材料,以期实现模拟真实语言环境下对声调识别能力的客观评价方案.方法 确立符合言语测听和语音学要求,兼顾简短、常用、有意义的编写原则.参考现代汉语常用字表,科学选取日常生活中常用的80个音节且四个声调均有对应实际含义的320个实词(80个音节×四声),构成声调识别测试材料词库.由两位专业播音员在本底噪声<30 dB(A)的专业录音工作室中,使用Electro Voice RE-20麦克风连接Huilian RMC-200型记录系统分别录制男声版和女声版的音频素材.采用Cool Edit Pro 2.0声音处理软件而对实词的音频素材进行强度处理、降低背景噪声并加入2 ms的静音间隔形成基础音频材料,并进一步行数字化处理.以听力正常人为受试者,根据其主观感受对基础音频材料的响度进行调整.结果 以16名听力正常人为受试者对320个实词进行主观响度调整,去除变异度过大的32个测试项,最终确立288个测试实词(即72个音节×四声),录制男、女声普通话声调识别测试材料各一套.以录制本组测试材料播音员的长时平均语谱为目标,采用FIR滤波器对高斯白噪声进行滤波,调整竞争噪声的均方根幅度,提取具有言语特异性的掩蔽噪声.在言语识别测试平台的控制下,可根据测试要求对噪声强度进行调整,实现固定信噪比条件下的汉语普通话声调识别测试.结论 成功编制具有言语特异性掩蔽噪声的汉语普通话声调识别测试材料,可为声调识别能力的研究提供评价工具. | 刘博 亓贝尔 Andreas Krenmayr 陈雪清 王硕 Reinhold Schatzer Clemens Zierhofer 韩德民 | 2014 | 中华耳鼻咽喉头颈外科杂志2014，49，9： | 6 |
| 12 | A global assessment of recent trends in gastrointestinal cancer and lifestyle-associated risk factors显示文摘Background:Gastrointestinal(GI)cancers were responsible for 26.3%of cancer cases and 35.4%of deaths worldwide in 2018.This study aimed to analyze the global incidence,mortality,prevalence,and contributing risk factors of the 6 major GI cancer entities[esophageal cancer(EC),gastric cancer(GC),liver cancer(LC),pancreatic cancer(PC),colon cancer,and rectal cancer].Methods:Using the Global Cancer Observatory and the Global Health Observatory databases,we reviewed the current GI cancer incidence,prevalence,and mortality,analyzed the association of GI cancer prevalence with national human development indices(HDIs),identified the contributing risk factors,and estimated developing age-and sex-specific trends in incidence and mortality.Results:In 2020,the trend in age-standardized rate of incidence of GI cancers closely mirrored that of mortality,with the highest rates of LC,EC,and GC in Asia and of colorectal cancer(CRC)and PC mainly in Europe.Incidence and mortality were positively,but the mortality-to-incidence ratio(MIR)was inversely correlated with the national HDI levels.High MIRs in developing countries likely reflected the lack of preventive strategies and effective treatments.GI cancer prevalence was highest in Europe and was also positively correlated with HDIs and lifestyle-associated risk factors,such as alcohol consumption,smoking,obesity,insufficient physical activity,and high blood cholesterol level,but negatively correlated with hypertension and diabetes.Incidences of EC were consistently and those of GC mostly decreasing,whereas incidences of CRC were increasing in most countries/regions,especially in the younger populations.Incidences of LC and PC were also increasing in all age-gender populations except for younger males.Mortalities were decreasing for EC,GC,and CRC in most countries/regions, and age-specific trends were observed in PC and LC with adecrease in the younger but an increase in the older population.Conclusions: On the global scale, higher GI cancer burden was accompanied,for the most part, by factors associated with the so-called Western lifestylereflected by high and very high national HDI levels. In countries/regionswith very high HDI levels, patients survived longer, and increasing GI cancercases were observed with increasing national HDI levels. Optimizing GI cancer prevention and improving therapies, especially for patients with comorbidmetabolic diseases, are thus urgently recommended. | Lili Lu Christina S.Mullins Clemens Schafmayer Sebastian Zeißig Michael Linnebacher | 2021 | Cancer Communications2021，41，11： | 6 |
| 13 | Alcoholic pancreatitis:Lessons from the liver显示文摘The association between alcohol consumption and pancreatitis has been recognized for over 100 years. Despite the fact that this association is well recognized, the mechanisms by which alcohol abuse leads to pancreatic tissue damage are not entirely clear. Alcohol abuse is the major factor associated with pancreatitis in the Western world. Interestingly, although most cases of chronic pancreatitis and many cases of acute pancreatitis are associated with alcohol abuse, only a small percentage of individuals who abuse alcohol develop this disease. This situation is reminiscent of the association between alcohol abuse and the incidence of alcoholic liver disease. The liver and the pancreas are developmentally very closely related. Even though these two organs are quite different, they exhibit a number of general structural and functional similarities. Furthermore, the diseases mediated by alcohol abuse in these organs exhibit some striking similarities. The diseases in both organs are characterized by parenchymal cell damage, activation of stellate cells, aberrant wound healing, and fibrosis. Because of the similarities between the liver and the pancreas, and the alcohol-associated diseases of these organs, we may be able to apply much of the knowledge that we have gained regarding the effects of alcohol on the liver to the pancreas. | Dahn L Clemens Katrina J Mahan | 2010 | World Journal of Gastroenterology2010，16，11： | 5 |
| 14 | Hybrid multi-chip assembly of optical communication engines by in situ 3D nanolithography显示文摘Three-dimensional(3D)nano-printing of freeform optical waveguides,also referred to as photonic wire bonding,allows for efficient coupling between photonic chips and can greatly simplify optical system assembly.As a key advantage,the shape and the trajectory of photonic wire bonds can be adapted to the mode-field profiles and the positions of the chips,thereby offering an attractive alternative to conventional optical assembly techniques that rely on technically complex and costly high-precision alignment.However,while the fundamental advantages of the photonic wire bonding concept have been shown in proof-of-concept experiments,it has so far been unclear whether the technique can also be leveraged for practically relevant use cases with stringent reproducibility and reliability requirements.In this paper,we demonstrate optical communication engines that rely on photonic wire bonding for connecting arrays of silicon photonic modulators to InP lasers and single-mode fibres.In a first experiment,we show an eight-channel transmitter offering an aggregate line rate of 448 Gbit/s by low-complexity intensity modulation.A second experiment is dedicated to a four-channel coherent transmitter,operating at a net data rate of 732.7 Gbit/s-a record for coherent silicon photonic transmitters with co-packaged lasers.Using dedicated test chips,we further demonstrate automated mass production of photonic wire bonds with insertion losses of(0.7±0.15)dB,and we show their resilience in environmental-stability tests and at high optical power.These results might form the basis for simplified assembly of advanced photonic multi-chip systems that combine the distinct advantages of different integration platforms. | Matthias Blaicher Muhammad Rodlin Billah Juned Kemal Tobias Hoose Pablo Marin-Palomo Andreas Hofmann Yasar Kutuvantavida Clemens Kieninger Philipp-Immanuel Dietrich Matthias Lauermann Stefan Wolf Ute Troppenz Martin Moehrle Florian Merget Sebastian Skacel Jeremy Witzens Sebastian Randel Wolfgang Freude Christian Koos | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 15 | A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V显示文摘 | István Vermes Clemens Haanen Helga Steffens-Nakken Chris Reutellingsperger | 1995 | Journal of Immunological Methods1995，，1： | 4 |
| 16 | Converting lateral scanning into axial focusing to speed up three-dimensional microscopy显示文摘In optical microscopy,the slow axial scanning rate of the objective or the sample has traditionally limited the speed of volumetric imaging.Recently,by conjugating either a movable mirror to the image plane in a remote-focusing geometry or an electrically tuneable lens(ETL)to the back focal plane,rapid axial scanning has been achieved.However,mechanical actuation of a mirror limits the axial scanning rate(usually only 10–100 Hz for piezoelectric or voice coil-based actuators),while ETLs introduce spherical and higher-order aberrations that prevent high-resolution imaging.In an effort to overcome these limitations,we introduce a novel optical design that transforms a lateral-scan motion into a spherical aberration-free axial scan that can be used for high-resolution imaging.Using a galvanometric mirror,we scan a laser beam laterally in a remote-focusing arm,which is then back-reflected from different heights of a mirror in the image space.We characterize the optical performance of this remote-focusing technique and use it to accelerate axially swept light-sheet microscopy by an order of magnitude,allowing the quantification of rapid vesicular dynamics in three dimensions.We also demonstrate resonant remote focusing at 12 kHz with a two-photon raster-scanning microscope,which allows rapid imaging of brain tissues and zebrafish cardiac dynamics with diffraction-limited resolution. | Tonmoy Chakraborty Bingying Chen Stephan Daetwyler Bo-Jui Chang Oliver Vanderpoorten Etai Sapoznik Clemens F.Kaminski Tuomas P.J.Knowles Kevin M.Dean Reto Fiolka | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 17 | Targeted nanoparticles for the non-invasive detection of traumatic brain injury by optical imaging and fluorine magnetic resonance imaging显示文摘坏死是仅仅在象 ischemic 疾病和创伤的大脑损害(TBI ) 那样的病理学的条件下面发生的房间死亡的一种形式。影响组织的非侵略的成像是新奇治疗学的干预的一个关键部件和在病人的治疗回答的测量。这里,我们为察觉报导一条 bimodal 途径并且 TBI 监视。PEGylated poly (lactic-co-glycolic 酸)(PLGA ) nanoparticles (NP ) ,包含两个近红外线(NIR ) fluorophores 和 perfluorocarbons (陆军) ,被指向到坏死的房间。我们使用了象 IRDye 800CW,我们以前为表明了到失去了膜正直的房间的细胞内部的蛋白质的特定的指向那样的花青染料。这里,我们出现在由光成像和氟的符号的坏死的 vivo 察觉特定磁性的回声成像(19 F MRI ) 用最新设计的 PLGA NP (NIR700 + 陆军)-PEG-800CW。量的前 vivo 光成像和 19 在受伤大脑区域并且在主要机关的 NIR 陆军内容的 F 先生光谱学很好被相关。允许的两种形式在里面在 TBI 的一个老鼠模型的坏死的大脑损害的 vivo 鉴定,与比 19 F MRI。我们的结果证实与木钉层并且损坏 TBI 的织物的成功的指向涂的 PLGA NP 的增加的血水池住处时间。包含 NIR 陆军的单个 PLGA NP 启用两个快速由 MRI 的在损害的程度上的从更深的纸巾的 TBI 州、量的 3D 信息的质的光监视。这些指向坏死的 PLGA NP 能潜在地被用于大脑损害的临床的诊断。 | Luis Javier Cruz Ivo Que Markus Aswendt Alan Chan Mathias Hoehn Clemens Lowik | 2016 | Nano Research2016，9，5： | 3 |
| 18 | Observation of an α-synuclein liquid droplet state and its maturation into Lewy body-like assemblies显示文摘Misfoldedα-synudein is a major component of Lewy bodies,which are a hallmark of Parkinson's disease(PD).A large body of evidence shows thatα-synuclein can aggregate into amyloid fibrils,but the relationship between a-synuclein self-assembly and Lewy body formation remains unclear.Here,we show,both in vitro and in a Caenorhabditis elegans model of PD,thatα-synuclein undergoes liquid-liquid phase separation by forming a liquid droplet state,which converts into an amyloid-rich hydrogel with Lewy-body-like properties.This maturation process towards the amyloid state is delayed in the presence of model synaptic vesicles in vitro.Taken together,these results suggest that the formation of Lewy bodies may be linked to the arrested maturation ofα-synuclein condensates in the presence of lipids and other cellular components. | Maarten C.Hardenberg Tessa Sinnige Sam Casford Samuel T.Dada Chetan Poudel Elizabeth A.Robinson Monika Fuxreiter Clemens F.Kaminksi Gabriele S.Kaminski Schierle Ellen A.A.Nollen Christopher M.Dobson Michele Vendruscolo | 2021 | Journal of Molecular Cell Biology2021，13，4： | 3 |
| 19 | Decline of semen quality during IVF is not associated with subjective male stress显示文摘如果精液质量衰退在期间,现在的学习的目的是估计在 vitro 授精(IVF ) 并且这现象是否被长期的男应力触发。以便测试这个假设,我们首先调查了 155 个男 IVF 病人(严峻的队) 的一个回顾的队。随后,我们在经历他们的第一 IVF 的人开始了未来的队研究并且用一个验证工具估计了精液质量和主观男长期的应力,即富饶问题库存(FPI ) 问询表。在应力和精子质量衰落之间的协会在 IVF (T1 ) 的开始前是 4-6 星期,在卵母细胞的日子,检索(T2 ) 是主要结果。实时出生率,第一三个月流产和差的应答者的率是第二等的结果。在严峻的队,吝啬的进步活动性,然而并非吝啬的精子密度显著地衰退了。有 78/154 (51%) 人和在进步活动性显示出衰落的 50/154 (32%) 人,在精液密度看了衰落。在确认队,进步活动性衰退了,而,从 T1 增加到 T2 的精子密度。78 个人, 27 个人增加了应力(FPI 分数 >146 ) 。精子密度和进步活动性不在有或没有应力的人是显著地不同的。面对男应力,然而,夫妇们有差的应答者,流产和实时出生的更低的率的更高的率。主观应力没在在 IVF 期间观察的精液质量与衰落被联系,但是可以与不利怀孕结果被联系。 | Kazem Nouri Brigitte Litschauer Michael Sator Denise Tiringer Johannes Ott Katherina Walch Lukas A Hefler Clemens B Tempfer | 2014 | Asian Journal of Andrology2014，16，4： | 3 |
| 20 | “易五码”查字法在国外汉语教学中的应用显示文摘文章采用实验的方法对非汉字文化圈汉语学习者掌握'易五码'查字法的可能性和实际学习效果进行测试。以奥地利各高校不同专业未学习过汉语的学生为主要实验对象,分别对汉字字形特征的学习和使用'易五码'查字法的查字效果进行测试。测试结果显示,将汉字作为图形,通过对外形和内构特征的学习,可以使非汉字文化圈汉语学习者,特别是初学者在短时间内掌握'易五码'查字法,以及'识''别'汉字的字形特征。 | 周昊 Clemens Schweizer | 2008 | 广州大学学报(社会科学版)2008，7，12： | 3 |
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