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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | 高速电镀钯-镍合金工艺显示文摘由于金用作电子连接接触表面镀层,成本高,电镀钯-镍合金已成为最具吸引力的接触材料的替代品。然而,传统氨系电镀钯-镍工艺和新的无氨电镀钯-镍工艺有许多环保特征未能达到最佳。与早期电镀钯-镍合金相比,低氨高速电镀钯-镍合金工艺具有技术性能卓越,物料消耗降低和环境状况改善等优势。 | CLAUSS M GUEBEY J SCHWAGER F | 2009 | 电镀与环保2009，29，6： | 3 |
| 3 | Phenotype and course of hutchinson-gilford progeria syndrome显示文摘 | Merideth M A Gordon L B Clauss S | 2008 | N Engl J Med2008，358，6： | 1 |
| 4 | Prospective randomized study comparing docetaxel,estramustine,and prednisone with docetaxel and prednisone in metastatic hormone-refractory prostate cancer显示文摘 | Machiels JP Mazzeo F Clausse M | 2008 | J Clin Oncol2008，26，32： | 1 |
| 5 | Ectomycorrhizal symbiosis affects functional diversity of rhizosphere fluorescent pseudomonads显示文摘 | Frey-Klett P Chavatte M Clausse M L | 2005 | New Phytologist2005，165，1： | 1 |
| 6 | Vascular permeability factor: a tumor derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration 显示文摘 | Clauss M Gerlach M Gerlach H | 1990 | J Exp Med1990，172，6： | 1 |
| 7 | Molecular biology of the VEGF and the VEGF receptor family 显示文摘 | Clauss M | 2000 | Semin Thromb Hemost2000，26，5： | 1 |
| 8 | , Comparative in- vestigations on digestion in grazing (Ceratotherium simum ) and browsing ( Diceros bicornis ) rhinoceroses 显示文摘 | STEUER P CLAUSS M S' DEKUM K H | 2010 | Comparative Bio- chemistry and Physiology-Part A: Molecular & Integrative Physi- ology2010，156，4： | 1 |
| 9 | Seed germination in desert annuals:An empirical test of adaptive bet hedging显示文摘 | Clauss M Venable D | | 0，，： | 1 |
| 10 | A combined region growing and deformable model method for extraction of closed surfaces in 3D CT and MRI scans显示文摘 | FRESNO M VENERE M CLAUSSE A | 2009 | Computerized Medical Imaging and Graphics2009，33，5： | 1 |
| 11 | Molecular biology of the VEGF and the VEGF receptor family显示文摘 | Clauss M | 2000 | Semin Thromb Hemost2000，26，5： | 1 |
| 12 | Stabilization strategies for weatherable PU 显示文摘 | S M Anedrews M Clauss | 1997 | Rubber World1997，，4： | 1 |
| 13 | Bicontinous structurezones in microemulsions显示文摘 | Clausse M Peyrelasse J Heil J | 1981 | Nature1981，293，43： | 1 |
| 14 | The vaccine candidate BLSOmp31 protects mice against Brucella canis infection显示文摘 | CLAUSSE M DIAZ A G GHERSI G | 2013 | Vaccine2013，31，51： | 1 |
| 15 | The New Year Wave: spatial evolution of an extreme sea state显示文摘 | CLAUSS G F KLEIN M | 2009 | Journal of Offshore Mechanics and Arctic Engineering2009，131，4： | 1 |
| 16 | Influence of leg lengthdiscrepancy on clinical results after total hip arthroplasty-a pro- spective clinical trial 显示文摘 | Plaass C Clauss M Ochsner PE | 2011 | Hip Int2011，21，4： | 1 |
| 17 | Valproic acid is effective in migraine prophylaxis at low serum levels:a prospective open-label study显示文摘 | Kinze S Clauss M Reuter U | 2001 | Headache2001，41，8： | 1 |
| 18 | Function of the VEGF Receptor-1 (FLT) in the Vasculature显示文摘 | Clauss M | 1998 | Trends Cardiovasc Med1998，8，： | 1 |
| 19 | Properties of Langmuir surface and interracial films built up by asphaltenes and resins: influence of chemical demulsifiers 显示文摘 | Ese M H Galet L Clausse D | 1999 | Colloid Interface Sci1999，220，： | 1 |
| 20 | Lung endothelial monocyte-activating protein 2 is a mediator ofcigarette smoke-induced emphysema in mice显示文摘 | Clauss M Voswinckel R Rajashekhar G | | 0，，： | 1 |
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