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1Molecular pathogenesis of bone metastases in breast cancer: Proven and emerging therapeutic targets显示文摘Metastatic occurrence is the principal cause of death in breast cancer patients. The high osteotropism makes breast cancer the most common primary tumor type associated with metastatic bone disease. The peculiar clinical aspects associated with metastases limited to the skeletal system suggest considering these cases as a distinctive subset of metastatic patients with a better prognosis. Because bone is frequently the first metastatic site in disease relapse, it is feasible that the next improvement in therapeutic options for bone metastatic disease could be associated with an improvement of survival expectation and quality of life in breast cancer patients. Study of the molecular basis of bone remodeling and breast cancer osteotropism has allowed identification of several therapeutic candidates involved in formation and progression of bone metastases. These targets are frequently the determinants of positive feedback between the tumor and bone cells whose clinical outcome is osteolytic lesions. In this review, we discuss the physiopathologic features underlying targeted therapeutic strategies aimed at interfering with the aberrant bone remodeling associated with breast cancer metastases.Nadia Rucci Patrizia Sanità Simona Delle Monache Edoardo Alesse Adriano Angelucci 2014World Journal of Clinical Oncology2014,5,3:18
2Effect of depressing agents on the flotation of oxidized zinc minerals显示文摘MARABINI A M ALESSE V G BELARDI G 1994Miner Metall Process SME1994,11,:1
3Oxygen-radical absorbance capacity assay for antioxidants 显示文摘Cao G Alession H M Cutler R G 1993Free Radical Biology and Medicine1993,14,:1
4REN: a novel, developmentally regulated gene that promotes neural cell differentiation 显示文摘Gallo R Zazzeroni F Alesse E 2002J Cell Biol2002,158,4:1
5Plasma plasminogen activator inhibitor-1 in angina pectoris: Influence of plasma insulin and acute phase response显示文摘JUHAN-VAGUE I ALESSIC MC JOLY P 1989Arteriosclerosis1989,9,3:1
6查看详情显示文摘Katta P. Aless roM. Rams ier R.D 0,,:1
7Effect of Ultra-high Hydrostatic Pressure Treatments on the Quality of Tomato Juice显示文摘Sebastiano P Aless Er B Claudio G 1995Food Chemistry1995,52,1:1
8Gastric bypass surgery enhances glucagon-like peptide 1 stimulated postprandial insulin secretion in humans显示文摘Salehi M Prigeon RL D'Alession DA 0,,09:1
9New reagents in sulphide mineral flotation 显示文摘Marabini A M Barbaro M Alesse V 1991International Journal of Mineral Processing1991,33,:1
10Synergistic action between aryl phosphates and henolic resin in PBT 显示文摘LEVCHIK S V BRIGHT D A ALESSION G R 2002Polym Degrad Stab2002,77,4:1
11Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice显示文摘Bellavia D Campese AF Alesse E 0,,13:1
12Validityofserum testosterone, free androgen index,and calculat-ed free testosterone in women with suspected hyperan -drogenism显示文摘Alkindi M K Alessry F S Aless F S 2012OmanMed J2012,27,6:1
13Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice显示文摘Diana Bellavia Antonio F Campese Edoardo Alesse 2000EMBO2000,19,13:1
14New reagents in sulphide mineral flotation显示文摘MARABINI A M BARBARO M ALESSE V 1991International Journal of Mineral Processing1991,33,:1
15Effects of glucagons like peptide I-(7-36) on release of insulin,glucagon,and somatostatin by rat pancreatic islet cell monolayer cultures显示文摘D'Alession D A Fujimoto W Y Ensinck J W 1989Diabetes1989,38,12:1
16The growth arrest and downregulati o n of c-myc transcription induced by ceramide are related events dependent on p2 1 induction,Rb underphosphorylation and E2F sequestering显示文摘Alesse E Zazzeroni F Angelucci A 0,,:1
17Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice显示文摘Bellavia D Campese AF Alesse E 2000EMBO J2000,19,13:1
18REN: a novel, developmentally regulated gene that promotes neural cell differentiation 显示文摘Gallo R Zazzeroni F Alesse E 2002J Cell Biol2002,158,4:1
19New reagents insulphide mineral flotation 显示文摘Marabini A M Barbaro M Alesse V 1991International Journal ofMineral Processing1991,33,:1
20Deinking recycled paper with a high flexographic ink content 显示文摘Aless V Belarfi G Cozza C 2001TAPPI J2001,84,8:1
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