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| 1 | IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis显示文摘AIM To investigate the association of seven single nucleotide polymorphisms(SNPs) of the IL23 R gene with the clinical picture of ulcerative colitis(UC). METHODS Genomic DNA samples of 131 patients (66 males, 65 females, mean age 55.4 ± 15.8 years) with Caucasian origin, diagnosed with UC were investigated. The diagnosis of UC was based on the established clinical, endoscopic, radiological, and histopathological guidelines. DNA was extracted from peripheral blood leukocytes by routine salting out method. Polymerase chain reaction and restriction fragment length polymorphism were used to identify the alleles of seven SNPs of IL23 R gene(rs11209026, rs10889677, rs1004819, rs2201841, rs7517847, rs10489629, rs7530511).RESULTS Four out of seven analyzed SNPs had statistically significant influence on the clinical picture of UC. Two SNPs were associated with greater colonic extension(rs2201841 P = 0.0084; rs10489629 P = 0.0405). For two of the SNPs, there was more frequently need for operations (rs2201841 P = 0.0348, OR = 8.0; rs10889677 P = 0.0347, OR = 8.0). The rs2201841 showed to be a risk factor for the development of iron deficiency (P = 0.0388, OR = 6.1837). For patients with the rs10889677, a therapy with azathioprine was more frequently necessary(P = 0.0116, OR = 6.1707). Patients with rs10489629 SNP had a lower risk for weight loss(P = 0.0169, OR = 0.3394). Carriers of the heterozygous variant had a higher risk for an extended disease (P = 0.0284). The rs7517847 showed a protective character leading to mild bowel movements. Three SNPs demonstrated no statistically significant influence on any examined clinical features of UC.CONCLUSION We demonstrated susceptible or protective character of the investigated IL23 R SNPs on the phenotype of UC, confirming the genetic association. | Sarah Fischer Erzsébet Kovesdi Lili Magyari Veronika Csongei Kinga Hadzsiev Béla Melegh Péter Hegyi Patrícia Sarlós | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | Laurifolin, a novel acetogenin from Rollinia laurifolia leaves显示文摘 | Lu cia P Santos Pimcnta Francisco Chagas do Nascimento Angela Cristina S Assun etal | 2001 | Tetrahedron Letters2001，42，48： | 1 |
| 4 | Distinct differentiation characteristics of individual human embryonic stem cell lines显示文摘 | MILLA M CIA O JAAN P | | 0，，： | 1 |
| 5 | Vaginal flora alterationsand clinica symptoms in low - risk pregnant women 显示文摘 | Fausto G M~cia GS Jossimara P | 2011 | Gynecol Obstet Invest2011，71，1： | 1 |
| 6 | Sequential Measurement of procalcitonin Levels in diagnosing Ventilator-associated preunonia显示文摘 | Ramirez P Gar Cia MA Ferrer M | 2008 | Eur Respir J2008，31，2： | 1 |
| 7 | Circle detection on images using Genetic Algorithms 显示文摘 | RAMIREZ V A GARCIA CAPULIN H GAR- CIA A P | 2006 | Pattern Recognition2006，27，6： | 1 |
| 8 | Converting gin and dairy wastes to methane 显示文摘 | Funk P A Annijo C B Hanson A T Samani Z A Ma- cias Corral M A Smith G B Riordan J T | 2005 | Transactions of the ASAE2005，48，3： | 1 |
| 9 | Metal complexes of 2-benzoylpyridine semicarbazone: Spectral, electrochemical and structural studies显示文摘 | Anayive Pérez-Rebolledo Oscar E. Piro Eduardo E. Castellano Letícia R. Teixeira Alzir A. Batista Heloisa Beraldo | 2006 | Journal of Molecular Structure2006，，1： | 1 |
| 10 | Modified atmosphere packaging for extending the storage life of 'Fuyu' persimmon 显示文摘 | CIA P BENATO E A SIGRIST J M M | 2006 | Postharvest Biology and Technology2006，42，： | 1 |
| 11 | Addressing soil protection concerns in forest ecosystem management under climate change显示文摘Background: Climate change may strongly influence soil erosion risk, namely through variations in the precipitation pattern. Forests may contribute to mitigate the impacts of climate change on soil erosion and forest managers are thus challenged by the need to define strategies that may protect the soil while addressing the demand for other ecosystem services. Our emphasis is on the development of an approach to assess the impact of silvicultural practices and forest management models on soil erosion risks under climate change. Specifically, we consider the annual variation of the cover-management factor(C) in the Revised Universal Soil Loss Equation over a range of alternative forest management models to estimate the corresponding annual soil losses, under both current and changing climate conditions. We report and discuss results of an application of this approach to a forest area in Northwestern Portugal where erosion control is the most relevant water-related ecosystem service.Results: Local climate change scenarios will contribute to water erosion processes, mostly by rainfall erosivity increase.Different forest management models provide varying levels of soil protection by trees, resulting in distinct soil loss potential.Conclusions: Results confirm the suitability of the proposed approach to address soil erosion concerns in forest management planning. This approach may help foresters assess management models and the corresponding silvicultural practices according to the water-related services they provide. | Ana Raquel Rodrigues Brigite Botequim Catarina Tavares Patrícia Pécurto JoséGBorges | 2020 | Forest Ecosystems2020，7，3： | 1 |
| 12 | Development and Validation of Passive Samplers for Atmo- spheric Monitoring of SO2, NO2, 03 and H:S in Tropical Areas 显示文摘 | VANIA P Campos L CIA P S Cruz RICARDO H M Godoi | 2010 | Microchemical Journal2010，96，： | 1 |
| 13 | Effects ofgamma and UV-C irradiation on the postharvest controlof papaya anthracnose显示文摘 | Cia P Pascholati S F Benato E A | 2007 | Postharvest Biology andTechnology2007，43，3： | 1 |
| 14 | Effect of key designparameter on the efficiency of horizontal subsurface flowconstructed wetlands 显示文摘 | G4 CIA J AGUIRRE P BARRA GAN J | 2005 | Ecological Engineering2005，25，4： | 1 |
| 15 | Effects of gamma and UVC irradiation on the postharvest control of papaya anthraenose显示文摘 | CIA P PASCHOLATI S F BENATO E A | 2007 | Postharvest Biology and Technoloy2007，43，3： | 1 |
| 16 | Development of higher strength H2S resistant steels for oil field applications显示文摘 | Grobner P J Sponseller D L Cias W W | 1975 | Material Performance1975，14，6： | 1 |
| 17 | Giant cell rich parosteal osteo- sarcoma 显示文摘 | Sciot R Samson I Dal Cia P | 1995 | Histopathology1995，27，1： | 1 |
| 18 | Advanced Technologies for Oral Controlled Release:Cyclodextrins for Oral Controlled Release显示文摘 | PAULO J PATRCIA P CLA'UDIA C | 2011 | AAPS PharmSciTech2011，12，4： | 1 |
| 19 | Modified atmosphere packaging for extending the storage life of ‘Fuyu' persimmon显示文摘 | CIA P BENATO E A SIGRIST J M M | 2006 | Postharvest Biology and Technology2006，42，3： | 1 |
| 20 | Selenium reduces bradykinesia and DNA damage in a rat model of Parkinson’s disease显示文摘 | Joel Henrique Ellwanger Molz Patrícia Danieli Rosane Dallemole Ariana Pereira dos Santos Talise Ellwanger Müller Lucas Cappelletti Manoela Gon?alves da Silva Silvia Isabel Rech Franke Daniel Prá Jo?o Antonio Pêgas Henriques | 2014 | Nutrition2014，，： | 1 |
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