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| 1 | Lateral lymph node dissection for low rectal cancer: Is it necessary?显示文摘Rectal cancer constitutes a major public health issue.Total mesorectal excision has remained the gold standard treatment for mid and low rectal tumors since its introduction in the late 1980s.Removal of all lymph nodes located in the mesorectum has indeed improved pathological and oncological outcomes.However,when cancer spreads to the lateral lymph nodes(located along the iliac and obturator arteries)Western and Japanese practices differ.Where the Western guidelines consider this condition as an advanced form of the disease and use neoadjuvant radiochemotherapy liberally,the Japanese guidelines define it as a local disease and proceed to lateral lymph node dissection with or without neoadjuvant treatment.Herein,we review the current literature regarding both therapeutic strategies,with the aim of contributing to potential improvements in treatment and outcome for patients with low and mid rectal cancer. | Niki Christou Jeremy Meyer Christian Toso Frédéric Ris Nicolas Christian Buchs | 2019 | World Journal of Gastroenterology2019，25，31： | 11 |
| 2 | Challenges and opportunities in the application of artificial intelligence in gastroenterology and hepatology显示文摘Artificial intelligence(AI)is an umbrella term used to describe a cluster of interrelated fields.Machine learning(ML)refers to a model that learns from past data to predict future data.Medicine and particularly gastroenterology and hepatology,are data-rich fields with extensive data repositories,and therefore fruitful ground for AI/ML-based software applications.In this study,we comprehensively review the current applications of AI/ML-based models in these fields and the opportunities that arise from their application.Specifically,we refer to the applications of AI/ML-based models in prevention,diagnosis,management,and prognosis of gastrointestinal bleeding,inflammatory bowel diseases,gastrointestinal premalignant and malignant lesions,other nonmalignant gastrointestinal lesions and diseases,hepatitis B and C infection,chronic liver diseases,hepatocellular carcinoma,cholangiocarcinoma,and primary sclerosing cholangitis.At the same time,we identify the major challenges that restrain the widespread use of these models in healthcare in an effort to explore ways to overcome them.Notably,we elaborate on the concerns regarding intrinsic biases,data protection,cybersecurity,intellectual property,liability,ethical challenges,and transparency.Even at a slower pace than anticipated,AI is infiltrating the healthcare industry.AI in healthcare will become a reality,and every physician will have to engage with it by necessity. | Chrysanthos D Christou Georgios Tsoulfas | 2021 | World Journal of Gastroenterology2021，27，37： | 5 |
| 3 | Reducing anastomotic leak in colorectal surgery: The old dogmas and the new challenges显示文摘Anastomotic leak(AL)constitutes a significant issue in colorectal surgery,and its incidence has remained stable over the last years.The use of intra-abdominal drain or the use of mechanical bowel preparation alone have been proven to be useless in preventing AL and should be abandoned.The role or oral antibiotics preparation regimens should be clarified and compared to other routes of administration,such as the intravenous route or enema.In parallel,preoperative antibiotherapy should aim at targeting collagenase-inducing pathogens,as identified by the microbiome analysis.AL can be further reduced by fluorescence angiography,which leads to significant intraoperative changes in surgical strategies.Implementation of fluorescence angiography should be encouraged.Progress made in AL comprehension and prevention might probably allow reducing the rate of diverting stoma and conduct to a revision of its indications. | Jeremy Meyer Surennaidoo Naiken Niki Christou Emilie Liot Christian Toso Nicolas Christian Buchs Frédéric Ris | 2019 | World Journal of Gastroenterology2019，25，34： | 3 |
| 4 | Role of three-dimensional printing and artificial intelligence in the management of hepatocellular carcinoma:Challenges and opportunities显示文摘Hepatocellular carcinoma(HCC)constitutes the fifth most frequent malignancy worldwide and the third most frequent cause of cancer-related deaths.Currently,treatment selection is based on the stage of the disease.Emerging fields such as three-dimensional(3D)printing,3D bioprinting,artificial intelligence(AI),and machine learning(ML)could lead to evidence-based,individualized management of HCC.In this review,we comprehensively report the current applications of 3D printing,3D bioprinting,and AI/ML-based models in HCC management;we outline the significant challenges to the broad use of these novel technologies in the clinical setting with the goal of identifying means to overcome them,and finally,we discuss the opportunities that arise from these applications.Notably,regarding 3D printing and bioprinting-related challenges,we elaborate on cost and cost-effectiveness,cell sourcing,cell viability,safety,accessibility,regulation,and legal and ethical concerns.Similarly,regarding AI/ML-related challenges,we elaborate on intellectual property,liability,intrinsic biases,data protection,cybersecurity,ethical challenges,and transparency.Our findings show that AI and 3D printing applications in HCC management and healthcare,in general,are steadily expanding;thus,these technologies will be integrated into the clinical setting sooner or later.Therefore,we believe that physicians need to become familiar with these technologies and prepare to engage with them constructively. | Chrysanthos D Christou Georgios Tsoulfas | 2022 | World Journal of Gastrointestinal Oncology2022，14，4： | 2 |
| 5 | Multiple organ dysfunction score:a reliable descriptor of a complex clinical outcome显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，： | 2 |
| 6 | Soluble L-selectin at levels present in septic patients diminishes leukocyte-endothelial cell interactions in mice in vivo:A mechanism for decreased leukocyte delivery to remote septic sites in sepsis显示文摘 | Ferri LE Swartz D Christou NV | 2001 | Crit Care Med2001，29，： | 2 |
| 7 | Multiple organ dysfunction score:a reliable description of a complex clinical outcome显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，10： | 1 |
| 8 | Multiple organ dysfunction score:a reliable descriptor of a complex clinical outcome显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，10： | 1 |
| 9 | Over-weight and obese humans demonstrate increased vascular en- dothelial NAD(P)H oxidase p47(phox) expression and evidence of endothelial oxidative stress显示文摘 | SILVER A E BESKE S D CHRISTOU D D | 2007 | Circulation2007，115，5： | 1 |
| 10 | Multiple organ dysfunction seore:a reliable descriptor of a complex clinical outeome显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，10： | 1 |
| 11 | The use of Geographic Information Systems in major accident riskassessment and management显示文摘 | Sergio Contini Furio Bellezza Michalis D Christou | 2000 | Journal of Hazardous Materials2000，，78： | 1 |
| 12 | Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome 显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，10： | 1 |
| 13 | Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，10： | 1 |
| 14 | Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies显示文摘 | Stoger E Vaquero C Tortes E Sack M Nicholson L Drossard J Williams S Keen D Perrin Y Christou P and Fischer R | 2000 | Plant Molecular Biology2000，42，： | 1 |
| 15 | Multiple organdysfunction score:a reliable descriptor of a complex clinicaloutcome显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，10： | 1 |
| 16 | Land-use plan- ning in the vicinity of chemical sites : risk-informed de- cision making at a local community level 显示文摘 | CHRISTOU M D MATrARELLI M | 2000 | Journal of Hazardous Materials2000，78，13： | 1 |
| 17 | Images from astronomical speckle data: weighted shift-and-add analysis 显示文摘 | J C Christou E K Hege J D Freeman | 1985 | SPIE1985，556，： | 1 |
| 18 | Multiple organ dysfunction score: A reliable descriptor of a complex clinical outcome 显示文摘 | Marshall J C Cook D J Christou N V | 1995 | Crit Care Med1995，23，10： | 1 |
| 19 | Multiple organ dysfunction seore: a reliable descritor of a complex clinical outcome显示文摘 | MARSHALL J C COOK D J CHRISTOU N Y | 1995 | Crit Care Med1995，23，10： | 1 |
| 20 | Increased abdominal-to-peripheral fat distribution contributes to altered autonomic-circulatory control with human aging显示文摘 | Christou D D Jones P P Pimentel A E | 2004 | Am J Physiol Heart Circ Physiol2004，287，4： | 1 |
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