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| 1 | 1400W reduces ischemia reperfusion injury in an ex-vivo porcine model of the donation after circulatory death kidney donor显示文摘AIM: To investigate the effects of 1400W-a selective inducible nitric oxide synthase(iN OS) inhibitor in a model of donation after circulatory death(DCD) kidneys. METHODS: Porcine kidneys were retrieved after 25 min warm ischemia. They were then stored on ice for 18 h before being reperfused ex vivo with oxygenated autologous blood on an isolated organ perfusion system. The selective i NOS inhibitor 1400W(10 mg/kg) was administered before reperfusion(n = 6) vs control group(n = 7). Creatinine(1000 μmol/L) was added to the system, renal and tubular cell function and the level of ischemia reperfusion injury were assessed over 3 h of reperfusion using plasma, urine and tissue samples. RESULTS: Kidneys treated with 1400 W had a higher level of creatinine clearance(CrC l) [area under the curve(AUC) CrC l: 2.37 ± 0.97 mL /min per 100 g vs 0.96 ± 0.32 mL /min per 100 g, P = 0.004] and urine output [Total: 320 ± 96 mL vs 156 ± 82 mL, P = 0.008]. There was no significant difference in levels of fractional excretion of sodium(AUC, Fr ex Na+: Control, 186.3% ± 81.7%.h vs 1400 W, 153.4% ± 12.1%.h, P = 0.429). Levels of total protein creatinine ratio were significantly lower in the 1400 W group after 1 h of reperfusion(1h Pr/Cr: 1400 W 9068 ± 6910 mg/L/mmol/L vs Control 21586 ± 5464 mg/L/mmol/L, P = 0.026). Levels of 8-isoprostane were significantly lower in the 1400 W group [8-iso/creatinine ratio: Control 239 ± 136 pg/L/mmol/L vs 1400 W 139 ± 47 pg/L/mmol/L, P = 0.041].CONCLUSION: This study demonstrated that 1400 W reduced ischaemia reperfusion injury in this porcine kidney model of DCD donor. Kidneys had improved renal function and reduced oxidative stress. | Sarah A Hosgood Phillip J Yates Michael L Nicholson | 2014 | World Journal of Transplantation2014，4，4： | 2 |
| 2 | Protein dynamics measurement by TROSY-based NMR experiments显示文摘 | Zhu G Xia Y L Nicholson L K | 2000 | J Magn Reson2000，143，： | 1 |
| 3 | The issue of races Colletotrichum gra- minicola pathogenic to corn显示文摘 | Nicholson R L | 1981 | Plant Disease1981，65，： | 1 |
| 4 | Distribution of EGF and its receptor in growing red deer antler显示文摘 | Barling P M Lai A K Nicholson L F | 2005 | Cell Biol Int2005，29，3： | 1 |
| 5 | Resistance of bacterial endospores to extreme terrestrial and extraterrestrial environments显示文摘 | Nicholson W L Munakata N Horneck G | 2000 | Microbiology and Molecular Biology Reviews2000，64，3： | 1 |
| 6 | Configuration of the connective tissue in the posterior atlanto-oecipital interspace: a sheet plastination and eonfocal microscopy study显示文摘 | Nash L Nicholson H Lee AS | 2005 | Spine2005，30，12： | 1 |
| 7 | Coinfection of pigs with porcine respiratory coronavirus and Bordetella bronchiseptica显示文摘 | Brockmeier S L Loving C L Nicholson T L | 2008 | Veterinary Microbiology2008，128，12： | 1 |
| 8 | Resistance of Bacillus endospores to extreme terrestrial and extraterrestrial environments显示文摘 | Nicholson W L Munakata N Horneck G | 2000 | Microbiology and Molecular Biology Reviews2000，64，3： | 1 |
| 9 | ‘Metabonomics':understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data显示文摘 | Nicholson L K Lindon J C Holmes E | 1999 | Xenobiotica1999，29，2： | 1 |
| 10 | Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death 显示文摘 | Caciola-Rosen L Nicholson DW Chong T | 1996 | J Exp Med1996，183，5： | 1 |
| 11 | Spectral profiles of cultured neuronal and glial cells derived from HRMAS (1)HNMR spectroscopy显示文摘 | Griffin J L Bollard M Nicholson J K | 2002 | NMR Biomed2002，15，6： | 1 |
| 12 | Anal Biochem显示文摘 | Gray M C Plant A L Nicholson J M May W E | | 224: 286-2920，224，： | 1 |
| 13 | Mechanical impact induces cartilage degradation via mitogen activated protein kinases显示文摘 | Ding L Heying E Nicholson N | 2010 | Osteoarthritis Cartilage2010，18，11： | 1 |
| 14 | Consensus Based Clinical Guideline for Oral Hygiene in the Critically Ill显示文摘 | Berry A M Davidson P M Nicholson L | 2011 | Intensive Crit Care Nuts2011，27，4： | 1 |
| 15 | Resistance of Bacillus endospores to extreme terrestrial and extraterrestrial environments显示文摘 | NICHOLSON W L MUNAKATA N HORNECK G | 2000 | Microbiol Mol Biol Rev2000，64，3： | 1 |
| 16 | CCR5 and CXCR4 expression on memory and naive T cells in HIV-1 infection and response to highly active antiretroviral therapy显示文摘 | NICHOLSON J K BROWNING S W HENGELR L | 2001 | J Acquir Immune Defic Syndr2001，27，2： | 1 |
| 17 | The roleof interpersonal liking in building trust in long-term chan-nel relationships显示文摘 | NICHOLSON C Y COMPEAU L D SETHI R | 2001 | Journal of the Academy of MarketingScience2001，29，1： | 1 |
| 18 | The utilization of bryophytes in bioclimatic modeling: predicted north- ward migration of peatlands in the Mackenzie River basin, Canan- da, as a result of global warming显示文摘 | Gignac L Dennis Barbara J Nicholson Suzanne E Bayley | 1998 | The Bryologist1998，101，： | 1 |
| 19 | Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies显示文摘 | Stoger E Vaquero C Tortes E Sack M Nicholson L Drossard J Williams S Keen D Perrin Y Christou P and Fischer R | 2000 | Plant Molecular Biology2000，42，： | 1 |
| 20 | Detection of antibodies to avian leukosis/sarcoma viruses (ALSV) and reticuloendotheliosis viruses (REV) in humans by ELISA显示文摘 | Johnson E S Nicholson L G Durack D T | 1995 | Cancer Detect Prev1995，19，5： | 1 |
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