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| 1 | Potential implications of Helicobacter pylori-related neutrophil-activating protein显示文摘Helicobacter pylori (H.pylori) virulence factors promote the release of various chemoattractants/inflammatory mediators,including mainly the neutrophilattractant chemokine interleukin-8 and neutrophilactivating protein (NAP),involved in H.pylori-induced gastric pathologies.Co-administration of Chios mastic gum (CMG),which inhibits H.pylori NAP,with an H.pylori eradication regimen might add clinical benefits against H.pylori-related gastric pathologies,but possibly not CMG as main therapy.Although H.pylori NAP and other H.pylori-related cytotoxins [i.e.,vaculating cytotoxin (VacA)] appear to play a major role in generating and maintaining the H.pylori-associated gastric inflammatory response and H.pylori NAP is a promising vaccine candidate against H.pylori infection (H.pylori-I),concerns regarding its potential drawbacks,particularly neurogenic ones,due to possible crossmimicry,should be considered.Possible cross-mimicry between H.pylori NAP and/or bacterial aquaporin (AQP) and neural tissues may be associated with the anti-AQP-4 antibody-related neural damage in multiple sclerosis (MS)/neuromyelitis optica patients.Moreover,the sequence homology found between H.pylori VacA and human Na+/K+-ATPase A subunit suggests that antibodies to VacA involve ion channels in abaxonal Schwann cell plasmalemma resulting in demyelination in some patients.A series of factors have been implicated in inducing blood-brain barrier (BBB) disruption,including inflammatory mediators (e.g.,cytokines and chemokines induced by H.pylori-I) and oxidative stress.BBB disruption permits access of AQP4-specific antibodies and T lymphocytes to the central nervous system,thereby playing a major role in multiple sclerosis pathogenesis.Relative studies show a strong association between H.pylori-I and MS.H.pylori-I induces humoral and cellular immune responses that,owing to the sharing of homologous epitopes (molecular mimicry),cross-react with components of nerves,thereby contributing and perpetuating neural tissue damage.Finally,H.pylori NAP also plays a possible pathogenetic role in both gastric and colon oncogenesis. | Jannis Kountouras Christos Zavos Georgia Deretzi Emmanuel Gavalas Dimitrios Chatzopoulos Panagiotis Katsinelos Elena Tsiaousi Stergios Gagalis Stergios A Polyzos Ioannis Venizelos | 2012 | World Journal of Gastroenterology2012，18，5： | 5 |
| 2 | Primary biliary cirrhosis-specific autoantibodies in first degree relatives of Greek primary biliary cirrhosis patients显示文摘AIM:To determine the prevalence and significance of primary biliary cirrhosis (PBC)-specific autoantibodies in firstdegree relatives (FDRs) of Greek PBC patients. METHODS:The presence of antimitochondrial antibodies (AMA) and PBCspecific antinuclear antibodies (ANA) were determined using indirect immunofluores-cence assays, dot-blot assays, and molecularly based enzyme-linked immunosorbent assays in 101 asymp-tomatic for liver-related symptoms FDRs of 44 PBCpatients. In order to specify our results, the same investigation was performed in 40 healthy controls and in a disease control group consisting of 40 asymptomatic for liver-related symptoms FDRs of patients with other autoimmune liver diseases namely, autoimmune hepati-tis-1 or primary sclerosing cholangitis (AIH-1/PSC). RESULTS: AMA positivity was observed in 19 (only 4 with abnormal liver function tests) FDRs of PBC patients and none of the healthy controls. The preva-lence of AMA was significantly higher in FDRs of PBC patients than in AIH-1/PSC FDRs and healthy controls [18.8%, 95% confidence interval (CI):12%-28.1% vs 2.5%, 95% CI:0.1%-14.7%, P = 0.01; 18.8%, 95% CI:12%-28.1% vs 0%, 95% CI: 0%-10.9%, P = 0.003, respectively]. PBC-specific ANA positivity was observed in only one FDR from a PSC patient. Multivariate analysis showed that having a proband with PBC independently associated with AMA positivity (odds ratio: 11.24, 95% CI:1.27-25.34, P = 0.03) whereas among the investigated comorbidities and risk factors, a positive past history for urinary tract infections (UTI) was also independently associated with AMA detection in FDRs of PBC patients (odds ratio:3.92, 95% CI:1.25-12.35,P = 0.02). CONCLUSION:In FDRs of Greek PBC patients, AMA prevalence is significantly increased and independently associated with past UTI. PBC-specific ANA were not detected in anyone of PBC FDRs. | Theodoros A Zografos Nikolaos Gatselis Kalliopi Zachou Christos Liaskos Stella Gabeta George K Koukoulis George N Dalekos | 2012 | World Journal of Gastroenterology2012，18，34： | 4 |
| 3 | The omega-3 and retinopathy of prematurity relationship显示文摘The aim of this article is to examine the effect of omega-3(ω-3) long-chain polyunsaturated fatty acids(LCPUFAs) intake on retinopathy of prematurity(ROP) by reviewing the experimental and clinical trials conducted on animal models and infants.LCPUFAs demonstrate cytoprotective and cytotherapeutic actions contributing to a number of anti-angiogenic and neuroprotective mechanisms within the retina.Their intake appears to have a beneficial effect on ischemia,oxidative stress,inflammation and cellular signaling mechanisms,influencing retinal cell gene expression and cellular differentiation.ω-3 LCPUFAs may modulate metabolic processes that activate molecules implicated in the pathogenesis of vasoproliferative and neurodegenerative retinal diseases such as ROP. | Angelakis Malamas Angeliki Chranioti Christos Tsakalidis Stavros A Dimitrakos Asimina Mataftsi | 2017 | International Journal of Ophthalmology(English edition)2017，10，2： | 4 |
| 4 | 直接评估吗啡刺激糖尿病人隐静脉内皮一氧化氮释放减少显示文摘to directly measure in real time basal and stimulated levels of NO released from human saphenous vein endothelium and to quantify the expression of the μopiate receptor, which has been linked with NO release. METHODS: Saphenous vein segments from patients with type 2 diabetes ( n = 12) and patients without diabetes (n =8) were obtained. The release of NO was measured directly from the endothelium using a NO-specific amperometric probe. NΩ-nitro-L-arginine methyl ester (L-NAME, 0.1 mmol/L), a NO synthase (NOS) inhibitor, or morphine (1 μmol/L), a stimulant, was administered and the measurements were repeated. Values were reported relative to the mean initial measurement of NO release from diabetic endothelium, which was defined as the relative zero level of NO release. A RT-PCR was then performed on the endothelium to measureμ opiate receptor expression. RESULTS: Diabetic patients (n = 12) showed a relative and significantly diminished basal level of released NO, (0.049± 0.012) nmol/L, compared | Thomas V BILHNGER, James A VOSSWINKEL, Patrick CADET, Christos M RIALAS, Harold I MAGAZINE, George B STEFANO(Division of Cardiothoracic Surgery, Department of Surgery, University Hospital and Medical Center, HSC, T19-080, Stony Brook, New York 11794-8191 Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York , USA) | 2002 | Acta Pharmacologica Sinica2002，23，2： | 3 |
| 5 | Phase -transfer catalytic determination of phenols as methylated derivatives by gas chromatography with flame ionization and massselective detection显示文摘 | Fiamegos Yiannis C Nanos Christos G Pilidis George A | 2003 | Journal of Chromatography A2003，1183，12： | 1 |
| 6 | Phase Ⅱ trial of paclitaxel and cisplatin in metastatic and recurrent carcinoma of the uterine cervix显示文摘 | Christos A Papadimitriou Kyrillos S | 1999 | J Clin Oncol1999，17，3： | 1 |
| 7 | On array failure mitigation using genetic algorithms and a priori joint optimization 显示文摘 | Stelios A Mifilineos Christos N Capsalis | 2005 | IEEE Antennas and Propagation Magazine2005，47，4： | 1 |
| 8 | On array failure mitigation with respect to probability of failure, using constant excitation coefficients and a genetic algorithm显示文摘 | Stelios A Mifilineos Stelios C A Thomopoulos Christos N Capsalis | 2006 | IEEE Antennas and Wireless Propagation Letters2006，5，1： | 1 |
| 9 | Environmental, social and economic information management for the evaluation of sustainability in urban areas: A system of indieators for Thessaloniki, Greece 显示文摘 | Nicolas M Charisios A Christos V | 2010 | Cities2010，，27： | 1 |
| 10 | Synthesis, design and operation optimization of a marine energy system 显示文摘 | GEORGE G D ARISTOTELIS V K CHRISTOS A F | 2008 | Energy2008，33，2： | 1 |
| 11 | Deterministic adaptive control based on Laguerre series representation显示文摘 | CHRISTOS C Z DUMOUT G A | 1988 | Int J Control1988，48，6： | 1 |
| 12 | Laguerre based adaptive control of pH in bleach plant extraction stage显示文摘 | DUMOUT G A CHRISTOS C | 1990 | Automatica1990，26，4： | 1 |
| 13 | Outcomeo f deferred initial therapy in mantlecell lymphoma显示文摘 | Martin P Chadbum A Christos P | 2009 | J Clin Oncol2009，，27： | 1 |
| 14 | Chemical composition and antibacterial activity of Brazilian propolis显示文摘 | Christo R Kujumgiev A | 1995 | Z Naturforsch1995，50，34： | 1 |
| 15 | Bone and brain metastases from ampullary adenocarcinoma显示文摘Ampullary carcinoma is the second most common cancer of the peri-ampullary area after pancreatic carcinoma and metastasizes mostly intra-abdominally and to the liver.Extra-abdominal metastases are less frequent.In this report we describe the case of a patient with resected adenocarcinoma of the ampulla of Vater who developed skeletal metastases in the lower extremity and brain metastases.We briefly discuss aspects of this comparatively rare gastrointestinal malignancy. | Ioannis A Voutsadakis Stergios Doumas Konstantinos Tsapakidis Maria Papagianni Christos N Papandreou | 2009 | World Journal of Gastroenterology2009，15，21： | 1 |
| 16 | Considerations in the Statistical Analysis of Hemodialysis Patient Survival显示文摘 | Christos A Chung C Laura P | 2009 | J Am Soc Nephrol2009，20，9： | 1 |
| 17 | Safflower yield, chlorophyll content, photosynthesis, and water use efficiency response to nitrogen fertilization under rainfed conditions显示文摘 | Christos A D Christos S | 2008 | Industrial Crops andProducts2008，27，1： | 1 |
| 18 | A mobile agent platform for distributed network and systems manage- ment 显示文摘 | DAMIANOS G GEORGE E T CHRISTOS A | 2009 | The Journal of Systems and Software2009，82，： | 1 |
| 19 | Improved Batch Fuzzy Learning Vector Quantization for Image Compression显示文摘 | George E T Mamalis A Christos A | 2008 | Information Sciences2008，178，20： | 1 |
| 20 | Rise and demise of bioinformatics? Promise and progress 显示文摘 | Christos A O | 2012 | PLoS Comput Biol2012，8，10： | 1 |
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