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| 1 | Twenty-five years of research on the effects of exercise training in breast cancer survivors:A systematic review of the literature显示文摘AIM:To investigate the role of exercise training the past 25 years on major physiological-psychological outcomes studied thus far in this patient population.METHODS:Pub Med, Medline Plus, the Cochrane Library, Web of Science, SportD iscus, Embase, Scorpus, and Google Scholar were searched from September to November 2013 to identify exercise training studies that used objective measurements of fitness and/or patient reported outcomes assessed pre and post-exercise training with statistical analyses performed in at least one of the following outcome measurements:Cardiorespiratory function, body composition, muscular strength, fatigue, depression, and overall quality of life. Five reviewers independently identified the studies that met the criteria for the review and discrepancies were resolved by consensus among all authors.RESULTS:Fifty-one studies were included in this review with 5 from the period between 1989-1999, 11 from 2000-2006, and 35 from 2007-2013. The evolution of study designs changed from aerobic only exercise training interventions(1989-1999), to a combination of aerobic and resistance training(2000-2006), to studies including an arm of resistance training or examining the effects of resistance training as the main mode of exercise(2007-2013). Overall, the benefits of exercise showed improvements in cardiorespiratory function, body composition, strength, and patient reported outcomes including fatigue, depression, and quality of life.CONCLUSION:Exercise training appears to be safe for most breast cancer patients and improvements in physiological, psychological, and functional parameters can be attained with regular participation in moderate intensity exercise. | Claudio L Battaglini Robert C Mills Brett L Phillips Jordan T Lee Christina E Story Marcelo GB Nascimento Anthony Carl Hackney | 2014 | World Journal of Clinical Oncology2014，5，2： | 3 |
| 2 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 3 | Relation-Based Combinations Versus Property-Based Combinations: A Test of the CARIN Theory and the Dual-Process Theory of Conceptual Combination显示文摘 | Christina L Gagné | 2000 | Journal of Memory and Language2000，，3： | 2 |
| 4 | What leaders need to know: A review of social and contextual factors that can foster or hinder creativity显示文摘 | Christina E Shalley Lucy L Gilson | 2004 | The Leadership Quarterly2004，，1： | 2 |
| 5 | Auxin Binding Protein 1 Reinforces Resistance to Sugarcane Mosaic Virus in Maize显示文摘 | Pengfei Leng Qing Ji Torben Asp Ursula K. Frei Christina R. Ingvardsen Yongzhong Xing Bruno Studer Margaret Redinbaugh Mark Jones Priyanka Gajjar Sisi Liu Fei Li Guangtang Pan Mingliang Xu Thomas Lǖbberstedt | 2017 | Molecular Plant2017，10，10： | 2 |
| 6 | Liver bioengineering:Current status and future perspectives显示文摘The present review aims to illustrate the strategies that are being implemented to regenerate or bioengineer livers for clinical purposes.There are two general pathways to liver bioengineering and regeneration.The first consists of creating a supporting scaffold,either synthetically or by decellularization of human or animal organs,and seeding cells on the scaffold,where they will mature either in bioreactors or in vivo.This strategy seems to offer the quickest route to clinical translation,as demonstrated by the development of liver organoids from rodent livers which were repopulated with organ specific cells of animal and/or human origin.Liver bioengineering has potential for transplantation and for toxicity testing during preclinical drug development.The second possibility is to induce liver regeneration of dead or resected tissue by manipulating cell pathways.In fact,it is well known that the liver has peculiar regenerative potential which allows hepatocyte hyperplasia after amputation of liver volume.Infusion of autologous bone marrow cells,which aids in liver regeneration,into patients was shown to be safe and to improve their clinical condition,but the specific cells responsible for liver regeneration have not yet been determined and the underlying mechanisms remain largely unknown.A complete understanding of the cell pathways and dynamics and of the functioning of liver stem cell niche is necessary for the clinical translation of regenerative medicine strategies.As well,it will be crucial to elucidate the mechanisms through which cells interact with the extracellular matrix,and how this latter supports and drives cell fate. | Christopher Booth Tom Soker Pedro Baptista Christina L Ross Shay Soker Umar Farooq Robert J Stratta Giuseppe Orlando | 2012 | World Journal of Gastroenterology2012，18，47： | 2 |
| 7 | The Actin cross-linking domain of the Vibrio cholerae RTX toxin directly catalyzes the covalent cross-linking of actin显示文摘 | Christina L Cordero Dmitry S | 2006 | Biological Chemistry2006，281，32： | 1 |
| 8 | Is deep vein thrombosis a good proxy for pulmonary embolus显示文摘 | Javad P Christina L J Orhan B | 2010 | The Journal of Arthroplasty2010，15，6： | 1 |
| 9 | Tumor angiogenesis is regulated by CXC ehemokines显示文摘 | Bethany M B Douglas A A Christina A L | 1998 | J laband Clin Med1998，132，： | 1 |
| 10 | The Influenza a virus NS1 protein inhibit s activation of jun N2terminal kinase and AP-1 transcription factors显示文摘 | Stephan L Wang XY Christina E | 2002 | J Virology2002，76，11： | 1 |
| 11 | Epigallocatechin gallate, the main polyphenoL in green tea, binds to the T-cell receptor, CD4: Potential for HIV-ltherapy显示文摘 | Williamson M P McCormick T G Nance Christina L | 2006 | Journal of Allergy and ClinicaL Immunology2006，8，6： | 1 |
| 12 | Gene expression analysis of toll - like receptor path- ways in heterophils from genetic chicken lines that dif- fer in their susceptibility to salmonella enteritidis 显示文摘 | MICHAEL H K HSIN I C CHRISTINA L S | 2012 | Front Genet2012，3，： | 1 |
| 13 | Targetoid hemosiderotic he-mangiomas (hobnail hemangiomas) are vascular lymphatic malforma-tions :A study of 12 pediatric cases 显示文摘 | Rola AD Christina L Afshin H | 2012 | J AM ACAD DERMATOL2012，66，1： | 1 |
| 14 | Intratum oral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer mode显示文摘 | Christina L William J Frank L | 1995 | Proc Natl Acad Sci USA1995，92，： | 1 |
| 15 | Use of WL medium to profile native flora fermentations显示文摘 | CHRISTINA L P JAMES A B TAMMI L O | 2001 | American Journal of Enology and Viticulture2001，52，3： | 1 |
| 16 | Molecular epidemiological analysis of Escherichia coli isolates producing Extend-spectrumβ-laetamasefou identification of Nosocomial ourbreaks in Stockholm, Sweden显示文摘 | Hong F Christina L Barbro OL | 2004 | J Clin Microbiol2004，42，12： | 1 |
| 17 | Clinical recovery and circulatingbotulinum toxin type F in adult patient显示文摘 | Sobel J Dill T Christina L | 2009 | Emerg Infect Dis2009，15，： | 1 |
| 18 | Milk plasmin activity influence oncheddar cheese quality during ripening显示文摘 | NANA Y F CHRISTINA F L | 1992 | Journal of Food Science1992，57，3： | 1 |
| 19 | An unsung carbon sink显示文摘 | Christina L | 2011 | Science2011，334，6058： | 1 |
| 20 | Physiology of resistant Deinococcus geothermalis bacterium aerobically cultivated in low-Manganese medium显示文摘 | Christina L Minna P J?rg B Peter N Mirja S S | 2012 | Journal of Bacteriology2012，194，6： | 1 |
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