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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Is deep vein thrombosis a good proxy for pulmonary embolus显示文摘 | Javad P Christina L J Orhan B | 2010 | The Journal of Arthroplasty2010，15，6： | 1 |
| 3 | Epigallocatechin gallate, the main polyphenoL in green tea, binds to the T-cell receptor, CD4: Potential for HIV-ltherapy显示文摘 | Williamson M P McCormick T G Nance Christina L | 2006 | Journal of Allergy and ClinicaL Immunology2006，8，6： | 1 |
| 4 | Use of WL medium to profile native flora fermentations显示文摘 | CHRISTINA L P JAMES A B TAMMI L O | 2001 | American Journal of Enology and Viticulture2001，52，3： | 1 |
| 5 | Physiology of resistant Deinococcus geothermalis bacterium aerobically cultivated in low-Manganese medium显示文摘 | Christina L Minna P J?rg B Peter N Mirja S S | 2012 | Journal of Bacteriology2012，194，6： | 1 |
| 6 | Understanding zinc (Ⅱ) chelation with quercetin and luteolin: a combined NMR and theoretical study显示文摘 | ALEXANDRA P GLORIA M CHRISTINA L | 2015 | J Phys Chem B2015，119，1： | 1 |
| 7 | γδ T cells:an important source of IL-17 Christina显示文摘 | Christina L Roark P L Simonian A P | 2008 | Curr Opin Immunol2008，20，3： | 1 |
| 8 | Use of WL medium to profile native flora fermentations显示文摘 | CHRISTINA L P JAMES A B TAMMI L O | 2001 | American Journal of Enology and Viticulture2001，52，3： | 1 |
| 9 | Effect of Calcium Silicate Sources on Geopolymerisation 显示文摘 | Christina K Y Grant C L John L P | 2008 | Cement and Concrete Research2008，38，： | 1 |
| 10 | Use of WL Medium to Profile Natire Flora Fermentations 显示文摘 | Christina L P James A B Tammi L O | 2001 | American Journal of Enology and Viticulture2001，52，3： | 1 |
| 11 | Use of WL medium to profile native flora fermentations显示文摘 | Christina L P James A B TammiL O | 2001 | American Journal of Enology and Viticulture2001，52，3： | 1 |
| 12 | Use of WL mediumto profile native flora fermentations显示文摘 | CHRISTINA L P JAMES A B TAMMI L O | 2001 | American Journal of Enology andViticulture2001，52，3： | 1 |
| 13 | The effect of molecular oxygen on the activated carbon adsorption of natural organic matter in Ohio River water显示文摘 | Christina L Warta Spyridon P Papdimas George A Sorial | 1995 | Wat Res1995，29，2： | 1 |
| 14 | Use of wL medium to profile native flora fermentations显示文摘 | Christina L P James A B Tammi L O | 2001 | AM J Enol Vitic2001，52，3： | 1 |
| 15 | Family - centered care: Helping parents to help their child with procedural and everyday pain:Practical, evidence - based advice显示文摘 | Nina P Christina L Linda F | 2007 | JSPN2007，12，3： | 1 |
| 16 | Time-course ofattention bias for pain-related cues in chronic daily headachesufferers显示文摘 | Christina L Daniel E S Brendan P B | 2009 | European Journal of Pain2009，13，： | 1 |
| 17 | Use of WL medium to profile native flora fermentations显示文摘 | Christina L P James A B TammiL O | 2001 | American Journal of Enology and Viticulture2001，52，3： | 1 |
| 18 | Systematic significance of cell inclusions in Haemodoraceae and allied famillies:silica bodies and tapetal raphides显示文摘 | CHRISTINA J P CAROL A F PAULA J R L | 2003 | Annals of Botany2003，92，： | 1 |
| 19 | Modeling the vaporization of ash constituents in a coal-fired boiler显示文摘 | CHRISTINA M L KEVIN A D MICHAEL P H | 2000 | Proceedings of the Combustion Institute2000，28，2： | 1 |
| 20 | Oral immunization of wild boar and domestic pigs with attenuated live vaccine protects against pseudorabies virus infection 显示文摘 | Christina M Elke L Jens P | 2012 | Vet Mierobiol2012，161，： | 1 |
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