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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Sleep,immunity and inflammation in gastrointestinal disorders显示文摘Sleep disorders have become a global issue,and discovering their causes and consequences are the focus of many research endeavors.An estimated 70 million Americans suffer from some form of sleep disorder.Certain sleep disorders have been shown to cause neurocognitive impairment such as decreased cognitive ability,slower response times and performance detriments.Recent research suggests that individuals with sleep abnormalities are also at greater risk of serious adverse health,economic consequences,and most importantly increased all-cause mortality.Several research studies support the associations among sleep,immune function and inflammation.Here,we review the current research linking sleep,immune function,and gastrointestinal diseases and discuss the interdependent relationship between sleep and these gastrointestinal disorders.Different physiologic processes including immune system and inflammatory cytokines help regulate the sleep.The inflammatory cytokines such as tumor necrosis factor,interleukin-1(IL-1),and IL-6 have been shown to be a significant contributor of sleep disturbances.On the other hand,sleep disturbances such as sleep deprivation have been shown to up regulate these inflammatory cytokines.Alterations in these cytokine levels have been demonstrated in certain gastrointestinal diseases such as inflammatory bowel disease,gastro-esophageal reflux,liver disorders and colorectal cancer.In turn,abnormal sleep brought on by these diseases is shown to contribute to the severity of these same gastrointestinal diseases.Knowledge of these relationships will allow gastroenterologists a great opportunity to enhance the care of their patients. | Tauseef Ali James Choe Ahmed Awab Theodore L Wagener William C Orr | 2013 | World Journal of Gastroenterology2013，19，48： | 15 |
| 3 | Ciprofloxacin-induced vasculitis显示文摘 | Rothsghild BM Laitman L | 1989 | N Engl J Med1989，320，4： | 1 |
| 4 | An animal model of autoimmune emphysema 显示文摘 | Taraseviciene-Stewart L Scerbavicius R Choe KH | 2005 | Am J Respir Crit Care Med2005，171，： | 1 |
| 5 | Workflow for quantita- tive proteomic analysis of Clostridium acetobutylicum ATCC 824 using iTRAQ tags显示文摘 | HOU S JONES S W CHOE L H | 2013 | Methods2013，61，3： | 1 |
| 6 | A two-dimensional electrophoresis map of Chinese hamster ovary cell proteins based on fluorescence staining显示文摘 | Hayduk E J Choe L H Lee K H | 2004 | Electrophoresis2004，25，： | 1 |
| 7 | Prognostic significance of immunohistochemical micrometas tases in node negative gastric cancer patients显示文摘 | Harrison L E Choe J K Goldstein M | 2000 | J Surg Oncol2000，73，3： | 1 |
| 8 | Autologous, cadaveric,and synthetic materials used in sling surgery:comparative biomechanical ananlysis显示文摘 | Choe JM Kothandapani R James L | 2001 | Urology2001，58，： | 1 |
| 9 | A comparison of three commercially available isoelectric focusing units for proteome analysis : the muhiphor, the IPG phor and the protean IEF cell 显示文摘 | Choe L H Lee K H | 2000 | Electrophoresis2000，21，5： | 1 |
| 10 | Impaired synaptic vesicle release and immaturity of neuromuscular junc- tions in spinal muscular atrophy mice 显示文摘 | Kong L Wang X Choe D W | 2009 | J Neurosci2009，29，3： | 1 |
| 11 | The RUNX2 transcription factor negatively regulates SIRT6 expression to alter glucose metabolism in breast cancer cells 显示文摘 | Choe M Bmsgard J L Chumsri S | 2015 | J Cell Biochem2015，116，10： | 1 |
| 12 | The role of T cells in cutaneous autoimmune disease显示文摘 | Choe S Rizzo C Ravitskiy L | | 0，，04： | 1 |
| 13 | Uptake and biotransformation of trichloroethylene byhybrid poplars显示文摘 | Newman L A Strand S E Choe N | 1997 | Environmental Science Technology1997，31，： | 1 |
| 14 | Uptake and biotranslorma- tion of triehloroethylene by hybrid poplars 显示文摘 | Newman L A Strand S E Choe N | 1997 | Environmental Science & Technology1997，31，4： | 1 |
| 15 | Venous microanastomosis with the Unilink system, sleeve and suture techniques:A comparative study in the rat显示文摘 | Zhang L Kolker AR Choe E | 1997 | J Reconstr Mierosurg1997，13，4： | 1 |
| 16 | Autologous, cadaveric, and synthetic materials used in sling surgery:comparative biomechanical analysis显示文摘 | Choe JM Kothandapani R James L | 2001 | Urology2001，58，3： | 1 |
| 17 | Simvastatin causes endothelial cell apoptosis and attenuates severe pulmonary hypertension显示文摘 | Taraseviciene-Stewart L Scerbavieius R Choe KH | 2006 | Am J Physiol Lung Cell Mol Physiol2006，291，6： | 1 |
| 18 | An animal model of autoimmune emphysema 显示文摘 | Tarasevieiene-Stewart L Seerbavieius R Choe KH | 2005 | Am J Respir Crit Care Med2005，171，7： | 1 |
| 19 | Reliability and life study of hydraulic solenoid value Part 2:Experinental study显示文摘 | ANGADI S V JACKSON R L CHOE S Y | 2009 | Engineering Failure Analysis2009，16，： | 1 |
| 20 | RUNX2 and TAZ-dependent signaling pathways regulate soluble E-cadherin levels and tumorsphere formation in breast cancer ceils 显示文摘 | Bmsgard J L Choe M Chumsri S | 2015 | Oncotarget2015，6，28： | 1 |
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