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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Making and breaking covalent bonds across the magnetic transition in the giant magentocaloric material Gd5Si2Ge2 显示文摘 | Choe W Pecharsky V K | 2000 | Phys Rev Lett2000，84，20： | 2 |
| 3 | Synthesis of polysty- rene/silica composite particles by soap- free emulsion polymerization using positively charged colloidal silica 显示文摘 | Lee J W Hong C K Choe S J | 2007 | Journal of Colloid and Inteace Science2007，310，： | 1 |
| 4 | The Economic Benefits of Surface Water Quality Improvements in Development Countries:a Case Study of Davao Philippine显示文摘 | Choe K Whittington D | | 0，，72： | 1 |
| 5 | Pulmonary embolism of polymethyl methacrylate during percutaneous vertebroplasty and kyphoplasty 显示文摘 | Choe DH Marom EM Ahrar K | 2004 | Roentgenol2004，183，4： | 1 |
| 6 | T-DNA tagged knockout mutation of rice OsGSK1, an orthologue of Arabidopsis BIN2, with enhanced tolerance to various abiotic stresses 显示文摘 | Koh S Lee S C Kim M K Koh J H Lee S An G Choe S Kim S R | 2007 | Plant Molecular Biology2007，65，4： | 1 |
| 7 | Surface analysis of clinically failed dental implant fixture显示文摘 | CHOE H C HONG K S KO Y M KIM B O | 2006 | J Kor Inst Met & Mater2006，44，： | 1 |
| 8 | Hysteroscopic treatment of septate uterine with Neodymium YAG laser 显示文摘 | Choe J K | 1992 | Fertil Steril1992，58，4： | 1 |
| 9 | Stability characteristics of Pt1Ni1/C as cathode catalysts in membrane electrode assembly of polymer electrolyte membrane fuel cell显示文摘 | CHO Y H JEON T Y YOO S J LEE K S AHN M KIM O H CHO Y H LIM J W JUNG N YOON W S CHOE H SUNG Y E | 2012 | Electrochim Acta2012，59，： | 1 |
| 10 | Sonochemical synthesis of amorphous iron显示文摘 | SUSLICK K S CHOE S B CICHOWLAS A A | 1991 | Nature1991，353，： | 1 |
| 11 | Activation of protein kinase A induces neuronal differentiation of HiB5 hippocampal progenitor cells 显示文摘 | Kim G Choe Y Park J Cho S Kim K | 2002 | Mol Brain Res2002，109，12： | 1 |
| 12 | 显示文摘 | Choe S B Cichowlas | 1991 | Nature1991，353，： | 1 |
| 13 | A two-dimensional electrophoresis map of Chinese hamster ovary cell proteins based on fluorescence staining显示文摘 | Hayduk E J Choe L H Lee K H | 2004 | Electrophoresis2004，25，： | 1 |
| 14 | Prognostic significance of immunohistochemical micrometas tases in node negative gastric cancer patients显示文摘 | Harrison L E Choe J K Goldstein M | 2000 | J Surg Oncol2000，73，3： | 1 |
| 15 | The multifunctional fish gill:dominant site of gas exchange,osmoregulation,acid-base regulation,and excretion of nitrogenous waste显示文摘 | EVANS D H PIERMARINI P M CHOE K P | 2005 | Physicalogical Reviews2005，85，： | 1 |
| 16 | Sediment-water exchange of total mercury and monomethyl in the San Francisco Bay-Delta显示文摘 | Choe K Y Gill G A Lehman R D | 2004 | Limnology and Oceanography2004，49，： | 1 |
| 17 | Spinal intraosseous schwan- noma: a case report and review 显示文摘 | Park S C Chung S K Choe G | 2009 | J Korean Neurosurg Soc2009，46，4： | 1 |
| 18 | COX-2 in a euryhaline teleost, Fundulus heteroclitus: primary sequence, distribution, localization, and potential function in gills during salinity acclimation 显示文摘 | CHOE K P HAVIRD J ROSE R | 2006 | Journal of Experimental Biolo- gy2006，209，9： | 1 |
| 19 | SCL-90-Rand 16PF Profiles of Senior Hi School Students With Exces-sive Internet Use显示文摘 | YangC K Choe B M Baity M Lee J H Cho J S | 2005 | Canadian Journal of Psychiatry2005，，7： | 1 |
| 20 | The multifunctional fish gill : dominant site of gas exchange, osmoregulation, acid-base regulation, and excretion of nitrogenous waste 显示文摘 | Evans D H Pierrnarini P M Choe K P | 2005 | Physiol Rev2005，85，1： | 1 |
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