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| 1 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 2 | Physiological response of natural plants to the change of groundwater level in the lower reaches of Tarim River, Xinjiang显示文摘Based on the analysis of the three-year (2000-2002) monitoring data of the four times intermittent stream water conveyance to the lower reaches of Tarim River where the stream flow was dried up for more than 30 years and the measurement of PRO, SOD and POD in plants collected from 24 vegetation plots, it is concluded that the stream water conveyance plays an important role in lifting groundwater level. The groundwater nearby the watercourse was raised from 5~8 m in depth before the stream water conveyance to 2.5~5 m after stream water conveyance. The physiological response of Phragmites communis, Tamarix spp. and Populus euphratica to the change of groundwater is sensitive and represents a grads change obviously. The growth of the plants in the lower reaches of Tarim River is stressed by drought to various degrees. Lengthways, the drought stress exposed to the plants increases with groundwater depth from the upper sections to the lower sections; and breadthwise, the drought stress exposed to the plants is increased with the increase of distance away from the river channel of stream intermittent water releases and of the groundwater depth. Combining the field investigation and the analysis of the plots, it is considered that the stress groundwater depths for the Phragmites communis, Tamarix spp. and Populus euphratica are 3.5 m, 5 m and 4.5 m respectively. | CHENYaning LIWeihong CHENYapeng ZHANGHongfeng ZHUANGLi | 2004 | Progress in Natural Science:Materials International2004，14，11： | 22 |
| 3 | Collagen-binding basic fibroblast growth factor improves functional remodeling of scarred endometrium in uterine infertile women: a pilot study显示文摘Intrauterine adhesion(IUA) is a common cause of uterine infertility and one of the most severe clinical features is endometrial fibrosis namely endometrial scarring for which there are few cures currently. Blocked angiogenesis is the main pathological change in the scarred endometrium. The fibroblast growth factor 2(b FGF), a member of FGF family, is usually applied to promote healing of refractory ulcer and contributes to angiogenesis of tissues. In this study, the sustained-release system of b FGF100 μg was administrated around scarred endometrium guiding by ultrasound every 4 weeks in 18 patients(2–4 times). Results showed that after treatment, the menstrual blood volume, endometrial thickness and the scarred endometrial area were improved.Histological study showed blood vessel density increased obviously. Three patients(3/18) achieved pregnancy over 20 gestational weeks. Therefore, administrating the b FGF surrounding scarred endometrium may provide a new therapeutic approach for the patients with endometrial fibrosis. | Peipei Jiang Xiaoqiu Tang Huiyan Wang Chenyan Dai Jing Su Hui Zhu Minmin Song Jingyu Liu Ziqing Nan Tong Ru Yaling Li Jingmei Wang Jun Yang Bing Chen Jianwu Dai Yali Hu | 2019 | Science China(Life Sciences)2019，62，12： | 16 |
| 4 | Characteristics of secondary inorganic aerosol and sulfate species in size-fractionated aerosol particles in Shanghai显示文摘Sulfate, nitrate and ammonium(SNA) are the dominant species in secondary inorganic aerosol, and are considered an important factor in regional haze formation. Size-fractionated aerosol particles for a whole year were collected to study the size distribution of SNA as well as their chemical species in Shanghai. SNA mainly accumulated in fine particles and the highest average ratio of SNA to particulate matter(PM) was observed to be 47% in the fine size fraction(0.49–0.95 μm). Higher sulfur oxidation ratio and nitrogen oxidation ratio values were observed in PM of fine size less than 0.95 μm. Ion balance calculations indicated that more secondary sulfate and nitrate would be generated in PM of fine size(0.49–0.95 μm). Sulfur K-edge X-ray absorption near-edge structure(XANES) spectra of typical samples were analyzed. Results revealed that sulfur mainly existed as sulfate with a proportion(atomic basis) more than 73% in all size of PM and even higher at 90% in fine particles. Sulfate mainly existed as(NH4)2SO4 and gypsum in PM of Shanghai. Compared to non-haze days, a dramatic increase of(NH4)2SO4 content was found in fine particles on haze days only, which suggested the promoting impact of(NH4)2SO4 on haze formation. According to the result of air mass backward trajectory analysis, more(NH4)2SO4 would be generated during the periods of air mass stagnation. Based on XANES, analysis of sulfate species in size-fractionated aerosol particles can be an effective way to evaluate the impact of sulfate aerosols on regional haze formation. | Shilei Long Jianrong Zeng Yan Li Liangman Bao Lingling Cao Ke Liu Liang Xu Jun Lin Wei Liu Guanghua Wang Jian Yao Chenyan Ma Yidong Zhao | 2014 | Journal of Environmental Sciences2014，26，5： | 10 |
| 5 | Sulfur speciation and bioaccumulation in camphor tree leaves as atmospheric sulfur indicator analyzed by synchrotron radiation XRF and XANES显示文摘Analyzing and understanding the effects of ambient pollution on plants is getting more and more attention as a topic of environmental biology.A method based on synchrotron radiation X-ray fluorescence and X-ray absorption near edge structure spectroscopy was established to analyze the sulfur concentration and speciation in mature camphor tree leaves (CTLs),which were sampled from 5 local fields in Shanghai,China.Annual SO2 concentration,SO42-concentration in atmospheric particulate,SO42-and sulfur concentration in soil were also analyzed to explore the relationship between ambient sulfur sources and the sulfur nutrient cycling in CTLs.Total sulfur concentration in mature camphor tree leaves was 766-1704 mg/kg.The mainly detected sulfur states and their corresponding compounds were +6 (sulfate,include inorganic sulfate and organic sulfate),+5.2 (sulfonate),+2.2 (suloxides),+0.6 (thiols and thiothers),+0.2 (organic sulfides).Total sulfur concentration was strongly correlated with sulfate proportion with a linear correlation coefficient up to 0.977,which suggested that sulfur accumulated in CTLs as sulfate form.Reduced sulfur compounds (organic sulfides,thiols,thioethers,sulfoxide and sulfonate) assimilation was sufficed to meet the nutrient requirement for growth at a balanced level around 526 mg/kg.The sulfate accumulation mainly caused by atmospheric sulfur pollution such as SO2 and airborne sulfate particulate instead of soil contamination.From urban to suburb place,sulfate in mature CTLs decreased as the atmospheric sulfur pollution reduced,but a dramatic increase presented near the seashore,where the marine sulfate emission and maritime activity pollution were significant.The sulfur concentration and speciation in mature CTLs effectively represented the long-term biological accumulation of atmospheric sulfur pollution in local environment. | Jianrong Zeng Guilin Zhang Liangman Bao Shilei Long Mingguang Tan Yan Li Chenyan Ma Yidong Zhao | 2013 | Journal of Environmental Sciences2013，25，3： | 9 |
| 6 | Complete mitochondrial genome of Oxya chinensis (Orthoptera, Acridoidea)显示文摘Oxya chinensis 的完全的顺序(O。chinensis ) mitochondrial 染色体这里被报导。它是在长度的 15,443 bp 并且包含 75.9% A+T。编码蛋白质的基因有一个类似的 A+T 内容(75.2%) 。开始鳕鱼在上细胞色素氧化酶子单元我在 O 的 mitochondrial 染色体的基因。chinensis 看起来是 ATC,而不是在草之小穗 migratoria 被报导了的 tetranucleotides (L。migratoria ) mitochondrial 染色体。大、小的 ribosomal RNA 基因的尺寸分别地是 1319 和 850 bp。转移 RNA 基因被建模并且证明到 dipteran 转移 RNA 的强壮的相似,和所有反密码子与 dipteran 的那些相同。A+T 富有的区域是 562 bp,比另外的已知的直翅目昆虫的短。六个保存领域被另外的蚂蚱把它的顺序与那些作比较在 A+T 富有的区域以内识别。基于包含的数据集, 12 并置的蛋白质定序的种系发生的分析的结果证实 O 的靠近的关系。有 L 的 chinensis。migratoria。 | Chenyan Zhang Yuan Huang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，1： | 9 |
| 7 | INTERFERENCE-FREE TOOL POSTURE GENERATION FOR 5-AXIS NC MILLING FREE-FORM SURFACES WITH CYLINDRICAL MILL显示文摘The 5-axis NC machining offers the potential of efficient and accurate machining. However, the present CAM system for 5-axis control is still an unsolved problem due to interference between tool and surrounding objects. A new method is presented. There are two steps in this procedure. First, it detects the interference by calculating the shortest distance between the tool-axis and the surrounding surfaces. Then upon the maximum gouging, the interference-free tool posture for 5-axis NC cylindrical milling free-form surfaces is obtained by adjusting tool. The validity of the proposed method has been confirmed by machining an impeller. | ChenLiping ChenYan HuDejin | 2004 | Chinese Journal of Mechanical Engineering2004，17，3： | 6 |
| 8 | Mapping the Wind Hazard of Global Tropical Cyclones with Parametric Wind Field Models by Considering the Effects of Local Factors显示文摘Tropical cyclones(TCs) cause catastrophic loss in many coastal areas of the world. TC wind hazard maps can play an important role in disaster management. A good representation of local factors reflecting the effects of spatially heterogeneous terrain and land cover is critical to evaluation of TC wind hazard. Very few studies, however,provide global wind hazard assessment results that consider detailed local effects. In this study, the wind fields of historical TCs were simulated with parametric models in which the planetary boundary layer models explicitly integrate local effects at 1 km resolution. The topographic effects for eight wind directions were quantified over four types of terrain(ground, escarpment, ridge, and valley),and the surface roughness lengths were estimated from a global land cover map. The missing TC parameters in the best track datasets were reconstructed with local regression models. Finally, an example of a wind hazard map in the form of wind speeds under a 100-year return period and corresponding uncertainties was created based on a statistical analysis of reconstructed historical wind fields over seven of the world's ocean basins. | Chenyan Tan Weihua Fang | 2018 | International Journal of Disaster Risk Science2018，9，1： | 5 |
| 9 | Embryonic and larval development of Babylonia formosae habei (Altena and Gittenberger, 1981) (Gastropoda:Buccinidae) on China's coast显示文摘The development of embryos and larvae of Babyloniaformosae habei living along the southeast coast of China is observed under laboratory conditions. The egg masses are laid by females on hard substrate at night and each capsule contains 100-500 eggs. Each egg is 250-280 mm in diameter. The fast two cleavages of the embryo are meridional and equal, and a polar lobe is produced. Larval kidney, which only consists of a single cell, appears during the gastrula stage on each side of the embryo. The right tentacle develops prior to the left one. At 25-27 ℃, an intracapsulate veliger stage is reached about 4.5 d after deposition. The larvae hatch on the fifth day as swimming veligers with a shell length of 360 -500 mm. The newly hatched larva can ingest suspended algal cells from the water column and remains in the pelagic stage for 8-10 d. The newly settled juveniles are 900-1 200 mm in shell length. | CHENYan ZHOUShiqiang LIFuxue | 2004 | Acta Oceanologica Sinica2004，23，3： | 5 |
| 10 | Comparison of fatty acid profile of three adipose tissues in Ningxiang pigs显示文摘The present study is conducted to determinate fatty acids(FA) composition in 3 adipose tissues. Subcutaneous and perirenal adipose tissues were prepared from 24 Ningxiang castrated boars and 24 castrated gilts fattened by a traditional diet for 56 d, respectively. The results showed that the FA profile in the 3 adipose tissues(dorsal subcutaneous adipose [DSA], abdominal subcutaneous adipose [ASA], and perirenal adipose [PA]) differed greatly. In boars, the proportions of oleic acid(c18:1 n9 c)(P < 0.05), cis-11-20 c acid(c20:1)(P < 0.05), and a-linolenic acid(c18:3 n3)(P < 0.05) in DSA were the highest among 3 adipose tissues, whereas palmitic acid(c16:0)(P < 0.05) and stearic acid(c18:0)(P < 0.05) in DSA had the lowest proportion. In gilts, cis-11-20 c acid(c20:1)(P < 0.05) in DSA was the highest, while stearic acid(c18:0)(P < 0.05) in subcutaneous adipose was the lowest among these deposits. Overall, the results indicate that from external to inner carcass of boars, the sum of saturated fatty acids(SFA) increase, but the sum of monounsaturated fatty acids(MUFA) decrease, while ASA of gilts have the greatest proportion of MUFA and the lowest SFA. Sex and adipose locations as significant effects on the FA profile are interaction. | Qianming Jiang Chenyan Li Yuannian Yu Yueteng Xing Dingfu Xiao Bin Zhang | 2018 | Animal Nutrition2018，，3： | 3 |
| 11 | Dynamical variations in groundwater chemistry influenced by intermittent water delivery at the lower reaches of the Tarim River显示文摘The water of Bosten Lake was released to lower reaches of the Tarim River for 5 times from 2000 to 2002. The changes of total dissolved solid (TDS) and the major ions (SO4^2-, Cl^-, Na^-,Ca^2+, Mg^2- and HCO3^- ) were analyzed during this period. It was found out that TDS and the concentrations of the major ions initially and quickly increased and then decreased, but finally increased again. These changes were different at different distances from the river, which indicated that the groundwater changes relied on the distance from the river. In addition, the salt in groundwater was only diluted but not removed by the water. It was suggested that ecological measures should be sought to really promote the quality of the groundwater at the lower reaches of the Tarim River. | CHENYongjin CHENYaning LIUJiazhen LIWeihong IJun XUChangchun | 2005 | Journal of Geographical Sciences2005，15，1： | 3 |
| 12 | Clinical effect of acupuncture along fascia,meridians,and nerves combined with ultrasound-guided paravertebral nerve block in the treatment of postherpetic neuralgia:a randomized parallel-controlled study显示文摘OBJECTIVE:To observe the clinical efficacy of acupuncture along fascia,meridians,and nerves combined with ultrasound-guided nerve blockage in the treatment of postherpetic neuralgia.METHODS:A total of 61 outpatients with post-chest and back herpes zoster neuralgia were recruited in the Department of Pain at the Xiyuan Hospital,China Academy of Chinese Medical Sciences from May 2019 to June 2021.They were randomly divided into two groups.Thirty-one patients in the control group were treated with ultrasound-guided thoracic paravertebral nerve block(PVB)alone,one patient declined to continue during treatment(n=30),and thirty patients in the observation group received the acupuncture along the fascia,meridians,and nerves combined with ultrasound-guided PVB treatment(n=30).Both control and observation group received treatment weekly for 4 weeks.The medical history data such as age,sex,presence or absence of comorbidities and disease course were analyzed.The visual analog scale(VAS)score was used to assess the pain degree of two groups at T0(before treatment),T1(1-time treatment ended),T2(2 times treatment ended),T3(3 times treatment ended),and T4(4 times treatment ended).The sleep state was examined by Pittsburgh Sleep Quality Index(PSQI)before and after the study.RESULTS:There was no significant difference in general conditions between the control group and the observation group(P>0.05).The VAS score in both control and observation group was decreased in a time-dependent manner after 1-4 weeks of treatment.There were no significant differences in VAS scores between the two groups after 1 or 2 weeks of treatment(P>0.05).After 3 and 4 weeks of treatment,the VAS score was significantly decreased in the observation group compared with that in the control group(P<0.001).In addition,the reduction in VAS score(after treatment-before treatment)between the two groups was statistically significant[D value:-1.53,95%CI(-2.32,0.74),P<0.001].Furthermore,the sleep state of patients in both groups markedly improved and much obvious in the observation group than that in the control group(P<0.05).CONCLUSION:These results suggest that a combination of acupuncture along fascia,meridians,and nerves with ultrasound-guided PVB treatment is more effective than ultrasound-guided PVB treatment alone. | GAO Xiumei WANG Chenyan NI Yong ZHANG Huiling | 2023 | Journal of Traditional Chinese Medicine2023，43，2： | 3 |
| 13 | Proteomic analysis of nuclear matrix proteins during arsenic trioxide induced apoptosis in leukemia K562 cells显示文摘Background Arsenic trioxide (As2O3) has been identified as a very potent antiacute leukemic agent However its role in apoptosis needs to be elucidated As2O3 interferes with the proliferation and survival of tumor cells via a variety of mechanisms Drugtarget interactions at the level of nuclear matrix (NM) may be critical events in the induction of cell death by As2O3 This study dealt with As2O3-target interactions at the level of NM in chronic myelogenous leukemia cell line K562 by proteomics Methods K562 cells were cultured in MEM and treated with different concentrations of As2O3 The nuclear matrix proteins were analyzed by highresolution twodimensional gel electrophoresis and computerassisted image analysis Results As2O3 significantly inhibited the growth of chronic myelogenous leukemia cell line K562 at low concentrations While more than 200 protein spots were shared among the nuclear matrices, about 18 distinct spots in the nuclear matrices were found characteristic for As2O3 treated cells Conclusions: As2O3 induces apoptosis in K562 cells in a dose and timedependent manner Our results demonstrated that for the detection of the onset of apoptosis, the alteration in the composition of nuclear matrix proteins was a more sensitive indicator than nucleosomal DNA fragmentation test These results indicated that As2O3 might be clinically useful in the treatment of chronic myelogenous leukemia. The changes of nuclear matrix proteins in the treated cells can be used as a useful indicator for this | WANGZi-hui YUDing CHENYan HAOJian-zhong | 2005 | Chinese Medical Journal2005，，2： | 3 |
| 14 | Thermal property of biological tissues characterized by piezoelectric photoacoustic technique显示文摘A photoacoustic piezoelectric method based on a simplified thermoelastic theory is employed to determine thermal diffusivities of biological tissues. The thermal diffu-sivities of porcine tissues with different preparation condi-tions, including fresh, dry and specially prepared conditions, are characterized. Comparing the experimental evaluated diffusivities of the tissues in three conditions with each other, it can be seen that the diffusivities of the fresh tissues are the biggest and the diffusivities of the specially prepared tissues are bigger than that of the dry ones generally. The results show that the piezoelectric photoacoustic method is espe-cially effective for determining macro-effective (average) thermal diffusivities of biological materials with micro- inhomogeneity and easy to be performed, which can provide useful information for researching thermal characters of biological tissues. | GAOChunming ZHANGShuyi CHENYan SHUIXiuji YANGYuetao | 2004 | Chinese Science Bulletin2004，49，20： | 3 |
| 15 | A survey of remote sensing image classification based on CNNs显示文摘With the development of earth observation technologies,the acquired remote sensing images are increasing dramatically,and a new era of big data in remote sensing is coming.How to effectively mine these massive volumes of remote sensing data are new challenges.Deep learning provides a new approach for analyzing these remote sensing data.As one of the deep learning models,convolutional neural networks(CNNs)can directly extract features from massive amounts of imagery data and is good at exploiting semantic features of imagery data.CNNs have achieved remarkable success in computer vision.In recent years,quite a few researchers have studied remote sensing image classification using CNNs,and CNNs can be applied to realize rapid,economical and accurate analysis and feature extraction from remote sensing data.This paper aims to provide a survey of the current state-of-the-art application of CNN-based deep learning in remote sensing image classification.We first briefly introduce the principles and characteristics of CNNs.We then survey developments and structural improvements on CNN models that make CNNs more suitable for remote sensing image classification,available datasets for remote sensing image classification,and data augmentation techniques.Then,three typical CNN application cases in remote sensing image classification:scene classification,object detection and object segmentation are presented.We also discuss the problems and challenges of CNN-based remote sensing image classification,and propose corresponding measures and suggestions.We hope that the survey can facilitate the advancement of remote sensing image classification research and help remote-sensing scientists to tackle classification tasks with the state-of-art deep learning algorithms and techniques. | Jia Song Shaohua Gao Yunqiang Zhu Chenyan Ma | 2019 | Big Earth Data2019，3，3： | 3 |
| 16 | Bacterial community response to petroleum contamination in brackish tidal marsh sediments in the Yangtze River Estuary, China显示文摘The brackish tidal marsh in the Baimaosha area of the Yangtze River Estuary was severely contaminated by 400 tons of heavy crude petroleum from a tanker that sank in December 2012.The spill accident led to severe environmental damage owing to its high toxicity,persistence and wide distribution.Microbial communities play vital roles in petroleum degradation in marsh sediments.Therefore,taxonomic analysis,high-throughput sequencing and 16 S rRNA functional prediction were used to analyze the structure and function of microbial communities among uncontaminated(CK),lightly polluted(LP),heavily polluted(HP),and treated(TD)sediments.The bacterial communities responded with increased richness and decreased diversity when exposed to petroleum contamination.The dominant class changed from Deltaproteobacteria to Gammaproteobacteria after petroleum contamination.The phylum Firmicutes increased dramatically in oil-enriched sediment by 75.78%,346.19%and 267.26%in LP,HP and TD,respectively.One of the suspected oil-degrading genera,Dechloromonas,increased the most in oil-contaminated sediment,by 540.54%,711.27%and 656.78%in LP,HP and TD,respectively.Spore protease,quinate dehydrogenase(quinone)and glutathione-independent formaldehyde dehydrogenase,three types of identified enzymes,increased enormously with the increasing petroleum concentration.In conclusion,petroleum contamination altered the community composition and microorganism structure,and promoted some bacteria to produce the corresponding degrading enzymes.Additionally,the suspected petroleum-degrading genera should be considered when restoring oil-contaminated sediment. | Min Wang Chenyan Sha Jian Wu Jinghua Su Jianqiang Wu Qing Wang Juan Tan Shenfa Huang | 2021 | Journal of Environmental Sciences2021，33，1： | 2 |
| 17 | Enantiomeric Separation of Meptazinol Hydrochloride by Capillary Electrophoresis显示文摘Aim To establish a capillary electrophoresis method for enantiomerie separation of meptazinol hydrochloride. Methods The separation conditions such as cyclodextrin(CD)type, buffer pH, concentration of 2,3,6-O-triInethyl-β-cyclodextrin and organic additives were optimized. An optimum concentration was 30 mmol·L^-1 phosphate (pH 7.02)with 10% (W/V) TM-β-CD and 2% acetonitrile. Results Basehne resolution of the enantiomer was readily achieved using 2,3,6-O-trimethyl-β-cyclodextrin. Conclusion This is a convenient method for fast enantiomeric resolution of meptazinol hydrochloride. | YUYun-qiu CHENYan LINi QIUZhui-bai | 2004 | Journal of Chinese Pharmaceutical Sciences2004，13，3： | 2 |
| 18 | Preserved egg white alleviates DSS-induced colitis in mice through the reduction of oxidative stress,modulation of inflammatory cytokines,NF-κB,MAPK and gut microbiota composition显示文摘Traditional Chinese preserved egg products have exhibited some anti-inflammatory effects,but their mechanisms of action remain unknown.This study aimed to investigate the anti-inflammatory effects of preserved egg white(PEW)treatment on dextran sulfate sodium(DSS)-induced colitis in mice and the underlying mechanisms.The results showed that treatment with PEW in mice with DSS-induced colitis for 14 days effectively improved the clinical signs,inhibited the secretion and gene expression of pro-inflammatory cytokines,and reduced myeloperoxidase(MPO)activity and oxidative stress levels.In addition,western blotting results showed that PEW significantly suppressed DSS-induced phosphorylation levels of nuclear factor-kappa B(NF-κB)p65 and p38 mitogen-activated protein kinase(MAPK)in colon tissues of mice with colitis.PEW also enhanced the production of short-chain fatty acids(SCFAs)and modulated gut microbiota composition in mice with DSS-induced colitis,including increasing the relative abundance of beneficial bacteria Lachnospiraceae,Ruminococcaceae and Muribaculaceae,and reducing the relative abundance of harmful bacteria Proteobacteria.Taken together,our study demonstrated that preserved egg white could alleviate DSS-induced colitis in mice through the reduction of oxidative stress,modulation of inflammatory cytokines,NF-κB,MAPK and gut microbiota composition. | Lingyu Li Ning Qiu Yaqi Meng Chenyan Wang Yoshinori Mine Russell Keast Vincent Guyonnet | 2023 | Food Science and Human Wellness2023，12，1： | 2 |
| 19 | Disease-tolerance of transgenic tobacco plants expressing Ah-AMP gene of Amaranthus hypochondriacus显示文摘An antimicrobial peptide gene from Amaranthus hypochondriacus, Ah-AMP, was amplified by PCR and cloned. Sequence analysis results revealed that this gene is 261 bp in length encoding a precursor polypeptide of 87 amino acid residues. Ah-AMP gene was inserted in the binary vector pBin438 to construct a plant expression vector pBinAH916. Leave explants of Nicotiana tabacum var. SR1 were transformed with Agrobacterium tumefaciens LBA4404 harboring the above expression vector. Results from PCR, Southern and Northern blot analyses confirmed that the Ah-AMP gene had been integrated into the tobacco genome and was transcribed at mRNA level. Two bacterial-resistant transgenic plants were selected by inoculating the plants with Pseudomonas solanacearum and statistic analysis of two T1 lines showed that the resistance increased by 2.24 and 1.62 grade and the disease index decreased by 49.6% and 37.3% respectively when compared with the non-transformed control plants SR1. The results from challenging the plants with inoculums of Phytophthora parasitica showed that the symptom development was delayed and disease index was significantly reduced. These results suggest that Ah-AMP gene may be a potentially valuable gene for genetic engineering of plant for disease-resistance. | CHENYan GUOHongnian JIANGYing LIChangqing ZHAOWenming TIANYingchuan | 2003 | Progress in Natural Science:Materials International2003，13，5： | 2 |
| 20 | Comparison of genotypes C and D of the hepatitis B virus in Japan: A clinical and molecular biological study显示文摘 | Tran NhuDuong NorioHoriike KojiroMichitaka ChenYan MasashiMizokami YasuhitoTanaka KoujiJyoko KazutoshiYamamoto HiroakiMiyaoka YoshimasaYamashita NaofumiOhno MorikazuOnji | 2004 | J Med Virol2004，，4： | 1 |
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