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| 1 | Mn-containing bioceramics inhibit osteoclastogenesis and promote osteoporotic bone regeneration via scavenging ROS显示文摘Osteoporosis is caused by an osteoclast activation mechanism.People suffering from osteoporosis are prone to bone defects.Increasing evidence indicates that scavenging reactive oxygen species(ROS)can inhibit receptor activator of nuclear factorκB ligand(RANKL)-induced osteoclastogenesis and suppress ovariectomy-induced osteoporosis.It is critical to develop biomaterials with antioxidant properties to modulate osteoclast activity for treating osteoporotic bone defects.Previous studies have shown that manganese(Mn)can improve bone regeneration,and Mn supplementation may treat osteoporosis.However,the effect of Mn on osteoclasts and the role of Mn in osteoporotic bone defects remain unclear.In present research,a model bioceramic,Mn-containedβ-tricalcium phosphate(Mn-TCP)was prepared by introducing Mn intoβ-TCP.The introduction of Mn intoβ-TCP significantly improved the scavenging of oxygen radicals and nitrogen radicals,demonstrating that Mn-TCP bioceramics might have antioxidant properties.The in vitro and in vivo findings revealed that Mn^(2+)ions released from Mn-TCP bioceramics could distinctly inhibit the formation and function of osteoclasts,promote the differentiation of osteoblasts,and accelerate bone regeneration under osteoporotic conditions in vivo.Mechanistically,Mn-TCP bioceramics inhibited osteoclastogenesis and promoted the regeneration of osteoporotic bone defects by scavenging ROS via Nrf2 activation.These results suggest that Mn-containing bioceramics with osteoconductivity,ROS scavenging and bone resorption inhibition abilities may be an ideal biomaterial for the treatment of osteoporotic bone defect. | Jianmei Li Cuijun Deng Wanyuan Liang Fei Kang Yun Bai Bing Ma Chengtie Wu Shiwu Dong | 2021 | Bioactive Materials2021，6，11： | 7 |
| 2 | Crosslinking strategies for preparation of extracellular matrix-derived cardiovascular scaffolds显示文摘Heart valve and blood vessel replacement using artificial prostheses is an effective strategy for the treatment of cardiovascular disease at terminal stage.Natural extracellular matrix(ECM)-derived materials(decellularized allogeneic or xenogenic tissues)have received extensive attention as the cardiovascular scaffold.However,the bioprosthetic grafts usually far less durable and undergo calcification and progressive structural deterioration.Glutaraldehyde(GA)is a commonly used crosslinking agent for improving biocompatibility and durability of the natural scaffold materials.However,the nature ECM and GA-crosslinked materials may result in calcification and eventually lead to the transplant failure.Therefore,studies have been conducted to explore new crosslinking agents.In this review,we mainly focused on research progress of ECM-derived cardiovascular scaffolds and their crosslinking strategies. | Bing Ma Xiaoya Wang Chengtie Wu Jiang Chang | 2014 | Regenerative Biomaterials2014，1，1： | 6 |
| 3 | Multifunctional mesoporous bioactive glass/upconversion nanoparticle nanocomposites with strong red emission to monitor drug delivery and stimulate osteogenic differentiation of stem cells显示文摘为源于恶意的骨头肿瘤的骨头缺点的治疗和新生,开发能交付治疗学的药的多功能的 biomaterials 是必要的,监视药版本,并且刺激骨头形成。此处,多功能的 mesoporous bioactive 玻璃( MBG ) /upconversion nanoparticle ( UCNP ) nanocomposite [ UCNPs@SiO 2@mSiO2-XCa ( X = 0 , 5 , 10 , 15 ,和 20 )]与交付反癌症药的能力,监视器药版本,并且刺激骨头髓 stromal 房间( BMSC )的 osteogenic 区别成功地用 layer-by-layer 策略被准备。nanocomposite 范围拥有与 100 nm 的一致尺寸分布由 UCNP 和 mesoporous SiO 2/Ca 层组成的核心壳结构。进 nanocomposites 的 Ca 的加入从一个纯六角形的阶段导致了阶段转变到一个立方的阶段,并且便于红排放的出现,它显著地为深织物成像改进了荧光穿入。另外,自从红,排放强烈与反癌症药锌酞毒(ZnPc ) 的最大的吸收度重叠,红光能被 ZnPc 强烈熄灭。因而,药版本能被在荧光紧张监视变化确定。而且,进 MBG/UCNP nanocomposites 的 Ca 的加入显著地改进了 bioactivity,即,它在模仿的身体液体刺激了磷灰石矿化作用并且为 200-500 g/mL 的集中范围在 BMSC 提高了房间增长和骨头相关的基因表示。我们的结果建议准备 MBG/UCNP nanocomposites 为由于他们的不同 multifunctionality 源于恶意的骨头肿瘤的骨头缺点的治疗和新生是有用的,包括在监视的药交货和 osteostimulation 的强壮的红排放和功能。 | Fangfang Wang Dong Zhai Chengtie Wu Jiang Chang | 2016 | Nano Research2016，9，4： | 4 |
| 4 | Design of a biofluid-absorbing bioactive sandwich-structured Zn-Si bioceramic composite wound dressing for hair follicle regeneration and skin burn wound healing显示文摘The deep burn skin injures usually severely damage the dermis with the loss of hair follicle loss,which are difficult to regenerate.Furthermore,severe burns often accompanied with large amount of wound exudates making the wound moist,easily infected,and difficult to heal.Therefore,it is of great clinical significance to develop wound dressings to remove wound exudates and promote hair follicle regeneration.In this study,a sandwich-structured wound dressing(SWD)with Janus membrane property was fabricated by hot compression molding using hydrophilic zinc silicate bioceramics(Hardystonite,ZnCS)and hydrophobic polylactic acid(PLA).This unique organic/inorganic Janus membrane structure revealed excellent exudate absorption property and effectively created a dry wound environment.Meanwhile,the incorporation of ZnCS bioceramic particles endowed the dressing with the bioactivity to promote hair follicle regeneration and wound healing through the release of Zn^(2+)and SiO^(2-)_(3)��ions,and this bioactivity of the wound dressing is mainly attributed to the synergistic effect of Zn^(2+)and SiO^(2-)_(3)��to promote the recruitment,viability,and differentiation of hair follicle cells.Our study demonstrates that the utilization of the Janus membrane and synergistic effect of different type bioactive ions are effective approaches for the design of wound dressings for burn wound healing. | Zhaowenbin Zhang Wenbo Li Ying Liu Zhigang Yang Lingling Ma Hui Zhuang Endian Wang Chengtie Wu Zhiguang Huan Feng Guo Jiang Chang | 2021 | Bioactive Materials2021，6，7： | 3 |
| 5 | Bioceramic-based scaffolds with antibacterial function for bone tissue engineering:A review显示文摘Bone defects caused by trauma,tumor,congenital abnormality and osteoarthritis,etc.have been substantially impacted the lives and health of human.Artificial bone implants,like bioceramic-based scaffolds,provide significant benefits over biological counterparts and are critical for bone repair and regeneration.However,it is highly probable that bacterial infections occur in the surgical procedures or on bioceramic-based scaffolds.Therefore,it is of great significance to obtain bioceramic-based scaffolds with integrative antibacterial and osteogenic functions for treating bone implant-associated infection and promoting bone repair.To fight against infection problems,bioceramic-based scaffolds with various antibacterial strategies are developed for bone repair and regeneration and also have made great progresses.This review summarizes recent progresses in bioceramic-based scaffolds with antibacterial function,which include drug-induced,ion-mediated,physical-activated and their combined antibacterial strategies according to specific antibacterial mechanism.Finally,the challenges and opportunities of antibacterial bioceramic-based scaffolds are discussed. | Chaoqian Zhao Weiye Liu Min Zhu Chengtie Wu Yufang Zhu | 2022 | Bioactive Materials2022，7，12： | 2 |
| 6 | Medical Additive Manufacturing: From a Frontier Technology to the Research and Development of Products显示文摘1.Research and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many other fields,making them an important basis in the field of three-dimensional(3D)printing.Problems and challenges related to material types,powder properties,formability,viscoelasticity,and so forth also share common features.For example,many metal materials are used in the field of aviation,while metals,polymers,and inorganic materials are used in the field of biomedicine.The most widely used materials in biomedicine are biocompatible.Various homogeneous and non-homogeneous composites are also available for 3D printing,and impose an additional challenge in additive manufacturing;the use of heterogeneous composites in 3D printing is particularly challenging. | Guixing Qiu Wenjiang Ding Wei Tian Ling Qin Yu Zhao Lianmeng Zhang Jian Lu Daijie Chen Guangyi Yuan Chengtie Wu Bingheng Lu Ruxu Du Jimin Chen Mo Elbestawi Zhongwei Gu Dichen Li Wei Sun Yuanjin Zhao Jie He Dadi Jin Bin Liu Kai Zhang Jianmo Li Kam WLeong Dewei Zhao Dingjun Hao Yingfang Ao Xuliang Deng Huilin Yang ShaoKeh Hsu Yingqi Chen Long Li Jianping Fan Guohui Nie Yun Chen Hui Zeng Wei Chen Yuxiao Lai | 2020 | Engineering2020，6，11： | 1 |
| 7 | Silicate bioceramic/PMMA composite bone cement with distinctive physicochemicaland bioactive properties 显示文摘 | Lei Chen Chengtie Wu Jiang Chang | 2015 | RSC Advances2015，5，37： | 1 |
| 8 | Proliferation and osteoblastic differentiation of human bone marrow-derived stromal cells on akermanite-bioactive ceramics显示文摘 | Hongli Sun Chengtie Wu Kerong Dai Jiang Chang Tingting Tang | 2006 | Biomaterials2006，，33： | 1 |
| 9 | Heavy metal contamination in western Xiamen Bay sediments and its vicinity, China显示文摘 | Luoping Zhang Xin Ye Huan Feng Youhai Jing Tong Ouyang Xingtian Yu Rongyuan Liang Chengtie Gao Weiqi Chen | 2007 | Marine Pollution Bulletin2007，，7： | 1 |
| 10 | The responses of osteoblasts,osteoclasts and endothelial cells to zirconium modified calcium-silicate-based ceramic显示文摘 | Yogambha Ramaswamy Chengtie Wu Annika Van Hummela | 2008 | Biomaterials2008，29，33： | 1 |
| 11 | 肝放疗耐受的剂量体积直方图分析[J]显示文摘 | Austin-SeymourMM ChenGTY CastroJR etal | | 国际放射肿瘤生物物理0，，： | 1 |
| 12 | The influence of transverse shear and rotation inertia on the dynamic instability of laminated composite plates显示文摘 | Zhou chengti Wang Litung Jia Hongyu | 1989 | The Seventh International Conference on Composite Materials (ICCM-7)1989，2224，： | 1 |
| 13 | Three-dimensional printing of hier- archical and tough mensoporous bioactive glass scaffolds with a controllable pore architecture,excellent mechanical strength and mineralization ability 显示文摘 | Chengtie wu Yongxiang luo Gianaurelio Cuniberti Yin xi- ao Michael Genlinsky | 2011 | Acat Biomaterialia2011，，7： | 1 |
| 14 | Dual drug re- lease from electrospun poly(lactic-co-glycolic acid)/meso- porous silica nanoparticles composite mats with distinct re- lease profile显示文摘 | Song Botao Wu Chengtie Chang Jiang | 2012 | Acta Biomater2012，8，5： | 1 |
| 15 | Serum midkine as a prognostic biomarker for patients with hepatocellular carcinoma显示文摘 | HungYJ LinZH ChengTI etal | 2011 | Am J Clin Pathol2011，136，： | 1 |
| 16 | Manganese-Doped Calcium Silicate Nanowire Composite Hydrogels for Melanoma Treatment and Wound Healing显示文摘Melanoma is a serious malignant skin tumor.Effectively eliminating melanoma and healing after-surgical wounds are always challenges in clinical studies.To address these problems,we propose manganese-doped calcium silicate nanowire-incorporated alginate hydrogels(named MCSA hydrogels)for in situ photothermal ablation of melanoma followed by the wound healing process.The proposed MCSA hydrogel had controllable gelation properties,reasonable strength,and excellent bioactivity due to the incorporated calcium silicate nanowires as the in situ cross-linking agents and bioactive components.The doping of manganese into calcium silicate nanowires gave them excellent photothermal effects for eradicating melanoma effectively under near infrared(NIR)irradiation.Moreover,the synergistic effect of manganese and silicon in the MCSA hydrogel effectively promotes migration and proliferation of vascular endothelial cells and promotes angiogenesis.Hence,such bifunctional bioactive hydrogels could achieve combined functions of photothermal therapy and wound healing,showing great promise for melanoma therapy and tissue regeneration. | Zhongcao Wu Hui Zhuang Bing Ma Yin Xiao Bahattin Koc Yufang Zhu Chengtie Wu | 2021 | Research2021，，1： | 1 |
| 17 | A robust and efficientcross-layer optimal design in wireless sensor networks 显示文摘 | Li Mingwei Jing Yuanwei Li Chengtie | 2013 | Wire-less Personal Communications2013，72，4： | 1 |
| 18 | 显示文摘 | Wu Chengtie Jiang Chang | 1990 | J Non-Cryst Solids1990，120，： | 1 |
| 19 | 显示文摘 | Wu Chengtie Jiang Changa Wang Junying | 2005 | Biomaterials2005，26，： | 1 |
| 20 | Nano-calcium silicate mineralized fish scale scaffolds for enhancing tendon-bone healing显示文摘Tendon-bone healing is essential for an effective rotator cuff tendon repair surgery,however,this remains a significant challenge due to the lack of biomaterials with high strength and bioactivity.Inspired by the high-performance exoskeleton of natural organisms,we set out to apply natural fish scale(FS)modified by calcium silicate nanoparticles(CS NPs)as a new biomaterial(CS-FS)to overcome the challenge.Benefit from its“Bouligand”microstructure,such FS-based scaffold maintained excellent tensile strength(125.05 MPa)and toughness(14.16 MJ/m^(3)),which are 1.93 and 2.72 times that of natural tendon respectively,allowing it to well meet the requirements for rotator cuff tendon repair.Additionally,CS-FS showed diverse bioactivities by stimulating the differentiation and phenotypic maintenance of multiple types of cells participated into the composition of tendon-bone junction,(e.g.bone marrow mesenchymal stem cells(BMSCs),chondrocyte,and tendon stem/progenitor cells(TSPCs)).In both rat and rabbit rotator cuff tear(RCT)models,CS-FS played a key role in the tendon-bone interface regeneration and biomechanical function,which may be achieved by activating BMP-2/Smad/Runx2 pathway in BMSCs.Therefore,natural fish scale-based biomaterials are the promising candidate for clinical tendon repair due to their outstanding strength and bioactivity. | Fei Han Tian Li Mengmeng Li Bingjun Zhang Yufeng Wang Yufang Zhu Chengtie Wu | 2023 | Bioactive Materials2023，，2： | 1 |
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