|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Schistosoma japonicum infection induces macrophage polarization显示文摘The role of macrophages(Mφ)as the first line of host defense is well accepted.These cells play a central role in orchestrating crucial functions during schistosomal infection.Thus,understanding the functional diversity of these cells in the process of infection as well as the mechanisms underlying these events is crucial for developing disease control strategies.In this study,we adopted a Mφpolarization recognition system.Ml macrophage was characterized by expressing CD16/32,IL-12 and iNOS.M2 macrophage was characterized by expressing CD206,IL-10 and arg-1.In vivo(mouse peritoneal macrophages of different infection stages were obtained)and in vitro(different 5.japonicum antigens were used to stimulate RAW264.7)were characterized by using the above mentioned system.NCA and ACA stimulated RAW264.7 express significantly higher levels of IL-12 while significantly higher levels of IL-10 were detected after soluble egg antigen(SEA)stimulation.The results showed that dramatic changes of antigen in the microenvironment before and after egg production led to macrophage polarization.Furthermore,through TLR blocking experiments,the TLR4 signaling pathway was found to play a role in the process of macrophage polarization toward Ml.Our data suggest that macrophage polarization during S.japonicum infection had significant effects on host immune responses to S.japonicum. | Jingwei Xu Hao Zhang Lin Chen Donghui Zhang Minjun Ji Haiwei Wu Guanling Wu | 2014 | The Journal of Biomedical Research2014，28，4： | 20 |
| 2 | Antimicrobial susceptibility of Gram-negative bacteria causing intra-abdominal infections in China: SMART China 2011显示文摘 | Zhang Hui Yang Qiwen Xiao Meng Chen Minjun Robert E. Badal Xu Yingchun | 2014 | Chinese Medical Journal2014，，13： | 10 |
| 3 | Particulate matter(PM(2.5)) exposure season-dependently induces neuronal apoptosis and synaptic injuries显示文摘Epidemiological studies have shown that particulate matter 2.5(PM_(2.5)) not only increases the incidence of cardiopulmonary illnesses but also relates to the development of neurodegenerative diseases. Considering that PM_(2.5)is highly heterogeneous with regional disparity and seasonal variation, we investigated whether PM_(2.5)exposure induced neuronal apoptosis and synaptic injuries in a season-dependent manner. The results indicated that PM_(2.5)altered the expression of apoptosis-related proteins(mainly bax and bcl-2), activated caspase-3 and caused neuronal apoptosis. Additionally, PM_(2.5)decreased the levels of synaptic structural protein postsynaptic density(PSD-95) and synaptic functional protein N-methyl-D-aspartate(NMDA) receptor subunit(NR2B) expression. These effects occurred in a season-dependent manner, and PM_(2.5)collected from the winter showed the strongest changes. Furthermore, the effect was coupled with the inhibition of phosphorylated extracellular signal-regulated kinase 1/2(p-ERK1/2) and phosphorylated c AMP-response element binding protein(p-CREB). Based on the findings, we analyzed the correlations between the chemical composition of PM_(2.5)samples and the biological effects, and confirmed that winter PM_(2.5)played a major role in causing neuronal apoptosis and synaptic injuries among different season samples. | Minjun Chen Ben Li Nan Sang | 2017 | Journal of Environmental Sciences2017，29，4： | 10 |
| 4 | Xeno-repopulation of Fah^(-/-)Nod/Scid mice livers by human hepatocytes显示文摘Functional human hepatocytes xenografted into the liver of mice can be used as a model system to study pharmacokinetics,infection of hepatitis viruses,and the efficacy of hepatitis vaccines.Significant levels of liver xeno-repopulation have been reported in Fah-/-Rag2-/-Il2rg-/-mice.However,the high mortality and low breeding rate of this model may hinder its application.A new model,termed Fah-/-Nod/Scid mice,which combines the advantages of liver repopulation in Fah-/-mice with the ease of xenotransplantation in Nod/Scid mice was obtained by gradual cross-breeding.Fah-/-Nod/Scid mice were easily maintained in breeding colonies and in adult animal care facilities.FK506 treatment combined with gradual withdrawal of NTBC before cell transplantation ensured that Fah-/-Nod/Scid mice were susceptible to liver xeno-repopulation by human hepatocytes;the proportion of engrafted human hepatocytes reached 33.6%.The function of the expanded human hepatocytes within the chimeric liver was confirmed by weight curve analysis,the expression of characteristic proteins,and the biochemical analysis of liver function.These results show that Fah-/-Nod/Scid mice are an ideal humanized liver mouse model with many useful applications. | SU BaoLiang LIU ChangCheng XIANG Dao ZHANG HaiBin YUAN SiMing WANG MinJun CHEN Fei ZHU HaiYing HE ZhiYing WANG Xin HU YiPing | 2011 | Science China(Life Sciences)2011，54，3： | 5 |
| 5 | IFN-inducible p47 GTPases display differential responses to Schistosoma japonicum acute infection显示文摘Interferon gamma induced GTPase(IGTP)(also named lrgm3)and interferon gamma inducible protein 47(IRG-47)(also named lIrgd)are interferon(IFN)-inducible p47 GTPases that have been shown to regulate host resistance to intracellular pathogens.Little knowledge has been known about the role of p47 GTPases in host responses against extracellular pathogens.To investigate possible roles of IGTP and IRG-47 in the course of Schistosoma japonicum infection,IGTP and IRG-47 knockout and wild-type(WT)mice were challenged with cercariae of S.japonicum,and host responses were analyzed.At the acute stage of S.japonicum infection,mice that lacked IGTP displayed similar parasite burden and pathological damage to WT mice.Importantly,S.japonicum-infected lRG-47-deficient mice,in contrast to IGTP-deficient mice and WT mice,showed significantly reduced worms and lower egg-burden,but intense granulomatous reaction evoked by schistosome eggs in peripheral parts of liver lobes.In addition,upregulation of inflammation-related gene expression was observed in the spleen of IRG-47-deficient mice using oligonucleotide microarrays,in which multiple pathways of cytokine-cytokine receptor interaction,T-cell receptor signaling,complement,coagulation cascades and cell adhesion molecules were highlighted.Taken together,these data suggest that IGTP and IRG-47 might have distinct features that were differentially required for resistance to S.japonicum. | Xuesong Chen Xiaotang Du Meijuan Zhang Donghui Zhang Minjun Ji Guanling Wu | 2010 | Cellular & Molecular Immunology2010，7，1： | 2 |
| 6 | Drug-induced liver injury: Interactions between drug properties and host factors显示文摘 | Minjun Chen Ayako Suzuki Jürgen Borlak Raúl J. Andrade M Isabel Lucena | 2015 | Journal of Hepatology2015，，2： | 1 |
| 7 | Nanopolyphenol rejuvenates microglial surveillance of multiple misfolded proteins through metabolic reprogramming显示文摘Microglial surveillance plays an essential role in clearing misfolded proteins such as amyloid-beta,tau,andα-synuclein aggregates in neurodegenerative diseases.However,due to the complex structure and ambiguous pathogenic species of the misfolded proteins,a universal approach to remove the misfolded proteins remains unavailable.Here,we found that a polyphenol,α-mangostin,reprogrammed metabolism in the disease-associated microglia through shifting glycolysis to oxidative phosphorylation,which holistically rejuvenated microglial surveillance capacity to enhance microglial phagocytosis and autophagy-mediated degradation of multiple misfolded proteins.Nanoformulation ofα-mangostin efficiently deliveredα-mangostin to microglia,relieved the reactive status and rejuvenated the misfolded-proteins clearance capacity of microglia,which thus impressively relieved the neuropathological changes in both Alzheimer’s disease and Parkinson’s disease model mice.These findings provide direct evidences for the concept of rejuvenating microglial surveillance of multiple misfolded proteins through metabolic reprogramming,and demonstrate nanoformulatedα-mangostin as a potential and universal therapy against neurodegenerative diseases. | Dayuan Wang Xiao Gu Xinyi Ma Jun Chen Qizhi Zhang Zhihua Yu Juan Li Meng Hu Xiaofang Tan Yuyun Tang Jianrong Xu Minjun Xu Qingxiang Song Huahua Song Gan Jiang Zaiming Tang Xiaoling Gao Hongzhuan Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 1 |
| 8 | Toward predictive models for drug induced liver injury in humans: are we there yet? 显示文摘 | Minjun Chen Halil Bisgin Lillian Tong | 2014 | Biomarkers Med2014，8，2： | 1 |
| 9 | Causative agent distribution and antibiotic therapy assessment among adult patients with community acquired pneumonia in Chinese urban population显示文摘 | Youning Liu Minjun Chen Tiemei Zhao | 2009 | BMC Infectious Diseases2009，9，： | 1 |
| 10 | Metabonomic study on the-biochemical profile of hydrocortisone induced anilmal model显示文摘 | Minjun Chen Liping Zhao Weij ia et a 1 | 2005 | Joumal ofProteme Research2005，4，61： | 1 |
| 11 | Evaluation of the in vitro antimicrobial activity of cefepime compared to other broad -spectrum beta -lactams tested against recent clinical isolates from 10 Chinese hospitals显示文摘 | Xu yingchun Chen minjun Douglas J | 1999 | Diagn Microbial Infect Dis1999，35，： | 1 |
| 12 | Metabonomic study on the biochemical profiles of a hydrocortisone-induced animal model 显示文摘 | CHEN Minjun ZHAO Liping JIA Wei | 2005 | J Proteome Res2005，4，6： | 1 |
| 13 | 显示文摘 | Xin Minjun Chen Yiqing | 2008 | Materials Letters2008，62，： | 1 |
| 14 | Evaluation of the in anti-microbial activity of cefepime compared to other troad-spectrum β-lactams testd against recent clinical isolates from 10 Chinese hopital显示文摘 | Xu Yingchun Chen Minjun | 1999 | Diagn Microbial Infect Dis1999，35，： | 1 |
| 15 | China 1994-2001 ICU-sugar changes Bacterial Resistance显示文摘 | WAN GHUI CHEN MINJUN | 2003 | China Medical Journal2003，83，5： | 1 |
| 16 | In vitro activity of cefditoren and other comparators against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis causing community-acquired respiratory tract infections in China显示文摘 | Qiwen Yang Yingchun Xu Minjun Chen | 2012 | Diagnostic Microbiology and InfectiousDisease2012，73，2： | 1 |
| 17 | Extended-spectrum β-lactamases in clinical isolates of Enterobacter gergoviae and Escherichia coli in China显示文摘 | Yulin Cheng Minjun chen | 1994 | Antimicrobial Agents and Chemotherapy1994，38，20： | 1 |
| 18 | Antibiotic susceptibility patters of streptococcus pneumoniae in China and comparison of MICs by agar dilution and Etest methods显示文摘 | Hui Wang Robin H Minjun Chen | 1998 | Antimicrob Agents and Chemoth1998，42，10： | 1 |
| 19 | Metabonomic Study on the Biochemical Profiles of A Hydrocortisone Induced Animal Model显示文摘 | Minjun Chen Liping Zhao Wei Jia | 2005 | Journal of Proteome Research2005，4，6： | 1 |
| 20 | Fractal fingerpringting of chromatographic profiles based on wavelet analysis and its application to characterize the quality grade of medicinal herbs显示文摘 | Cheng Yiyu Chen Minjun William J Welsh | 2003 | J Chem Inf Comput Sci2003，43，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员