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| 1 | Whether Syndrome Differentiation Affects Treatment Result:Study Protocol of MaZiRenWan(麻子仁丸)for Functional Constipation in A Randomized Controlled Trial显示文摘Background: Syndrome is one of the most important concepts in Chinese medicine(CM) theory. However, it was not well accounted in most of randomized controlled trials(RCTs). Objective: To determine whether CM syndrome differentiation affects the treatment results, functional constipation(FC) was selected as a target disease, and MaZiRenWan(麻子仁丸, MZRW), a classic CM formula commonly used for constipation with excessive heat syndrome, was selected for study. Methods: It is an 18-week prospective double-blinded, doubledummy RCT, including 2-week run-in, 8-week treatment and 8-week post treatment follow-up. A total of 120 FC patients diagnosed as excessive heat syndrome will be recruited from the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine and the Baokang Affiliated Hospital of Tianjin University of Traditional Chinese Medicine. Patients will be randomly allocated into fixed MZRW(f_MZRW) granule group, modified MZRW(m_MZRW) granule group or bisacodyl group. For m_MZRW group, no more than two herbal granules can be added according to the syndrome differentiation for individual participants. The primary end point is the mean of complete spontaneous bowel movements(CSBMs) per week during the treatment period. Secondary end points include mean of CSBMs per week during follow-up, stool form, global symptom improvement, constipation and constipation-related symptoms assessment, CM syndrome change, and reported adverse events. Discussion: This trial is designed to evaluate the effectiveness of these three interventions for FC patients with the CM syndrome of excessive heat, and to determine the change of CM syndrome and the progress of disease during the treatment course. The results are important to explore whether syndrome differentiation is important for the therapeutic effect of a formula on a disease. | CHENG Chung-wah ZHANG Li ZHAO Chen ZHONG Linda LD SHI Li-jie DAI Liang ZHENG Rui CHEN Jing LI Ge ZHAI Jing-bo KUN Wai LU Ai-ping SHANG Hong-cai BIAN Zhao-xiang | 2019 | Chinese Journal of Integrative Medicine2019，25，3： | 3 |
| 2 | A novel approach to glioma gene therapy: down-regulation of the vascular endothelial growth factor in glioma cells using ribozymes显示文摘 | Fueyo J Chen X | 1998 | Int J Oncol1998，12，6： | 1 |
| 3 | Kimura disease:A clinicopathologic study of 21 cases显示文摘 | Thompson LD Aguilera NS | 2004 | Am J Surg Pathol2004，28，4： | 1 |
| 4 | The signal transduetion pathways of heat shock protein 27 phosphorylation in vascular smooth muscle cells显示文摘 | Chen HF Xie LD Xu CS | 2010 | Mol Cell Biochem2010，333，12： | 1 |
| 5 | Transcriptional regulation of corticotro-phin releasing factor gene by furocou-marins isolated from seeds of Psoraleacorylifolia显示文摘 | Chen Y Cheung YT Kong LD | 2008 | Life Sci2008，82，2122： | 1 |
| 6 | Leydig cell aging:steroidogenic acute regulatory protein (StAR) and cholesterol side-chain cleavage enzyme显示文摘 | Luo LD Chen HL Zirkin BR | 2001 | J Androl2001，22，2： | 1 |
| 7 | Chymase is upregulated in diabetic nephropathy:Implication for an alternative pathway of angiotensin Ⅱ-mediated diabetic renal and vascular disease显示文摘 | Huang XR Chen WY Truong LD | 2003 | J Am Soc Nephrol2003，14，： | 1 |
| 8 | Effectiveness and safety of tranexa- mic acid in reducing blood loss in total knee arthroplasty : a meta- analysis显示文摘 | Yang ZG Chen WP Wu LD | 2012 | J Bone Joint Surg Am2012，94，： | 1 |
| 9 | A strategy to control transmission of Schistosomajaponicum in China显示文摘 | Wang LD Chen HG Guo JG | 2009 | N Engl J Med2009，360，2： | 1 |
| 10 | Effectiveness and safety of tranexamic acid in reducing blood loss in total knee arthroplasty: a meta - analy- sis显示文摘 | Yang ZG Chen WP Wu LD | 2012 | J Bone Joint Surg Am2012，13，： | 1 |
| 11 | Necrotizing fasciitis with escherichia coli显示文摘 | Li DM Lun LD Chen XR | | 0，，07： | 1 |
| 12 | Melatonin, a hydroxyl radical-mediated oxidative damage and aging: A hypothesis 显示文摘 | Reiter RJ Tan DX Chen LD Mancheste LC | 1993 | J Pineal Res1993，14，4： | 1 |
| 13 | A randomized trial comparing mitomycin C and conjunctival autograft after excision of primary pterygium 显示文摘 | Chen PP Aniyasu RG Kaza V LaBree LD McDonnell PJ | 1995 | Am J Ophthalmol1995，120，2： | 1 |
| 14 | A strategy to control transmission of schistosoma iaponicum in China 显示文摘 | Wang LD Chen HG Guo JG | 2009 | The New England Journal of Medicine2009，360，2： | 1 |
| 15 | A reliabil ity test of standard-based quantitatire PeR:exogenous vs endogenous standards显示文摘 | Ke LD Chen Z Yung WK | 2000 | Mol Cell Probes2000，14，2： | 1 |
| 16 | Effectiveness and safety of tranex- amic acid in reducing blood loss in total knee arthroplasty: a meta- analysis显示文摘 | Yang ZG Chen WP Wu LD | 2012 | J Bone Joint Surg Am2012，94，13： | 1 |
| 17 | The mood - stabilizing agent valproate inhinbits the activity of glycogen synthase kinase - 3 显示文摘 | Chen G Huang LD Jiang YM | 1999 | J Neurochem1999，72，： | 1 |
| 18 | Effectiveness and safety of tranexamic acid in reducing blood loss in total knee ar- throplasty:a meta-analysis显示文摘 | Yang ZG Chen WP Wu LD | 2012 | J Bone Joint Surg Am2012，94，13： | 1 |
| 19 | Contrast-enhanced ultrasound of intrahepatic cholangiocarcinoma: correlation with pathological examination 显示文摘 | Xu HX Chen LD Liu LN | 2012 | Br J Radiol2012，85，1016： | 1 |
| 20 | Intrahepatic cholangiocarcinoma and hepatocellular carcinoma:differential diagnosis with contrastenhanced ultrasound显示文摘 | Chen LD Xu HX Xie XY | | 0，，03： | 1 |
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