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| 1 | Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal crohn's disease显示文摘AIM To examine the relationship between elevated granulocyte-macrophage colony-stimulating factor(GMCSF) auto-antibodies(Ab) level and time to surgical recurrence after initial surgery for Crohn's disease(CD). METHODS We reviewed 412 charts from a clinical database at tertiary academic hospital. Patients included in the study had ileal or ileocolonic CD and surgical resection of small bowel or ileocecal region for management of disease. Serum samples were analyzed for serological assays including GM-CSF cytokine, GM-CSF Ab, ASCA Ig G and Ig A, and genetic markers including SNPs rs2066843, rs2066844, rs2066845, rs2076756 and rs2066847 in NOD2, rs2241880 in ATG16 L1, and rs13361189 in IRGM. Cox proportional-hazards models were used to assess the predictors of surgical recurrence.RESULTS Ninety six percent of patients underwent initial ileocecal resection(ICR) or ileal resection(IR) and subsequently 40% of patients required a second ICR/IR for CD. GMCSF Ab level was elevated at a median of 3.81 mcg/mL. Factors predicting faster time to a second surgery included elevated GM-CSF Ab [hazard ratio(HR) 3.52, 95%CI: 1.45-8.53, P = 0.005] and elevated GM-CSF cytokine(HR = 2.48, 95%CI: 1.31-4.70, P = 0.005). Factors predicting longer duration between first and second surgery included use of Immunomodulators(HR = 0.49, 95%CI: 0.31-0.77, P = 0.002), the interaction effect of low GM-CSF Ab levels and smoking(HR = 0.60, 95%CI: 0.45-0.81, P = 0.001) and the interaction effect of low GM-CSF cytokine levels and ATG16 L1(HR = 0.65, 95%CI: 0.49-0.88, P = 0.006).CONCLUSION GM-CSF bioavailability plays a critical role in maintaining intestinal homeostasis. Decreased bioavailability coupled with the genetic risk markers and/or smoking results in aggressive CD behavior. | Grace Gathungu Yuanhao Zhang Xinyu Tian Erin Bonkowski Leahana Rowehl Julia Krumsiek Billy Nix Claudia Chalk Bruce Trapnell Wei Zhu Rodney Newberry Lee Denson Ellen Li | 2018 | World Journal of Gastroenterology2018，24，5： | 5 |
| 2 | Challenges for fuel cells in transport applications显示文摘 | Chalk S G Miller J F Wagner F W | 2000 | Journal of Power Sources2000，86，： | 2 |
| 3 | Metabolism of pyruvate and glucose by intact cells of Helicobacter pylori studied by 13C NMR spectroscopy显示文摘 | Chalk PA Roberts AD Blows WM | 1994 | Microbiology1994，140，： | 1 |
| 4 | Loss of connectivity in Alzheimer's disease:an evaluation of white matter tract integrity with color coded MR diffusion tensor imaging显示文摘 | Rose SE Chen F Chalk JB | 2000 | J Neurol Neurosurg Psychiat2000，69，4： | 1 |
| 5 | Loss of connectivity in Alzheimer's disease:an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging显示文摘 | Rose SE Chen F Chalk JB | 2000 | J Neurol Neurosurg Psychiatry2000，69，4： | 1 |
| 6 | Aldose reductase inhibitors for the treatment of diabetic polyneuropathy显示文摘 | Chalk C Benstead TJ Moore F | 2007 | Cochrane Database Syst Rev2007，17，00： | 1 |
| 7 | Using Blended Learning to Improve Student Success Rates in Learning to Program显示文摘 | TOM BOYLE CLAIRE BRADLEY PETER CHALK etc | 2003 | Journal of Educational Media2003，28，23： | 1 |
| 8 | Helicobacter pylori porCDAB andoorDABC genes encode distinct pyruvate:flavodoxin and 2-oxoglutarate:acceptor oxidoreductases whichmediate electron transport to NADP显示文摘 | Nicky J Hughes Chris L Clayton Peter A Chalk | 1998 | Journal of bacteriology1998，180，5： | 1 |
| 9 | Loss of connec- tivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffu- sion tensor imaging显示文摘 | Rose SE Chen F Chalk JB | 2000 | J Neurol Neurosurg Psy chiatryry2000，69，5： | 1 |
| 10 | Nitrogen gas preparative system for isotope-ratio analysis by mass spectrometry显示文摘 | SMITH C S CHALK P M | 1979 | Anal Chem Acta1979，104，： | 1 |
| 11 | Improved and Automated Prediction of Effective siRNA显示文摘 | ALISTAIR M CHALK CLAES WAHLESTEDT ERIK L L SONNHAMMER | | 0，，01： | 1 |
| 12 | Sources of N uptake by wheat and N transformations in soil treated with a nitrification inhibitor ( nitrapyrin ) 显示文摘 | CRAWFORD M D Chalk P M | 1993 | Plant and Soil1993，149，： | 1 |
| 13 | Challenges for fuel cells in transport applications 显示文摘 | CHALK S G MILLER J F WAGNER F W | 2000 | J Power Sources2000，86，： | 1 |
| 14 | New concepts in acute paint herapy: preemptive analgesia 显示文摘 | Gotts chalk A Smith DS | 2001 | Am Fam Physician2001，63，10： | 1 |
| 15 | Challenges for fuel cell in transport applications 显示文摘 | CHALK S G MILLER J F WAGNER F W | 2000 | Journal of Power Sources2000，86，1： | 1 |
| 16 | Water Balance and Unsaturated Flow 显示文摘 | WELLINGS S R Recharge of the Chalk Aquifer at a Site in Hampshire England 1 | 1984 | Journal of Hydrology1984，69，1： | 1 |
| 17 | Purification of an insect defensin from the mosquito, Aedes aegypti 显示文摘 | Townson H Natori S | 1994 | Insect Biochem Molec Biol1994，24，4： | 1 |
| 18 | The thyroid hormone receptor-associated protein TRAP220 is required at distinct embryonic stages in placental,cardiac,and hepatic development显示文摘 | Landles C Chalk S Steel JH | 2003 | Mol Endocrinol2003，17，12： | 1 |
| 19 | Loss of connectivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging显示文摘 | Rose SE Chen F Chalk JB | 2000 | J Neurol Neurosurg Psychiatryry2000，69，5： | 1 |
| 20 | Pushing in the second stage of labour: Part 1 显示文摘 | Manda Chalk | 2004 | British Journal of Midwifery2004，12，8： | 1 |
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