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| 1 | Endoscopic submucosal dissection for premalignant lesions and noninvasive early gastrointestinal cancers显示文摘AIM: To investigate the indication, feasibility, safety, and clinical utility of endoscopic submucosal dissection (ESD) in the management of various gastrointestinal pathologies. METHODS: The medical records of 60 consecutive patients (34 female, 26 male) who underwent ESD at the gastroenterology department of Kocaeli University from 2006-2010 were examined. Patients selected for ESDhad premalignant lesions or non-invasive early cancers of the gastrointestinal tract and had endoscopic and histological diagnoses. Early cancers were considered to be confined to the submucosa, with no lymph node involvement by means of computed tomography and endosonography. RESULTS: Sixty ESD procedures were performed. The indications were epithelial lesions (n = 39) (33/39 adenoma with high grade dysplasia, 6/39 adenoma with low grade dysplasia), neuroendocrine tumor (n = 7), cancer (n = 7) (5/7 early colorectal cancer, 2/7 early gastric cancer), granular cell tumor (n = 3), gastrointestinal stromal tumor (n = 2), and leiomyoma (n = 2). En bloc and piecemeal resection rates were 91.6% (55/60) and 8.3% (5/60), respectively. Complete and incomplete resection rates were 96.6% (58/60) and 3.3% (2/60), respectively. Complications were major bleeding [n = 3 (5%)] and perforations [n = 5 (8.3%)] (4 colon, 1 stomach). Two patients with colonic perforations and two patients with submucosal lymphatic and microvasculature invasion (1 gastric carcinoid tumor, 1 colonic adenocarcinoma) were referred to surgery. During a mean follow-up of 12 mo, 1 patient with adenoma with high grade dysplasia underwent a second ESD procedure to resect a local recurrence. CONCLUSION: ESD is a feasible and safe method for treatment of premalignant lesions and early malignant gastrointestinal epithelial and subepithelial lesions. Successful en bloc and complete resection of lesions yield high cure rates with low recurrence. | Sadettin Hulagu Omer Senturk Cem Aygun Orhan Kocaman Altay Celebi Tolga Konduk Deniz Koc Goktug Sirin Ugur Korkmaz Ali Erkan Duman Neslihan Bozkurt Gokhan Dindar Tan Attila Yesim Gurbuz Orhan TarcinDivision of Gastroenterology Derince State Hospital Kocaeli 41900 Turkey Cem Kalayci | 2011 | World Journal of Gastroenterology2011，17，13： | 23 |
| 2 | Expression of COX-2, PCNA, Ki-67 and p53 in gastrointestinal stromal tumors and its relationship with histopathological parameters显示文摘AIM: To investigate the expression of Cyclooxygenase-2 (COX-2), proliferating cell nuclear antigen (PCNA), Ki-67 and p53 in gastrointestinal stromal tumors (GISTs) and its relationship with histopathological parameters. METHODS: Twenty-five GISTs were examined by light microscopy and immunohistochemistry. c-kit, CD34, SMA, S-100 protein, COX-2, PCNA, Ki-67 and p53 were detected immunohistochemically and the relationship was evaluated among histopathologic parameters such as mitotic index (MI), tumor grade, tumor size, COX-2, PCNA, Ki-67 and p53. RESULTS: COX-2 protein expression was found in 19 of 25 (76%) of the tumors, and expression was noted in the cytoplasm of the tumor cells. p53 was significantly related to MI and tumor grade but no relationship was found between COX-2, proliferation markers and MI, tumor grade and tumor size. CONCLUSION: COX-2 is expressed in most GISTs and it may play an important role in the proliferation and progression of these tumors or a useful marker to identify GIST. Although immunohistochemical assessment of p53 can be used for distinguishing the risk groups of GISTs, tumor size and mitotic rate should be considered at the same time. | Derya Gumurdulu Seyda Erdogan Fazilet Kayaselcuk Gulsah Seydaoglu Cem K Parsak Orhan Demircan Ilhan Tuncer | 2007 | World Journal of Gastroenterology2007，13，3： | 21 |
| 3 | Association of serum lipid levels with diabetic retinopathy显示文摘AIM: To assess the association between serum lipids and diabetic retinopathy (DR). · METHODS: Sixty -one diabetic patients without retinopathy (NDR), 55 diabetic patients with non - proliferative retinopathy (NPDR) and 75 diabetic patients with proliferative retinopathy (PDR) according to ETDRS grading scale were enrolled in this study. Total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL) and triglyceride values were compared between the groups. ·RESULTS: The groups were well-balanced in terms of age and gender (P =0.071, P =0.265 respectively). The mean HbA1c values were significantly lower in NDR group than the NPDR and PDR groups(P =0.004, P =0.009 respectively). Mean total cholesterol, triglyceride, LDL, HDL and VLDL levels were not significantly different between the groups (P =0.693, P =0.774, P =0.644, P = 0.910 and P =0.967 respectively, one way ANOVA). Mean total cholesterol, triglyceride, LDL, HDL and VLDL levels were not significantly different between the patients with ME and patients without ME(P =0.622, P =0.113, P =0.955, P =0.735 and P =0.490 respectively, t -test). The mean blood glucose significantly correlated with total cholesterol (r =0.173, P =0.017) and LDL (r =0.190, P = 0.008). The mean HbA1c significantly correlated with total cholesterol (r =0.158, P =0.030) and triglyceride (r =0.148, P =0.042). ·CONCLUSION: Serum lipid levels were not significantly associated with the severity of DR or existence of ME despite the significant correlation between the mean blood glucose, HbA1c and total cholesterol. | Ebru Nevin Cetin Yunus Bulgu Seyfullah Ozdemir Senay Topsakal Fulya Akln Hulya Aybek Cem Ylldlrlm | 2013 | International Journal of Ophthalmology(English edition)2013，6，3： | 14 |
| 4 | Synergistic effect of multiple predisposing risk factors on the development of bezoars显示文摘AIM:To describe the clinical characteristics of patients with gastric or intestinal bezoars recently treated in our hospital.METHODS:In this study,a retrospective chart review of consecutive patients with gastrointestinal bezoars,who were treated at the Samsun Education and Research Hospital between January 2006 and March 2011,was conducted.Data on demographic characteristics,clinical presentation,history of risk factors,diagnostic procedures,localization of bezoars,treatment interventions,and postoperative morbidity and mortality rates were collected and evaluated.RESULTS:Forty-two patients [26 (61.9%) males and 16 (31.1%) females] with a mean±SD (range) age of 55.8±10.5 (37-74) years were enrolled in this study.Thirty-six patients (85.7%) had one or more predisposing risk factors for gastrointestinal bezoars.The most common predisposing risk factor was a history of previous gastric surgery which was identified in 18 patients (42.8%).Twenty three patients (54.8%) had multiple predisposing risk factors.Phytobezoars were identified in all patients except one who had a trichobezoar in the stomach.Non-operative endoscopic fragmentation was performed either initially or after unsuccessful medical treatment in 14 patients with gastric bezoars and was completely successful in 10 patients (71.5%).Surgery was the most frequent treatment method in our study,which was required in 28 patients (66.7%).Intestinal obstruction secondary to bezoars was the most common complication (n=18,42.8%) in our study.CONCLUSION:The presence of multiple predisposing factors may create a synergistic effect in the development of bezoars. | Metin Kement Nuraydin Ozlem Elif Colak Sadik Kesmer Cem Gezen Selahattin Vural | 2012 | World Journal of Gastroenterology2012，18，9： | 11 |
| 5 | Comparison of subconjunctivally injected bevacizumab, ranibizumab, and pegaptanib for inhibition of corneal neovascularization in a rat model显示文摘AIM: To compare the efficacies of subconjunctival bevacizumab, ranibizumab, and pegaptanib sodium injections for the inhibition of corneal neovascularization in an experimental rat model. METHODS: Sixteen corneas of 16 rats were chemically cauterized and randomized into four groups: bevacizumab group that treated with 0.05mL/1.25mg bevacizumab, ranibizumab group that treated with 0.05mL/0.5mg ranibizumab, pegaptanib group that treated with 0.05mL/0.15mg pegaptanib sodium, and control group that treated with 0.05mL saline solution. Digital photographs of the corneas were taken and analyzed using an image analysis software program. All corneas were excised and examined histologically on the 15 th day. RESULTS: Each treatment group had significantly less neovascularized corneal areas and fewer blood vessels than the control group (all P <0.05). In addition, bevacizumab group had significantly less neovascu-larized corneal areas and fewer blood vessels than ranibizumab and pegaptanib groups (both P <0.05). However, there was no significant difference between the ranibizumab and pegaptanib groups regarding percentage of neovascularized corneal areas and number of blood vessels (both P >0.05). CONCLUSION: Subconjunctival bevacizumab, ranibiz-umab, and pegaptanib sodium were effective with no corneal epitheliopathy for inhibiting corneal neovascularization after corneal burn in rats .Bevacizumab was more effective than ranibizumab and pegaptanib sodium. | Ebru Eren Akar Veysi ner Cem Küükerdnmez Yonca Aydin Akova | 2013 | International Journal of Ophthalmology(English edition)2013，6，2： | 9 |
| 6 | Effect of honey on bacterial translocation and intestinal morphology in obstructive jaundice显示文摘AIM:To evaluate the effects of honey on bacterial translocation and intestinal villus histopathology in experimental obstructive jaundice.METHODS:Thirty Wistar-Albino rats were randomly divided into three groups each including 10 animals:group Ⅰ,sham-operated;group Ⅱ,ligation and section of the common bile duct(BDL);group Ⅲ,bile duct ligation followed by oral supplementation of honey(BDL+honey) 10 g/kg per day.Liver,blood,spleen,mesenteric lymph nodes,and ileal samples were taken for microbiological,light and transmission electrone microscopic examination.RESULTS:Although the number of villi per centimeter and the height of the mucosa were higher in sham group,there was no statistically significant difference between sham and BDL + honey groups(P>0.05).On the other hand,there was a statistically significant difference between BDL group and other groups(P<0.05).The electron microscopic changes werealso different between these groups.Sham and honey groups had similar incidence of bacterial translocation(P>0.05).BDL group had significantly higher rates of bacterial translocation as compared with sham and honey groups.Bacterial translocation was predominantly detected in mesenteric lymph nodes.CONCLUSION:Supplementation of honey in presence of obstructive jaundice ameliorates bacterial translocation and improves ileal morphology. | Cem Gencay Kemal Kismet Bulent Kilicoglu Serap Erel Mehmet Ali Akkus Sibel Serin Kilicoglu Sabahattin Muratoglu Asli Elif Sunay Esra Erdemli | 2008 | World Journal of Gastroenterology2008，14，21： | 8 |
| 7 | Hepatocellular Carcinoma and the Role of Liver Transplantation:A Review显示文摘Hepatocellular carcinoma(HCC)is one of the leading causes of cancer deaths worldwide and liver transplantation(LT)is the only potentially curative treatment.Over the years,Milan criteria has been used for patient selection.There is ongoing research in this field with introduction of new biomarkers for HCC that can help guide future treatment.Furthermore,newer therapies for downstaging of the tumor are being implemented to prevent dropout from the transplant list.In addition,combination therapies for better outcome are under investigation.Interestingly,the concept of living-donor LT and possible use of hepatitis C virus-positive donors has been implemented as an attempt to expand the organ pool.However,there is a conflict of opinion between different centers regarding its efficacy and data is scarce.The aim of this review article is to outline the various selection criteria for LT,discuss the outcomes of LT in HCC patients,and explore future directions of LT for HCC.Therefore,a comprehensive PubMed/MEDLINE review was conducted.To expand our search,references of the retrieved articles were also screened for additional data.After selecting the studies,the authors independently reviewed them to identify the relevant studies.After careful evaluation 120 studies relevant to out topic are cited in the manuscript.Three tables and two figures are also included.In conclusion LT for HCC has evolved over the years.With the introduction of several expanded criteria beyond Milan,the introduction of bridging therapies,such as transcatheter arterial chemoembolization and radiofrequency ablation,and the approval of newer systemic therapies,it is evident that there will be more LT recipients in the future.It is promising to see ongoing trials and the continuous evolution of protocols.Prospective studies are needed to guide the development of a pre-LT criteria that can ensure low HCC recurrence risk and is not overly stringent,clarify the role of LDLT,and determine the optimal bridging therapies to LT. | Haris Muhammad Aniqa Tehreem Peng-Sheng Ting Merve Gurakar Sean Young Li Cem Simsek Saleh A.Alqahtani Amy K.Kim Ruhail Kohli Ahmet Gurakar | 2021 | Journal of Clinical and Translational Hepatology2021，9，5： | 7 |
| 8 | Clindamycin-induced acute cholestatic hepatitis显示文摘我们为牙齿的感染在 clindamycin 的管理以后在一个 42 岁的女人报导尖锐 hepatotoxicity 的一个案例。在治疗的 6 d 以后,她有疲劳,恶心,呕吐,厌食,瘙痒和黄疸。她的实验室分析显示出丙氨酸 aminotransferase (中高音) , 1795 IU/L (正常范围 0-40 ) ;aspartate aminotransferase (著名计算机生产厂商) , 1337 IU/L (正常范围 5-34 ) ;硷性磷酸酯酶(高山) , 339 IU/L (正常范围 40-150 ) ;gamma-glutamyl transpeptidase (GGT ) , 148 IU/L (正常范围 9-64 IU/L ) ;全部的胆红素, 4.1 mg/dL;直接胆红素, 2.9 mg/dL 和前凝血酶时间(磅) , 13.5 s 与国际规范的比率(INR ) , 1.04。她被就医,与立即的药中止。她的肝活体检视标本显示出混合类型(肝细胞和胆汁郁积的) 肝的损害,与导致药的肝炎的诊断兼容。用 Naranjo 概率规模的一个客观诱发性评价建议 clindamycin 是尖锐肝炎的可能的原因。在易受影响的个人, clindamycin 使用可以导致尖锐混合类型肝毒性。如果在严重肝损伤被建立以前,这药被中止,完全的恢复可能是可能的。 | Cem Aygün Orhan Kocaman Yesim Gürbüz mer Sentürk Sadettin Hülagü | 2007 | World Journal of Gastroenterology2007，13，40： | 6 |
| 9 | Long-term spaceflight and the cardiovascular system显示文摘While early investigations into the physiological effects of spaceflight suggest the body’s ability to reversibly adapt,the corresponding effects of long-term spaceflight(>6months)aremuch less conclusive.Prolonged exposure to microgravity and radiation yields profound effects on the cardiovascular system,including a massive cephalad fluid translocation and altered arterial pressure,which attenuate blood pressure regulatory mechanisms and increase cardiac output.Also,central venous pressure decreases as a result of the loss of venous compression.The stimulation of baroreceptors by the cephalad shift results in an approximately 10%–15%reduction in plasma volume,with fluid translocating from the vascular lumen to the interstitium.Despite possible increases in cardiac workload,myocyte atrophy and notable,yet unexplained,alterations in hematocrit have been observed.Atrophy is postulated to result from shunting of protein synthesis from the endoplasmic reticulum to the mitochondria via mortalin-mediated action.While data are scarce regarding their causative agents,arrhythmias have been frequently reported,albeit sublethal,during both Russian and American expeditions,with QT interval prolongation observed in long,but not short duration,spaceflight.Exposure of the heart to the proton and heavy ion radiation of deep space has also been shown to result in coronary artery degeneration,aortic stiffness,carotid intima thickening via collagen-mediated action,accelerated atherosclerosis,and induction of a pro-inflammatory state.Upon return,long-term spaceflight frequently results in orthostatic intolerance and altered sympathetic responses,which can prove hazardous should any rapidmobilization or evacuation be required,and indicates that these cardiac risks should be especially monitored for future missions. | Nicholas A.Vernice Cem Meydan Ebrahim Afshinnekoo Christopher E.Mason | 2020 | Precision Clinical Medicine2020，3，4： | 6 |
| 10 | Novel biomarkers for patients with idiopathic acute anterior uveitis:neutrophil to lymphocyte ratio and platelet to lymphocyte ratio显示文摘AIM: To assess the levels of the neutrophil to lymphocyte ratio(N/L) and the platelet to lymphocyte ratio(P/L) in patients with idiopathic acute anterior uveitis(AAU) and to compare with healthy controls.METHODS: Thirty-six male patients with idiopathic AAU and 36 male healthy subjects were enrolled in this retrospective study.Complete ophthalmological examination and complete blood count measurements results of all subjects were evaluated.RESULTS: There was a significant difference in N/L and P/L between idiopathic AAU and control groups(P=0.006,P=0.022).Also,correlation analysis revealed a significant correlation between C-reactive protein(CRP) and N/L(P= 0.002;r=0.461).CONCLUSION: Our study for the first time provides evidence of N/L and P/L may be useful biomarkers in patients with idiopathic AAU.N/L is correlated with CRP,so it can be a useful biomarker to predict the prognosis in idiopathic AAU. | Cem Ozgonul Erdim Sertoglu Onder Ayyildiz Tarkan Mumcuoglu Murat Kucukevcilioglu Gokcen Gokce Ali Hakan Durukan | 2017 | International Journal of Ophthalmology(English edition)2017，10，2： | 5 |
| 11 | 烧伤后深静脉血栓预防实用指南显示文摘深静脉血栓及其引起的肺栓塞是我国烧伤专科医护人员相对忽视的一种严重并发症,因其'极少发生'而疏于防范,在烧伤临床工作中,我们常常认为某些患者的猝死是由于'严重吸入性损伤'气道突然堵塞(尤其是使用翻身床翻身的患者)、脂肪乳输注不当、对重症烧伤患者护理不到位等引起,事实上,在这些猝死的患者中可能有一定比例的患者是由于致命性的肺血栓栓塞引起的,有些患者的深静脉血栓(DVT)由于同时合并下肢烧伤而'认为肢体肿胀系创面引起',从而遗漏了DVT的早期诊断、早期治疗,因此,可以认为目前我国烧伤临床所诊断的DVT/PTE可能只是冰山一角。事实上,近年来现代临床医学发现,DVT的发生率远较既往的'认为'要大,因此越来越重视DVT的预防和治疗,尤其是外科患者,在循证医学的基础上制定了外科患者DVT防治指南,烧伤专业虽系外科学的一个分支,但有其特殊性,目前国内外还没有一致的烧伤后DVT防治指南。我国烧伤专科医生对烧伤患者尤其是下肢烧伤、大面积烧伤患者普遍没有采取DVT/PTE的预防,但在美国,2005年有71个烧伤中心参与的一项调查发现,有75%的烧伤中心常规对烧伤患者进行DVT、预防,预防措施包括持续使用压迫器(装置)、皮下注射肝素和低分子肝素、静滴肝素,因此通过此文,希望能够提醒广大烧伤专科医护人员,要重视DVT/PTE的防治,同时也呼吁大家能够开展烧伤后DVT/PTE的流行病学调查和防治研究,因为到目前为止尚无有关DVT的循证医学的Ⅰ类证据指导临床。 | Lee D. Faucher MD KatheM.Conlon BSN RN CEM 高建川(编译) 丁一妹(编译) 孙永华(编译) | 2007 | 中华损伤与修复杂志(电子版)2007，2，4： | 5 |
| 12 | Coagulation of a giant hemangioma in glans penis with holmium laser显示文摘在也引起一个可勃起的机能障碍(编辑) 那的龟头上与一个扩大的巨大的缝血管瘤介绍的一个 21 岁的人部分对 intracavernous 注射刺激测试作出回应。尽管在磁性的回声成像(MRI ) 的调查结果显示了一个腺的缝血管瘤,阴茎有颜色的 Doppler 超声揭示了一个入侵的 cavernausal 缝血管瘤到龟头。外科的切除根据腺损害的宽广延期被避免。钬激光凝结由于化妆联盟者担心被用于损害。然而,在钬激光申请不是出色的以后,化妆品是没有改进,在 intracavernous 注射刺激测试期望结果。在结论,钬激光申请不应该习惯于与阴茎海绵体有关的龟头的 heman-giomas,但是进一步的研究被需要在限制为龟头的小缝血管瘤揭示钬激光申请的效果。 | Emin Aydur Bulent Erol Lutfi Tahmaz Hasan Cem Irkilata Cenker Eken Ahmet Fuat Peker | 2008 | Asian Journal of Andrology2008，10，5： | 4 |
| 13 | 自然杀伤细胞和T淋巴细胞在银屑病发病中作用的研究显示文摘用免疫组化法检侧10例银屑病患者皮损、皮损周围外观正常皮肤和正常对照组自然杀伤细胞(NK细胞)、T细胞表面抗原的表达。结果表明:患者皮损处真皮乳头NK细胞表面抗原CD16、CD56、CD57、CD94、CD158a,T细胞表面抗原CD2、CD3、CD4、CD8和皮肤白细胞相关抗原(CLA)阳性表达的细胞数,较皮损周围外观正常皮肤和正常对照组明显增多(P<0.05或<0.01)。作者认为:T细胞、NK细胞共同参入银屑病的发病,并分析了二者之间相互关系。 | 王飞 Griffiths CEM Kirby B Cameron AL | 2002 | 临床皮肤科杂志2002，31，8： | 4 |
| 14 | Vasospastic myocardial infarction:An even rarer occurrence of a rare entity显示文摘INTRODUCTION Vasospastic angina(VSA)is an important functional cardiac disorder that leads to transient myocardial ischemia and is caused by sudden,intense and reversible coronary artery spasm resulting in subtotal or total occlusion.[1,2]VSA is associated with cardiac conditions such as stable or unstable angina,acute coronary syndromes and lethal arrhythmias.The patients | Cem Ertan Mehmet Emre Ozpelit Onder Limon Dcniz Oray Nihat Pekel | 2017 | World Journal of Emergency Medicine2017，8，1： | 4 |
| 15 | Hepatic cystic echinococcosis:Percutaneous treatment as an outpatient procedure显示文摘Objective:To demonstrate utility and safety of the puncture aspiration injection and reospiration(PAIR)technique for outpatients.Methods:Percutaneous treatment with US guidance was applied to 33 patients for 44 cysts.Patients treated with the PAIR technique,were outpatients.PAIR and catheterization technique were evaluated for efficacy and safety of procedure and complication rates.Results:Thirty-five of 44 cysts were treated with the PAIR and 9 of 44 were treated with the catheterization technique.The success rate of the cysts Gharbi type 1(CEI)and type 2(Ct3a)treated with the PAIR technique was 1009.hi the follow up of 9 cysts treated with the catheterization technique,2 of them(22%)developed cyst infection and 1(11%)developed a biliary fistula.Conclusions:The PAIR technique was found to be an effective and safe approach in order to treat Gharbi type 1 and type 2 cysts percutaneously for outpatients.It has a very low complication rate in comparison with the catheterization technique.So every effort should be mode to finish the treatment with PAIR technique. | Mert Kroglu Bekir Erol Cemil Gürses Baris Türkbey Cem Yunus Bas Ahmet Sükrü Alparslan Banu Kale Kroglu Iclal Erdem Toslak Bülent eki Okan Akhan | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，3： | 4 |
| 16 | Kefir treatment ameliorates dextran sulfate sodium-induced colitis in rats显示文摘AIM: To investigate the preventive effect of kefir on colitis induced with dextran sulfate sodium(DSS) in rats.METHODS: Twenty-four male Wistar-albino rats were randomized into four groups: normal control,kefircontrol,colitis,and kefir-colitis groups. Rats in the normal and kefir-control groups were administered tap water as drinking water for 14 d. Rats in the colitis and kefir-colitis groups were administered a 3% DSS solution as drinking water for 8-14 d to induce colitis. Rats in the kefir-control and kefir-colitis groups were administered 5 m L kefir once a day for 14 d while rats in the normal control and colitis group were administered an identical volume of the placebo(skim milk) using an orogastric feeding tube. Clinical colitis was evaluated with reference to the disease activity index(DAI),based on daily weight loss,stool consistency,and presence of bleeding in feces. Rats were sacrificed on the 15 th day,blood specimens were collected,and colon tissues were rapidly removed. Levels of myeloperoxidase(MPO),tumor necrosisfactor(TNF)-α,interleukin(IL)-10,malondialdehyde,and inducible nitric oxide synthase(i NOS) were measured in colon tissue.RESULTS: The DAI was lower in the kefir-colitis group than in the colitis group(on the 3rd and 5th days of colitis induction; P < 0.01). The DAI was also significantly higher in the colitis group between days 2 and 6 of colitis induction when compared to the normal control and kefir-control groups. The DAI was statistically higher only on the 6th day in the kefircolitis group when compared to that in the normal control groups. Increased colon weight and decreased colon length were observed in colitis-induced rats. Mean colon length in the colitis group was significantly shorter than that of the kefir-control group. Kefir treatment significantly decreased histologic colitis scores(P < 0.05). MPO activity in the colitis group was significantly higher than in the kefir-control group(P < 0.05). Kefir treatment significantly reduced the DSS colitis-induced TNF-α increase(P < 0.01). No statistically significant differences were observed among groups for IL-10 and MDA levels. Colon tissue i NOS levels in the colitis group were significantly higher than those in the control and kefir-colitis groups(P < 0.05).CONCLUSION: Kefir reduces the clinical DAI and histologic colitis scores in a DSS-induced colitis model,possibly via reduction of MPO,TNF-α,and i NOS levels. | Altug Senol Mehmet Isler Recep Sutcu Mete Akin Ebru Cakir Betul M Ceyhan M Cem Kockar | 2015 | World Journal of Gastroenterology2015，21，46： | 3 |
| 17 | Clinical and impression cytology findings of amniotic membrane and oral mucosal membrane transplantation for the management of socket contracture显示文摘AIM:To investigate and compare the cytopathological and clinical effects of amniotic membrane transplantation(AMT)and oral mucosal membrane transplantation(OMMT)in socket contraction.METHODS:Twelve patients who could not be fitted with ocular prosthesis due to socket contracture were included in this study.Seven patients underwent AMT and 5 patients underwent OMMT.Thirteen patients who had healthy sockets were included as control group.Depth of inferior fornix,degree of inflammation,extent of the socket contracture and socket volume were measured in the preoperative period and at sixth and twelfth weeks postoperatively.Impression cytology of conjunctival fornices and tear transforming growth factor beta-1(TGFβ1)levels were determined.RESULTS:In the AMT group,socket volume and lower fornix depth values were significantly higher(P=0.030and P=0.004 respectively)and inflammation levels and impression cytology stages(P=0.037 and P=0.022respectively)were significantly lower in postoperative period compared to preoperative period.In the OMMT group,no statistical differences were found in terms of clinical parameters,inflammation levels and impression cytology stages of preoperative versus postoperative values.Preoperative tear TGFβ1 levels were higher in AMT and OMMT groups compared to the control group(25.5 ng/mL,26.3 ng/mL and 21.7 ng/mL respectively).Decreased tear TGFβ1 levels were observed in both the AMT and OMMT groups postoperatively(median decrease value=2.1 ng/mL and 2.7 ng/mL respectively).CONCLUSION:AMT is associated with postoperative improvement in inferior fornix depth,socket volume,inflammation and impression cytology levels and may bea more proper alternative method than OMMT in the management of socket contracture. | Bengi Ece Kurtul Ugur Erdener Mehmet Cem Mocan Murat Irkec Mehmet Orhan | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 3 |
| 18 | Comparison of contrast sensitivity and visual acuity between deep anterior lamellar keratoplasty and penetrating keratoplasty in patients with keratoconus显示文摘AIM: To evaluate postoperative visual acuity and contrast sensitivity results following deep anterior lamellar keratoplasty (DALK) and penetrating keratoplasty (PK) in patients with keratoconus (KC). METHODS: All the patients' records with KC who had PK or DALK surgery between May 2010 and May 2011 were retrospectively reviewed. Sixty patients who underwent successful corneal transplantation for KC: 30 eyes underwent DALK and 30 eyes underwent PK were included in this study. Preoperative and postoperative mean logarithm of the minimum angle of resolution (logMAR) uncorrected visual acuity (UCVA), logMAR best spectacle-corrected visual acuity (BSCVA) and intraocular pressure (IOP) were evaluated. Contrast sensitivity tests (CS) were done preoperative and 2 months after all sutures had removed. All surgeries were performed under regional anesthesia (retrobulbar anesthesia) by 1 surgeon (B.K.) who was experienced in penetrating and lamellar keratoplasty techniques. RESULTS: The mean age of the DALK group was 29.67±4.95 (range 18-40) years and the PK group was 28.7±3.53 (range 18-39) years. Preoperatively there was no significant difference in the logMAR UCVA, logMAR BSCVA and IOP between the DALK (1.281±0.56; 0.97±0.85; 12.07±2.12mmHg) and PK (1.34±0.21; 0.98±0.21; 13±2.12mmHg) groups. One-year after surgery there was no significant difference in the mean logMAR UCVA and IOP between the DALK (0.46±0.37; 11.73±2.1mmHg) and PK (0.38±0.21; 12±2.12mmHg) groups. The mean contrast sensitivity was evaluated by CC-100 Topcon LCD at 1.5, 2.52, 4.23, 7.10 and 11.91 cycles per degree (cs/deg) spatial frequencies before and 2 months after the all sutures had removed. CONCLUSION: All patients with keratoconus in both DALK and PK groups performed good visual function postoperatively. The mean contrast sensitivity increased considerably at all spatial frequencies compared with preoperative levels in the DALK and PK groups. The mean post-operative evaluation of contrast sensitivity measurements was not significantly different between the two groups. | Mehmet Orcun Akdemir Baran Kandemir Isil Bahar Sayman Cem Selvi OmerKamil Dogan | 2012 | International Journal of Ophthalmology(English edition)2012，5，6： | 3 |
| 19 | Association of Apolipoprotein E Polymorphisms in Patients with Non-Alcoholic Steatohepatitis显示文摘 | Ali Sazci Gurler Akpinar Cem Aygun Emel Ergul Omer Senturk Sadettin Hulagu | 2008 | Digestive Diseases and Sciences2008，，12： | 3 |
| 20 | Plasma and aqueous humor levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy显示文摘AIM: To evaluate plasma and aqueous levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy.METHODS: The study included three age and gendermatched groups of 20 cataract patients with no diabetes or additional disease(Group C), 20 cataract patients with diabetes and no retinopathy(Group DM+C), and 20 cataract patients with diabetic retinopathy(Group DR+C).All the patients were examined with respect to body mass index(BMI), fasting plasma glucose, hemoglobin A1c(HbA1c), and lipid profile.Phacoemulsification and intraocular lens(Phaco+IOL) implantation were performed to all patients in all the groups, and aqueous samples were taken during the operation.The plasma and aqueous adiponutrin and pannexin 1 levels were analyzed using enzyme-linked immunosorbent assays.RESULTS: A statistically significant difference was determined between the groups with respect to BMI, fasting plasma glucose, and HbA1c levels(P<0.05 for all parameters tested).The plasma adiponutrin levels of Group DR+C were statistically significantly lower than those of Group C and Group DM+C(P<0.001, P=0.004).No statistically significant difference was determined in the aqueous adiponutrin levels in three groups.The plasma pannexin 1 levels of Groups DM+C and DR+C were statistically significantly lower than those of Group C(both P=0.001).The aqueous pannexin 1 levels of Group DR+C were statistically significantly higher than those of Group C and Group DM+C(P=0.001, P<0.001).CONCLUSION: Adiponutrin and pannexin 1, which play an important role in the pathophysiology of diabetes and obesity, and have a regulatory role in hyperglycemia and insulin resistance.The measurement of adiponutrin and pannexin 1 levels may support clinicians in determining the risk of DR development. | Fatih Cem Gül Sabiha Güngör Kobat FatihÇelik Süleyman Aydin Ramazan Fazil Akkoç | 2022 | International Journal of Ophthalmology(English edition)2022，15，3： | 3 |
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