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| 1 | Solutions for submucosal injection: What to choose and how to do it显示文摘During the past decades, endoscopic resection techniques have gradually improved and gained more importance for the management of premalignant lesions and early cancers. These endoscopic resection techniques can be divided in 3 major groups: snare polipectomy, endoscopic mucosal resection(EMR) and endoscopic submucosal dissection(ESD). The use of submucosal injection is essential for the majority of EMR techniques and is an integral part of ESD,whereas during polipectomy it is not crucial in most cases except to prevent bleeding in large polyps and/or those with large stalks as an alternative to mechanical methods. Injection provides a lifting up effect of the lesion separating it from the muscular layer, thereby reducing thermal injury and the risk of perforation and bleeding while also facilitating en-bloc resection by improving technical feasibility. With this work, we aim to review the most common endoscopic resection techniques and the importance of submucosal injection in each one of them. For that, we present some of the most commonly used submucosal injection solutions, taking into account their advantages and disadvantages. We also discuss, based on current recommendations and our own experience, how and when to preform submucosal injection, depending on lesions features and endoscopic resection technique that′s being used, to assure complete resection and to prevent associated adverse events. Finally, we also present and discuss some new proposed submucosal injection solutions,endoscopic resection techniques and devices that may have a major impact on the future of therapeutic endoscopy. | Rui Castro Diogo Libanio Inês Pita Mário Dinis-Ribeiro | 2019 | World Journal of Gastroenterology2019，25，7： | 13 |
| 2 | Susceptibility Genetic Variants Associated With Colorectal Cancer Risk Correlate With Cancer Phenotype显示文摘 | Anna Abulí Xavier Bessa Juan Ramón González Clara Ruiz–Ponte Alejandro Cáceres Jenifer Mu?oz Victoria Gonzalo Francesc Balaguer Ceres Fernández–Rozadilla Dolors González Luisa de Castro Juan Clofent Luís Bujanda Joaquín Cubiella Josep M a Re?é Juan Diego | 2010 | Gastroenterology2010，，3： | 2 |
| 3 | Left ventricular remodelling index (LVRI) in various pathophysiological conditions: a real-time three-dimensional echocardiographic study 显示文摘 | De Castro S Caselli S Maron M | 2007 | Heart2007，93，2： | 1 |
| 4 | Carbon nanotubes/poly (e- caprolactone) composite vapour sensors显示文摘 | Castro M Lu J Bruzaud S | 2009 | Carbon2009，47，8： | 1 |
| 5 | Pathogenic variation a- mong isolates of Pyrlcularia grisea infecting rice,wheat and grasses in Brazil显示文摘 | Prabhu A S Filippi M C Castro N | 1992 | Trop Pest Manage1992，38，： | 1 |
| 6 | Propolis: recent advances in chemistry and plant origin显示文摘 | BANKOVA V S DE CASTRO S L MARCUCI M C | 2000 | Apidologie2000，31，： | 1 |
| 7 | Perturbation of membrane dynamics in nerve cells as an early event during bilirubin-induced apoptosis 显示文摘 | RODRIGUES C M SOLA S CASTRO R E | 2002 | J Lipid Res2002，43，6： | 1 |
| 8 | First record of Meloidogyne enterolobii on guava in the state of Alagoas,Brazil显示文摘 | Castro J M C Santana T A S | 2010 | Nematologia Brasileira2010，34，3： | 1 |
| 9 | A neutralizing recombinant single chain antibody, scFv, against BaP1, A P-I hemorrhagic metalloproteinase from Bothrops asper snake venom 显示文摘 | CASTRO J M OLIVEIRA T S SILVEIRA C R l | 2014 | Toxicon2014，87，1： | 1 |
| 10 | Atmospheric nitrogen deposition to estuaries in the Mid-Atlantic and Northeastern United States显示文摘 | CASTRO M S DRISCOLL C T | 2002 | Environ Sci Technol2002，36，： | 1 |
| 11 | Influence of Nb5+and Sb3+dopants on the defect profile,PTCR effect and GB-BLcharacteristic s of BaTiO3 ceramics显示文摘 | Castro M S | 2004 | Journal of the European Ceramic Society2004，24，： | 1 |
| 12 | Plant defense and antimicrobial peptides显示文摘 | CASTRO M S FONTES W | 2005 | Protein Pept Lett2005，12，1： | 1 |
| 13 | A study of combustion method to prepare fine ferrite particles显示文摘 | Castro S Gayoso M | 1997 | Journal of Solid State Chemistry1997，134，： | 1 |
| 14 | Electrical properties and thermal expansion of cordierite and cordierite-mullite materials显示文摘 | Camerucci M A Urretavizcaya G Castro M S | 2001 | J Euro Ceram Soc2001，21，： | 1 |
| 15 | Defect profile and microstructural development in SnO2-based varistors显示文摘 | Fayat J Castro M S | 2003 | Journal of the European Ceramic Society2003，23，10： | 1 |
| 16 | Thermal and high-pressure stability of purified pectin methylesterase from plums (prunus domestica) 显示文摘 | Nunes C S Castro S M Saraiva J A | 2006 | Journal of Food Biochemistry2006，30，2： | 1 |
| 17 | Cano- la cake as a potential substrate for proteolytie enzymes production by a selected strain of Aspergillus oryzae: se- lection of process conditions and product characterization 显示文摘 | Freitas A C Castro R J S Fontenele M A | 2013 | ISI:N Microbiology2013，2013，： | 1 |
| 18 | Atmospheric nitrogen deposition to estuaries in the Mid-Atlantic and Northeastern United States显示文摘 | Castro M S Driscoll C T | 2002 | Environmental Science & Technology2002，36，15： | 1 |
| 19 | Effect of silane as coupling agent on the dielectric properties of BaTiO3-epoxy composites 显示文摘 | Ramajo L Castro M S Reboredo M M | 2007 | Composites: Part A2007，38，8： | 1 |
| 20 | Plant defense and antimicrobial pep- tides显示文摘 | CASTRO M S FONTES W | 2005 | Protein Pept Lett2005，12，1： | 1 |
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