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| 1 | Antidiabetic therapy and increased risk of hepatocellular carcinoma in chronic liver disease显示文摘AIM:To explore the association between hepatocellular carcinoma(HCC) and type 2 diabetes mellitus, describe the temporal relations between the onset of diabetes and the development of HCC and evaluate the possible effects of antidiabetic therapy on HCC risk.METHODS:We recruited 465 HCC patients, 618 with cirrhosis and 490 control subjects.We evaluated the odds ratio(OR) for HCC by univariate and multivariate analysis.Moreover, OR for HCC in diabetic subjects treated with insulin or sulphanylureas and with metformin were calculated.RESULTS:The prevalence of diabetes mellitus was 31.2% in HCC, 23.3% in cirrhotic patients and 12.7% in the Control group.By univariate and multivariate analysis, the OR for HCC in diabetic patients were respectively 3.12(CI 2.2-4.4, P < 0.001) and 2.2(CI 1.2-4.4, P = 0.01).In 84.9% of cases, type 2 diabetes mellitus was present before the diagnosis of HCC.Moreover, we report an OR for HCC of 2.99(CI 1.34-6.65, P = 0.007) in diabetic patients treated with insulin or sulphanylureas, and an OR of 0.33(CI 0.1-0.7, P = 0.006) in diabetic patients treated with metformin.CONCLUSION:Our study confi rms that type 2 diabetes mellitus is an independent risk factor for HCC and pre-exists in the majority of HCC patients.Moreover, in male patients with type 2 diabetes mellitus, our data shows a direct association of HCC with insulin and sulphanylureas treatment and an inverse relationship with metformin therapy. | Valter Donadon Massimiliano Balbi Michela Ghersetti Silvia Grazioli Antonio Perciaccante Giovanni Della Valentina Rita Gardenal Maria Dal Mas Pietro Casarin Giorgio Zanette Cesare Miranda | 2009 | World Journal of Gastroenterology2009，15，20： | 23 |
| 2 | Association between hepatocellular carcinoma and type 2 diabetes mellitus in Italy:Potential role of insulin显示文摘AIM: To investigate the relationships between Type 2 diabetes mellitus (DM2) and the risk of hepatocellular carcinoma (HCC). METHODS: We studied the association between DM2 and HCC in a large case-control study that enrolled 465 consecutive Caucasian patients with HCC (78.3% males, mean age 68.5 ± 8.9 years) compared with an age and sex matched control group of 490 subjects. RESULTS: Prevalence of DM2 was significantly higher in HCC patients (31.2% vs 12.7%; OR = 3.12, 95% CI: 2.22-4.43) and in HCC cases with alcohol abuse. DM2 has been diagnosed before the appearance of HCC in 84.1% of diabetic HCC subjects with mean duration of 141.5 mo, higher in cases treated with insulin than in those with oral antidiabetic agents (171.5 vs 118.7 mo). Compared to controls, males DM2 with HCC were more frequently treated with insulin (38.1% vs 17.6%, P = 0.009) and with sulfonylurea with or without metformin than with diet with or without metformin (84% vs 68.3%, P = 0.049). CONCLUSION: DM2 in our patients is associated with a 3-fold increase risk of HCC. In most of our cases DM2 pre-existed to HCC. Patients with DM2 and chronic liver disease, particularly insulin treated males, should be considered for HCC close surveillance programs. | Valter Donadon Massimiliano Balbi Pietro Casarin Alessandro Vario Alfredo Alberti | 2008 | World Journal of Gastroenterology2008，14，37： | 11 |
| 3 | Optimal flow conditions of a tracheobronchial model to reengineer lung structures显示文摘The high demand for lung transplants cannot be matched by an adequate number of lungs from donors. Since fully ex-novo lungs are far from being feasible, tissue engineering is actively considering implantation of engineered lungs where the devitalized structure of a donor is used as scaffold to be repopulated by stem cells of the receiving patient. A decellularized donated lung is treated inside a bioreactor where transport through the tracheobronchial tree(TBT) will allow for both deposition of stem cells and nourishment for their subsequent growth, thus developing new lung tissue. The key concern is to set optimally the boundary conditions to utilize in the bioreactor. We propose a predictive model of slow liquid ventilation, which combines a one-dimensional(1-D) mathematical model of the TBT and a solute deposition model strongly dependent on fluid velocity across the tree. With it, we were able to track and drive the concentration of a generic solute across the airways, looking for its optimal distribution. This was given by properly adjusting the pumps' regime serving the bioreactor. A feedback system, created by coupling the two models, allowed us to derive the optimal pattern. The TBT model can be easily invertible, thus yielding a straightforward flow/pressure law at the inlet to optimize the efficiency of the bioreactor. | Stefano Casarin Federico Aletti Giuseppe Baselli Marc Garbey | 2017 | Acta Mechanica Sinica2017，33，2： | 2 |
| 4 | Morbidity and mortality in compensated cirrhosis type C: A retrospective follow-up study of 384 patients显示文摘 | G Fattovich G Giustina F Degos F Tremolada G Diodati P Almasio F Nevens A Solinas D Mura JT Brouwer H Thomas C Njapoum C Casarin P Bonetti P Fuschi J Basho A Tocco A Bhalla R Galassini F Noventa SW Schalm G Realdi | 1997 | Gastroenterology1997，，2： | 2 |
| 5 | Protein S-100β: a serum marker for ischemic and infectious in- jury of cerebral tissue显示文摘 | Bertsch T Casarin W Kretschmar M | 2001 | Clin Chem Lab Med2001，39，4： | 1 |
| 6 | Keratinolytic protease of Bacillus species isolated from the Amazon basin showing remarkable de-hairing activity显示文摘 | Giongo J L Lucas F S Casarin F | 2007 | Microbiol Biotechnol2007，23，3： | 1 |
| 7 | Optical spectroscopy of trivalent lanthanide ions in strontium meta-phosphate glasses显示文摘 | Zaccaria S Casarin M Speghini A | 1999 | Spectochim Acta Part A1999，55，： | 1 |
| 8 | Experimental Demonstratoin of the Principles of Thermal Energy Storage and Chemical Heat Pumps显示文摘 | CASARIN C IBANEZ J G | 1993 | J Chem Educ1993，70，2： | 1 |
| 9 | Root surface defect produced by hand instruments and ultrasonic scaler with different power settings: an in vitro study显示文摘 | Casarin RC Ribeiro FV Sallum A W | 2009 | Braz DentJ2009，20，1： | 1 |
| 10 | Haploinsufficiency of COQ4 causes coenzyme Q10 deficiency显示文摘 | Salviati L Trevisson E Rodriguez Hernandez MA Casarin A Pertegato V Doimo M | 2012 | J Med Genet2012，49，： | 1 |
| 11 | Protein S- 100B: a serum marker for ischemic and infectious injury of cer ebral tissue显示文摘 | 3 Bertsch T Casarin W Kretschmar M | 2001 | Clin Chem Lab Med2001，39，4： | 1 |
| 12 | Protain S-100B:A Serum Maker for Ischemic and Infectious Injury of Cerebral Tissue显示文摘 | BERTSCH T CASARIN W KRETSCHMAR M | 2001 | Clin Chem Lab Med(S1434-6621)2001，39，： | 1 |
| 13 | Protein S-100β:a serum marker for ischemic and infectious injury of cerebral tissue显示文摘 | Bertsch T Casarin W Kretschmar M | 2001 | Clin Chem Lad Med2001，39，4： | 1 |
| 14 | Molecular characterization of the human COQ5 C-methyltransferase in coenzyme Q10 biosynthesis显示文摘 | Nguyen TP Casarin A Desbats MA Doimo M Trevisson E Santos-Ocana C | 2014 | Biochim Biophys Acta2014，1841，： | 1 |
| 15 | Angiosonography in suslaicious breast lesion with non-diagnostic FNAC; com- parison with power US显示文摘 | Caumo F Carbognin G Casarin A | 2006 | Radiol Med (Torino)2006，111，： | 1 |
| 16 | Subgingival biodiversity in subjects with uncontrolled type-2 diabetes and chronic periodontitis显示文摘 | Casarin RC Barbagallo A Meulman T | 2013 | J Periodont Res2013，48，1： | 1 |
| 17 | Protein S-100B: a serum marker for ischemic and infectious injury of cerebral tissue显示文摘 | Bertsch T Casarin W Kretschmar M | 2001 | Clin Chem Lab Med2001，39，4： | 1 |
| 18 | Angiosonography in suspicious breast lesions with non-diagnostic FNAC:comparison with power Doppler US显示文摘 | Caumo FG Carbognin A Casarin L | 2006 | Radiolmed2006，111，1： | 1 |
| 19 | Protein S-100B: a Serum Marker for Ischemie and Infectious Injury of Cerebral Tissue显示文摘 | Bertsch T Casarin W Kretschmar M et aI | 2001 | Clin Chem Lab Med2001，39，4： | 1 |
| 20 | Levels of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, inflammatory cytokines and species-specific immunoglobulin G in generalized aggressive and chronic periodontitis显示文摘 | Casarin RC Ribeiro Edel P Mariano FS | 2010 | J Periodont Res2010，45，5： | 1 |
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