|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Urinary neutrophil gelatinase-associated lipocalin as biomarker in the differential diagnosis of impairment of kidney function in cirrhosis显示文摘 | Claudia Fagundes Marie-No?lle Pépin Mónica Guevara Rogelio Barreto Gregori Casals Elsa Solà Gustavo Pereira Ezequiel Rodríguez Elisabet Garcia Verónica Prado Esteban Poch Wladimiro Jiménez Javier Fernández Vicente Arroyo Pere Ginès | 2012 | Journal of Hepatology2012，，2： | 2 |
| 2 | Percutaneous left atrial appendage occlusion for patients in atrial fibrillation suboptimal for warfarin therapy:5-year results of the PLAATO (Percutanous Left Atrial Appendage Transcatheter Occlusion) Study显示文摘 | Block PC Burstein S Casale PN | 2009 | JACC Cardiovasc Interv2009，2，： | 1 |
| 3 | What is the role of inspiratory muscle training in the treatment of chronic obstructive pulmonary disease? 显示文摘 | Mota Casals S | 2005 | Arch Bronconeunol2005，41，： | 1 |
| 4 | Percutaneous left atrial appendage occlusion for patients in atrial fibrillation suboptimal for warfarin therapy : 5 - year results of the PLAATO ( Percutaneous Left Atrial Appendage Transcatheter Occlusion) Study 显示文摘 | Block PC Burstein S Casale PN | 2009 | JACC Cardiovasc Interv2009，2，： | 1 |
| 5 | Molecular cloning, sequencing and expression in Escherichiacoli of thecapsid protein gene from rabbit haemorrhagic disease virus (Spanishisolate AST/89)显示文摘 | Boga J A Casals R Marin M S | 1994 | J Gen Virol1994，75，： | 1 |
| 6 | Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision显示文摘 | Bro ek J L Bousquet J Baena-Cagnani C E Bonini S Canonica G W Casale T B | 2010 | J Allergy Clin Immunol2010，126，： | 1 |
| 7 | Free and Conjugated Biogenic Amines in Green and Roasted Coffee Beans显示文摘 | Casal S Mendes E Alves M R | 2004 | Journal of Agricul- tural and Food Chemistry2004，，20： | 1 |
| 8 | Development and Validation of a Matrix Solid - Phase Dispersion Method to Determine Acrylamide in Coffee and Coffee Substi- tutes 显示文摘 | Soares CMD Alves RC Casal S | 2010 | Journal of food science2010，75，： | 1 |
| 9 | The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation显示文摘 | Holgate S Casale T Wenzel S | 2005 | J Allergy Clin Immunol2005，115，3： | 1 |
| 10 | Sjogren syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases显示文摘 | Ramos - Casals M Loustaud - Ratti V De Vita S | 2005 | Medicine (Baltimore)2005，84，2： | 1 |
| 11 | Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer显示文摘Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)device for CRC detection with high diagnostic ability. | Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas | 2021 | Engineering2021，7，10： | 1 |
| 12 | Role of suilysin in pathogenesis of Streptococcus suis capsular serotype 2显示文摘 | Lun S Perez Casal J Connor W | 2003 | Microb Pathog2003，34，1： | 1 |
| 13 | Gas chromatographic-mass spectrometric quantification of 4-(5- )- methylimidazole in roasted coffee after ion-pair extraction 显示文摘 | S Casal J O Fernandes M B P P Oliveira | 2002 | Journal of Chromatography A2002，976，： | 1 |
| 14 | Concealed penis in childhood: a spectrum of eliology and treatment 显示文摘 | CASALE A J BECK S D CAIN M P | 1999 | J Urol1999，162，32： | 1 |
| 15 | Purification and characterization of a keratinase from a feather - degrading Bacillus licheniformis strain 显示文摘 | Lin X Lee C G Casale E S | 1992 | Applied and Environmental Microbiology1992，58，10： | 1 |
| 16 | A methodology for predicting the severity of environmental impacts related to the construction process of residential buildings 显示文摘 | Gangolells M Casals M Gass6 S | 2009 | Building and Environment2009，44，3： | 1 |
| 17 | Performance comparison between VBR speech coders for adaptive VoIP applications显示文摘 | BERITELLI F CASALE S RUGGERI G | 2001 | IEEE Communications Letters2001，5，10： | 1 |
| 18 | The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation显示文摘 | Holgate S Casale T Wenzel S | | 0，，： | 1 |
| 19 | Modifications of Coking Coal and Metallurgical Coke Properties Induced by Coal Weathering显示文摘 | Casal M D Gonza lez A I Canga C S | 2003 | Fuel Processing Technology2003，84，： | 1 |
| 20 | Sappres-sion of hypothalamic - pituitary - adrend axis activity with inhaledflunisolide and fluticasowe propiouate in adult asthma patients显示文摘 | CASALE T B NELSON H S STRICKER W E | 2001 | Ann Allergy Asthma Immunol2001，87，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员