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| 1 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 2 | Ageing affects chondroitin sulfates and their synthetic enzymes in the intervertebral disc显示文摘The depletion of chondroitin sulfates(CSs)within the intervertebral disc(IVD)during degenerative disc disease(DDD)results in a decrease in tissue hydration,a loss of fluid movement,cell apoptosis,a loss of nerve growth inhibition and ultimately,the loss of disc function.To date,little is known with regards to the structure and content of chondroitin sulfates(CSs)during IVD ageing.The behavior of glycosaminoglycans(GAGs),specifically CSs,as well as xylosyltransferase I(XT-I)and glucuronyltransferase I(GT-I),two key enzymes involved in CS synthesis as a primer of glycosaminoglycan(GAG)chain elongation and GAG synthesis in the nucleus pulposus(NP),respectively,were evaluated in a bovine ageing IVD model.Here,we showed significant changes in the composition of GAGs during the disc ageing process(6-month-old,2-year-old and 8-year-old IVDs representing the immature to mature skeleton).The CS quantity and composition of annulus fibrosus(AF)and NP were determined.The expression of both XT-I and GT-I was detected using immunohistochemistry.A significant decrease in GAGs was observed during the ageing process.CSs are affected at both the structural and quantitative levels with important changes in sulfation observed upon maturity,which correlated with a decrease in the expression of both XT-I and GT-I.A progressive switch of the sulfation profile was noted in both NP and AF tissues from 6 months to 8 years.These changes give an appreciation of the potential impact of CSs on the disc biology and the development of therapeutic approaches for disc regeneration and repair. | Estelle C Collin Oliver Carroll Michelle Kilcoyne Marianna Peroglio Eugene See Doris Hendig Mauro Alini Sibylle Grad Abhay Pandit | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 2 |
| 3 | Soluble CD14 and lipopolysaccharide -binding protein from bovine serum enable bacterial lipopolysacch- aride-mediated cytotoxicity and activation of bovine vascular endothelial cells in vitro显示文摘 | Yang Z Breider M A Carroll R C | | J Leukoc Biol0，199，： | 2 |
| 4 | Immunosurveillance and Survivin-specific T-cell immunity in children with high-risk neuroblastoma显示文摘 | Coughlin C M Fleming M D Carroll R G | 2006 | J Clin Oncol2006，24，36： | 1 |
| 5 | Influence of im- purity elements on electrochemical activity of aluminum activated by indium显示文摘 | Breslin C B Friery L P Carroll W M | 1993 | Corrosion1993，49，11： | 1 |
| 6 | Ftmgal endophytes in stems and leaves: from latent pathogen to mutualistic symbiont显示文摘 | CARROLL G C | 1988 | Ecology1988，69，： | 1 |
| 7 | Alkali treatment for rapid preparation of plant material for reliable PCR analysis显示文摘 | Klimyuk V I Carroll BJ Thomas C M | 1993 | Plant J1993，，3： | 1 |
| 8 | Runoff and sediment losses from natural and man made erosion control materials显示文摘 | Krenitsky E C Carroll M J Hill R L | 1998 | Crop Science1998，38，4： | 1 |
| 9 | Laparo,copic splenectomy显示文摘 | Carroll B J Phillips EH Semel C J | 1992 | Surg Endosc1992，6，4： | 1 |
| 10 | Designing a soil quality assessment tool for sustainable agroecosystem management显示文摘 | Andrews S S Carroll C R | | 0，，： | 1 |
| 11 | Gene duplication and the adaptive evolution of a classic genetic switch显示文摘 | Hittinger C T Carroll S B | 2007 | Na- ture2007，449，7163： | 1 |
| 12 | Freeze-thaw-induced changes of the zona pellucida explains decreased rates of fertilization in frozen-thawed mouse oocytes显示文摘 | Carroll J Depypere H Matthews C D | 1990 | Reprod Fertil1990，90，： | 1 |
| 13 | Drought stress,plant water status and floral trait expression in fireweed,Epilobium angustifoliun(Onagraceae)显示文摘 | Carroll A B Pallardy S G Galen C | 2001 | American Journal of Botany2001，88，3： | 1 |
| 14 | Identification, Sequencing targeted mutagenesis, and expression of a recA gene required for the extreme radio resistance of Deinococcus radiodurans 显示文摘 | Gutman P D Carroll J D Masters C L | 1994 | Gene1994，141，1： | 1 |
| 15 | Comparison Utility in a Growth Mode显示文摘 | Carroll C Overland J D Weil | 1997 | Journal of Economic Growth1997，，2： | 1 |
| 16 | Laparoscopic sp lenectomy 显示文摘 | Carroll B J Phillips EH Semel C J | 1992 | Surg endosc1992，6，6： | 1 |
| 17 | Chemoprevention of colorectal cancer:systematic review and economic evaluation显示文摘 | Cooper K Squires H Carroll C | | 0，，32： | 1 |
| 18 | The cyclic depsipep- tide backbone of the didemnins 显示文摘 | Mayer S C Carroll P J Joullie M M | 1995 | Acta Crystallogr1995，51，： | 1 |
| 19 | Static and dynamic pore-collapse relations for ductile porous materials显示文摘 | Carroll M M Holt A C | 1972 | Journal of Applied Physics1972，43，： | 1 |
| 20 | Saving and Growth with Habit Formation显示文摘 | Carroll C Overland J D Weil | 2000 | American Economic Review2000，，90： | 1 |
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