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| 1 | 成人自发性脑出血处理指南——2007年更新版:美国心脏协会/美国卒中协会卒中委员会、高血压研究委员会、医疗质量和转归研究跨学科工作组指南:美国神经病学学会确认本指南作为神经科医生教学工具的价值显示文摘目的:本指南旨在为急性自发性脑出血的诊断和治疗提供最新的综合性推荐意见。方法:通过Medline正式检索截止2006年8月的相关文献,并将撰写委员会已知相关问题的其他论文作为补充,用证据表合并资料。采用美国心脏协会卒中委员会的证据水平分级标准对每项推荐意见进行分级。由5位同行评议专家和卒中委员会领导委员会成员对指南草案进行发表前审阅。预期本指南在3年内完全更新。结果:本文陈述了脑出血的诊断、动脉血压和颅内压增高的处理、脑出血内科并发症的治疗以及复发性脑出血的预防等方面的循证指南。对重组Ⅶ因子延缓早期出血的近期试验进行了讨论。对自发性脑出血治疗的各种外科手术方法提出了推荐意见。最后,对脑出血患者的撤销治疗和临终问题进行了分析。 | Joseph Broderick Sander Connolly Edward Feldmann Daniel Hanley Carlos Kase Derk Krieger Marc Mayberg Lewis Morgenstern Christopher S. Ogilvy Paul Vespa Mario Zuccarello 王玉洁(译) 刘娟(译) 白璇(译) 李新辉 孙虹(译) 姚志成(译) 张慧(译) 牛英翔(译) | 2007 | 国际脑血管病杂志2007，15，7： | 234 |
| 2 | 儿童功能性胃肠病罗马Ⅳ标准显示文摘罗马标准是目前关于功能性胃肠病( FGID)分类最全面且不断更新的标准。罗马Ⅰ、Ⅱ标准分别于1994年、1999年发布。罗马Ⅱ标准开始单列儿童FGID分类。2006年,根据年龄不同,婴幼儿(0-36个月)和儿童(〉36个月) FGID的罗马Ⅲ诊断标准发布,但相关的流行病学、病理生理学、诊断检查、治疗策略以及预后等资料都很少。 | Marc A. Benninga Samuel Nurko Christophe Faure Paul E. Hyman Ian St. James Roberts Neil L. Schechter Jeffrey S. Hyams Carlo Di Lorenzo Miguel Saps Robert J. Shulman Annamaria Staiano Miranda van Tilburg | 2017 | 中华儿科杂志2017，55，1： | 108 |
| 3 | 大数据与开放数据的政策框架:问题、政策与建议显示文摘大数据与开放数据对电子公共服务、开放和透明政府以及政府公众与企业间的互动,都蕴藏着巨大的变革潜力。从'智慧'政府到变革政府,开放数据与大数据可推动协作,为农业、健康和交通运输等领域面临的挑战提出实时解决方案,推动更大程度的开放,并引领政策制定走向新时代。然而,开放数据与大数据也面临着一系列的政策挑战,如数据获取和发布、数字资产管理、归档和保存、隐私及安全等。本文以美国为背景,选择了有关开放数据与大数据的关键政策问题进行评论,并提出建议,以期推进数据驱动的创新。 | John Carlo Bertot 郑磊 徐慧娜 包琳达 | 2014 | 电子政务2014，，1： | 69 |
| 4 | Nitrosamine and related food intake and gastric and oesophageal cancer risk: A systematic review of the epidemiological evidence显示文摘瞄准:学习在亚硝酸根和亚硝基胺吸入和胃的癌症(GC ) 之间的协会在肉和处理的肉吸入之间, GC 和食道的癌症(OC ) ,并且在保存的鱼,蔬菜和吸的食物摄取和 GC 之间。方法:在这篇文章,我们从 1985-2005 考察了所有出版的队和盒子控制研究,并且分析了在亚硝基胺和亚硝酸根吸入和最重要的相关食物摄取(喝的肉和处理的肉,保存蔬菜和鱼,吸的食物和啤酒) 和 GC 或 OC 风险之间的关系。61 研究, 11 个队和 50 盒子控制研究被包括。结果:从盒子控制研究的证据与 GC 支持了在亚硝酸根和亚硝基胺吸入之间的一个协会,但是证据在与 OC 的关系是不够的。盒子控制研究的一个高比例为两个瘤(GC 上的 16 研究中的 11 个和 OC 上的 18 研究中的 11 个) 与肉吸入发现了一个积极协会。盒子控制研究的一个相对大的数字显示出支持在处理的肉吸入和 GC 和 OC 风险之间的一个积极协会的相当一致的结果(GC 上的 14 研究中的 10 个和 9 中的 8 个在 OC 上学习) 。几乎所有盒子控制研究发现了在保存的鱼,蔬菜和吸的食物摄取和 GC 之间的一个积极、重要的协会。关于 OC 的证据是更有限的。从队的证据学习的外套从盒子控制研究比那不够或更不一致。结论:可得到的证据支持在亚硝酸根和亚硝基胺吸入和 GC 之间的一个积极协会,在肉和处理的肉吸入和 GC 和 OC 之间,并且在保存的鱼,蔬菜和吸的食物摄取和 GC 之间,但是不是最后的。 | Paula Jakszyn Carlos Alberto González | 2006 | World Journal of Gastroenterology2006，12，27： | 42 |
| 5 | Blood loss,predictors of bleeding,transfusion practice and strategies of blood cell salvaging during liver transplantation显示文摘Blood loss during liver transplantation (OLTx) is a common consequence of pre-existing abnormalities of the hemostatic system,portal hypertension with multiple collateral vessels,portal vein thrombosis,previous abdominal surgery,splenomegaly,and poor 'functional' recovery of the new liver.The intrinsic coagulopathic features of end stage cirrhosis along with surgical technical difficulties make transfusion-free liver transplantation a major challenge,and,despite the improvements in understanding of intraoperative coagulation profiles and strategies to control blood loss,the requirements for blood or blood products remains high.The impact of blood transfusion has been shown to be significant and independent of other well-known predictors of posttransplant-outcome.Negative effects on immunomodulation and an increased risk of postoperative complications and mortality have been repeatedly demonstrated.Isovolemic hemodilution,the extensive utilization of thromboelastogram and the use of autotransfusion devices are among the commonly adopted procedures to limit the amount of blood transfusion.The use of intraoperative blood salvage and autologous blood transfusion should still be considered an important method to reduce the need for allogenic blood and the associated complications.In this article we report on the common preoperative and intraoperative factors contributing to blood loss,intraoperative transfusion practices,anesthesiologic and surgical strategies to prevent blood loss,and on intraoperative blood salvaging techniques and autologous blood transfusion.Even though the advances in surgical technique and anesthetic management,as well as a better understanding of the risk factors,have resulted in a steady decrease in intraoperative bleeding,most patients still bleed extensively.Blood transfusion therapy is still a critical feature during OLTx and various studies have shown a large variability in the use of blood products among different centers and even among individual anesthesiologists within the same center.Unfortunately,despite the large number of OLTx performed each year,there is still paucity of large randomized,multicentre,and controlled studies which indicate how to prevent bleeding,the transfusion needs and thresholds,and the 'evidence based' perioperative strategies to reduce the amount of transfusion. | Feltracco Paolo Brezzi Marialuisa Barbieri Stefania Galligioni Helmut Milevoj Moira Carollo Cristiana Ori Carlo | 2013 | World Journal of Hepatology2013，5，1： | 37 |
| 6 | 乳腺囊内型乳头状癌显示文摘 | Collins L C Carlo V P Hwang H 魏兵(摘译) 步宏(审校) | 2006 | 临床与实验病理学杂志2006，22，5： | 38 |
| 7 | Global epidemiology of sexually transmitted diseases显示文摘性传播疾病(性传播疾病) 在在在在年轻成年女人开发国家和讨厌的疾病的第二个主要原因的年轻成年男性的讨厌的疾病的开始的十个原因之中。青少年和年轻成年人(15-24 岁) 仅仅完成 25% 性活跃的人口,但是代表几乎 50% 所有新获得的性传播疾病。一般来说,性传播疾病是流行病并且介绍庞大的健康和经济后果。为性传播疾病的足够的屏蔽应该在世界的每部分在一个平淡的基础上被做。许多性传播疾病是无征状的因此装对控制困难。性传播疾病报导的目的是保证被感染的人将快速被诊断并且适当地对待控制感染并且也的传播以便搭挡们被通知,测试并且适当地对待。报导性传播疾病的案例在美国代表仅仅可报告的性传播疾病感染的 50%-80% ,这被估计,反映有限屏蔽并且低疾病报导。当它经常导致少年怀孕和 HIV/AIDS,高风险的性行为是这个过程的一个高度贡献的因素。对这行为的一可能的解释是人们没关于性传播疾病的传播有足够的信息或忽略为安全的性要求的措施。世界范围的约 60% 新 HIV 感染发生在年轻人。在少年之中的高风险的行为的频率可以被机会也影响从事他们,特别地他们由成年人是无指导的时间的数量。在诊断并且对待这些病人,然而,我们能有效地阻止 HIV/AIDS 的传播。感染性传播疾病的个人比 uninfected 个人更多半是 5-10 时间通过性接触获得或播送 HIV。碎生殖道衬里或皮为 HIV 创造侵入门户,,因此有另外的性传播疾病的感染 HIV 的个人是更可能的在他们的生殖器的分泌物流 HIV。迄今为止,避孕套是为为对性传播疾病的保护的男性可得到的最有效的方法。性传播疾病,和预防能是这个过程的钥匙,对控制重要。预防能通过这些病人和他们的搭挡的人口,征兆、无征状的人的鉴定,和有效诊断和治疗的教育被完成。 | Carlos T. Da Ros Caio da Silva Schmitt | 2008 | Asian Journal of Andrology2008，10，1： | 38 |
| 8 | 猪伪狂犬病活疫苗(Bartha K61株)对变异株的保护效力显示文摘本研究旨在检测仔猪免疫猪伪狂犬病活疫苗(Bartha K61株)后,抵抗伪狂犬病病毒(PRV)变异株攻击的保护效果。取4~6周龄PRV抗体阴性仔猪,接种猪伪狂犬病活疫苗,1周后用PRV变异株(AH02LA株)攻毒,检测攻毒后临床症状、直肠温度、鼻腔排毒和肺部病变。疫苗免疫组在免疫后7 d均可以检测到gB抗体。攻毒对照组攻毒后出现典型伪狂犬症状,发病率为100%,死亡率为60%,所有猪只鼻拭子均检出排毒,所有猪只肺部均有出血、淤血等病变。免疫组的猪只攻毒后,所有猪只均未出现明显临床症状,部分猪只鼻拭子检出排毒,排毒持续时间缩短,排毒量显著减少,所有免疫猪只肺部未见明显病变。结果表明:伪狂犬病活疫苗免疫猪后对PRV变异株的攻击具有良好的保护效果。 | 王继春 曾容愚 Daniel Torrents Carlos Martinez 乔永峰 顾一奇 柳畅 | 2015 | 畜牧与兽医2015，47，12： | 39 |
| 9 | 大型坳陷湖盆异重流成因的水道-湖底扇系统--以松辽盆地白垩系嫩江组一段为例显示文摘以松辽盆地齐家—古龙地区白垩系嫩江组一段为研究对象,通过地震沉积学、沉积构造和沉积序列等分析,发现异重流成因的大型水道—湖底扇系统,对大型坳陷湖盆深水区分布的异重流及其形成的异重岩进行研究,构建了陆相湖盆异重流成因的水道—湖底扇沉积模式。研究表明,异重流发源于盆地边缘,经北部三角洲后在深水区形成完整的水道—湖底扇系统。自北向南依次发育顺直水道和弯曲水道,直线延伸距离超过80 km,宽度100~900 m;水道末端发育湖底扇,最大面积可达20 km^2。该系统主要以细粒沉积为主,发育块状砂岩和流水成因的沉积构造,内部发育侵蚀接触面,富含陆源有机质碎屑,具底床载荷和悬浮载荷兼有的形成机制。异重岩沉积序列表现为向上变粗和向上变细的旋回成对出现,反映洪水逐渐增强随后又减弱的动力学特点。 | 潘树新 刘化清 ZAVALA Carlos 刘彩燕 梁苏娟 张庆石 白忠峰 | 2017 | 石油勘探与开发2017，44，6： | 35 |
| 10 | Diabetic foot syndrome:Immune-inflammatory features as possible cardiovascular markers in diabetes显示文摘Diabetic foot ulcerations have been extensively reported as vascular complications of diabetes mellitus associated with a high degree of morbidity and mortality. Diabetic foot syndrome(DFS), as defined by the World Health Organization, is an 'ulceration of the foot(distally from the ankle and including the ankle) associated with neuropathy and different grades of ischemia and infection'. Pathogenic events able to cause diabetic foot ulcers are multifactorial.Among the commonest causes of this pathogenic pathway it's possible to consider peripheral neuropathy, foot deformity, abnormal foot pressures, abnormal joint mobility, trauma, peripheral artery disease. Several studies reported how diabetic patients show a higher mortality rate compared to patients without diabetes and in particular these studies under filled how cardiovascular mortality and morbidity is 2-4 times higher among patients affected by type 2 diabetes mellitus. This higher degree of cardiovascular morbidity has been explained as due to the observed higher prevalence of major cardiovascular risk factor, of asymptomatic findings of cardiovascular diseases, and of prevalence and incidence of cardiovascular and cerebrovascular events in diabetic patients with foot complications. In diabetes a fundamental pathogenic pathway of most of vascular complications has been reported as linked to a complex interplay of inflammatory, metabolic and procoagulant variables. These pathogenetic aspects have a direct interplay with an insulin resistance, subsequent obesity, diabetes, hypertension, prothrombotic state and blood lipid disorder. Involvement of inflammatory markers such as IL-6 plasma levels and resistin in diabetic subjects as reported by Tuttolomondo et al confirmed the pathogenetic issue of the a 'adipo-vascular' axis that may contribute to cardiovascular risk in patients with type 2 diabetes. This 'adipo-vascular axis' in patients with type 2 diabetes has been reported as characterized by lower plasma levels of adiponectin and higher plasma levels of interleukin-6 thus linking foot ulcers pathogenesis to microvascular and inflammatory events. The purpose of this review is to highlight the immune inflammatory features of DFS and its possible role as a marker of cardiovascular risk in diabetes patients and to focus the management of major complications related to diabetes such as infections and peripheral arteriopathy. | Antonino Tuttolomondo Carlo Maida Antonio Pinto | 2015 | World Journal of Orthopedics2015，6，1： | 37 |
| 11 | Early respiratory complications after liver transplantation显示文摘The poor clinical conditions associated with end-stage cirrhosis,pre-existing pulmonary abnormalities,and high comorbidity rates in patients with high Model for End-Stage Liver Disease scores are all well-recognized factors that increase the risk of pulmonary complications after orthotopic liver transplantation(OLT)surgery.Many intraoperative and postoperative events,such as fluid overload,massive transfusion of blood products,hemodynamic instability,unexpected coagulation abnormalities,renal dysfunction,and serious adverse effects of reperfusion syndrome,are other factors that predispose an individual to postoperative respiratory disorders.Despite advances in surgical techniques and anesthesiological management,the lung may still suffer throughout the perioperative period from various types of injury and ventilatory impairment,with different clinical outcomes.Pulmonary complications after OLT can be classified as infectious or non-infectious.Pleural effusion,atelectasis,pulmonary edema,respiratory distress syndrome,and pneumonia may contribute considerably to early morbidity and mortality in liver transplant patients.It is of paramount importance to accurately identify lung disorders because infectious pulmonary complications warrant speedy and aggressive treatment to prevent diffuse lung injury and the risk of evolution into multisystem organ failure.This review discusses the most common perioperative factors that predispose an individual to postoperative pulmonary complications and these complications’early clinical manifestations after OLT and influence on patient outcome. | Paolo Feltracco Cristiana Carollo Stefania Barbieri Tommaso Pettenuzzo Carlo Ori | 2013 | World Journal of Gastroenterology2013，19，48： | 32 |
| 12 | 成人自发性脑出血处理指南——2007年更新版 美国心脏协会/美国卒中协会卒中委员会、高血压研究委员会、医疗质量和转归研究跨学科工作组指南 美国神经病学学会确认本指南作为神经科医生教学工具的价值显示文摘目的:本指南旨在为急性自发性脑出血的诊断和治疗提供最新的综合性推荐意见。方法:通过Medline正式检索截止2006年8月的相关文献,并将撰写委员会已知相关问题的其他论文作为补充,用证据表合并资料。采用美国心脏协会卒中委员会的证据水平分级标准对每项推荐意见进行分级。由5位同行评议专家和卒中委员会领导委员会成员对指南草案进行发表前审阅。预期本指南在3年内完全更新。结果:本文陈述了脑出血的诊断、动脉血压和颅内压增高的处理、脑出血内科并发症的治疗以及复发性脑出血的预防等方面的循证指南。对重组Ⅶ因子延缓早期出血的近期试验进行了讨论。对自发性脑出血治疗的各种外科手术方法提出了推荐意见。最后,对脑出血患者的撤销治疗和临终问题进行了分析。 | Joseph Broderick Sander Connolly Edward Feldmann Daniel Hanley Carlos Kase Derk Krieger Marc Mayberg Lewis Morgenstern Christopher S.Ogilvy Paul Vespa Mario Zuccarello 王玉洁 刘娟 白璇 李新辉 孙虹 姚志成 张慧 牛英翔 | 2008 | 中华脑血管病杂志(电子版)2008，2，1： | 29 |
| 13 | Immune regulatory properties of multipotent mesenchymal stromal cells:Where do we stand?显示文摘Multipotent mesenchymal stromal cells (MSC) can be isolated and efficiently expanded from almost every single body tissue and have the ability of self-renewal and differentiation into various mesodermal cell lineages. Moreover, these cells are considered immunologically privileged, related to a lack of surface expression of costimulatory molecules required for complete T cell activation. Recently, it has been observed that MSC are capable of suppressing the immune response by inhibiting the maturation of dendritic cells and suppressing the function of T lymphocytes, B lymphocytes and natural killer cells in autoimmune and inflammatory diseases as a new strategy for immunosuppression. The understanding of immune regulation mechanisms by MSC is necessary for their use as immunotherapy in clinical applications for several diseases. | ênio José Bassi Carlos Alberto Mayora Aita Niels Olsen Saraiva Camara | 2011 | World Journal of Stem Cells2011，3，1： | 27 |
| 14 | Laparoscopic and robot-assisted laparoscopic digestivesurgery:Present and future directions显示文摘Laparoscopic surgery is applied today worldwide to most digestive procedures. In some of them, such as cholecystectomy, Nissen's fundoplication or obesity surgery, laparoscopy has become the standard in practice. In others, such as colon or gastric resection, the laparoscopic approach is frequently used and its usefulness is unquestionable. More complex procedures, such as esophageal, liver or pancreatic resections are, however, more infrequently performed, due to the high grade of skill necessary. As a result, there is less clinical evidence to support its implementation. In the recent years, robot-assisted laparoscopic surgery has been increasingly applied, again with little evidence for comparison with the conventional laparoscopic approach. This review will focus on the complex digestive procedures as well as those whose use in standard practice could be more controversial. Also novel robot-assisted procedures will be updated. | Juan C Rodríguez-Sanjuán Marcos Gómez-Ruiz Soledad Trugeda-Carrera Carlos Manuel-Palazuelos Antonio López-Useros Manuel Gómez-Fleitas | 2016 | World Journal of Gastroenterology2016，22，6： | 27 |
| 15 | Liver enzymes,metabolomics and genome-wide association studies:From systems biology to the personalized medicine显示文摘For several decades,serum levels of alanine(ALT) and aspartate(AST) aminotransferases have been regarded as markers of liver injury,including a wide range of etiologies from viral hepatitis to fatty liver.The increasing worldwide prevalence of metabolic syndrome and cardiovascular disease revealed that transaminases are strong predictors of type 2 diabetes,coronary heart disease,atherothrombotic risk profile,and overall risk of metabolic disease.Therefore,it is plausible to suggest that aminotransferases are surrogate biomarkers of 'liver metabolic functioning' beyond the classical concept of liver cellular damage,as their enzymatic activity might actually reflect key aspects of the physiology and pathophysiology of the liver function.In this study,we summarize the background information and recent findings on the biological role of ALT and AST,and review the knowledge gained from the application of genome-wide approaches and 'omics' technologies that uncovered new concepts on the role of aminotransferases in human diseases and systemic regulation of metabolic functions.Prediction of biomolecular interactions between the candidate genes recently discovered to be associated with plasma concentrations of liver enzymes showed interesting interconnectivity nodes,which suggest that regulation of aminotransferase activity is a complex and highly regulated trait.Finally,links between aminotransferase genes and metabolites are explored to understand the genetic contributions to the metabolic diversity. | Silvia Sookoian Carlos J Pirola | 2015 | World Journal of Gastroenterology2015，21，3： | 27 |
| 16 | Endoscopic management of biliary complications after liver transplantation: An evidence-based review显示文摘Biliary tract diseases are the most common complications following liver transplantation(LT) and usually include biliary leaks, strictures, and stone disease. Compared to deceased donor liver transplantation in adults, living donor liver transplantation is plagued by a higher rate of biliary complications. These may be promoted by multiple risk factors related to recipient, graft, operative factors and post-operative course. Magnetic resonance cholangiopancreatography is the first-choice examination when a biliary complication is suspected following LT, in order to diagnose and to plan the optimal therapy; its limitations include a low sensitivity for the detection of biliary sludge. For treating anastomotic strictures, balloon dilatation complemented with the temporary placement of multiple simultaneous plastic stents has become the standard of care and results in stricture resolution with no relapse in > 90% of cases. Temporary placement of fully covered self-expanding metal stents(FCSEMSs) has not been demonstrated to be superior(except in a pilot randomized controlled trial that used a special design of FCSEMSs), mostly because of the high migration rate of current FCSEMSs models. The endoscopic approach of non-anastomotic strictures is technically more difficult than that of anastomotic strictures due to the intrahepatic and/or hilar location of strictures, and the results are less satisfactory. For treating biliary leaks, biliary sphincterotomy and transpapillary stenting is the standard approach and results in leak resolution in more than 85% of patients. Deep enteroscopy is a rapidly evolving technique that has allowed successful treatment of patients who were not previously amenable to endoscopic therapy. As a result, the percutaneous and surgical approaches are currently required in a minority of patients. | Carlos Macías-Gómez Jean-Marc Dumonceau | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，6： | 25 |
| 17 | 异重流成因和异重岩沉积特征显示文摘河流在洪水期携带大量陆源碎屑,当其入湖或入海后,由于洪水密度大于周围水体的密度,洪水发生下沉并沿盆地底部长距离运移,形成陆源下潜流或异重流。异重流形成的相关沉积岩被统称为异重岩。异重岩通常由一个底部的反粒序单元和一个顶部的正粒序单元组成,反粒序单元反映了异重流能量的逐渐增强,正粒序反映了流体能量的逐渐减弱。异重流以3种方式搬运碎屑颗粒,即底载搬运、悬浮搬运和漂浮搬运。根据搬运方式的不同,异重岩分为3类岩相,即底载成因的B类岩相、悬载成因的S类岩相和漂浮物成因的L类岩相。异重流的沉积充填形成了河道、堤岸和朵叶体3类微相,内部岩相变化极为发育。异重岩的沉积特征虽然典型且较易识别,但是常被误认为是砂质碎屑流、滨岸相、三角洲相或河流相沉积。 | Carlos Zavala 潘树新 | 2018 | 岩性油气藏2018，30，1： | 26 |
| 18 | MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis b- and c-related-hepatocellularcarcinoma显示文摘Aim of the present review is to summarize the current knowledge about the potential relationship between mi RNAs and hepatitis B virus(HBV)-hepatitis C virus(HCV) related liver diseases. A systematic computerbased search of published articles, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis Statement, was performed to identify relevant studies on usefulness of serum/plasma/urine mi RNAs, as noninvasive biomarkers for early detection of HBV and HCV-induced hepatocellular carcinoma(HCC) development, as well as for its prognostic evaluation. The used Medical Subject Headings terms and keywords were: 'HBV', 'HCV', 'hepatocellular carcinoma', 'micro RNAs', 'mi RNAs', 'diagnosis', 'prognosis', 'therapy', 'treatment'. Some serum/plasma mi RNAs, including mi R-21, mi R-122, mi-125a/b, mi R-199a/b, mi R-221, mi R-222, mi R-223, mi R-224 might serve as biomarkers for early diagnosis/prognosis of HCC, but, to date, not definitive results or well-defined panels of mi RNAs have been obtained. More well-designed studies, focusing on populations of different geographical areas and involving larger series of patients, should be carried out to improve our knowledge on the potential role of mi RNAs for HCC early detection and prognosis. | Sirio Fiorino Maria Letizia Bacchi-Reggiani Michela Visani Giorgia Acquaviva Adele Fornelli Michele Masetti Andrea Tura Fabio Grizzi Matteo Zanello Laura Mastrangelo Raffaele Lombardi Luca Di Tommaso Arrigo Bondi Sergio Sabbatani Andrea Domanico Carlo Fabbri Paolo Leandri Annalisa Pession Elio Jovine Dario de Biase | 2016 | World Journal of Gastroenterology2016，22，15： | 25 |
| 19 | Different profile of cytokine synthesis according to the severity of acute pancreatitis显示文摘AIM: To evaluate the cellular synthetic ability of cytokines involved in pro- and anti-inflammatory reactions in patients with AP.METHODS: Sixty-seven patients with AP (16 severe,51 mild) and 10 controls were included in the study.Cultures of whole blood were performed in samples obtained within the first 72 h from the onset of pain.Serum levels of interleukins (IL) 6, 8, 10, and TNF-α were measured at baseline and in the supernatant of cultures with (functional reserve) or without stimulation with phytohemaglutinin.RESULTS: Basal levels of cytokines were significantly higher in patients with severe AP. A significant increase of all pro-inflammatory cytokines vs basal levels was observed in the supernatant after 24 h of whole blood cultures in patients, but not in controls. In contrast, IL-10 increased significantly in the supernatant of cultures only in patients with mild AP. Cells showed a statistically significant functional reserve for all IL in patients with mild, but only for pro-inflammatory cytokines in patients with severe AP.CONCLUSION: A marked activation of immune system may be observed in patients with AP, being balanced between pro- and anti-inflammatory cytokines in patients with mild but not severe AP. A reduced functional reserve for the synthesis of IL-10 may be observed in patients with severe AP, which might lead to a worst prognosis. | Raquel Laveda Juan Martínez Carlos Mu■oz Juan Carlos Penalva Jesus Sáez Germán Belda Salvador Navarro Faust Feu Anton Mas José Ma Palazón José Sánchez-Payá José Such Miguel Pérez-Mateo | 2005 | World Journal of Gastroenterology2005，11，34： | 24 |
| 20 | 利用声发射法和变形率变化法联合测定地应力显示文摘针对葡萄牙南部Neves-Corvo,SA(Somincor)矿区一垂直钻孔钻取的岩芯,利用声发射法(AE法)和变形率变化法(DRA法)联合测定该区域垂直向地应力。试验表明:矿区垂直向地应力呈现随深度增加而增加的趋势,但由于受褶皱、断裂等多种地质因素的影响,随深度的增加,由AE法和DRA法测得的地应力值差别也越大;通过AE和DRA试验曲线确定地应力在较大程度上依赖于对试验曲线中拐点的判断,而这种判断必须结合曲线本身的特点进行。在同一个试样上同时利用AE法和DRA法测定其地应力不仅是可行的,二者还可相互印证,确保了试验数据的可靠性。 | 谢强 邱鹏 余贤斌 Carlos Dinis da Gama | 2010 | 煤炭学报2010，35，4： | 24 |
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