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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018,9,2: | 8 |
| 2 | Practice Guidelines for Management of the Difficult Airway: An Updated Report by the American Society of Anesthesiologists Task Force on Management of the Difficult Airway显示文摘 | Jeffrey L. Apfelbaum Carin A. Hagberg Robert A. Caplan Casey D. Blitt Richard T. Connis David G. Nickinovich Carin A. Hagberg Robert A. Caplan Jonathan L. Benumof Frederic A. Berry Casey D. Blitt Robert H. Bode Frederick W. Cheney Richard T. Connis Orin F | 2013 | Anesthesiology2013,,2: | 4 |
| 3 | Protecting subjects' interests in genetics research 显示文摘 | Merz J F Magnus D Cho M K Caplan A L | 2002 | Am J Hum Genet2002,70,4: | 1 |
| 4 | Tolyporphin, a novel multidrug resistance reversing agent from the blue-green alga Tolypothrix nodosa显示文摘 | Prinsep M R Caplan F R Moore R E | 1992 | J Am Chem Soc1992,114,: | 1 |
| 5 | Rheumatoid arthritis treatment and the risk of severe interstitial lung disease 显示文摘 | WOLFE F CAPLAN L MICHAUD K | 2007 | Scand J Rheumatol2007,36,3: | 1 |
| 6 | Opiate analysis in cadaveric blowfly larvae as an indicator of narcotic intoxication显示文摘 | Introna F Dico C L Caplan Y H | 1990 | Journal of Forensic: Sciences1990,35,1: | 1 |
| 7 | Synthesis,structure and electrochemistry of nitr-ogen base adducts of tetraacetato diruthenium(Ⅱ,Ⅲ):Dependence of redox potential and ru-Ru bond lengthon axial ligand donor strength显示文摘 | Vamvounis G Caplan J F Cameron T S | 2000 | Inorg Chim Acta2000,304,: | 1 |
| 8 | Treatment for rheumatoid arthritis and the risk of hospitalization for pneumonia:associations with prednisone,disease-modifying antirheumatic drugs,and anti-tumor necrosis factor therapy显示文摘 | Wolfe F Caplan L Michaud K | | 0,,02: | 1 |
| 9 | Treatment for rheumatoid arthritis and the risk of hospitalization for pneumonia: associations with prednisone, disease modifying antirheumatic drugs,and anti-tumor necrosis factor therapy显示文摘 | Wolfe F Caplan L Michaud K | 2006 | Arthritis Rheum2006,54,: | 1 |
| 10 | Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts 显示文摘 | Hsueh W Caplan MS Qu XW Tan XD De Plaen IG Gonzalez-Crussi F | 2003 | Pediatr Dev Pathol2003,6,1: | 1 |
| 11 | Rheumatoid arthritis treatment and the risk of severe interstitial lung disease显示文摘 | Wolfe F Caplan L Michaud K | 2007 | Scand J Rheumatol2007,36,3: | 1 |
| 12 | PAF increases mucosal permeability in rat intestine via tyrosine phosphorylation of E-cadherin 显示文摘 | Tan XD Chang H Qu XW Caplan MS Gonzalez-Grussi F Hsueh W | 2000 | Br J Pharmacol2000,129,7: | 1 |
| 13 | Gastric intestinal metaplasia development in African American predominant United States population显示文摘BACKGROUND Gastric cancer significantly contributes to cancer mortality globally.Gastric intestinal metaplasia(GIM)is a stage in the Correa cascade and a premalignant lesion of gastric cancer.The natural history of GIM formation and progression over time is not fully understood.Currently,there are no clear guidelines on GIM surveillance or management in the United States.AIM To investigate factors associated with GIM development over time in African American-predominant study population.METHODS This is a retrospective longitudinal study in a single tertiary hospital in Washington DC.We retrieved upper esophagogastroduodenoscopies(EGDs)with gastric biopsies from the pathology department database from January 2015 to December 2020.Patients included in the study had undergone two or more EGDswith gastric biopsy.Patients with no GIM at baseline were followed up until they developed GIM or until the last available EGD.Exclusion criteria consisted of patients age<18,pregnancy,previous diagnosis of gastric cancer,and missing data including pathology results or endoscopy reports.The study population was divided into two groups based on GIM status.Univariate and multivariate Cox regression was used to estimate the hazard induced by patient demographics,EGD findings,and Helicobacter pylori(H.pylori)status on the GIM status.RESULTS Of 2375 patients who had at least 1 EGD with gastric biopsy,579 patients were included in the study.138 patients developed GIM during the study follow-up period of 1087 d on average,compared to 857 d in patients without GIM(P=0.247).The average age of GIM group was 64 years compared to 56 years in the non-GIM group(P<0.001).In the GIM group,adding one year to the age increases the risk for GIM formation by 4%(P<0.001).Over time,African Americans,Hispanic,and other ethnicities/races had an increased risk of GIM compared to Caucasians with a hazard ratio(HR)of 2.12(1.16,3.87),2.79(1.09,7.13),and 3.19(1.5,6.76)respectively.No gender difference was observed between the study populations.Gastritis was associated with an increased risk for GIM development with an HR of 1.62(1.07,2.44).On the other hand,H.pylori infection did not increase the risk for GIM.CONCLUSION An increase in age and non-Caucasian race/ethnicity are associated with an increased risk of GIM formation.The effect of H.pylori on GIM is limited in low prevalence areas. | Akram I Ahmad Arielle Lee Claire Caplan Colin Wikholm Ioannis Pothoulakis Zaynab Almothafer NishthaRaval Samantha Marshall Ankit Mishra Nicole Hodgins In Guk Kang Raymond K Chang Zachary Dailey Arvin Daneshmand Anjani Kapadia Jae Hak Oh Brittney Rodriguez Abhinav Sehgal Matthew Sweeney Christopher B Swisher Daniel F Childers Corinne O'Connor Lynette M Sequeira Won Cho | 2022 | World Journal of Gastrointestinal Endoscopy2022,14,10: | 1 |
| 14 | A kinematic comparison of overground and treadmill walking显示文摘 | Alton F Baldey L Caplan S | 1998 | Clinical Biomechanics1998,13,6: | 1 |
| 15 | Rheumatoid arthritis treatment and the risk of severe interstitial lung disease 显示文摘 | Wolfe F Caplan L Michaud K | 2007 | Scand J Rheumatol2007,36,3: | 1 |
| 16 | Neonatal necrotizing enterocolitis: clinical considera tions and pathogenetic concepts 显示文摘 | Caplan MS Qu XW Tan XD Deplaen IG Gonza lez-Crussi F | 2003 | Pediatr Dev Pathol2003,6,1: | 1 |
| 17 | Synthesis,structure and electrochemistry of nitrogen base adducts of tetraacetato diruthenium (Ⅱ,Ⅲ):Dependence of redox potential and Ru -Ru bond lengthon axial ligand donor strength显示文摘 | GV amvounis J F Caplan Cameron T S | 2000 | Inorg Chim Acta2000,304,: | 1 |
| 18 | Characterization of a S-adenosylmethionine synthase gene in rice 显示文摘 | Breusegem F Van Dekeyser R Gielen J Caplan A | 1994 | Plant Physiology1994,105,: | 1 |
| 19 | Practice Guidelines for Management of the Difficult Airway: An Updated Report by the American Society of Anesthesiologists Task Force on Management of the Difficult Airway显示文摘 | Jeffrey L. Apfelbaum Carin A. Hagberg Robert A. Caplan Casey D. Blitt Richard T. Connis David G. Nickinovich Carin A. Hagberg Robert A. Caplan Jonathan L. Benumof Frederic A. Berry Casey D. Blitt Robert H. Bode Frederick W. Cheney Richard T. Connis Orin F | 2013 | Anesthesiology2013,,2: | 1 |
| 20 | Comparing on -pump and off- pump coronary artery bypass grafting: numerous studies but few conclusions: a scientific statement from the American Heart Association council on cardiovascular surgery and anesthesia in collaboration with the interdisciplinary working group on quality of care and outcomes research显示文摘 | SELLKE F W DIMAIO J M CAPLAN L R | 2005 | Circulation2005,111,21: | 1 |