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| 1 | 动脉粥样硬化血栓形成门诊患者1年内心血管事件的发生率显示文摘背景:目前,有关社区中动脉粥样硬化血栓形成稳定患者心血管(cardiovascular,CV)事件发生率的资料比较少,既往也无国际性队列研究对冠状动脉病(coronary artery disease,CAD)、脑血管病(cerebrovascular disease,CVD)、外周动脉病(peripheral arterial disease,PAD)确诊患者以及此类疾病高危患者不同事件的发生率进行评估。
目的:在患有动脉疾病的门诊患者或存在多个动脉粥样硬化血栓形成危险因素的门诊患者中确定当今世界1年内CV事件的发生率。
设计、地点及参试者:“减少动脉粥样硬化血栓形成维系健康(Reduction of Artherotllrombosis for Continued Health,REACH)”注册研究是一项国际前瞻性队列研究。研究人员于2003—2004年从44个国家、5587名医生入选68236例已确诊的动脉粥样硬化性血管病患者(CAD、PAD、CVD;n=55814)以及至少存在3个动脉粥样硬化血栓形成危险因素的患者(n=12422)。
主要观测指标:CV死亡、心肌梗死(myocardial infarction,MI)及卒中的发生率。结果:截至2006年7月,共有95.22%的患者(n=64977)提供了1年内的结局。心血管死亡、MI及卒中的总体发生率为4.24%;动脉粥样硬化性血管病患者为4.69%,仅存在多个危险因素的患者为2.15%。CAD、CVD及PAD患者CV死亡、MI及卒中的总体发生率分别为4.52%、6.47%和5.35%。CAD、CVD及PAD患者发生终点事件(即CV死亡、MI、卒中)以及因动脉粥样硬化血栓形成事件入院的几率分别为15.20%、14.53%和21.14%。上述事件发生率随症状性动脉疾病病变部位数量的增加而增加,仅存在危险因素的患者为5.31%,有1处症状性动脉疾病的患者为12.58%,有2处症状性动脉疾病的患者为21.14%,有3处症状性动脉疾病的患者为26.27%(趋势P〈0.001)。
结论:在这项当代大型国际研究中,患有动脉粥样硬化性血管病的门诊患者以及有动脉粥样硬化血栓形成危险的门诊患者CV事件的年发生率相对较高。存在多部位病变者CV事件的1年发生率升高。 | Gabriel Steg Deepak L. Bhatt Peter W. F. Wilson Ralph D' Agostino E. Magnus Ohman Joachim Roether Chiau-Suong Liau Alan T. Hirsch Jean-Louis Mas Yasuo Ikeda Michael J. Pencina Shinya Goto 徐成斌(译) 李呈亿(校) | 2007 | 美国医学会杂志(中文版)2007，26，4： | 20 |
| 2 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 3 | Protecting subjects' interests in genetics research 显示文摘 | Merz J F Magnus D Cho M K Caplan A L | 2002 | Am J Hum Genet2002，70，4： | 1 |
| 4 | Integrons: natural tools for bacterial genome evolution显示文摘 | Rowe Magnus DA Mazel D | 2001 | Curt Opin Mierobiol2001，4，5： | 1 |
| 5 | A survey of faults on induction motors in offshore oil industry,petrochemical industry,gas terminals,and oil refineries显示文摘 | Olav V T Magnus D | 1995 | IEEE Transactions on Industry Applications1995，31，5： | 1 |
| 6 | ML estimation of time and frequency offset in OFDM systems 显示文摘 | JAN - JAAP V D B MAGNUS S | 1997 | IEEE Transactions on Signal Processing1997，45，7： | 1 |
| 7 | Microvesicles as me- diators of intercellular communication in cancer-the e- merging science of cellular debris 显示文摘 | Lee TH D'Asti E Magnus N | 2011 | Semin Immuno- pathol2011，33，5： | 1 |
| 8 | Sulfur accumulation in the timbers of King Henry VIII's warship Mary Rose: A pathway in the sulfur cycle of conservation concern显示文摘 | Magnus S Farideh J Emiliana D | 2005 | Proc Nat Acad Sci USA2005，102，14： | 1 |
| 9 | Bacterial resistance evolution by recruitment of super - integron gene cassettes 显示文摘 | ROWE MAGNUS D A GUEROUT A M MAZEL D | 2002 | Mol Microbiol2002，43，6： | 1 |
| 10 | Genetic pathways linking hemostasis and cancer显示文摘 | Garnier D Magnus N D'Asti E | 2012 | Thromb Res2012，1291，： | 1 |
| 11 | Microvesicles as mediators of intercellular communication in cancer-the emerging science of cellular 'debris' 显示文摘 | Lee TH D'Asti E Magnus N | 2011 | Semin Immunopathol2011，33，2： | 1 |
| 12 | Influence of plasticizer-free CAPD bags and tubings on serum, urine, and dialysate levels of phthalic acid esters in CAPD patients显示文摘 | Mettang T Pauli Magnus C Alscher D M | 2000 | Perit Dial Int2000，20，1： | 1 |
| 13 | Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations显示文摘 | Magnus N Garnier D Meehan B | 2014 | Proc Natl Acad Sci U S A2014，111，9： | 1 |
| 14 | Super integrons 显示文摘 | Rowe Magnus DA Guerout AM Mazel D | 1999 | Res Microbio1999，150，910： | 1 |
| 15 | Early response to false claims in Wikipedia显示文摘 | Magnus P D | 2008 | First Monday2008，13，9： | 1 |
| 16 | The Karolinska cocktail for phenotyping of five human cytochrome P450 enzymes显示文摘 | Magnus C Katarina A Per D | 2003 | Clin Pharmacol Ther2003，73，6： | 1 |
| 17 | The role of integrons in antibiotic re- sistance gene capture 显示文摘 | Rowe - Magnus DA Mazel D | 2002 | Int J Med Microbiol2002，292，2： | 1 |
| 18 | Oncogenic epidermal growth factor receptor upregulates multiple elements of the tissue factor signaling pathway in human glioma cells显示文摘 | MAGNUS N GARNIER D RAK J | | Blood0，116，5： | 1 |
| 19 | Serologic syndrome induced by venlafaxine and fluoxetine:a casein polypharmacy and potential pharmacody mamic and pharmacokinetic mechanisms显示文摘 | Bhatera V S Magnus R D Paul K L | 1998 | J Ann Pharmacotherapy1998，32，： | 1 |
| 20 | Oxidation of phenols to hydroxycyclohexadienones using diphenylseleninic anhydride显示文摘 | Magnus P D Rosenfeld M N | 1975 | J Chem Soc Chem Commun1975，，8： | 1 |
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