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| 1 | Dietary approach and gut microbiota modulation for chronic hepatic encephalopathy in cirrhosis显示文摘Hepatic encephalopathy(HE)is a common and serious neuropsychiatric complication of cirrhosis,acute liver failure,and porto-systemic shunting.HE largely contributes to the morbidity of patients with liver disease,severely affecting the quality of life of both patients and their relatives and being associated with poor prognosis.Its presentation is largely variable,manifesting with a broad spectrum of cognitive abnormalities ranging from subtle cognitive impairment to coma.The pathogenesis of HE is complex and has historically been linked with hyperammonemia.However,in the last years,it has become evident that the interplay of multiple actors,such as intestinal dysbiosis,gut hyperpermeability,and neuroinflammation,is of crucial importance in its genesis.Therefore,HE can be considered a result of a dysregulated gut-liverbrain axis function,where cognitive impairment can be reversed or prevented by the beneficial effects induced by“gut-centric”therapies,such as non-absorbable disaccharides,non-absorbable antibiotics,probiotics,prebiotics,and fecal microbiota transplantation.In this context dietary modifications,by modulating the intestinal milieu,can also provide significant benefit to cirrhotic patients with HE.This review will provide a comprehensive insight into the mechanisms responsible for gut-liver-brain axis dysregulation leading to HE in cirrhosis.Furthermore,it will explore the currently available therapies and the most promising future treatments for the management of patients with HE,with a special focus on the dietary approach. | Daniela Campion Ilaria Giovo Paola Ponzo Giorgio M Saracco Federico Balzola Carlo Alessandria | 2019 | World Journal of Hepatology2019，11，6： | 8 |
| 2 | Early dynamic transcriptomic changes during preoperative radiotherapy in patients with rectal cancer: A feasibility study显示文摘AIM: To develop novel biomarkers of rectal radiotherapy, we measured gene expression profiles on biopsies taken before and during preoperative radiotherapy. METHODS: Six patients presenting with a locally advanced rectal cancer (T>T2, N0/Nx, M0) eligible for preoperative radiotherapy (45 Gy in 25 fractions) were selected in a pilot study. Six tumor and 3 normal tissues biopsies were taken before and during radiotherapy,after a dose of 7.2 Gy at a median time of 1 h following irradiation (0:27-2:12). Tumor or normal tissue purity was assessed by a pathologist prior to RNA extraction. Mean RNA content was 23 μg/biopsy (14-37) before radiotherapy and 22.7 μg/biopsy (12-35) during radiotherapy. After RNA amplification, biopsies were analysed with 54K HG-U133A Plus 2.0 Affymetrix expression micro-arrays. Data were normalized according to MAS5 algorithm. A gene expression ratio was calculated as: (gene expression during radiotherapy-gene expression before radiotherapy)/gene expression before radiotherapy. Were selected genes that showed a ratio higher than ± 0.5 in all 6 patients. RESULTS: Microarray analysis showed that preoperative radiotherapy significantly up-regulated 31 genes and down-regulated 6 genes. According to the Gene Ontology project classification, these genes are involved in protein metabolism (ADAMDEC1 ; AKAP7 ; CAPN5 ; CLIC5 ; CPE ; CREB3L1 ; NEDD4L ; RAB27A), ion transport (AKAP7 ; ATP2A3 ; CCL28 ; CLIC5 ; F2RL2 ; NEDD4L ; SLC6A8), transcription (AKAP7 ; CREB3L1 ; ISX ; PAB-PC1L ; TXNIP), signal transduction (CAPN5 ; F2RL2 ; RA- B27A ; TNFRSF11A), cell adhesion (ADAMDEC1 ; PXDN ; SPON1 ; S100A2), immune response (CCL28 ; PXDN ; TNFRSF11A) and apoptosis (ITM2C ; PDCD4 ; PVT1). Up-regulation of 3 genes (CCL28 ; CLIC5 ; PDCD4) was detected by 2 different probes and up-regulation of 2 genes (RAB27A ; TXNIP) by 3 probes. CONCLUSION: Micro-arrays can efficiently assess early transcriptomic changes during preoperative radiotherapy for rectal cancer, and may help better understand tumor radioresistance. | Stephane Supiot Wilfried Gouraud Loc Campion Pascal Jezéquel Bruno Buecher Josiane Charrier Marie-Francoise Heymann Marc-Andre Mahé Emmanuel Rio Michel Chérel | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 3 | Inhibition of proteasome and Shaggy/Glycogen synthase kinase-3beta kinase prevents clearance of phosphorylated tau in Drosophila显示文摘 | BLARD O FRéBOURG T CAMPION D | 2006 | J Neurosci Res2006，84，5： | 1 |
| 4 | Sentinel lymph node biopsy after neoadjuvant chemotherapy for advanced breast cancer: results of Ganglion Sentinelle et Chimiotherapie Neoadjuvante, a French prospective muhicentric study 显示文摘 | Classe JM Bordes V Campion L | 2009 | J Clin Oncol2009，27，5： | 1 |
| 5 | Immunity显示文摘 | Theze J Mccanee OJ Campion MJ | 1996 | Today1996，17，10： | 1 |
| 6 | Association study between schizophrenia and monoamine oxidase A and B DNA polymorphisms显示文摘 | Coron B Campion D Thibaut F | 1996 | Psychiatry Res1996，62，3： | 1 |
| 7 | Pneumonectomy vs lobectomy in the treatment of pathologic N1 NSCLC:could the type of surgical resection dictate survival显示文摘 | Luzzi L Voltolini L Campione A | | Journal of Cardiovascular Surgery(Torino)0，，： | 1 |
| 8 | Beyond employment interview validity:A comprehensive narrative review of recent research and trends over time显示文摘 | Posthuma R A Morgeson F P Campion M A | | 0，，01： | 1 |
| 9 | Doing competencies well:best practics in competency modeling显示文摘 | Michael A Campion Alexis A Fink Brian J Ruggeberg Linda Carr Geneva M Phillips Ronald B Odman | 2011 | Personnel Psychology2011，，22： | 1 |
| 10 | Aldosterone impairs insulin responsiveness in U-937 hunmn promonocytic cells via the downregulation of its own receptor显示文摘 | Campion J Maestro B Molero S | 2002 | Cell Biochem Funct2002，20，3： | 1 |
| 11 | Siliclastic sequence stratigraphy in well logs, cores, and outcrop concepts for high-resolution correlation of time and facies显示文摘 | Van Wagoner J C Mitchum R M Campion K M | 1990 | AAPG Methods in Exploration Series1990，7，： | 1 |
| 12 | A review of the role of swine skeletal muscle in malignant hyperthermia 显示文摘 | Campion D R Topel D G | 1975 | Journal of Animal Science1975，41，： | 1 |
| 13 | Silieiclastic sequence stratigraphy in well logs, cores, and outcrops: Con- cepts for high resolution correlation of time and facies显示文摘 | Van W J C Mitchum R M Campion K M et at | 1990 | AAPG Methods in Exploration1990，7，： | 1 |
| 14 | Sentinel lymph nodebiopsy after neoadjuvant chemotherapy for advanced breast cancer:results of Ganglion Sentinelle et Chimiotherapie Neoadjuvante,a French prospective multicentric study显示文摘 | Classe JM Bordes V Campion L | 2009 | J Clin Oncol2009，27，5： | 1 |
| 15 | Leptin and TNF-alpha promoter methylation levels measured by MSP could predict the response to a low-calorie diet显示文摘 | Cordero P Campion J Milagro FI | | 0，，03： | 1 |
| 16 | Hydrogen photoproduction by Nation/cadmium sulfide/platinum films in water/sulfide ion solutions 显示文摘 | Mau AWH Huang CB Kakuta N Bard AJ Campion A Fox MA | 1984 | J Am Chem Soc1984，106，22： | 1 |
| 17 | Silicielastic sequence stratigraphy in well logs, cores and outcrops : Concept for high-rsolution correlation of time and faeies显示文摘 | Van Wagone J C Mitchum R M Campion K M | 1990 | AAPG (Methods in Exploration Series)1990，7，： | 1 |
| 18 | Hip fractures in the elderly: A world-wide projection 显示文摘 | Cooper C Campion G Melton LJ | 1992 | Osteoporosis Int1992，2，6： | 1 |
| 19 | The use of high-dose immunoglobulin in the treatment of pyoderma gangrenosum显示文摘 | Hagman JH Carrozzo AM Campione E | 2001 | J Dermatolog Treat2001，12，1： | 1 |
| 20 | Aldosterone impairs insulin responsiveness in U-937 human promonocytic cells via the downregulation of its own receptor显示文摘 | Campion J Maestro B Molero S | 2002 | Cell Biochem Funct2002，20，3： | 1 |
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