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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort显示文摘BACKGROUND Colorectal cancer(CRC) is the second most common cause of cancer death worldwide. It is broadly described that cyclooxygenase-2(COX-2) is mainly overexpressed in CRC but less is known regarding post-translational modifications of this enzyme that may regulate its activity, intracellular localization and stability. Since metabolic and proteomic profile analysis is essential for cancer prognosis and diagnosis, our hypothesis is that the analysis of correlations between these specific parameters and COX-2 state in tumors of a high number of CRC patients could be useful for the understanding of the basis of this cancer in humans.AIM To analyze COX-2 regulation in colorectal cancer and to perform a detailed analysis of their metabolic and proteomic profile.METHODS Biopsies from both healthy and pathological colorectal tissues were taken under informed consent from patients during standard colonoscopy procedure in the University Hospital of Bellvitge(Barcelona, Spain) and Germans Trias i Pujol University Hospital(Campus Can Ruti)(Barcelona, Spain). Western blot analysis was used to determine COX-2 levels. Deglycosylation assays were performed in both cells and tumor samples incubating each sample with peptide N-glycosidase F(PNGase F). Prostaglandin E2(PGE2) levels were determined using a specific ELISA. 1 H high resolution magic angle spinning(HRMAS) analysis was performed using a Bruker AVIII 500 MHz spectrometer and proteomic analysis was performed in a nano-liquid chromatography-tandem mass spectrometer(nano LC-MS/MS) using a QExactive HF orbitrap MS.RESULTS Our data show that COX-2 has a differential expression profile in tumor tissue of CRC patients vs the adjacent non-tumor area, which correspond to a glycosylated and less active state of the protein. This fact was associated to a lesser PGE2 production in tumors. These results were corroborated in vitro performing deglycosylation assays in HT29 cell line where COX-2 protein profile was modified after PNGase F incubation, showing higher PGE2 levels. Moreover,HRMAS analysis indicated that tumor tissue has altered metabolic features vs non-tumor counterparts, presenting increased levels of certain metabolites such as taurine and phosphocholine and lower levels of lactate. In proteomic experiments, we detected an enlarged number of proteins in tumors that are mainly implicated in basic biological functions like mitochondrial activity,DNA/RNA processing, vesicular trafficking, metabolism, cytoskeleton and splicing.CONCLUSION In our colorectal cancer cohort, tumor tissue presents a differential COX-2 expression pattern with lower enzymatic activity that can be related to an altered metabolic and proteomic profile. | Patricia Prieto Rafael I Jaén Daniel Calle María Gómez-Serrano Estefanía Nú?ez María Fernández-Velasco Paloma Martín-Sanz Sergio Alonso Jesús Vázquez Sebastián Cerdán Miguel ángel Peinado Lisardo Boscá | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 3 | Real-time detection of chlorpyrifos at part per trillion levels in ground,surface and drinking water samples by a portable surface plasmon resonance immunosensor显示文摘 | Mauriz E Calle A Lechuga LM | | 0，，1： | 1 |
| 4 | On-line determination of 3,5,6-trichloro-2-pyridinol in human urine samples by surface plasmon resonance immunosensing显示文摘 | Mauriz E Calle A Manclús J | | 0，，08： | 1 |
| 5 | Controver- sies in the Current Manageas显示文摘 | Moreno Egea A Baena Enrique G Calle Miquel C | 2007 | Arch Surg2007，142，： | 1 |
| 6 | Evidence for early defects in insulin sensitivity and secretion before the onset of glucose dysregulation in obese youths a longitudinal study显示文摘 | Giannini C Weiss R Call A | 2012 | Diabetes2012，61，3： | 1 |
| 7 | (6S)- Hydroxy - 3- oxo- a- ionol glucosides from Capparis spinosa fruits 显示文摘 | CALLS I KURUUZUM A LORENZETTO P A | 2002 | Phytochemistry2002，59，4： | 1 |
| 8 | Determination of carbaryl in natural water samples by a surface plasmon resonance flow-through immunosensor显示文摘 | Mauriz E Calle A Abad A | | 0，，11： | 1 |
| 9 | Hydrogen production by ethanol steam reforming over Cu-Ni supported catalysts显示文摘 | Vizcaíno A J Carrero A Calles J A | 2007 | Int J Hydrogen Energy2007，32，： | 1 |
| 10 | Preliminary pharmacologic and clinical evaluation of camptothecin sodium (NSC-100880) 显示文摘 | Gottlieb J A Guarino A M Call J B | 1970 | Cancer Chemother Rep1970，54，6： | 1 |
| 11 | Ce and La modification of mesoporous Cu-Ni/SBA-15 catalysts for hydrogen production through ethanol steam reforming 显示文摘 | Calles J A Carrero A Vizcaino A J | 2009 | Microporous and Mesoporous Materials2009，119，13： | 1 |
| 12 | Perspectives on fuel ethanol consumption and trade 显示文摘 | Walter A Rosillo Calle F Dolzan P | 2008 | Biomass and Bioenergy2008，32，8： | 1 |
| 13 | Integrated Mach-Zehnder interferometer based on ARROW structures for biosensor applications显示文摘 | Prieto F Sepulvede B Calle A | 2003 | Sensors and Actuators B2003，92，12： | 1 |
| 14 | Determination of environmental organic pollutans with a portable optical immunosensor显示文摘 | MAURIZ E CALLE A MONTOYA A | 2006 | Talanta2006，7，： | 1 |
| 15 | Cattle dung pat microenvironmental effects on germination and establishment on crested wheatgrass显示文摘 | Akbar G Call C A Wiedmeier R D | 1995 | Soil Research1995，，： | 1 |
| 16 | Optical immunosensor for fast and sensitive detection of DDT and related compounds in river water samples显示文摘 | Mauriz E Calle A Manclús JJ | | 0，，07： | 1 |
| 17 | Determination of environm ental organic pollutans with aportable optical immunosensor显示文摘 | MAURIZ E CALLE A MONTOYA A | 2006 | Talanta2006，69，2： | 1 |
| 18 | Method development for the determination of anthocyanins in red wines by high-performance liquid chromatography and classification of German red wines by means of multivariate statistical methods显示文摘 | Ba?lint Berente Demetrio De la Calle Garc??a Manfred Reichenba' cher edc | 2000 | Journal of Chromatography A2000，，871： | 1 |
| 19 | Sperm deoxyribonucleic acid fragmentation as assessed by the sperm chromatin dispersion test in assisted reproduc- tive technology programs~ results of a large prospective multicenter study显示文摘 | Velez de la Calle JF Muller A Walschaerts M | 2008 | Fertil Steril2008，90，5： | 1 |
| 20 | Mechanical Properties and Bio- compatibility of Two Polyepoxy Matrices:DGEBA-DDM and DGE- BA-IPD显示文摘 | Bemiet R Vinardt Calle A | 1987 | Biomaterials1987，8，3： | 1 |
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