|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | H pylori receptor MHC classⅡcontributes to the dynamic gastric epithelial apoptotic response显示文摘AIM: To investigate the role of MHC classⅡin the modulation of gastric epithelial cell apoptosis induced by H pylon infection. METHODS: After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specific for MHC classⅡand CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a fluorometric assay, a cytometric bead array, and confocal microscopy, respectively. RESULTS: Pretreatment of N87 cells with the anti-MHC classⅡIgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class n resulted in markedly reduced caspase activation, while simple ligation of MHC classⅡdid not. Crosslinking of MHC class n also resulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC classⅡIgM blocked the recruitment of FADD to the cell surface. CONCLUSION: The ability of MHC class n to modulate gastric epithelial apoptosis is at least partially dependent on its crosslinking. The crosslinking of this molecule has anti-apoptotic effects during the earlier time points of H pylori infection. This effect is possibly mediated by the ability of MHC classⅡto modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by H pylori-infected gastric epithelial cells. | David A Bland Giovanni Suarez Ellen J Beswick Johanna C Sierra Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，29： | 3 |
| 2 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 3 | H pylori receptor MHC class Ⅱ contributes to the dynamic gastric epithelial apoptotic response显示文摘AIM: To investigate the role of MHC class Ⅱ in the modulation of gastric epithelial cell apoptosis induced by H pylori infection.METHODS: After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specifi c for MHC class Ⅱ and CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a ? uorometric assay, a cytometric bead array, and confocal microscopy, respectively.RESULTS: Pretreatment of N87 cells with the anti-MHC class Ⅱ IgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class Ⅱ resulted in a marked re-duced caspase activation, while simple ligation of MHC class Ⅱ did not. Crosslinking of MHC class Ⅱ also re-sulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC class Ⅱ IgM blocked the recruitment of FADD to the cell surface.CONCLUSION: The results presented here demonstrate that the ability of MHC class Ⅱ to modulate gastric epi-thelial apoptosis is at least partially dependent on its crosslinking. Furthermore, while previous research has demonstrated that MHC class Ⅱ signaling can be pro-apoptotic during extended ligation, we have shown that the crosslinking of this molecule has anti-apoptotic ef-fects during the earlier time points of H pylori infection. This effect is possibly mediated by the ability of MHC class Ⅱ to modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by H pylori-infected gastric epithelial cells. | David A Bland Giovanni Suarez Ellen J Beswick Johanna C Sierra Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，33： | 2 |
| 4 | Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis显示文摘 | Suarez Y Fernandez Hernando C Yu J | 2008 | Proc Natl Acad Sci USA2008，105，14： | 1 |
| 5 | Biochemical traits and antimicrobial susceptibility of Streptococcus suis isolated from slaughtered pigs显示文摘 | Prieto C Garcia F J Suarez P | 1994 | J Vet Med1994，41，9： | 1 |
| 6 | Effect of transglutaminase- induced cross - linking on gelation of myofibrillar/soy protein mixtures 显示文摘 | Ramirez- Suarez J C Xiong Y L | 2003 | Meat Science2003，65，： | 1 |
| 7 | Ethyl carbamate production by selected yeasts and lactic acid bacteria in red wine显示文摘 | UTHURRY C A SUAREZ LEPE J A | 2006 | Food Chem2006，94，2： | 1 |
| 8 | Strategies for survival in fast changing industries显示文摘 | CHRISTENSEN C SUAREZ F UTTERBACK J | 1998 | Management Science1998，44，8： | 1 |
| 9 | Value of the ankle-brachial index in cardiovascular risk stratification of patients without known atherotrom-hotic disease显示文摘 | MANZANO L MOSTAZA J M SUAREZ C | 2007 | Med Clin (Barc)2007，128，： | 1 |
| 10 | Effect of vaccine use in the evolution of Mexican Lineage H5N2 avian influenza virus显示文摘 | Lee C W Sanne D A Suarez D L | 2004 | J Virol2004，78，15： | 1 |
| 11 | Competi-tive enzymelinked immunosorbent assay based on a rhoptry-associated protein 1epitope specifically identifies Babesia bo-vis-infected cattle显示文摘 | GOFF W L MCELWAIN T F SUAREZ C E | 2003 | Clin Diagn Lab Immunol2003，10，1： | 1 |
| 12 | Usefulness of the myocardial performance index for early detection of anthracycline-induced cardiotoxicity in children 显示文摘 | Eidem B W Sapp B G Suarez C R | 2001 | Am J Cardiol2001，87，9： | 1 |
| 13 | Primary treatment of the anterior vocal commissure squamous carcinoma 显示文摘 | BRADLEY P J RINALDO A SUAREZ C | 2006 | Eur Arch Otorhinolaryngal2006，263，10： | 1 |
| 14 | Cutting edge: TNF-induced microRNAs regulate TNF-induced expression of E-selectin and intercellular adhesion molecule-1 on human endothelial cells: feedback control of inflammation 显示文摘 | Suarez Y Wang C Manes TD | 2010 | J Immunol2010，184，1： | 1 |
| 15 | The Babesia borismerozoite surface antigen 2 locus contains four tandemly ar- ranged and expressed genes encoding immunologically distinct proteins显示文摘 | FLORIN C M SUAREZ C E HINES S A | 2002 | Infect Immun2002，70，7： | 1 |
| 16 | Protection of chickens against avian influenza with non--replicating adenovirus--vectored vaccine 显示文摘 | Toro H H Tang D C Suarez D L | 2008 | Vaccine2008，26，： | 1 |
| 17 | Absorption kinetics of sulfur dioxide in flint corn during steeping 显示文摘 | HAROS C M AGUERRE R J SUAREZ C | 2001 | LWT-Food Science and Technology2001，34，5： | 1 |
| 18 | Dicer dependent microRNAs regu late gene expression and functions in human endothe lial cells显示文摘 | SUAREZ Y FERNANDEZ-HERNANDO C POBER J S | 2007 | Circ Res2007，100，： | 1 |
| 19 | Petiveria alliacea: 2 Further flavonoids and triterpenes 显示文摘 | Delle M F Menichini F Suarez L E C | 1996 | Gaz Chim ltal1996，126，5： | 1 |
| 20 | C-reactive protein is associated with psychologcal risk factor of cardiovascular disease in apparently healthy adults 显示文摘 | SUAREZ E C | 2004 | Psychosom Med2004，66，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员